LOCUS       NM_001315532             550 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens parvalbumin (PVALB), transcript variant 2, mRNA.
ACCESSION   NM_001315532 XM_006724285 XM_006725404
VERSION     NM_001315532.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 550)
  AUTHORS   O'Brien,J.T., Jalilvand,S.P., Suji,N.A., Jupelly,R.K., Phensy,A.,
            Mwirigi,J.M., Elahi,H., Price,T.J. and Kroener,S.
  TITLE     Elevations in the Mitochondrial Matrix Protein Cyclophilin D
            Correlate With Reduced Parvalbumin Expression in the Prefrontal
            Cortex of Patients With Schizophrenia
  JOURNAL   Schizophr Bull 50 (5), 1197-1207 (2024)
   PUBMED   38412332
  REMARK    GeneRIF: Elevations in the Mitochondrial Matrix Protein Cyclophilin
            D Correlate With Reduced Parvalbumin Expression in the Prefrontal
            Cortex of Patients With Schizophrenia.
REFERENCE   2  (bases 1 to 550)
  AUTHORS   Dienel,S.J., Fish,K.N. and Lewis,D.A.
  TITLE     The Nature of Prefrontal Cortical GABA Neuron Alterations in
            Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene
            Expression Without Missing Neurons
  JOURNAL   Am J Psychiatry 180 (7), 495-507 (2023)
   PUBMED   37073488
  REMARK    GeneRIF: The Nature of Prefrontal Cortical GABA Neuron Alterations
            in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene
            Expression Without Missing Neurons.
REFERENCE   3  (bases 1 to 550)
  AUTHORS   Vologzhannikova,A.A., Shevelyova,M.P., Kazakov,A.S., Sokolov,A.S.,
            Borisova,N.I., Permyakov,E.A., Kircheva,N., Nikolova,V., Dudev,T.
            and Permyakov,S.E.
  TITLE     Strontium Binding to alpha-Parvalbumin, a Canonical Calcium-Binding
            Protein of the 'EF-Hand' Family
  JOURNAL   Biomolecules 11 (8), 1158 (2021)
   PUBMED   34439824
  REMARK    GeneRIF: Strontium Binding to alpha-Parvalbumin, a Canonical
            Calcium-Binding Protein of the ''EF-Hand'' Family.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 550)
  AUTHORS   Craig,M.M., Misic,B., Pappas,I., Adapa,R.M., Menon,D.K. and
            Stamatakis,E.A.
  TITLE     Propofol sedation-induced alterations in brain connectivity reflect
            parvalbumin interneurone distribution in human cerebral cortex
  JOURNAL   Br J Anaesth 126 (4), 835-844 (2021)
   PUBMED   33386125
  REMARK    GeneRIF: Propofol sedation-induced alterations in brain
            connectivity reflect parvalbumin interneurone distribution in human
            cerebral cortex.
REFERENCE   5  (bases 1 to 550)
  AUTHORS   Calio,A., Ammendola,S., Brunelli,M., Pedron,S., Gobbo,S. and
            Martignoni,G.
  TITLE     Parvalbumin immunohistochemical expression in the spectrum of
            perivascular epithelioid cell (PEC) lesions of the kidney
  JOURNAL   Virchows Arch 478 (4), 785-791 (2021)
   PUBMED   32524185
  REMARK    GeneRIF: Parvalbumin immunohistochemical expression in the spectrum
            of perivascular epithelioid cell (PEC) lesions of the kidney.
REFERENCE   6  (bases 1 to 550)
  AUTHORS   Winsky,L. and Kuznicki,J.
  TITLE     Distribution of calretinin, calbindin D28k, and parvalbumin in
            subcellular fractions of rat cerebellum: effects of calcium
  JOURNAL   J Neurochem 65 (1), 381-388 (1995)
   PUBMED   7790883
REFERENCE   7  (bases 1 to 550)
  AUTHORS   Fohr,U.G., Weber,B.R., Muntener,M., Staudenmann,W., Hughes,G.J.,
            Frutiger,S., Banville,D., Schafer,B.W. and Heizmann,C.W.
  TITLE     Human alpha and beta parvalbumins. Structure and tissue-specific
            expression
  JOURNAL   Eur J Biochem 215 (3), 719-727 (1993)
   PUBMED   8354278
REFERENCE   8  (bases 1 to 550)
  AUTHORS   Ritzler,J.M. and Berchtold,M.W.
  TITLE     An STS in the human parvalbumin gene (PVALB)
  JOURNAL   Nucleic Acids Res 20 (6), 1428 (1992)
   PUBMED   1561106
REFERENCE   9  (bases 1 to 550)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   10 (bases 1 to 550)
  AUTHORS   Berchtold,M.W.
  TITLE     Parvalbumin genes from human and rat are identical in intron/exon
            organization and contain highly homologous regulatory elements and
            coding sequences
  JOURNAL   J Mol Biol 210 (3), 417-427 (1989)
   PUBMED   2614829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA392417.1, DA054941.1 and
            AV724364.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001315532.1.
            
            Summary: The protein encoded by this gene is a high affinity
            calcium ion-binding protein that is structurally and functionally
            similar to calmodulin and troponin C. The encoded protein is
            thought to be involved in muscle relaxation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279837.662.1, ERR279846.9938.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417718.7/ ENSP00000400247.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               DA392417.1         1-425
            426-546             DA054941.1         427-547
            547-550             AV724364.1         526-529
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..550
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /note="parvalbumin"
                     /db_xref="GeneID:5816"
                     /db_xref="HGNC:HGNC:9704"
                     /db_xref="MIM:168890"
     exon            1..91
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..363
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /codon_start=1
                     /product="parvalbumin alpha"
                     /protein_id="NP_001302461.1"
                     /db_xref="CCDS:CCDS13933.1"
                     /db_xref="GeneID:5816"
                     /db_xref="HGNC:HGNC:9704"
                     /db_xref="MIM:168890"
                     /translation="MSMTDLLNAEDIKKAVGAFSATDSFDHKKFFQMVGLKKKSADDV
                     KKVFHMLDKDKSGFIEEDELGFILKGFSPDARDLSAKETKMLMAAGDKDGDGKIGVDE
                     FSTLVAES"
     exon            92..224
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /inference="alignment:Splign:2.1.0"
     exon            225..334
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /inference="alignment:Splign:2.1.0"
     exon            335..550
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /inference="alignment:Splign:2.1.0"
     regulatory      531..536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /note="hexamer: AATAAA"
     polyA_site      550
                     /gene="PVALB"
                     /gene_synonym="D22S749"
                     /note="major polyA site"
ORIGIN      
        1 acttgctctg cccgctcaaa cagttgcagg atgtcgatga cagacttgct gaacgctgag
       61 gacatcaaga aggcggtggg agcctttagc gctaccgact ccttcgacca caaaaagttc
      121 ttccaaatgg tcggcctgaa gaaaaagagt gcggatgatg tgaagaaggt gtttcacatg
      181 ctggacaagg acaaaagtgg cttcatcgag gaggatgagc tgggattcat cctaaaaggc
      241 ttctccccag atgccagaga cctgtctgct aaagaaacca agatgctgat ggctgctgga
      301 gacaaagatg gggacggcaa aattggggtt gacgaattct ccactctggt ggctgaaagc
      361 taagaagcac tgactgcccc tggtcttcca cctctctgcc ctgaacaccc aatctcggcc
      421 cctctcgcca ccctcctgca tttctgttca gttcgtttat gttatttttt actcccccat
      481 cccctgtggc cctctaatga caccattctt ctggaaaatg ctggagaagc aataaaggtt
      541 gtaccagtca
//
