LOCUS       NM_001171020            4173 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens PWWP domain containing 3B (PWWP3B), transcript variant
            1, mRNA.
ACCESSION   NM_001171020
VERSION     NM_001171020.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4173)
  AUTHORS   Zhang,L., Wu,X., Fan,X. and Ai,H.
  TITLE     MUM1L1 as a Tumor Suppressor and Potential Biomarker in Ovarian
            Cancer: Evidence from Bioinformatics Analysis and Basic Experiments
  JOURNAL   Comb Chem High Throughput Screen 26 (14), 2487-2501 (2023)
   PUBMED   36856181
  REMARK    GeneRIF: MUM1L1 as a Tumor Suppressor and Potential Biomarker in
            Ovarian Cancer: Evidence from Bioinformatics Analysis and Basic
            Experiments.
REFERENCE   2  (bases 1 to 4173)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4173)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB445635.1, DA720504.1,
            BC109292.1, Z68289.1 and AA412505.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001171020.1.
            
            Summary: This gene encodes a protein which contains a mutated
            melanoma-associated antigen 1 domain. Proteins which contain
            mutated antigens are expressed at high levels on certain types of
            cancers. Multiple alternatively spliced variants, encoding the same
            protein, have been identified. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.231585.1,
                                           SRR1803616.157917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357175.6/ ENSP00000349699.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               DB445635.1         1-136
            137-585             DA720504.1         126-574
            586-2847            BC109292.1         200-2461
            2848-4172           Z68289.1           23515-24839
            4173-4173           AA412505.1         12-12               c
FEATURES             Location/Qualifiers
     source          1..4173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..4173
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /note="PWWP domain containing 3B"
                     /db_xref="GeneID:139221"
                     /db_xref="HGNC:HGNC:26583"
     exon            1..121
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..249
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..435
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..4173
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..2740
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /note="mutated melanoma-associated antigen 1-like protein
                     1; PWWP domain-containing protein MUM1L1; MUM1-like
                     protein 1; melanoma associated antigen (mutated) 1-like 1;
                     MUM1 like 1"
                     /codon_start=1
                     /product="PWWP domain-containing DNA repair factor 3B"
                     /protein_id="NP_001164491.1"
                     /db_xref="CCDS:CCDS55469.1"
                     /db_xref="GeneID:139221"
                     /db_xref="HGNC:HGNC:26583"
                     /translation="MESEYVLCNWKDQLWPAKVLSRSETSSNSKRKKAFSLEVQILSL
