LOCUS       NM_031292              13567 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens pseudouridine synthase 7 like (PUS7L), transcript
            variant 3, mRNA.
ACCESSION   NM_031292
VERSION     NM_031292.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13567)
  AUTHORS   Martinez,N.M., Su,A., Burns,M.C., Nussbacher,J.K., Schaening,C.,
            Sathe,S., Yeo,G.W. and Gilbert,W.V.
  TITLE     Pseudouridine synthases modify human pre-mRNA co-transcriptionally
            and affect pre-mRNA processing
  JOURNAL   Mol Cell 82 (3), 645-659 (2022)
   PUBMED   35051350
REFERENCE   2  (bases 1 to 13567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 13567)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13567)
  AUTHORS   Lepur,A., Kovacevic,L., Beluzic,R. and Vugrek,O.
  TITLE     Combining Unique Multiplex Gateway Cloning and Bimolecular
            Fluorescence Complementation (BiFC) for High-Throughput Screening
            of Protein-Protein Interactions
  JOURNAL   J Biomol Screen 21 (10), 1100-1111 (2016)
   PUBMED   27455993
  REMARK    GeneRIF: We have validated the vectors and confirmed
            self-association of AHCY, AHCYL1, and galectin-3. In a
            high-throughput BiFC screen, we identified new AHCY interaction
            partners: galectin-3 and PUS7L. We also describe additional steps
            in protein interaction analysis, applied for AHCY-galectin-3
            interaction
REFERENCE   5  (bases 1 to 13567)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   6  (bases 1 to 13567)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 13567)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA950015.1, AL136759.1, BC068502.1, BX647494.1 and AC016143.34.
            
            On Jun 2, 2019 this sequence version replaced NM_031292.4.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092030.1, BC068502.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000344862.10/
                                                ENSP00000343081.5
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DA950015.1         28-70
            44-2217             AL136759.1         1-2174
            2218-3892           BC068502.1         2214-3888
            3893-3952           BX647494.1         4304-4363
            3953-13567          AC016143.34        6448-16062
FEATURES             Location/Qualifiers
     source          1..13567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..13567
                     /gene="PUS7L"
                     /note="pseudouridine synthase 7 like"
                     /db_xref="GeneID:83448"
                     /db_xref="HGNC:HGNC:25276"
     exon            1..61
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            62..987
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2183
                     /gene="PUS7L"
                     /EC_number="5.4.99.-"
