LOCUS       NM_001395996            8071 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens PWWP domain containing 4 (PWWP4), mRNA.
ACCESSION   NM_001395996
VERSION     NM_001395996.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8071)
  AUTHORS   Mallon,A.M., Platzer,M., Bate,R., Gloeckner,G., Botcherby,M.R.,
            Nordsiek,G., Strivens,M.A., Kioschis,P., Dangel,A., Cunningham,D.,
            Straw,R.N., Weston,P., Gilbert,M., Fernando,S., Goodall,K.,
            Hunter,G., Greystrong,J.S., Clarke,D., Kimberley,C., Goerdes,M.,
            Blechschmidt,K., Rump,A., Hinzmann,B., Mundy,C.R., Miller,W.,
            Poustka,A., Herman,G.E., Rhodes,M., Denny,P., Rosenthal,A. and
            Brown,S.D.
  TITLE     Comparative genome sequence analysis of the Bpa/Str region in mouse
            and Man
  JOURNAL   Genome Res 10 (6), 758-775 (2000)
   PUBMED   10854409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC236972.3.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458091.5/ ENSP00000498408.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC236972.3         132139-132216
            79-151              AC236972.3         133957-134029
            152-332             AC236972.3         136516-136696
            333-8071            AC236972.3         137394-145132
FEATURES             Location/Qualifiers
     source          1..8071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..8071
                     /gene="PWWP4"
                     /note="PWWP domain containing 4"
                     /db_xref="GeneID:728317"
                     /db_xref="HGNC:HGNC:55197"
     exon            1..78
                     /gene="PWWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            79..151
                     /gene="PWWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            152..332
                     /gene="PWWP4"
                     /inference="alignment:Splign:2.1.0"
     exon            333..8071
                     /gene="PWWP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..6729
                     /gene="PWWP4"
                     /codon_start=1
                     /product="PWWP domain-containing DNA repair factor 4"
                     /protein_id="NP_001382925.1"
                     /db_xref="CCDS:CCDS94692.1"
                     /db_xref="GeneID:728317"
                     /db_xref="HGNC:HGNC:55197"
                     /translation="MDSEYVLCSWKGRLWPAKVLCTRGTSPKTKPEKAISLEVQILAV
                     DEKIKVKSTDVKTPTKFEMEDIAASAAAQTKLGAPLREKMGYRGTLRVALEILKERTN
                     LGGGRKPHELESTTPSQLSQKVPEKPASSVPREDDWRCKGDLRRSLGKRENPSSPTVP
                     SESKRALRDDRSQEPTAIAPTPGALPGDRSGAPRAIAPTPGAMLSGRSRARRAIAPTP
                     SALRGYRSWAHRAIAPTPGCLYSDRSRAHRAIAPARGTKHGGRSWACRSIAPKPGSLC
                     GDRSQASRAIDPTLGARRGGRSRAHRAIAPTPGSLCGNRSRACGAIALTPGVLCGVRS
                     RVPKDITPTPGALRGYKSWVCRAIAPTPGALRGDRSAARTAVVRTPGALGRDRSRARS
                     AIASTPGTLQGNRSSVSKAIAPTPGALRGDRSAARTAFVPTPGALHRDRSRARSAIAS
                     TPGTLRGNTSSACKAIAPTPGALRGYKSWARRAIAPNPGAWRGYRSTTGTAIAPNLGA