                     DEKIKLDSTETKILNKSQIEAIAASLGLQSEDSAPPTEETAYGRSLKVALGILNERTN
                     LSQASTSDEEEITMLSQNVPQKQSDSPPHKKYRKDEGDLPGCLEERENSACLLASSES
                     DDSLYDDKSQAPTMVDTIPSEVETKSLQNSSWCETFPSLSEDNDEKENKNKIDISAVM
                     SVHSAVKEESACVKDEKFAPPLSPLSSDMLIMPKALKEESEDTCLETLAVPSECSAFS
                     ENIEDPGEGPSNPCLDTSQNQPSMESEMGAAACPGSCSRECEVSFSASNPVWDYSHLM
                     SSERNFQRLDFEELEEEGQASDKSLLPSRINLSLLDDDEEDEELPRFILHYETHPFET
                     GMIVWFKYQKYPFWPAVIKSIRRKERKASVLFVEANMNSEKKGIRVNFRRLKKFDCKE
                     KQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADISYPVRKETKQD
                     TFRNKFPKLHNEDAREPMAVTSQTKKMSFQKILPDRMKAARDRANKNLVDFIVNAKGT
                     ENHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEVCNQIDQIM
                     PTWIKDDKIKFILEVLLPEAIICSISAVDGLDYEAAEAKYLKGPCLGYRERELFDAKI
                     IYEKRRKAPTNEAH"
     regulatory      4152..4157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /note="hexamer: AATAAA"
     polyA_site      4173
                     /gene="PWWP3B"
                     /gene_synonym="MUM1L1"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcggg gaggagctgc attacacaca ggcttcggag gcttccgtgg agaagcttgg
       61 aggtaatggc tgtcgtaaat gctagttatt ttcagagagt tctcgaagat ttggaataaa
      121 gccgagcccc agaaagacag gtcaaccaca gaagtgctga gccaggtaaa gaccctgctg
      181 gacaagcagc tggagtgaga atcaagacag ctggaccaca ggaccagacc cagcagtatc
      241 catgtaacac ataggttaat atcagagaag cacatgacct gggcaatctg catgtgatgc
      301 caaccaagcc ttggaaagac agtgcaacca cagaagtgcc gagctgggta aaggccctgc
      361 tggacaagca gttggagtga gaatcaagac agccggacca caggaccaga cccaccagga
      421 tccacatgac agtggtatct tccggtatca tcctattcaa acaacgtgtt caagcatcct
      481 tggaaaattg aggtggagaa caggccacac aagctgtaaa ccctttgtag tcataagacg
      541 aaagaggatt tgttaagagt attgttttgg gtagaacttg cattagcagt gacaaagata
      601 gccacctcaa cctttggtaa taacccttgg cacacaaata taaaccataa tggagtctga
      661 gtatgtccta tgcaactgga aagaccagtt gtggccagca aaagttttgt ccagatctga
      721 aacttcatca aacagtaaga ggaaaaaggc attttctcta gaagttcaaa tactctcact
      781 agatgaaaaa attaaattgg acagcacaga aacaaagatc ctaaataaat ctcaaattga
      841 agccattgct gcctcattag gactacagtc agaggacagt gctccaccta cagaggaaac
      901 tgcctatgga agatcactaa aagtggcact gggtattctg aatgagagaa caaatttgag
      961 tcaagcaagc acttcagatg aagaggagat cactatgctg tctcaaaatg taccacaaaa
     1021 acagtccgat tcaccccctc ataaaaaata ccggaaggat gaaggtgact taccagggtg
     1081 tcttgaggaa agggaaaact cagcatgctt gttagcatct tcagagagtg atgattccct
     1141 gtatgatgat aaatcacaag cacccacaat ggtcgatact attccaagtg aagtggaaac
     1201 aaagtcatta caaaactcta gctggtgcga gactttccct tcactttcgg aagataatga
     1261 tgaaaaagag aacaagaata agattgatat ctcagcagtt atgtctgtgc attctgcagt
     1321 caaagaggaa agtgcatgtg ttaaagatga aaagtttgct ccacctttgt cacctttgtc
     1381 atcagatatg ctcattatgc ccaaagcttt gaaagaagag agcgaggata cctgcctaga
     1441 gaccctggct gttccctctg aatgctctgc tttctcagag aatattgagg atcctggaga
     1501 gggtccctca aatccatgct tagataccag ccagaatcaa ccttccatgg aatcagagat
     1561 gggggctgca gcatgccctg ggagttgttc aagggaatgc gaggtttcat ttagtgcctc