                     /note="isoform a is encoded by transcript variant 3;
                     pseudouridylate synthase 7 homolog-like protein;
                     pseudouridylate synthase 7 like; pseudouridylate synthase
                     PUS7L"
                     /codon_start=1
                     /product="pseudouridylate synthase PUS7L isoform a"
                     /protein_id="NP_112582.3"
                     /db_xref="CCDS:CCDS8743.1"
                     /db_xref="GeneID:83448"
                     /db_xref="HGNC:HGNC:25276"
                     /translation="MEEDTDYRIRFSSLCFFNDHVGFHGTIKSSPSDFIVIEIDEQGQ
                     LVNKTIDEPIFKISEIQLEPNNFPKKPKLDLQNLSLEDGRNQEVHTLIKYTDGDQNHQ
                     SGSEKEDTIVDGTSKCEEKADVLSSFLDEKTHELLNNFACDVREKWLSKTELIGLPPE
                     FSIGRILDKNQRASLHSAIRQKFPFLVTVGKNSEIVVKPNLEYKELCHLVSEEEAFDF
                     FKYLDAKKENSKFTFKPDTNKDHRKAVHHFVNKKFGNLVETKSFSKMNCSAGNPNVVV
                     TVRFREKAHKRGKRPLSECQEGKVIYTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSY
                     AGLKDKKAITYQAMVVRKVTPERLKNIEKEIEKKRMNVFNIRSVDDSLRLGQLKGNHF
                     DIVIRNLKKQINDSANLRERIMEAIENVKKKGFVNYYGPQRFGKGRKVHTDQIGLALL
                     KNEMMKAIKLFLTPEDLDDPVNRAKKYFLQTEDAKGTLSLMPEFKVRERALLEALHRF
                     GMTEEGCIQAWFSLPHSMRIFYVHAYTSKIWNEAVSYRLETYGARVVQGDLVCLDEDI
                     DDENFPNSKIHLVTEEEGSANMYAIHQVVLPVLGYNIQYPKNKVGQWYHDILSRDGLQ
                     TCRFKVPTLKLNIPGCYRQILKHPCNLSYQLMEDHDIDVKTKGSHIDETALSLLISFD
                     LDASCYATVCLKEIMKHDV"
     exon            988..1147
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1340
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1439
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1521
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1802
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1856
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..13567
                     /gene="PUS7L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3932..3937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUS7L"
                     /note="hexamer: AATAAT"
     polyA_site      3952
                     /gene="PUS7L"
                     /note="major polyA site"
     regulatory      10838..10843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUS7L"
                     /note="hexamer: ATTAAA"
     polyA_site      10859
                     /gene="PUS7L"
                     /note="major polyA site"
     regulatory      10929..10934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUS7L"
                     /note="hexamer: ATTAAA"
     polyA_site      10956
                     /gene="PUS7L"
                     /note="major polyA site"
     regulatory      13494..13499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUS7L"
                     /note="hexamer: AATAAA"
     polyA_site      13514