                     LGGNRSAARTDIAPTPGALRGYRSWTRRAIAPTPGTLSSYRSRSRRTIASTPATLRGE
                     KSRAHTSLAPTPGALRGDGSRARRAIVPTTCPLCEIWSRVGIGIAPIADALRRDRSPV
                     RRAIAPTPGTLSGYRSRARTAIAPTPGTLRGYRPRSRRAIASTPATLRGEKSRAHTSL
                     APAPGALRGDGSRARRAIVPTTCPLCEIWSRVGIGIAPIADALRRDRPPVRRAIAPTP
                     GALRCDRSRELTAIDPTPGALCSDRSGASRAIAPTPGTLCSERSRVRRAIAPTPCALC
                     GKGSQVGMGVAPTPGALRRDRSQAGRAIAPTPSALFRVGSRVGTGIALPAGALHRDRS
                     PVRRAVAPTPGTLHCDGSRKCTATGSTPGALPGDRSGVSKATAPAPGALCSERSRARR
                     SIAPTPCLLCGDRSWVGMGIAPTPGALLGGKSRKCRAIAITPGALRGGRSQKRRVVAP
                     TPEALHGDGSWTYMAIAPTPGALHGDSSPAHTSIIPSPGALHGDGPPAHMAFPSTPGT
                     LHGDASHAHMAIAPTPGTMRGDSSTARTATAPSPGALRGDRSWKRKAIASTPGALHGN
                     RSDRSRKCKAIASTPGTLHVERSPALRAIVPTPGTLGRDSSPGRTSIIPSPGALHGDR
                     SPAHLDIASTPGALHGDSSQAHTAIAPTPGTMRGDSSTARMAIAPSAGALRGDRSWKR
                     KAIASTPGALRGNRSDRSRKRKAIASTPGALLGNRSDRSRKHKAIAPTPGAPRIDRSP
                     ACRAIAPTPGALGDDSSTAIAPTPGTPRGDSSPANTAIASTPGALHGDTSQTHKAIAP
                     TPGDLGGGSSSAHKAITPSPGALHGDRSPAHTAIASTPGALHGDSSQVHTTIAPTPGA
                     LRDDKSWKRKAIAPTPGTLHCDSSRTCTAFAPTPGALHADRSPAHQDITLTSGALHCD
                     SSRESRAVAPILGALHRVGSQAHKAIASTPGPLRGDSSPFHTAIAPMPGALHGTRSWK
                     REAISQTPFVTLCGDSSGERMAIAPTPGALHSDRSQTHTAIDPTPSVLRSDSSPACMA
                     IDPTPGALGRDRSQALMAIAPTPVGMQAHVLQSPRACQDSLTLSRHVCEKKGKKRANA
                     STLMSLPPTVTEEGASLPPGLTSPAPPALKEETQDSRPKKALAASPESSPFSGNIQDP
                     GEGAWKPGWAGMAASSGSRQHRLPSSLRLANRKRKRPGPDFQRRPQGPQTPGDAKLAN
                     PVTTIQRAGGKQDGQPPSLAFPQEPHPIERGTMVWFKFQDHPFWPAVVKSVSNTDKTA
                     RVLLLEANLHHGKRGIQVPLRRLKHLDCKEKEKLLKRAQKAYKQSVNWCFSLISHYRE
                     GLVRGSFRGSFLDYYAADISYPIRRAIQEGDLQIDFPKVNYGDLEDWEEETSLGGKRP
                     CKKILPDRMRASWDRDNQKLVDFIVRRKGADPHLLDILQGRKQSRWLTAFLKPHRDLH
                     CIETYLEDDDQLEVVAKHLQEIYKQIDKARLTLIRDDKVNFVLEVLLPEAMICTIAAL
                     DGLDYKAAEEKYLRGPPVHYREKELFDRNILKKARREPATTHTAN"
ORIGIN      
        1 ctttcctggc ggcagacaca catcgcaagg atatttacag agcggacagc tggaatagct
       61 gtaggaacgt caagactaat cccggtatgc ggaagtagat caatatttgc acatcgtgat
      121 ctagctggat ctgcaatata gacaggtaaa ggttgacatt aggagtgcat aggtcctgag
      181 catctacacg cggtgccact gggtcgccag aagaacagcg cacttcaggg gcacagagtg
      241 gggttgaagg gtctgcacac cagcgcttgc agtgtgagca gcaagagatc cagctcacag
      301 aaccaaacct gctgcgatcc atgtgacact ggcatactcc agaattgtcc attggaaaca
      361 cgagttcaag tgcctcaggg agattcagga ggaggaacac agcccaccca cactgcaccc
      421 cctttgcagt ctgaaggcaa gggatgctct gaagagcagc ttggtttagg agagacctac
      481 ggtagcagag ggtgtggcag gcagacccct cggcctccct tagctacctt ttcccagctc
      541 atcatggact cggagtacgt cctatgctct tggaaaggcc gactatggcc agcaaaggtt
      601 ttgtgcacac gtgggacttc accaaaaacg aagcctgaaa aggcgatttc tctagaagtt
      661 caaatcctcg cagtagatga aaaaatcaag gtgaaaagca cagacgtgaa gaccccaact
