LOCUS       NM_005859              11511 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens purine rich element binding protein A (PURA), mRNA.
ACCESSION   NM_005859
VERSION     NM_005859.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11511)
  AUTHORS   Colombo,R.B., Maxit,C., Martinelli,D., Anderson,M., Masone,D. and
            Mayorga,L.
  TITLE     PURA and GLUT1: Sweet partners for brain health
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167261 (2024)
   PUBMED   38777099
  REMARK    GeneRIF: PURA and GLUT1: Sweet partners for brain health.
REFERENCE   2  (bases 1 to 11511)
  AUTHORS   Inoue,T., Bao,X., Kageyama,T., Sugino,Y., Sekito,S., Miyachi,S.,
            Sasaki,T. and Getzenberg,R.
  TITLE     Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix
            Protein, Has a Role in Prostate Cancer Progression
  JOURNAL   Int J Mol Sci 25 (13), 6911 (2024)
   PUBMED   39000020
  REMARK    GeneRIF: Purine-Rich Element Binding Protein Alpha, a Nuclear
            Matrix Protein, Has a Role in Prostate Cancer Progression.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11511)
  AUTHORS   Proske,M., Janowski,R., Bacher,S., Kang,H.S., Monecke,T.,
            Koehler,T., Hutten,S., Tretter,J., Crois,A., Molitor,L.,
            Varela-Rial,A., Fino,R., Donati,E., De Fabritiis,G., Dormann,D.,
            Sattler,M. and Niessing,D.
  TITLE     PURA syndrome-causing mutations impair PUR-domain integrity and
            affect P-body association
  JOURNAL   Elife 13, 93561 (2024)
   PUBMED   38655849
  REMARK    GeneRIF: PURA syndrome-causing mutations impair PUR-domain
            integrity and affect P-body association.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11511)
  AUTHORS   Chuang,H.C., Hsueh,C.H., Hsu,P.M., Tsai,C.Y., Shih,Y.C., Chiu,H.Y.,
            Chen,Y.M., Yu,W.K., Chen,M.H. and Tan,T.H.
  TITLE     DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha
  JOURNAL   J Clin Invest 133 (21), e166269 (2023)
   PUBMED   37909329
  REMARK    GeneRIF: DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11511)
  AUTHORS   Xu,W.W., Liao,L., Dai,W., Zheng,C.C., Tan,X.P., He,Y., Zhang,Q.H.,
            Huang,Z.H., Chen,W.Y., Qin,Y.R., Chen,K.S., He,M.L., Law,S.,
            Lung,M.L., He,Q.Y. and Li,B.
  TITLE     Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA
            interaction in cancer metastasis
  JOURNAL   EBioMedicine 92, 104587 (2023)
   PUBMED   37149929
  REMARK    GeneRIF: Genome-wide CRISPR/Cas9 screening identifies a targetable
            MEST-PURA interaction in cancer metastasis.
REFERENCE   6  (bases 1 to 11511)
  AUTHORS   Johnson,E.M., Chen,P.L., Krachmarov,C.P., Barr,S.M., Kanovsky,M.,
            Ma,Z.W. and Lee,W.H.
  TITLE     Association of human Pur alpha with the retinoblastoma protein, Rb,
            regulates binding to the single-stranded DNA Pur alpha recognition
            element
  JOURNAL   J Biol Chem 270 (41), 24352-24360 (1995)
   PUBMED   7592647
REFERENCE   7  (bases 1 to 11511)
  AUTHORS   Ma,Z.W., Pejovic,T., Najfeld,V., Ward,D.C. and Johnson,E.M.
  TITLE     Localization of PURA, the gene encoding the sequence-specific
            single-stranded-DNA-binding protein Pur alpha, to chromosome band
            5q31
  JOURNAL   Cytogenet Cell Genet 71 (1), 64-67 (1995)
   PUBMED   7606931
REFERENCE   8  (bases 1 to 11511)
  AUTHORS   Reijnders,M.R.F., Leventer,R.J., Lee,B.H., Baralle,D., Selber,P.,
            Paciorkowski,A.R. and Hunt,D.