                     /gene="PUS7L"
     regulatory      13548..13553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUS7L"
                     /note="hexamer: AATAAA"
     polyA_site      13567
                     /gene="PUS7L"
ORIGIN      
        1 acttaaggct tccgggcatg cgcacagcgt tgtgcaaatg aatgccttcc actgaaccga
       61 ggcactgtta tagaagaatg gaagaagata cagattatag aatcaggttt agttctttgt
      121 gtttctttaa tgatcacgtt ggatttcatg gcactataaa aagctcacca agtgacttta
      181 ttgttattga aattgatgaa cagggacagt tagttaataa gaccatcgat gagcctattt
      241 tcaagattag tgaaatacaa cttgagccaa ataattttcc caaaaaacca aaactagatc
      301 ttcaaaatct gtccttagaa gatggaagaa accaagaagt tcatactttg attaagtaca
      361 ctgatggtga ccaaaatcat cagtctggtt cagaaaagga agatactatc gttgatggaa
      421 cttccaaatg tgaagaaaaa gctgatgttt taagctcctt tttggatgaa aaaactcatg
      481 agttactgaa taattttgcc tgtgatgtaa gagagaagtg gctttctaaa acagagctaa
      541 ttggactacc tcctgaattc tcaataggca gaatccttga caaaaaccag agggctagtt
      601 tacacagtgc cattaggcag aaatttccat ttttagtaac tgtaggaaaa aacagtgaaa
      661 ttgttgtaaa accaaatctt gaatataaag aactttgtca tttggtatct gaagaggaag
      721 catttgactt ttttaaatat ttggatgcaa agaaagaaaa ttccaaattt acctttaaac
      781 ctgatacaaa caaagaccac agaaaagctg tccaccattt tgtcaacaaa aagtttggaa
      841 accttgtgga aaccaaatct ttttctaaaa tgaattgcag tgctggtaat ccgaatgtgg
      901 tggtaacagt aagatttcgg gaaaaagcac acaaacgtgg gaaaaggcct ctttctgaat
      961 gccaagaagg aaaagttata tatacagctt ttaccctacg aaaggaaaac ctggaaatgt
     1021 ttgaagcgat tggtttttta gctatcaaac ttggtgttat tccttcggat tttagttatg
     1081 caggccttaa agacaagaaa gccatcacct atcaagcaat ggttgttaga aaagtgactc
     1141 cagagaggtt gaaaaatatt gaaaaagaaa ttgaaaagaa aagaatgaat gtctttaata
     1201 ttcggtctgt agatgattcc ctgagacttg gtcagctcaa aggaaatcac tttgatattg
     1261 tcattagaaa tttaaaaaaa caaataaatg attctgcaaa cctgagggag agaattatgg
     1321 aagcaataga aaatgttaag aaaaaaggct ttgtgaatta ctatggacca cagagatttg
     1381 ggaagggaag gaaagttcac acagaccaaa ttggactagc tttgctgaag aatgaaatga
     1441 tgaaagccat aaaattgttt cttacaccag aagacttgga tgatcctgta aatagagcaa
     1501 agaagtattt tcttcaaact gaggatgcta aaggcacact ttcattgatg cctgaattca
     1561 aagtgcgtga gagagcattg ttggaggcat tgcaccgctt tggcatgacc gaggaaggtt
     1621 gtatccaggc atggttctct ttaccccatt ccatgcgcat attctatgtt cacgcatata
     1681 ccagcaaaat ttggaatgag gcagtatctt acagacttga aacctatgga gcaagagtag
     1741 tgcagggtga tttggtctgt ttggatgaag acattgatga cgagaatttc ccaaatagta
     1801 aaattcacct ggtaactgaa gaggagggat cagctaatat gtatgcaata catcaggtgg
     1861 ttcttccagt acttggatac aatattcagt acccgaagaa caaagtaggg cagtggtacc
     1921 atgacatact tagcagagat ggactacaga catgtaggtt taaagtacct actctgaaac
     1981 tgaatatacc aggttgctat agacagattt tgaaacatcc ctgtaatctc tcataccaac
     2041 taatggaaga tcatgacatt gatgtcaaaa cgaaaggttc ccacattgat gaaacagctt
