LOCUS       NM_006505               5792 bp    mRNA    linear   PRI 16-AUG-2024
DEFINITION  Homo sapiens PVR cell adhesion molecule (PVR), transcript variant
            1, mRNA.
ACCESSION   NM_006505
VERSION     NM_006505.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5792)
  AUTHORS   Sun,T., Yang,N., Li,L., Zhang,X., Liu,H., Kusuman,N., Chu,J.,
            Lu,G., Aji,T., Bi,X. and Lin,R.
  TITLE     sCD155 as a potential marker for diagnosing the vascular invasion
            in hepatic alveolar echinococcosis
  JOURNAL   Acta Trop 255, 107203 (2024)
   PUBMED   38604326
  REMARK    GeneRIF: sCD155 as a potential marker for diagnosing the vascular
            invasion in hepatic alveolar echinococcosis.
REFERENCE   2  (bases 1 to 5792)
  AUTHORS   Baker,F.L., Smith,K.A., Mylabathula,P.L., Zuniga,T.M., Diak,D.M.,
            Batatinha,H., Niemiro,G.M., Seckeler,M.D., Pedlar,C.R.,
            O'Connor,D.P., Colombo,J., Katsanis,E. and Simpson,R.J.
  TITLE     Exercise-induced beta2-adrenergic Receptor Activation Enhances the
            Antileukemic Activity of Expanded gammadelta T-Cells via DNAM-1
            Upregulation and PVR/Nectin-2 Recognition
  JOURNAL   Cancer Res Commun 4 (5), 1253-1267 (2024)
   PUBMED   38592213
  REMARK    GeneRIF: Exercise-induced beta2-adrenergic Receptor Activation
            Enhances the Antileukemic Activity of Expanded gammadelta T-Cells
            via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.
REFERENCE   3  (bases 1 to 5792)
  AUTHORS   Tahara,S., Okumura,G., Matsuo,T., Shibuya,A. and Shibuya,K.
  TITLE     Essential role of CD155 glycosylation in functional binding to
            DNAM-1 on natural killer cells
  JOURNAL   Int Immunol 36 (6), 317-325 (2024)
   PUBMED   38289706
  REMARK    GeneRIF: Essential role of CD155 glycosylation in functional
            binding to DNAM-1 on natural killer cells.
REFERENCE   4  (bases 1 to 5792)
  AUTHORS   Liang,J., Liao,L., Xie,L., Tang,W., Yu,X., Lu,Y., Chen,H., Xu,J.,
            Sun,L., Wu,H., Cui,C. and Tan,Y.
  TITLE     PITPNC1 Suppress CD8+ T cell immune function and promote
            radioresistance in rectal cancer by modulating FASN/CD155
  JOURNAL   J Transl Med 22 (1), 117 (2024)
   PUBMED   38291470
  REMARK    GeneRIF: PITPNC1 Suppress CD8[+] T cell immune function and promote
            radioresistance in rectal cancer by modulating FASN/CD155.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5792)
  AUTHORS   Huang,M., Yu,X., Wang,Q., Jiang,Z., Li,X., Chen,W. and Song,C.
  TITLE     The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 +
            T cells in TNBC through glucose metabolic reprogramming mediated by
            PI3K/AKT/mTOR signaling
  JOURNAL   Cell Commun Signal 22 (1), 35 (2024)
   PUBMED   38216949
  REMARK    GeneRIF: The immune checkpoint TIGIT/CD155 promotes the exhaustion
            of CD8 + T cells in TNBC through glucose metabolic reprogramming
            mediated by PI3K/AKT/mTOR signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5792)
  AUTHORS   Zibert,A. and Wimmer,E.
  TITLE     N glycosylation of the virus binding domain is not essential for
            function of the human poliovirus receptor
  JOURNAL   J Virol 66 (12), 7368-7373 (1992)
   PUBMED   1331527
REFERENCE   7  (bases 1 to 5792)
  AUTHORS   Koike,S., Ise,I. and Nomoto,A.
  TITLE     Functional domains of the poliovirus receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4104-4108 (1991)
   PUBMED   1851992
REFERENCE   8  (bases 1 to 5792)
  AUTHORS   Koike,S., Horie,H., Ise,I., Okitsu,A., Yoshida,M., Iizuka,N.,
            Takeuchi,K., Takegami,T. and Nomoto,A.