      721 aagtttgaga tggaagacat tgccgcctct gcagcagcac agacgaagct cggtgcccca
      781 ctcagagaga agatggggta cagaggaacc cttcgggtgg ccctggagat tctgaaagag
      841 agaacaaatc tgggtggagg aaggaaacca catgaactag agagcaccac accctctcag
      901 ctttctcaaa aggtgcccga aaagccagcc agttctgtcc ctcgtgaaga tgactggaga
      961 tgcaaaggcg acctaaggag gagtcttggg aagagggaaa acccaagctc accgacggtc
     1021 ccttcagaga gtaagcgtgc cctgcgggat gacaggtcgc aggagcccac agccattgcc
     1081 cctactccag gcgccctgcc cggggacagg tcaggggcgc ccagggccat tgcccctact
     1141 ccaggagcca tgctcagtgg caggtcacgg gcacgcaggg ccattgcccc tacgccaagc
     1201 gccctgcgag gttacaggtc ttgggcgcac agggccattg cccctacccc aggctgcctg
     1261 tacagtgaca ggtcacgggc gcacagggcc attgcccctg ctcgaggcac caagcatggt
     1321 ggcaggtcat gggcatgcag gtccattgcc cccaaaccag gctccctgtg cggggacagg
     1381 tcacaggcga gcagggccat tgaccctacc ttaggcgcca ggcgcggtgg caggtcacgg
     1441 gcccacagag ccattgcccc tactccaggc tccctgtgcg gcaacaggtc acgggcttgc
     1501 ggagccattg cccttactcc aggtgtcctg tgcggtgtca ggtcacgggt gccaaaggac
     1561 attaccccta ctccaggcgc cctgcgaggt tacaagtcat gggtgtgcag ggccattgcc
     1621 cctactccag gtgccctgcg cggagacagg tcagcagcac gcacggccgt tgtccgtact
     1681 ccaggtgccc ttggcaggga caggtcacgg gcacgcagcg ccattgcttc tactccaggg
     1741 accctgcagg gaaacaggtc atctgtgtcc aaggccattg cccctactcc aggtgccctg
     1801 cgtggagaca ggtcagcagc gcgcacggcc tttgtcccta ctccaggcgc ccttcacagg
     1861 gacaggtcac gggcccgcag cgccattgct tctactccag ggaccctgcg gggaaacacg
     1921 tcatctgcgt gcaaggccat tgcccctact ccaggtgccc tgcgaggtta caagtcatgg
     1981 gcgcgcaggg ccattgcacc taacccaggt gcctggcgcg gttacaggtc aacgacaggc
     2041 accgccattg cacctaatct gggcgccctg ggcggcaaca ggtcagcggc acgcacggac
     2101 attgccccta ctccaggcgc cctgcgaggt tacaggtcat ggacgcgcag ggccattgcc
     2161 cctactccag gcactctgag cagttacagg tcacggtccc gcaggaccat tgcctctact
     2221 ccagccaccc tgcgtggtga aaagtcacgg gcgcacacca gccttgcccc caccccaggt
     2281 gctttgcgcg gtgacggttc acgagcacgc agggccattg tccctactac atgcccattg
     2341 tgcgagatat ggtcacgggt gggcataggc attgccccta ttgcagatgc cctgcgccgt
     2401 gacaggtcac cagtgcgcag ggccattgcc cctactccag gcactctgag cggttacagg
     2461 tcacgggcac gcacggccat tgcccctact ccaggcaccc tgcgaggtta caggccacgg
     2521 tcccgcaggg ccattgcctc tactccagcc accctgcgtg gtgaaaagtc acgggcgcac
     2581 accagccttg cccccgcccc aggtgctttg cgcggtgacg gttcacgagc acgcagggcc
     2641 attgtcccta ctacatgccc attgtgcgag atatggtcac gggtgggcat aggcattgcc
     2701 cctattgcag atgccctgcg ccgtgacagg ccaccagtgc gcagggccat tgctcctact
     2761 ccaggcgccc tgcgctgtga caggtcacga gagctcacag ccattgatcc tactccagga
     2821 gctctgtgca gtgacaggtc aggggcaagc agggccattg cccccactcc aggcactttg
     2881 tgcagtgaaa ggtcccgggt gcgcagggcc attgccccta ctccatgcgc actgtgcggg
     2941 aaggggtcac aggtgggcat gggcgttgcc cctactccag gtgcactgcg cagggacagg
     3001 tcacaggcag gcagggccat tgcacctact ccatccgcac tgttcagggt tgggtcacgg
     3061 gtgggcacag gcattgccct tcctgcaggt gccctgcacc gtgacaggtc accggtgcgc
     3121 agggccgttg ctcccactcc aggcaccctg cactgtgacg ggtcacgaaa atgcacggcc
