LOCUS       NM_001397246            1182 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens PVR related immunoglobulin domain containing (PVRIG),
            transcript variant 3, mRNA.
ACCESSION   NM_001397246
VERSION     NM_001397246.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   Hu,S., Han,P., Wang,M., Cao,X., Liu,H., Zhang,S., Zhang,S., Liu,J.,
            Han,Y., Xiao,J., Chen,Q., Miao,K., Qi,J., Tan,S., Gao,G.F. and
            Wang,H.
  TITLE     Structural basis for the immune recognition and selectivity of the
            immune receptor PVRIG for ligand Nectin-2
  JOURNAL   Structure 32 (7), 918-929 (2024)
   PUBMED   38626767
  REMARK    GeneRIF: Structural basis for the immune recognition and
            selectivity of the immune receptor PVRIG for ligand Nectin-2.
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   Yang,C., Mandelkow,T., Bady,E., Raedler,J.B., Simon,R., Sauter,G.,
            Lennartz,M., Buscheck,F., Luebke,A.M., Dum,D., Menz,A.,
            Hoflmayer,D., Weidemann,S., Fraune,C., Lebok,P., Uhlig,R.,
            Bernreuther,C., Jacobsen,F., Clauditz,T.S., Wilczak,W., Minner,S.,
            Burandt,E., Steurer,S. and Blessin,N.C.
  TITLE     Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T
            Lymphocytes Located in T Cell Nests of Colorectal Cancer
  JOURNAL   Mod Pathol 36 (4), 100089 (2023)
   PUBMED   36788088
  REMARK    GeneRIF: Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on
            Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal
            Cancer.
REFERENCE   3  (bases 1 to 1182)
  AUTHORS   Li,J., Whelan,S., Kotturi,M.F., Meyran,D., D'Souza,C., Hansen,K.,
            Liang,S., Hunter,J., Trapani,J.A. and Neeson,P.J.
  TITLE     PVRIG is a novel natural killer cell immune checkpoint receptor in
            acute myeloid leukemia
  JOURNAL   Haematologica 106 (12), 3115-3124 (2021)
   PUBMED   33147937
  REMARK    GeneRIF: PVRIG is a novel NK cell immune checkpoint receptor in
            acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1182)
  AUTHORS   Hansen,K., Kumar,S., Logronio,K., Whelan,S., Qurashi,S.,
            Cheng,H.Y., Drake,A., Tang,M., Wall,P., Bernados,D., Leung,L.,
            Ophir,E., Alteber,Z., Cojocaru,G., Galperin,M., Frenkel,M.,
            White,M., Hunter,J., Liang,S.C. and Kotturi,M.F.
  TITLE     COM902, a novel therapeutic antibody targeting TIGIT augments
            anti-tumor T cell function in combination with PVRIG or PD-1
            pathway blockade
  JOURNAL   Cancer Immunol Immunother 70 (12), 3525-3540 (2021)
   PUBMED   33903974
  REMARK    GeneRIF: COM902, a novel therapeutic antibody targeting TIGIT
            augments anti-tumor T cell function in combination with PVRIG or
            PD-1 pathway blockade.
REFERENCE   5  (bases 1 to 1182)
  AUTHORS   Jin,H.S. and Park,Y.
  TITLE     Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for
            next-generation cancer immunotherapy
  JOURNAL   BMB Rep 54 (1), 2-11 (2021)
   PUBMED   33298247
  REMARK    GeneRIF: Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis
            for next-generation cancer immunotherapy.
            Review article
REFERENCE   6  (bases 1 to 1182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1182)
  AUTHORS   Whelan,S., Ophir,E., Kotturi,M.F., Levy,O., Ganguly,S., Leung,L.,
            Vaknin,I., Kumar,S., Dassa,L., Hansen,K., Bernados,D., Murter,B.,
            Soni,A., Taube,J.M., Fader,A.N., Wang,T.L., Shih,I.M., White,M.,
            Pardoll,D.M. and Liang,S.C.
  TITLE     PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell
            Function
  JOURNAL   Cancer Immunol Res 7 (2), 257-268 (2019)
   PUBMED   30659054
  REMARK    GeneRIF: we demonstrate that PVRIG and PVRL2 are expressed in human
            cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant
            inhibitory signaling pathways.
REFERENCE   8  (bases 1 to 1182)
  AUTHORS   Xu,F., Sunderland,A., Zhou,Y., Schulick,R.D., Edil,B.H. and Zhu,Y.
  TITLE     Blockade of CD112R and TIGIT signaling sensitizes human natural
            killer cell functions
  JOURNAL   Cancer Immunol Immunother 66 (10), 1367-1375 (2017)
   PUBMED   28623459
  REMARK    GeneRIF: Blockade of TIGIT or CD112R, separately or together,
            enhances trastuzumab-triggered antitumor response by human NK
            cells.