  TITLE     The poliovirus receptor protein is produced both as membrane-bound
            and secreted forms
  JOURNAL   EMBO J 9 (10), 3217-3224 (1990)
   PUBMED   2170108
REFERENCE   9  (bases 1 to 5792)
  AUTHORS   Schonk,D., van Dijk,P., Riegmann,P., Trapman,J., Holm,C.,
            Willcocks,T.C., Sillekens,P., van Venrooij,W., Wimmer,E., Geurts
            van Kessel,A. et al.
  TITLE     Assignment of seven genes to distinct intervals on the midportion
            of human chromosome 19q surrounding the myotonic dystrophy gene
            region
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 15-19 (1990)
   PUBMED   1701111
REFERENCE   10 (bases 1 to 5792)
  AUTHORS   Mendelsohn,C.L., Wimmer,E. and Racaniello,V.R.
  TITLE     Cellular receptor for poliovirus: molecular cloning, nucleotide
            sequence, and expression of a new member of the immunoglobulin
            superfamily
  JOURNAL   Cell 56 (5), 855-865 (1989)
   PUBMED   2538245
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK300349.1, AK290946.1 and
            AC243964.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006505.4.
            
            Summary: The protein encoded by this gene is a transmembrane
            glycoprotein belonging to the immunoglobulin superfamily. The
            external domain mediates cell attachment to the extracellular
            matrix molecule vitronectin, while its intracellular domain
            interacts with the dynein light chain Tctex-1/DYNLT1. The gene is
            specific to the primate lineage, and serves as a cellular receptor
            for poliovirus in the first step of poliovirus replication.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (alpha), also known as
            H20A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.58302.1,
                                           SRR1803612.130587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425690.8/ ENSP00000402060.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AK300349.1         1-312
            313-1629            AK290946.1         339-1655
            1630-5792           AC243964.3         76138-80300         c
FEATURES             Location/Qualifiers
     source          1..5792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..5792
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /note="PVR cell adhesion molecule"
                     /db_xref="GeneID:5817"
                     /db_xref="HGNC:HGNC:9705"
                     /db_xref="MIM:173850"
     exon            1..266
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1441
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; nectin-like protein 5; poliovirus receptor"
                     /codon_start=1
                     /product="poliovirus receptor isoform alpha precursor"
                     /protein_id="NP_006496.4"
                     /db_xref="CCDS:CCDS12640.1"
                     /db_xref="GeneID:5817"
                     /db_xref="HGNC:HGNC:9705"
                     /db_xref="MIM:173850"
                     /translation="MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDS
                     VTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAE
                     LRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEP
                     VPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKN
                     VTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTG
                     YNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPP
                     SEHSGMSRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASA
                     NGHVSYSAVSRENSSSQDPQTEGTR"
     exon            267..614
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..911
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1029
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1178
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1337