     3181 actggttcta ctccaggagc cctgcccggc gacaggtcag gggtgagcaa ggccactgcc
     3241 cctgctccag gcgccttgtg cagtgaaagg tcccgcgcac gcaggagcat tgcccctact
     3301 ccatgtttac tgtgcgggga caggtcatgg gtgggtatgg gcattgcacc tactccaggc
     3361 gccctgcttg gtggcaaatc aaggaaatgc agggccattg ctattactcc cggcgccctg
     3421 cgtggtggca ggtcacagaa acgcagggtc gttgctccta ctccagaggc cctgcacggt
     3481 gacgggtcat ggacttatat ggccattgct cctactccag gtgccctgca cggtgacagc
     3541 tcaccagccc acacgtccat tattccctct ccaggcgccc tgcatggtga cgggccacca
     3601 gcgcacatgg cctttccttc tactccaggc accctgcatg gtgatgcctc tcacgcacac
     3661 atggccattg ctcctactcc aggcacgatg cgcggtgaca gctcaacagc gcgcacggcc
     3721 actgccccat ctccaggggc cctgcgaggt gacaggtcat ggaaacgcaa ggccattgct
     3781 tctactccag gtgccctgca tggtaacagg tctgacaggt cacggaaatg caaggccatt
     3841 gcttctactc caggcaccct gcacgttgag aggtcaccag cactcagggc cattgttcca
     3901 actccaggca ccctgggccg tgacagctca ccagggcgca cgtccattat tccttctcca
     3961 ggcgccctgc atggtgacag gtcaccagca cacctggaca ttgcttctac tccaggcgcc
     4021 ctgcacggtg acagctctca ggcacacacg gccattgctc ctactccagg caccatgcgc
     4081 ggtgacagct caacagctcg catggccatt gccccatctg caggggccct gagaggtgac
     4141 aggtcatgga aacgcaaggc cattgcttct actccaggtg ccctgcgtgg taacaggtct
     4201 gacaggtcac ggaaacgcaa agccattgct tctactccag gtgccctgct cggtaacagg
     4261 tctgacaggt cacggaaaca caaggccatt gctcctactc caggtgcccc gcgcattgac
     4321 aggtcaccag catgcagggc cattgctcct actccaggcg ccctgggtga tgacagctca
     4381 acggccattg cccctactcc agggaccccg cgaggtgaca gttcgccagc aaacacggcc
     4441 attgcttcta ctccaggcgc cctgcacggt gacacctctc agacacacaa ggccattgct
     4501 cctactccag gtgacctggg cggtggcagc tcatcagcgc acaaggccat cactccttct
     4561 ccaggtgccc tgcatggtga caggtcacca gcacacacgg ccattgcttc tactccagga
     4621 gccctgcatg gtgacagctc ccaggtgcac acgaccattg ctccaactcc aggcgccctg
     4681 cgcgatgaca agtcatggaa acgcaaggcc attgctccca ctccaggcac cctgcactgt
     4741 gacagctcac gaacgtgcac cgcctttgct cctactccag gcgccctgca tgctgacagg
     4801 tcaccagcgc accaggacat tactcttact tcaggcgccc tgcactgtga cagctcaaga
     4861 gaaagcaggg ccgttgctcc tattctaggc gccctgcacc gtgtcggctc tcaggcacac
     4921 aaggctattg cttctactcc aggccctctg cgcggtgaca gctcaccatt tcacacagcc
     4981 attgcaccta tgccaggggc cctgcatggt accaggtcat ggaaacgcga agccatttct
     5041 cagactccat ttgtcaccct gtgtggtgac agctcaggag aacgcatggc cattgctcct
     5101 actccaggcg ccctgcacag tgacaggtca cagacacata cggccatcga tcctactcca
     5161 agtgtcctgc gcagtgacag ctcaccagcg tgcatggcca ttgatcctac tccaggtgcc
     5221 ctgggcaggg acaggtcaca ggcgctcatg gccattgctc ctactccagt tggaatgcaa
     5281 gcacatgtgt tgcaaagccc ccgagcctgc caggattccc tgacgctttc gcggcatgtt
     5341 tgtgagaaaa aggggaagaa aagggcaaac gcctcgactc ttatgtccct gcctcccaca
     5401 gtaacggagg agggtgcatc tctgcctcca ggtctcacca gccctgcacc ccccgctctg
     5461 aaggaagaga cacaggacag ccgcccgaag aaggccctgg ctgcatcccc ggaaagttct
     5521 cccttctcgg gaaacattca ggaccccgga gagggtgcct ggaagccagg ctgggcaggt
     5581 atggctgcat cctctgggtc ccgtcagcac aggctgcctt cttcactccg gcttgccaat