     2101 tgtctctttt gatctctttt gatcttgatg cttcatgcta tgctaccgtt tgtctgaagg
     2161 aaataatgaa gcatgacgtt taaaactgat acccttggta taaccatata tatgtcactc
     2221 tttgaaggaa agggggctaa aatgtcttaa gcaccttcca tgtgttagga acttcataat
     2281 tgttatctct tttaattttc acagcatcct gagaagttag gatttgatac tgtaatttta
     2341 tagaggatat gtaagtgtca gggtccaaat ttaaggtcca tgtgacccca aagcctgtgt
     2401 tttttttcta ttatatgttt cagtgacctt tattctgtgt cataaagtta caatctttta
     2461 aaaccattag gaatatatat aatactgcaa gataacattt aagaaaaaaa gttgtgaata
     2521 ttcatatcct ccagctcctt gcttagaaca ctagtaaaat taggtcgcag tgaagcaaat
     2581 gttggagaga aagatagatg aagcattttg ctaattatta ttgtccccct ttcctgtttt
     2641 tgaaattatt gatcagaaca atatacaagg gaaatgccat acctctgttt gtgatagata
     2701 ccccagagta gttattacct ctttgtgaga taagtaatct ttgatgaaga ttgaaataca
     2761 atttctcatc caatttttat atcttggcat acgctgaccc tcttgaccat ttgtaatttt
     2821 ttcatattat ctaaaacagg tgttagagtc agacagattc attcttagat tctagctctg
     2881 acacttacta gtgattttga gtatgttgtt gatttttttg tgtgtggtta ctgatagaat
     2941 caagacaatt acaacttcat aaatgacaaa taataggatt atctccacat tttctgttgc
     3001 tggaggaaca aaacattgtg cccatttgaa aattttaatt tttgttggtt taactatccc
     3061 acattataaa tcatccttca ccattttata tcagttaaat atgggtgtgt tggggaggaa
     3121 tgactggcat gtagacatgt attgatttag gaagatctga gcatttcttt cattgttggt
     3181 aagatataat gatgaaattt aaaaagcagt atggagcatt atatatcagt aatgtgatat
     3241 atatacttaa gccagtttaa ccattttggg aaatgttagc attaggaaat aaaatccaaa
     3301 agaaggaaga gaagctatat gcaatgcaaa atttgcttat tgcaatattt tcatatacag
     3361 acactaaaaa cagttttcaa agtccagcat tacgtaacta aagtaagtaa aatgatgtgt
     3421 atcaacttga tggtaaaata tgtagttatt taaaaaagca atgaacaatt tagtttcatg
     3481 agaaaatgtt gccccctaaa agtagaacac atatgttaca actgcaataa tactctgaat
     3541 tcatctttca caaataagag acatgttagc atagtgatta aaagcacaga tattggagac
     3601 aaactaaccc agtttgaacc ctggcactgc cacgtatagc actgcagcct tgggaaagtt
     3661 atttaaactc atgggcttca gtttcaacat ctgtaaaatg ggcatgttaa cattgcctac
     3721 ctcataggat tactgtgaga attttctaag ttaatatatg taaagcaact ttaaaaagtg
     3781 cctggcactt agttattgtt aagtaagtgt ctgcagatgc aagtttggaa gagaaaagca
     3841 aataaatgaa aatcccttcc tgttaagatg atggggtatt tggatttttt ttaatactaa
     3901 aaagtttttt ttgttatatg ttttggcaat aaataattct caatacacaa aattggatat
     3961 tgtagtacca ttgattttct ttggattact gccatcattt taatgttata ttgagaatga
     4021 agtgatcctc tattaggtag taaaaaaaat ttagaaaaaa tgttttattt tatatgataa
     4081 atcgtatcct ataaatgtaa tcataaaatg agttatatac attattaaat cctagttttt
     4141 aaaagttttg aatagcaatc agaaaatacg aaagcatgaa aatatatcat tgattttact
     4201 ttttttgcct gcagatggca ctataatttt agacatttat tgatttattt agtaaatact
     4261 tcagcagtgt ataaaggaac actaagttta tttcatcacc ataaaatgta ttgagatatc
     4321 attcatgtgg aatattattt tatatgccaa taagatgcca tgttaaactt tttttgttta