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1369
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..5792
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /note="hexamer: ATTAAA"
     polyA_site      3213
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /note="major polyA site"
     regulatory      5759..5764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
                     /note="hexamer: AATAAA"
     polyA_site      5792
                     /gene="PVR"
                     /gene_synonym="CD155; HVED; Necl-5; NECL5; PVS; TAGE4"
ORIGIN      
        1 agtcacttgt ctggagcttg aagaagtggg tattcccctt cccaccccag gcactggagg
       61 agcggccccc cggggattcc aggacctgag ctccgggagc tggactcgca gcgaccgcgg
      121 cagagcgagc gggcgccggg aagcgaggag acgcccgcgg gaggcccagc tgctcggagc
      181 aactggcatg gcccgagcca tggccgccgc gtggccgctg ctgctggtgg cgctactggt
      241 gctgtcctgg ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgcc
      301 cggcttcttg ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt
      361 gacgcatgtg tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt
      421 ccaccaaacg cagggcccca gctattcgga gtccaaacgg ctggaattcg tggcagccag
      481 actgggcgcg gagctgcgga atgcctcgct gaggatgttc gggttgcgcg tagaggatga
      541 aggcaactac acctgcctgt tcgtcacgtt cccgcagggc agcaggagcg tggatatctg
      601 gctccgagtg cttgccaagc cccagaacac agctgaggtt cagaaggtcc agctcactgg
      661 agagccagtg cccatggccc gctgcgtctc cacagggggt cgcccgccag cccaaatcac
      721 ctggcactca gacctgggcg ggatgcccaa tacgagccag gtgccagggt tcctgtctgg
      781 cacagtcact gtcaccagcc tctggatatt ggtgccctca agccaggtgg acggcaagaa
      841 tgtgacctgc aaggtggagc acgagagctt tgagaagcct cagctgctga ctgtgaacct
      901 caccgtgtac taccccccag aggtatccat ctctggctat gataacaact ggtaccttgg
      961 ccagaatgag gccaccctga cctgcgatgc tcgcagcaac ccagagccca caggctataa
     1021 ttggagcacg accatgggtc ccctgccacc ctttgctgtg gcccagggcg cccagctcct
     1081 gatccgtcct gtggacaaac caatcaacac aactttaatc tgcaacgtca ccaatgccct
     1141 aggagctcgc caggcagaac tgaccgtcca ggtcaaagag ggacctccca gtgagcactc
     1201 aggcatgtcc cgtaacgcca tcatcttcct ggttctggga atcctggttt ttctgatcct
     1261 gctggggatc gggatttatt tctattggtc caaatgttcc cgtgaggtcc tttggcactg
     1321 tcatctgtgt ccctcgagta cagagcatgc cagcgcctca gctaatgggc atgtctccta
     1381 ttcagctgtg agcagagaga acagctcttc ccaggatcca cagacagagg gcacaaggtg
     1441 acagcgtcgg gactgagagg ggagagagac tggagctggc aaggacgtgg gcctccagag
     1501 ttggacccga ccccaatgga tgaagacccc ctccaaagag accagcctcc ctccctgtgc
     1561 cagacctcaa aacgacgggg gcaggtgcaa gttcataggt ctccaagacc accctccttt
     1621 catttgctag aaggactcac tagactcagg aaagctgtta ggctcacagt tacagtttat
     1681 tacagtaaaa ggacagagat taagatcagc aaagggagga ggtgcacagc acacgttcca
     1741 cgacagatga ggcgacggct tccatctgcc ctctcccagt ggagccatat aggcagcacc
     1801 tgattctcac agcaacatgt gacaacatgc aagaagtact gccaatactg ccaaccagag
     1861 cagctcactc gagatctttg tgtccagagt tttttgtttg tcttgagaca gggtctggct
     1921 ctgttggcag actagagtac agtggtgaga tcacagttca ttgcagcctt gacttctcaa
     1981 cgccaagtca tcctcccacc tcagcctcct gagtagctat gactacaggt atgtgccacc
     2041 acgtctggct aatcttttta ttatttgtaa agtcgaggtt tccctgtgtt gcccaggctg
     2101 gtcttgaact cttggctcca agtgatactt ctgccttggc ctcccaaagt gctgaattaa
     2161 gcagctcacc atccacacgg ctgacctcat acatcaagcc aataccgtgt ggcccaagac
     2221 ccccaccata aatcacatca ttagcatgaa ccacccagag tggcccaaga ctccaagatc
     2281 agctaccagg caggatattc caagggctta gagatgaatg cccaggagct gaggataaag
     2341 ggcccgatct ttctttgggc aaggttaagc ctttactgca tagcagacca cacagaaggg
     2401 tgtgggccac cagagaattt tggtaaaaat ttggcctctg gccttgagct tctaaatctc
     2461 tgtatccgtc agatctctgt ggttacaaga aacagccact gaccctggtc accagaggct
     2521 gcaattcagg ccgcaagcag ctgcctgggg ggtgtccaag gagcagagaa aactactaga
     2581 tgtgaacttg aagaaggttg tcagctgcag ccactttctg ccagcatctg cagccacttt
     2641 ctgccagcat ctgcagccag caagctggga ctggcaggaa ataacccaca aaagaagcaa