  TITLE     PURA-Related Neurodevelopmental Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28448108
REFERENCE   9  (bases 1 to 11511)
  AUTHORS   Bergemann,A.D., Ma,Z.W. and Johnson,E.M.
  TITLE     Sequence of cDNA comprising the human pur gene and
            sequence-specific single-stranded-DNA-binding properties of the
            encoded protein
  JOURNAL   Mol Cell Biol 12 (12), 5673-5682 (1992)
   PUBMED   1448097
REFERENCE   10 (bases 1 to 11511)
  AUTHORS   Bergemann,A.D. and Johnson,E.M.
  TITLE     The HeLa Pur factor binds single-stranded DNA at a specific element
            conserved in gene flanking regions and origins of DNA replication
  JOURNAL   Mol Cell Biol 12 (3), 1257-1265 (1992)
   PUBMED   1545807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011379.7, M96684.1 and
            CK819077.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005859.4.
            
            Summary: This gene product is a sequence-specific, single-stranded
            DNA-binding protein. It binds preferentially to the single strand
            of the purine-rich element termed PUR, which is present at origins
            of replication and in gene flanking regions in a variety of
            eukaryotes from yeasts through humans. Thus, it is implicated in
            the control of both DNA replication and transcription. Deletion of
            this gene has been associated with myelodysplastic syndrome and
            acute myelogenous leukemia. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC036087.1, DRR138524.233110.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331327.5/ ENSP00000332706.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC011379.7         93014-93027         c
            15-1002             M96684.1           1-988
            1003-4740           AC011379.7         88288-92025         c
            4741-5308           CK819077.1         11-578              c
            5309-11511          AC011379.7         81517-87719         c
FEATURES             Location/Qualifiers
     source          1..11511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..11511
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="purine rich element binding protein A"
                     /db_xref="GeneID:5813"
                     /db_xref="HGNC:HGNC:9701"
                     /db_xref="MIM:600473"
     exon            1..11511
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1042
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="purine-rich single-stranded DNA-binding protein
                     alpha"
                     /codon_start=1
                     /product="transcriptional activator protein Pur-alpha"
                     /protein_id="NP_005850.1"
                     /db_xref="CCDS:CCDS4220.1"
                     /db_xref="GeneID:5813"
                     /db_xref="HGNC:HGNC:9701"
                     /db_xref="MIM:600473"
                     /translation="MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGGGGGGGGGSG
                     GGGGGAPGGLQHETQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGNKSRLTL
                     SMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRRALKSEFLVRENRKYYMDLK
                     ENQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGLIEFRDALAKLIDDYGVEEEPAEL
                     PEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSE
                     EMKKIQEKQREKRAACEQLHQQQQQQQEETAAATLLLQGEEEGEED"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="hexamer: ATTAAA"