     4381 aggactttta ttattaatag tatgctttgg accaactgat gactagtcac ttaggttttt
     4441 gcagttttgc tggggcattt cagaccttca taagcatgat ctttggatta gttttttttt
     4501 tttcttcacc tcattattag gagttaattt atttttaaag tgtcatctta aactgcaagg
     4561 atgtccttta aacatcacat gccaattaaa catgccgaag gagaagctgt gtcatcaaaa
     4621 tgcccactta acctacccaa acatctcaaa cctacccttt gctgaccttc tatagcccca
     4681 tttccaaagt tttgctttat ttttattttt tcttccaact tttattttag gtttaggggt
     4741 acatgtgcag gtttgttaca tgggtaaatt gcattttgtg ggagttctgc atacaaatta
     4801 tttaatcacc cagataatga gcatagtacc tgataggttg tttttctatc ctcatctttc
     4861 tcccaccctc caccctcaag taggccatgg tgcctattgt tcccttctta gagtccaagt
     4921 gtactcaaag ttcagctccc acttatgagt aagaacattt ggtatttggt tttctgttcc
     4981 tgcattaatt tgcttacaat aatggcctcc agctacatcc atgttgctgg aaagacatta
     5041 ttttgttctt ttttatgact gtgtagtatt atctggtata catgtactac attttcttta
     5101 tccagtccac tgtaatgggc atctaggttg gttccatgtc tttgctattg tcaatagtgc
     5161 tgtaatgaac ataggcgtgc atggtcttta tggtagaaca atttatattc ctttgggtat
     5221 ataaccaata atgggattgc tgggtcaaat ggtatgtctg ctttaagttc tttgagaaat
     5281 cttcaaactg ctttccacag aggctgaact aatttatatt cccatcagca gtgtatagca
     5341 ttcccttttc tctgcagcct ccccaacatc tgttattttt tgacttttta ataacagcca
     5401 ttctgactgg tgtgagatgg tatctcgttg tggttttgat ttgcatttcc ctaatgatta
     5461 gtgatgttca gcattttttc atatgctttt ggcccatgga tgtcttcttt tgagaagtgt
     5521 ctgttcatgt cctttcttcc gtttttaatg ggataatttt ttgcttgtta agttcttcat
     5581 agattctgga tatcagacct ttgttcatgc atactttgaa aatattctct cccattctgt
     5641 agattgtcag tttactctgt tgatagtttc tttggctgtg cagaagctat ttagtttaat
     5701 taggtcccac ttgtcaattt tttttttttt ttagatggag tttccttctg tcacccaggc
     5761 tggagtgcag tggtgcaatc tcggctcact gcaacctcct cctcctgggt tcaagccatt
     5821 ctcctgcccc agcctctcaa gtagctggga ttacaagtgg ccaccaccac acctggctaa
     5881 tttttgtatt tttattagag acggggtttc accatgttgg ccaggctggt ctcaaactct
     5941 tgacctcaag tgatctaccc acctcggcct cagaaagtgc taggattaca ggcatgagcc
     6001 accatgccca gccttcactt gtcaattatt ggctttgttc cagttgcttt tggagtctgt
     6061 catgatatct ttgttaggtc ttttgtccag aatgatattt cctaggtttt cttctagggt
     6121 ttttatagtt ttaggtttta catttacatt gttaacccat cttgagttga tttttgtata
     6181 tggtaaaaag aaggggtcca gtttcaatcc tcaggatgtg gctaaccagt tatcccagca
     6241 ccatttatta aatagggagt cctttccctg ttgcttgtta ttgttgactt taacaaaaat
     6301 caagtagctg taggtgtgtg gcctttattt ctgggttctc taacctgttc cattggtcta
     6361 tgtgtctgtt tttgtaccag taccatgctg ttttggttac tatagccttg tagtttagtt
     6421 tgatgtcagg ttgtgtgatg cctccctcat tgctatattt gaattagttt taattgccaa
     6481 ggttgtttga cgctgagcta gcagtagtgc ctgggagtcg gttaggtgaa acaaattgag
     6541 gtcttttact aatattaaaa ttaaaacacc ttgatttttt ttttgtgagc tgtaaaaaac
     6601 tgaaagtcat gtaacttttg atttaactaa cattttctga gtatctatta tgtcagtatc