     1621 taaccctgtc tgggattatt cacatcttat gagtagtgaa agaaattttc agagactgga
     1681 ttttgaagaa cttgaggaag aaggtcaagc ctctgacaag tcattgcttc caagtcgcat
     1741 taatctttct ctattagatg atgatgagga agacgaagaa cttccacgct tcattttaca
     1801 ttatgagaca catccgtttg aaacaggaat gatagtctgg tttaaatatc agaaatatcc
     1861 attttggcca gcagtgataa aaagtatcag acgaaaagag aggaaagcaa gtgtgctttt
     1921 tgttgaggca aacatgaatt ctgaaaagaa gggcattaga gtaaatttta gaagattaaa
     1981 gaaatttgat tgtaaagaga aacaaatgct agtggacaaa gccagggagg attatagtga
     2041 gagtattgac tggtgcatct cactaatttg tgactacaga gttagaatag gttgtggttc
     2101 tttcacgggc tctttgcttg agtattatgc tgctgatatt agttacccag ttaggaaaga
     2161 aacaaaacag gatactttca ggaacaaatt tccaaagctg cataatgaag atgccaggga
     2221 accgatggct gtaacttccc agaccaagaa aatgtccttc caaaaaattc tccctgaccg
     2281 gatgaaggct gctcgggacc gagccaacaa gaacctggtg gacttcattg tgaatgcaaa
     2341 gggaacagag aaccatcttc tggccattgt aaatggcaca aaaggatcca gatggctgaa
     2401 atcatttttg aatgcaaata ggttcacacc ctgtattgaa acatactttg aggatgaaga
     2461 tcagttggat gaagtggtga aatatttaca agaagtctgc aatcaaatag atcaaataat
     2521 gccaacttgg ataaaagatg ataaaattaa atttatccta gaagttcttc tgccagaagc
     2581 aattatttgt tcaatttctg ctgttgatgg gttagattac gaggcagctg aagcaaagta
     2641 tctaaaagga ccatgtctag gctacaggga aagagaatta tttgatgcaa aaataatata
     2701 tgaaaagaga cgaaaagcac caacaaatga agctcactaa atgtgctgaa agttgaaacc
     2761 atgacaggga gctctcatag atactagttg aaaaaagtct ctgaacaatt ctctctaata
     2821 catattttct gcaaatggga gcatggataa tgtgttcact tttttttgag atctctagga
     2881 tctgtggtta taattacatc tttatttcct tttcttgcgc ttcttcaaag ttaattttgt
     2941 caacatattt cagcagttct actttcccgt acatttttta gaaagcataa ttcctaaatg
     3001 attttgaagg gaaagtacta ttttgtttta tgacactttt gagtctatgc tgtattgtta
     3061 aatatattgt gcacaattat tttaatgtta aaattgcact ggtgttagat attaacgaag
     3121 atgattggaa aaaagtctga aagatacatc atttctatat tccttgctta atttttataa
     3181 aatattgggt tttcccttaa gatagttgaa gtatttttct tgccatgcct atttattttt
     3241 gcaaaaaaat tatctgctat atagaaccaa agatagattc gctttgctat atattataac
     3301 tatacttgct tttgcaataa aacaacttgt aattcaaaaa tgaagattat ctgcatatag
     3361 tatttatgtg tgtgaataac atcttggcat gcagaaaata attttggctg ctttgaacag
     3421 gattgttcat tctacacttc cctgaaattc catttttggg agtgtctatc cttcaatggc
     3481 tgaatagttc cttaaatcag acaagctcct ggctatcttc ataaccagca gtgagtagat
     3541 cttcttaata tagctgtctg accacatgtg gaaggcagct agacttattg tatttacagc
     3601 ctggccactc tagacatatg aatccaggct gactgcttaa gtgcccatct cgtttgatat
     3661 aaactgtaga aaaggcaagc actttgttct gagtctttta tctccaaata catagttgtc
     3721 tcaaaccaag caagctttat caaaatggct tatttgcaga atagttccaa tgatataaat
     3781 gccaactggc aagtcattcc aaactgcttg aaggagtaga tgaaccagaa tctgagaatt
     3841 tggaaatagg tcacagaaaa agcctccatt tggctaaata tgacaattat ctgagtatgg
     3901 ttaaatacat acaattaaat gtctgaagcc aatgagttgt ttattctaac ttgaaatata
     3961 tttttgtgag aataaatgtt agaaaagtta gtttattttg gaaacctgcc gtgaaaggaa
     4021 attctaaagg cttaacatga aactgtctgc atttctacct gttagacaat ggttgctctt
     4081 gggctcttgt tatacagtca tatggctaca cgtttatgta aagtttgcaa aagtttggtg
     4141 ttttgattta taataaaact gttatattat tca
//