     polyA_site      1866
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="major polyA site"
     regulatory      2606..2611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="hexamer: ATTAAA"
     polyA_site      2628
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="hexamer: ATTAAA"
     polyA_site      3152
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
     regulatory      5287..5292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="hexamer: AATAAA"
     polyA_site      5308
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="major polyA site"
     regulatory      8349..8354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
                     /note="hexamer: AATAAA"
     polyA_site      8371
                     /gene="PURA"
                     /gene_synonym="MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURALPHA"
ORIGIN      
        1 agcggcggct gaggcgactg aggcggcggg cggagcggca ggcggcggcg gcgcggcagc
       61 ggagcgcagc atcatggcgg accgagacag cggcagcgag cagggtggtg cggcgctggg
      121 ttcgggcggc tccctggggc accccggctc gggctcaggc tccggcgggg gcggtggtgg
      181 cggcgggggc ggcggcggca gtggcggcgg cggcggcggg gccccagggg ggctgcagca
      241 cgagacgcag gagctggcct ccaagcgggt ggacatccag aacaagcgct tctacctgga
      301 cgtgaagcag aacgccaagg gccgcttcct gaagatcgcc gaggtgggcg cgggcggcaa
      361 caagagccgc cttactctct ccatgtcagt ggccgtggag ttccgcgact acctgggcga
      421 cttcatcgag cactacgcgc agctgggccc cagccagccg ccggacctgg cccaggcgca
      481 ggacgagccg cgccgggcgc tcaaaagcga gttcctggtg cgcgagaacc gcaagtacta
      541 catggatctc aaggagaacc agcgcggccg cttcctgcgc atccgccaga cggtcaaccg
      601 ggggcctggc ctgggctcca cgcagggcca gaccattgcg ctgcccgcgc aggggctcat
      661 cgagttccgt gacgctctgg ccaagctcat cgacgactac ggagtggagg aggagccggc
      721 cgagctgccc gagggcacct ccttgactgt ggacaacaag cgcttcttct tcgatgtggg
      781 ctccaacaag tacggcgtgt ttatgcgagt gagcgaggtg aagcccacct atcgcaactc
      841 catcaccgtg ccctacaagg tgtgggccaa gttcggacac accttctgca agtactcgga
      901 ggagatgaag aagattcaag agaagcagag ggagaagcgg gctgcctgtg agcagcttca
      961 ccagcagcaa cagcagcagc aggaggagac cgccgctgcc accctgctac tgcagggtga
     1021 ggaagaaggg gaagaagatt gatcaaactg aatgaaaccc ccacacacac acacatgcat
     1081 acacacacac acacagccac acacacagaa aatatactgt aaagaaagag agaaaataaa
     1141 aagttaaaaa gttaaaaaaa aaaaaaaacc tgttaactcc aagggagcac cacccacaga
     1201 acctccacca actgacagtt tctcttcttg acttgccacc catcgctgga tgttgtccac
     1261 tttatccacc atataaaaca gtaagcagct gctaaaaaca aaaaaaatac aaaaagtaat
     1321 aacattatat gaactgtgtt tcctacttga ttaaaaaata taaagaactg agtgtttatt
     1381 tccctaatta accaagaact tttgtacacg tttaagctat tattattaaa aagtgtttgc
     1441 aaaatggtca agattataat attgctgaat tatataaaag tccttttcat gttgagctaa
     1501 catttgactt tagcacaaaa aagagatatt ttagaacacg taaaataata tttttagttt
     1561 ttctcatttt gttaccaaat ttcaaacctt acatggaggt tattatagta tatttgacac
     1621 cctatatacc tgtgattaga gatgtgtata tatatgaggg ctaggcatgc tgtgtgtctg
     1681 agctttgtct aaatgttatg cagaagtttg tagagttaaa ggtacgtagg tttaattcat
     1741 gcaaggtaaa caataagtgc tctcttttat acaatatgca ttgcatctgg accttaaact
     1801 tataaaaatg gtcagtgaaa cttctgtgaa catgaagaaa ttattaaaaa aggcatttaa
     1861 atgaaatttg ctaagttgtg atttttatgg ttggaaccaa agttattcaa atagtaaaag
     1921 gaaaaagaaa gaaaaaggag atctcccata atatttttct gcatctgttt gctttgactg
     1981 agtaggcgtt ttgtcattat tgtgtatatg agatgtactt gtatcgttca taatatattt
     2041 tttttattat gtgtagaaag attttaaaaa actaacgtgc agcaatttcc agtgaacctg