     6661 tcacacttta atccatattc ccaccctgtg tggaggtatt atcttccctt atttgcagat
     6721 tggaaacata cctgagtagt ttactaacct aatcaaggtc aaacaaaata gcgtgtggtt
     6781 gagcttgatt atgcttctta aatcagtact gttttcatct acctaacatt tgccttctga
     6841 gaacaagttt ttggatatta acttccattt aggccaggca cggtggctca cgcctgtaat
     6901 cccaacactt tggggaggcc aagacgagtg gatcacgagg tcaggagttc aagaccagcc
     6961 tggccaagat gctgaaaccc tgtctctact aaaaataaaa aaattagctg ggctacttgg
     7021 gaggctgagg ctggagaatc gcttgaaccc gggaggtgga ggttgcagtg agccgagatt
     7081 gcccagccta ggtgacagag cgaggctcca cctcaaaaaa aaaaaaaaac taaactaaaa
     7141 attaaaatat aacttccatt tctaccaact tgatataact tgccattgat ttaataggca
     7201 tattggggca tgtcttggga gagacaagat accttttgat tctgagacca aaatataaag
     7261 taaaggggat cccttcagga aatccccaaa tcattttgga gttttcccaa agtattttgg
     7321 gatttgtatc ataataatat gtaaaatcat tatagatcat aggaggtgtt ttagatggta
     7381 cctggcacaa atatcattga aaaagcatag tgagaaactt gttctttttc aatatacttt
     7441 cagtcctcac atcaatcatt ctgtttaagg aaggagaaag ctgattgata ctatttacat
     7501 atatcaacat tggctgattt acctttttag ccaactatgc aggcctcagg ctcagaaaca
     7561 tcagcagtca acaatataat atgtagctag aatgtaatag gattgcattg ttttattgaa
     7621 tttatcttcc cttttattta tggtaatcaa ttctggcttc ctgtttatgt gatggtatta
     7681 tgtttccttt aaaactaaat ttaattttaa agaggtagaa tcaatttaaa ggtattaaat
     7741 aaataatagt atagacatag cagtaattat gataccaata catgaaggat tagagtatgg
     7801 gaaatatact ggtacagttg agaatccctg aaatcagaga tgggctctac cactgcttta
     7861 atatgcgact ttagtaaccc actgattctg ttgtagaatt cttggacttg aagtactgtt
     7921 agttatcatt tttcagtcca ggatagtatt gcatcaaaca aaattatgaa atatatacaa
     7981 atttgagaca ttatgagcag aggcattgat gaccacatgc tatatcttaa aattttactg
     8041 atagttgatt ttagcaagtc ttatgaaaca ctaagaacaa tgtctggtgc ctagcaaatt
     8101 ctcagtaaat ttcagctagt attattacag ttagtattac tttactatgc tccctgataa
     8161 aatttttata ataaaatggt taatgacttt ccattgaggt ctgatctgac ttagttttag
     8221 cataaagtaa ttacaattca tatttttaga ggtttttttt tttgtagtag tagaaacaac
     8281 tatttctaaa tctggggatt cagtagttca ttcaaattag gatctttaag agctgtctag
     8341 gtcaatgttc cttaacgttt tctacctggg agtaatcttt aagagaacaa aaagaaaatg
     8401 aaactctata taatttaatg caaagtcttt tacattaatg taagggtagg aaaagaggtt
     8461 ggaggaagat atggggaggt aggaaaatgg gacttttttc ctccatttac ttttgatgtt
     8521 tgaatttcaa acatgagtat atttgtgtat tattttgcgg ttaaaaacac tgaagattgc
     8581 ataaagatca aagagggaaa tttaagggaa ttaatgggtt atgattgcat ttgttcagaa
     8641 tggttttggt ggctcatgac aacattttga gagagagaga ttttaatggc accaatggca
     8701 gctaggataa ctagtttaaa gtttagggcc tgtgttaata gattttgctt tctagtttca
     8761 gaaagattct cttatagtac tgttttaatc tgtttttcta agccctctga tttatgtata
     8821 tttaataggc cacaaaataa tgtcaaatat atggcataat aaccaacaaa tatttgaata
     8881 agtgaaaggt actctacaaa atgctatggg aaagacaaaa ataaataata tccctttctt
     8941 tgagggatta acagtgttaa tatcccttgt tttcatttga tttgaaatgc cacttgcaag