     5641 agaaaaagga agcgtccagg tccagatttt cagaggagac ctcaaggacc tcagacgcct
     5701 ggtgacgcta agcttgctaa tcctgtcacc accattcaaa gggctggcgg taaacaggat
     5761 gggcagcccc ccagccttgc ttttccacag gagccacatc ccatcgaaag gggaacgatg
     5821 gtctggttca aatttcaaga tcatccgttt tggccagcag tggtcaagag tgtcagcaac
     5881 acagacaaga ccgcgagggt gctcctgctt gaggccaacc tgcaccatgg aaagcggggc
     5941 attcaagttc ctcttcgaag gctgaagcac ctggattgta aggagaaaga gaaactgctg
     6001 aagagagccc agaaggccta caagcaaagc gtcaactggt gcttctcact gatctcccac
     6061 tacagagaag gactggtccg gggttctttc cggggctctt tcctggacta ttatgccgca
     6121 gacatcagct acccaatcag gagagccatc caagagggag acctgcagat tgactttcca
     6181 aaggtgaatt atggcgacct ggaagactgg gaggaggaga cctccctggg cgggaagagg
     6241 ccttgcaaga aaatcctccc ggaccggatg agggcctctt gggaccgaga caaccagaag
     6301 ctcgtggact tcatcgtgag gagaaagggg gccgaccccc accttctgga catcttgcaa
     6361 ggcaggaagc agtccaggtg gctgaccgcg tttctgaagc cacacaggga tttgcactgc
     6421 attgaaacat acctggagga tgacgatcag ttggaagtcg tggccaagca tttacaagaa
     6481 atctacaagc aaattgacaa ggccaggctg actctgataa gggatgacaa agtcaatttt
     6541 gttctggaag ttcttctgcc ggaagccatg atttgtacca tcgccgcact tgatgggctg
     6601 gattacaagg cagcagagga gaagtacctg cgaggaccac ctgtgcatta ccgggagaaa
     6661 gagctgtttg acagaaatat cttaaagaag gcaagaagag aaccagcaac cacccataca
     6721 gctaattagc tcccgcctgc ctcccccgca cccatacctt cccagggagc tgcctccttt
     6781 ctagaattaa tgaggaagcc tcctcccttc cccaacgcgt gtaagtatgt tctggatatt
     6841 cgagactttg ggaatgtgag gaattcattt ggggcccatc tctcgcatgt gctggtggca
     6901 cattcatcac caggtcttca tcgcaaactc gtgaagagct attttgttaa acgattgcaa
     6961 ccccttgcga ttccctcaac gtctttggat gtgtagttgt cccgataggt ttgaaagaca
     7021 agagcattga ttttcataac gtgtcttttg actggacttg gtactttcac ttaggaccta
     7081 tattctttta cacaaaaagc cactggtatc agcttttaaa caacaataat ttttaaagcc
     7141 taatgtatat ttttatggaa acgtcagtga gacttttcat tcttttggcg atacgtggat
     7201 agaaaccatc agattcctct ttcagataat tcctgccttt tccctgctag gcttgtttat
     7261 tttttgaaaa gtagccccga gagttgaatc ccatgagaga gtcattttct cctatgttaa
     7321 cacgaccttc cgatactttt tcaaaaagca aactgcaggc caaacatgaa gttaccgaat
     7381 ggcttgcacg tagtccatat gtgcttgagt gaaatctcag tgtgcagtga gcgtcttgtc
     7441 agcctcatgc aagattgtcg ctctgcattt ccctgaaatt ccacaccctc cttcaacggc
     7501 tgaactgttt cctagaacag gcttcaggct gtcttcataa ctgacagtga tggatcttct
     7561 ccctctaact gtcggtcccc tgtggagggc agctagagcc atctccttct tggcctggct
     7621 tctctccacc tgtgtggctg gcccaactgc ttaggagccc gtctacctgc ccgtaaactg
     7681 gagtaaagcc agctccttgt tctggatcca gaatccccca agacgtggcc atttgtctca
     7741 atgtcaccaa gcttcatctt ccaacttatt cacgggccgg ctccaacagg tcccaacaat
     7801 ctagacacag gctggtaagc cattcccggc tgctagaggc gccagggctg ggagttggaa
     7861 aaatgggtca caggggcagc cttcattccg ctaagtgggg ccggcccttg gtggaataat
     7921 attaaacaga tgcaattcag acctaagttg tgaagcccac agattgctag gctaacttga
     7981 aacaagatgg tttttgagga taagtgttat ggaaaagcca gtttgttttt caaacttgat
     8041 gctaaaataa acgtgaaggc cttcacatga a
//