     2701 atgcaatttc caacacaagg gggaagggat gcagggggag gcagcgctgc agttgctcag
     2761 gacacgctcc tataggacca agatggatgc gacccaagac ccaggaggcc cagctgctca
     2821 gtgcaactga caagttaaaa aggtctatga tcttgagggc agacagcaga attcctctta
     2881 taaagaaaac tgtttgggaa aatacgttga gggagagaag accttgggcc aagatgctaa
     2941 atgggaatgc aaagcttgag ctgctctgca agagaaaata agcaggacag aggatttgct
     3001 ctggacagag atggaagagc cgggaacaga gaagtgtggg gaagagatag gaaccagcag
     3061 gatggcaggg gcaaagggct caagggtgag gaggccagtg ggaccccaca gagttgggga
     3121 gataaaggaa cattggttgc tttggtggca cgtaagctcc ttgtctgtct ccagcaccca
     3181 gaatctcatt aaagcttatt tattgtacct ccagcggctg tgtgcaatgg ggtcttttgt
     3241 ggaaatcaag gagcagacag gtttcatgtg tactgtcacc acgtgggatg gaaccagagg
     3301 catggaagca agacgctaaa tgaagagggc cataagggct gggattccca ggcaccttag
     3361 gaacagcttg tctttttttt tttcctctcc aaaaaaaatg tttaagggac ggtgtctcct
     3421 gtcacccagg ctggagtgca atggcacgat catagctcat tgcagcctct aactccgggg
     3481 ctcaagcaat cctcccacct cagcctacca agtagctgtg accacagctg cccctcacca
     3541 tgctaagcta atttttttaa ttagatagta cataaacgtc ccaaaattag aagataaaaa
     3601 gacatgaggg atccattcta atttgtgttt ggagtgtaat ggtccagctc cattcttctg
     3661 cacatggata tccagtttta cacaacactg tgaatgtaat gaatgccact gaatcataca
     3721 ctcaaaaata gctaaaatgg caaattgtct gttatctctt tttaaccacc atttttgaaa
     3781 attaattata ccaaaaaacc attgaatagt gcactttatt tatttattta tttgtttatt
     3841 tatttattta ttttagaaat aagagtctca ctttgttgcc caggctggag tgcagtggcg
     3901 tgatcatggc tcattgcagc ctcgacctgc tgggctcggg ctatccttcc atctcagcct
     3961 cccgagtagc tgggactata ggtgggcgcc accccacctg gctaaatctc tttttaactt
     4021 ttgtagagat aggcatctcg ctatgttgcc taggctgggc tggaactcct gggctcaagt
     4081 gctcctcctg ccttggcctc ccaaagcgct aggattacag atgtgagcca ccgcgcccac
     4141 cctgaacctt actttttttg ctcagtttct ggtaattcag agaatgcctc ctgagttgtt
     4201 ctacacccac ctcatattcc atgggagggc tgtacagggc ttttttaacg aggcctctaa
     4261 ggacaggcat ttgtatcctt tccagccttt cactattaca atgttgtagt gaataacttt
     4321 acacactgtc atttatttta cttttttttt tttttatttt agagaaagga atcttgccat
     4381 cttgcccagg ctggtctcaa attcctgggc ccaaacaatc ctcccgcctt ggcctcctaa
     4441 agtactggga tttataggca taagccaccg tgcctggcca atgcacactg tcatttagct
     4501 catgttaaca cctgagtgta ggacacactc ctggaggtgg aattgctggg ccaaagagta
     4561 tgtttcttgt cattgtgata gatattgaca aatgaaccct cacagaagtt gtgctgagtt
     4621 ctgttcccac cagcgacgta ggcgatgacc tttttctgga gggagggggc atccttggag
     4681 tccacagagc caggaatgga gagtgggccc agaattttgg tataggtgtt gtataaactt
     4741 atagtaaggt taagaaaacc gcaactatcc ttatcagaga cttggcgggg ggcagggtat
     4801 gatggagatc ataaggaggc taaaacactc cacaccctcc ctctgcattg ctcctgcacg
     4861 ggagtcggga atcttttcag gttgatacga tctcaccttg aggagctgtg aggtcccaga
     4921 agcctctggg ttgcagattg cttggggtga aaatgtctgt gctactgaaa tctaactttt
     4981 tacaaaaaat tacgggctgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg
     5041 ctgcagcggg tggatcactt gaggtaagga gttcaagacc agaccatagt gaaaccgtgt
     5101 ctctacaaaa aaaattagcc aggtgtggtg gtgcatgctt gtaatcccag ctactcagaa
     5161 ggctgaggtg ggagaatccc ttgaacccgg gaagtggagg ctggagtaaa ccatgatcga
     5221 gttactgcac tccagcctgg gtgacaagag tgagactctg tctccaaaaa aaaaaaaaaa
     5281 aaaaaaaaaa ctggattgcc tggctctact ccgggcacag catgcaggcc cagttctgct
     5341 gctctgctgt ttgttctgct ttcctccaca tattggcatc accctctggt gccaagatgg
     5401 ctgctgcatt ccaggcatca catccagact cagacccaga gaagctgccc atccctacct
     5461 gggtgagcct ttgtaggaac gagaaaccgc atccagcagc agaaacctca cccagcagcg
     5521 tcttttccgg tctcattcac cagcgccgcc caccgctcaa ccaatccctg gccaaaagaa
     5581 tgggaccgcc tggaaggctg gaccaaacag gacctgccct ctggggctgg ggagaggccc
     5641 agatgaaggc tgcaggacag gatggactcc tagacctctg ttaccagcag tgactacctc
     5701 tgtctgggtg gttggaacat gtttgaattt tattctaagt actgtctaca agttctgcaa
     5761 taaaccttga ctcttctttt aataatgcaa aa
//