     9001 tggaatatgc agactaaatg gtaaagagaa aaacaagcag catcttttca tttcacttac
     9061 agctcactgt atgaccaata atatgttact tgacctctca gcactccatt ctaaatcctt
     9121 aaatgatact tatttagcat ttctaagcat cttgagatct cctcttaaaa tatgctttga
     9181 actattcagt ctaaatgctg ctttctaaaa agctactagt ttaaagaatg ggaaatggtg
     9241 ttaatggagt taatcttgtg taatttcagt gtgggttgtc aagaatacct ctaagtaaag
     9301 aaaatgactc taatcttctt aagcaattca ttttctcagc aactttgagg caggagttaa
     9361 tttactctgc ctgtgtacat aggccatctc ttacaaaaga aaaattttac tatggaaaga
     9421 agtcagaata gccatgaaat tatttaaatt tagtctttag aacatattac aaaatataag
     9481 atatattaaa ttgtcttttt tgttagaaac tcaactacca atgtagaaat aaaactcctg
     9541 ttgcaaggat ggagtttagc catggagtca aaacaagagc tatttggtta ttttaaaaga
     9601 gaagagatca aagagctggt cactccttaa ctaagggtgt ttgggcagca ggatagggtg
     9661 aagagtggag ggggttgaac tcaattcttt atgcttttat accaagcctc ccttttctaa
     9721 taagccttac tggcatttcc ttagactagt taagtcagga ttctgagttt ttcagtacaa
     9781 tagggtttta atctgagctg atcattgttt ccaatgcctc ccctgtggca ggggaacata
     9841 aaggactagt gttcttttct aaaaagggaa gatggatatt ttttctataa cctttataat
     9901 tccattataa taaaatgaat gataggttat aataaaatga attttttgca tatgattttc
     9961 aaaaggaaac taatttattt ttctataaaa tatcgcaaag gaatcgaata catttttatt
    10021 ctatgtaaat aataatataa ttttcacatt taggaggcaa tagcaaatct gggaagcagt
    10081 tattctaagt tggaagagca ttatcccaat gcattgaaaa catttgatga ctatttttta
    10141 tgtcttcttt attttgatga ttataataat gttctaactg ggtggccttc gtttttcact
    10201 ctagtcagtc catcttgttt actatgtcaa ttgttctcca aaaagtagaa atgtcattgt
    10261 tttggggcca tagaacattt cagaagcttt ccagtatcta tgcagtaaca gtccaaaccc
    10321 ctcaacataa cacatttaca cctgcaagta tggccccaaa tcttcaagtg gcttctgtca
    10381 ctactccata gtacataccc tttgttacag ctgtttcaca aatacaggtt gaatatccct
    10441 tatctaaaat gtttgggact aaaagtttca gatttcagat atgtttggat tttggaatat
    10501 ttgtacatgt ataatgagat actcttagag ttgggaccca agtctaaaca aaattcattt
    10561 atgtttcata tataccttat acacataacc tgaaggtaat ttatttttcc cttgggaaca
    10621 ctgaatagac tatatgttgt gcacctacat tttgactgtg acctatcaca tgaagtcagg
    10681 tgtggaattt tccatttgtg gcatcatgtc agtactcaaa aagttttgga ttttggattt
    10741 tgaattttca gattagagat gctcagccta atagcaaatg ttcccatgtt atacacctca
    10801 acctcccatt cccattggct ggaacatctc tgcttatatt aaatgtcttt tatgtgaaat
    10861 ctgtgttctc atagcctttt gtatagttct ctaccatctc atggctcaca ttgtattgta
    10921 cttatttgat taaatatctg gatcatctac tgtgaattat tcaagagcat tgatctttat
    10981 acctctggca cctatcagtg cctgacatat aacagggtta aaaatgctga gtgaatactg
    11041 caaatatacc ttagcaaatt tatttgctga atacacatct caagaaagtt ctgaaatagt
    11101 tatttcccct catagaaagt ttagagtatt aaaattgggt atctttataa tgctttttct
    11161 tttgtaatac tttcatcttt gccttttatt gaaatattaa atgcattgta gaatttgatt
    11221 taaaatttag aacaagctgt caggtatgat aactagtctc atttaacaaa tgaggattcc