REFERENCE   9  (bases 1 to 1182)
  AUTHORS   Zhu,Y., Paniccia,A., Schulick,A.C., Chen,W., Koenig,M.R.,
            Byers,J.T., Yao,S., Bevers,S. and Edil,B.H.
  TITLE     Identification of CD112R as a novel checkpoint for human T cells
  JOURNAL   J Exp Med 213 (2), 167-176 (2016)
   PUBMED   26755705
  REMARK    GeneRIF: Describe CD112R, a member of poliovirus receptor-like
            proteins, as a new coinhibitory receptor for T cells. CD112R is
            preferentially expressed on T cells and inhibits T cell
            receptor-mediated signals.
REFERENCE   10 (bases 1 to 1182)
  AUTHORS   Wilson,M.D., Cheung,J., Martindale,D.W., Scherer,S.W. and Koop,B.F.
  TITLE     Comparative analysis of the paired immunoglobulin-like receptor
            (PILR) locus in six mammalian genomes: duplication, conversion, and
            the birth of new genes
  JOURNAL   Physiol Genomics 27 (3), 201-218 (2006)
   PUBMED   16926269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005071.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073861.1, BX341127.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000699088.1/ ENSP00000514123.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC005071.2         17255-17334
            81-431              AC005071.2         17420-17770
            432-558             AC005071.2         17853-17979
            559-619             AC005071.2         18066-18126
            620-1182            AC005071.2         18234-18796
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1182
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /note="PVR related immunoglobulin domain containing"
                     /db_xref="GeneID:79037"
                     /db_xref="HGNC:HGNC:32190"
                     /db_xref="MIM:617012"
     exon            1..80
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..943
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; transmembrane protein PVRIG; poliovirus
                     receptor-related immunoglobulin domain-containing protein;
                     CD112 receptor; poliovirus receptor related immunoglobulin
                     domain containing; nectin-2 receptor"
                     /codon_start=1
                     /product="transmembrane protein PVRIG isoform 3 precursor"
                     /protein_id="NP_001384175.1"
                     /db_xref="CCDS:CCDS94154.1"
                     /db_xref="GeneID:79037"
                     /db_xref="HGNC:HGNC:32190"
                     /db_xref="MIM:617012"
                     /translation="MGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGF
                     LGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSG
                     ASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSG
                     VLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINT
                     SCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQA
                     GERPPHTGPGLTLFPDPRGPRAMEGPLGVR"
     exon            81..431
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /inference="alignment:Splign:2.1.0"
     exon            432..558
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /inference="alignment:Splign:2.1.0"
     exon            559..619
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1182
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1182
                     /gene="PVRIG"
                     /gene_synonym="C7orf15; CD112R"
                     /note="major polyA site"
ORIGIN      
        1 agaacctgga ctggaggggg ccatggggca ccggaccctg gtcctgccct gggtgctgct
       61 gaccttgtgt gtcactgcgg ggaccccgga ggtgtgggtt caagttcgga tggaggccac
      121 cgagctctcg tccttcacca tccgttgtgg gttcctgggg tctggctcca tctccctggt
      181 gactgtgagc tgggggggcc ccaacggtgc tggggggacc acgctggctg tgttgcaccc
      241 agaacgtggc atccggcaat gggcccctgc tcgccaggcc cgctgggaaa cccagagcag
      301 catctctctc atcctggaag gctctggggc cagcagcccc tgcgccaaca ccaccttctg
      361 ctgcaagttt gcgtccttcc ctgagggctc ctgggaggcc tgtgggagcc tcccgcccag
      421 ctcagaccca gggctctctg ccccgccgac tcctgccccc attctgcggg cagacctggc
      481 cgggatcttg ggggtctcag gagtcctcct ctttggctgt gtctacctcc ttcatctgct
      541 gcgccgacat aagcaccgcc ctgcccctag gctccagccg tcccgcacca gcccccaggc
      601 accgagagca cgagcatggg caccaagcca ggcctcccag gctgctcttc acgtccctta
      661 tgccactatc aacaccagct gccgcccagc tactttggac acagctcacc cccatggggg
      721 gccgtcctgg tgggcgtcac tccccaccca cgctgcacac cggccccagg gccctgccgc
      781 ctgggcctcc acacccatcc ctgcacgtgg cagctttgtc tctgttgaga atggactcta
      841 cgctcaggca ggggagaggc ctcctcacac tggtcccggc ctcactcttt tccctgaccc
      901 tcgggggccc agggccatgg aaggaccctt aggagttcga tgagagagac catgaggcca
      961 ctgggctttc cccctcccag gcctcctggg tgtcaccccc ttactttaat tcttgggcct
     1021 ccaataagtg tcccataggt gtctggccag gcccacctgc tgcggatgtg gtctctgtgt
     1081 gtgcgtgtgt gggcacaggt gtgagtgtgt gagtgacagt taccccattt cagtcatttc
     1141 ctgctgcaac taagtcagca acacagtttc tctgatgtcg gc
//
