LOCUS       NM_001323311            2218 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens purine rich element binding protein G (PURG),
            transcript variant C, mRNA.
ACCESSION   NM_001323311 XM_005273483
VERSION     NM_001323311.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Liu,H. and Johnson,E.M.
  TITLE     Distinct proteins encoded by alternative transcripts of the PURG
            gene, located contrapodal to WRN on chromosome 8, determined by
            differential termination/polyadenylation
  JOURNAL   Nucleic Acids Res 30 (11), 2417-2426 (2002)
   PUBMED   12034829
  REMARK    GeneRIF: Distinct proteins encoded by alternative transcripts of
            the PURG gene, located contrapodal to WRN on chromosome 8,
            determined by differential termination/polyadenylation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084736.5, DR003356.1 and
            AF195513.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001323311.1.
            
            Summary: The exact function of this gene is not known, however, its
            encoded product is highly similar to purine-rich element binding
            protein A. The latter is a DNA-binding protein which binds
            preferentially to the single strand of the purine-rich element
            termed PUR, and has been implicated in the control of both DNA
            replication and transcription. This gene lies in close proximity to
            the Werner syndrome gene, but on the opposite strand, on chromosome
            8p11. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (C) differs in the 5' UTR compared
            to variant A. Variants A and C encode the same isoform (A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3738659.1,
                                           SRR1803616.12171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523392.2/ ENSP00000466881.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC084736.5         64549-64710         c
            163-776             DR003356.1         6-619
            777-2218            AF195513.2         1425-2866
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..2218
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /note="purine rich element binding protein G"
                     /db_xref="GeneID:29942"
                     /db_xref="HGNC:HGNC:17930"
                     /db_xref="MIM:618041"
     exon            1..279
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /inference="alignment:Splign:2.1.0"
     exon            280..2218
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1329
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /note="isoform A is encoded by transcript variant C;
                     Pur-gamma; purine-rich element-binding protein gamma"
                     /codon_start=1
                     /product="purine-rich element-binding protein gamma
                     isoform A"
                     /protein_id="NP_001310240.1"
                     /db_xref="CCDS:CCDS6081.1"
                     /db_xref="GeneID:29942"
                     /db_xref="HGNC:HGNC:17930"
                     /db_xref="MIM:618041"
                     /translation="MERARRRGGGGGRGRGGKNVGGSGLSKSRLYPQAQHSHYPHYAA
                     SATPNQAGGAAEIQELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRGRQDNIRK
                     SKLTLSLSVAAELKDCLGDFIEHYAHLGLKGHRQEHGHSKEQGSRRRQKHSAPSPPVS
                     VGSEEHPHSVLKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRGTGMIGYFGHSLGQ
                     EQTIVLPAQGMIEFRDALVQLIEDYGEGDIEERRGGDDDPLELPEGTSFRVDNKRFYF
                     DVGSNKYGIFLKVSEVRPPYRNTITVPFKAWTRFGENFIKYEEEMRKICNSHKEKRMD
                     GRKASGEEQECLD"
     regulatory      2201..2206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /note="hexamer: AATATA"
     polyA_site      2218
                     /gene="PURG"
                     /gene_synonym="PURG-A; PURG-B; PURGA; PURGB"
                     /note="major polyA site"
ORIGIN      
        1 ctccccgcct ccccttccct cccctcctgg cgggtgcggg gccggtgtcc gaagtcaggc
       61 ggcggccccc gcagcggccg caggaggggc ggctgcggtg ggcgccgcgg gcgatgcccc
      121 tgcccggctg ctccggcggg gggcagtgcg agcggcggcg gcgggggagg aggcgggggg
      181 cggcggctgc ggcggctgca gcagaggggc cgagagctgg cggtggcggc ggcggtggtc
      241 gtgaagggca tcggcggcgg cggtgatggc agagatgatc tgaagatgga aagagccagg
      301 cgaaggggag gcggcggcgg ccgcggccgc ggaggcaaga atgtaggggg ctctggccta
      361 agcaagagta gactctatcc ccaggcccag cactcccact acccccacta cgcggcctca
      421 gccaccccta atcaggccgg gggcgcagcc gaaatccagg agctggcctc caaacgagtg
      481 gacatccaga aaaagaggtt ttacctagac gtgaagcaaa gctcccgggg ccgcttccta
      541 aagatagccg aagtctggat agggagaggc cggcaggaca acatcagaaa gagtaaactg
      601 accctctccc tgtctgtggc agcggagctg aaggactgtc taggggactt catcgagcac
      661 tatgcccacc tgggcctgaa aggccaccgg caagagcatg gccacagcaa agagcaaggc
      721 tccagaagga ggcagaagca ctcggcaccc tccccaccag tctcggtggg gtccgaagag
      781 catcctcaca gtgtcctgaa aacagactat atcgagaggg acaataggaa atattaccta
      841 gacctaaagg aaaatcagcg gggtcgcttc ctacggatta gacaaaccat gatgcggggg
      901 actggcatga taggttattt tggccacagt ttgggccaag aacagactat tgtcctccca
      961 gcacaaggaa tgattgagtt tcgtgatgcc ttggttcagc tgattgaaga ctatggcgaa
     1021 ggagacatag aagaacgaag aggtggagac gatgacccgc ttgaactccc agaggggact
     1081 tctttcagag tggacaataa aaggttctac tttgatgtgg gctctaataa atatggaatt
     1141 ttcctgaagg taagtgaggt gagaccacct taccgtaata ctattactgt tccattcaaa
     1201 gcttggacaa ggtttgggga gaattttatc aagtatgaag aagagatgag gaaaatttgc
     1261 aacagccata aagaaaagag aatggatggc agaaaggcca gtggtgaaga acaagaatgc
     1321 ctcgactaga gtgaaattga actccatcag gcaaaattta aaatcacaaa ttggctaaaa
     1381 gtactgatcc attatccttt gaagaagttt ttcctctttt ttggcccgtt gttattagta
     1441 atacctctag tagttgatac ttcaggaagt ctgattctca tgttatgtta cacatagatc
     1501 actataattc ttacgggaat tccaaccttc ccagagctaa atagtttagc tgcttcaact
     1561 gctccagact attgaagtat gcaaatcagc acaaaatgtg acattctgac attctaaata
     1621 ccataactaa gatttacatt gcactatgac ataatcccga aaaaagatac atatacttaa
     1681 atagaagtgt gactttcccc caaaagtatt tcaattctac ttcattaaaa gctgctaagc
     1741 ttacctgtag ggcagttacc acagaaacag aaattgacct ccggtatata taaatattta
     1801 cttataaaag tacaagtaga cgtatattgt ccgttgaata actgaatata ccatcaaagg
     1861 atcaaatctt attacctaat taaaccttaa aaatataatg tcataatatt tcttaagaat
     1921 actatagtat tctataattt caaactttgt ggtaacccta cattttatag ttgccatatc
     1981 aaagccatgg gagagtttta attcgttatt ctaagtttag ttacaatccc ttctttacct
     2041 ctacttaatg ttccatatat ttttattgac tttccaaagt ttcaggaatt acttttatgt
     2101 cacattgagt gggaggcttc atccaatggc tttgctatgg aaatcttggt ggtgtagctt
     2161 ttcatgctaa tttaaagatt gcaagaggtt tcttccccaa aatatatcat ggactcaa
//