    11281 agggcttgaa gaagttaagt agcttcctct agattgtaaa gagagtctaa cctggccctt
    11341 tttggtttta agggcatgat gataaccact tgctctactg atttctaatg gaaagtgctt
    11401 cagttttcca ctttgcctag ctagtgatta tttaatatct gcttatctct gaatttatct
    11461 gcatatttct aaaactttat gacattaagg aaagttgggg aaaattcact ttaagtgttg
    11521 taatgacaat agctatcaat cattgagtac tgtgtactaa gcattttata ttttatcaac
    11581 aagtacttac atgtgggata agtactgtta ttattttcat tttatagatg aggacacata
    11641 tagaatgcag ttaggaaact agagaaagag aaaacatgga gaattatctg gaactaataa
    11701 gacagtaaag tacagattta agaagttcag tgaatcccaa gcagtgtaaa ttaaaaaact
    11761 acattgagat acatcatagt gaatatgcaa aacatcaata ataaaaagaa aaaccttaaa
    11821 ggcagcttta acagtatact gaatgaccaa tatactcagc agccacagaa cctctattct
    11881 tttaaagcat ccatgggaca tttatagaaa ttgactatgc actggactat aagcatatgc
    11941 aataaaattt caaatgactg aaaccatatg agtatattct tttgccacaa cacaattagg
    12001 ctagaaatga acaacaaaaa gataacagga aaatctctat atatcagaaa ttaagagatg
    12061 cacttattta ttttttgttt tttgtgatgg agtctcactc tatcacccgt gcagtggcac
    12121 gatcttggct cactgcaacc tctgcctctt gggttcaagt gattctcctg tatcagcctc
    12181 ccaaggagct aggattacag gcgtgtgcca ccatacccag ctaatttttg tatttttatt
    12241 agagatggga tttcaccatg ttggccatgc tggtctcaaa ctcctgacct caaatgatct
    12301 gccagcctca gcctcccaaa atgctgggat tacagatgaa gagatacact tctaagtaat
    12361 ctatatgtca agtaagacaa aatgaaatta gaaaatattt ttaagtcaat gatattaaac
    12421 catactacac atcaaaactt gtgggatgca cttaaagcag catgtagagg gagattatat
    12481 tcataaatgc ttatggtaga aaagaaggaa gtctgtacat tatgtagcta tgcacccatc
    12541 taaagaagtt aggaaaatga catcaagtag aacatcaaaa gaaagaagga aaggataact
    12601 taaaacagaa atgaatgaaa taaaaccaga atagaagaga cgatctacaa atccaaaagt
    12661 tggtttgttg aaaatactag tagagctgac atacttgtgg tgagactgat ggaaataatg
    12721 cagttacaac taaccaatat cataattgga aaggaaatca ctataggtgc tgtaaaaatt
    12781 aaaaagataa tagaatatta tgaacaattt tctgccaata ttattgaaag tttagataaa
    12841 atggaaaatt catttaaaaa tataatttga cagtattatg ttatgtgaat actataatga
    12901 taatcctgta atcattaaat gaaccagtag tttaaaattt ttccatatag ggaaggtcag
    12961 ggccagatgt gttcaatggt tggttctact agacattcaa aaaaataata attcaagtct
    13021 acacaaactt tcctgagatt agaaaaaata aagaagagtc cccccacctg tttcttactt
    13081 tatgagacca cacctaaaag atagaagact gctttgcaac caagaaatcc ttcatgaaca
    13141 cctctttaat cacaagtcct caactccaag gttagcttta tttcaacttt tataatactt
    13201 ttcttacttt tcttgatagc tttaccaccc atgtattcat tcctaaaaaa tacacagttt
    13261 tgtctgattt tgaattttat gtgaatggaa ttgtacatat ctgtgtttgt gtcttccttg
    13321 ttttactcaa tactgtttct gagatcaatc acattatttg ttaatatttt gtttaggatt
    13381 tttgcatctc tatttcagtg tgtgtttgga atgtaaattt ccattctcag actatctttt
    13441 ggcctgaatt tggttacatg agtatatgtt ctaaaaatat tacttacact ttcaataaat
    13501 tttaaggact tttatattgt tatgtatcaa attttttaga atgcaagaat aaatattata
    13561 aaacatc
//