     2101 tacttggaca tcaggtagtg agtctatttg tggtcactag cactgtctcc taaacttgta
     2161 agaggtctga agctattctt tgatttttgc tagtgctatt aacttatgta gacctgttaa
     2221 aaagcagagc aacacaatta tagttatcct actgagccat ggattctgag ttttgtttta
     2281 aaagtgaaag ccaagttggt gtatgtaaag gatttccatg tagctgtggt gctagttatt
     2341 actggctaca ttatatgcta agtgtatttg tgttccccaa gtgtacaagc cttctatcaa
     2401 aagtatgttc tataactcat atattcaagg tgtagggtat gaaaatgcaa agtttaggag
     2461 agcactttac caagctggtg tcctccaaac tgaaattgtt tgtaacgata gtcttttaca
     2521 ggttttcctt taaagatgtt tgtgtgcttt taattgacaa ctaacttctt gctgctgtat
     2581 agtaaaatat taatatattt ttatcattaa actgctgcat gactatcatc tttgagtgaa
     2641 gagaaaatgt tataaaaaag atgccttaaa cagtacattt tggtttggaa ttctgtagaa
     2701 agtattttgg taaaaaaaaa aaaaaaaaaa aagggtcttg tctgacagag agttctgggg
     2761 atggaattgt ttcttggcaa atccagccat atagatctaa ctgctgtatg tataagacac
     2821 cacctgtagg agcgggaagg tatcagtgct tcttatattg taaagcattg gcctaggaag
     2881 gcaaacagtt gtctttttga aggatttttt tctgctggtc ctttgggttt tgatttgata
     2941 tttttatgct ccctggttga gtgtgttgtc ttcgtttttg agatctactg tatgtgttga
     3001 ataacaagct attttcattg tactgtgcat tttcccatta aattgtttgc ttttaatatt
     3061 caatgttaaa tatgaggtga ccgtacagta gttaggagtt tctttactta caaaatcact
     3121 ggaaatgatt aaattgcttt tccccctccc cagaggtgca tttttcttat ttccatatag
     3181 taaagttgag cttttacagt gcataatgtg acatttggaa tgcttatcaa ctgcatgtaa
     3241 acattaataa cctgcacttt tttgtcttaa ggtttgttga gctgttttgt tcactgtact
     3301 ttaactgtga tatggaaaag actgcattct ctgtgctgtt actaattagg aaagagaatt
     3361 gctttgattt tgtctcttgt ttactatagc ttcttaaagt taagccttgt actacaggtt
     3421 gttggagtac tcctagatca ctgtttcata gtagccagca ataagtagtg caagtcaaca
     3481 aaaacacagc aaacttaggc aaagtgtcct ttctttgaga tgcgagttct ttcatgaggt
     3541 tttctttagg gccagagtta cctaaagtga agcctttctt atctatagac ttcagattct
     3601 gcttggaatc ccaccggctc aagaagcaca tgtattgtgc aattaattgt ctttacacta
     3661 aaacagttta atacaatcta actacgattt tgaaaccagt gtctgattta tggtcagtgg
     3721 gtttaaaaag aaatccacat gcagatcttt taagacttaa aaagtgatca tagaaaagac
     3781 taagtgactg taaagatgct ctttttttaa gcatctcact ttacctcccc aagcaccctc
     3841 ccaaaccttg tcttccctct tctgttgcat cctttcccta cccttccctc ccaggtgctc
     3901 ggtactttac ctagtttcta tatatcagtg ttttatgttg gaatttttcc ttgtttttat
     3961 tttactagtt ggtaaaccct gtttatgctg aaacaaataa ggaaatggta tatttgacca
     4021 tatgtgttat tcatagaaga cagtatgatc aaatgtgcca aaaacaagca aacaaaactt
     4081 aattcctgag aagtatgcct tatttttatt gatctgcttt gtcttacaat taaggtccaa
     4141 gagcttggtt aaactgtatt atttgcctaa gtataaaaga aaacttgaac tgcattgcaa
     4201 tattgacgtt ctttaaaatg agagacactg tcaagtaatt taatccagag atcagccacc
     4261 agatttgaaa tgcttatgta tgtgtgtgtg tttggagttg tttttttctt ttaaatcacc
     4321 aaattttttt taagctactt tttatttgtg cctcctattt atcatgctga tgttagaagc
     4381 agcagtcatc cagccacaga gggagctaaa gttaactaac cagaactgta gaaatcatta
     4441 tacatgcctt tgacaacaaa ggaagttcat aagaaaagcc atgtcggctt ttcctctact
     4501 agatacagat tggaggtaga tgaatatttg ccaaatggaa aaaaagacaa tgctagtcag
     4561 aaaagacaaa ctgttttcca gcttctcaaa aagccatgga gagtagaaac caaaaccaac
     4621 agggaaataa aaaaccttga aagtctcact ttctagttgt cccatgcagg ggttgaaatt
     4681 tgattccaag cggaaagtat attatgtttt ttcaggcctt cacatctaga gagatggata
     4741 acttccaatt tgatttttca ggtaatagag aaagctgcta gtaattttaa cccctgccta
     4801 aagaagacat atacttcatt tgggagcaaa tacttattgc cttgaaaagt agcactgtaa
     4861 tagcctatga taattagttg tagaataacc tttatccctt tcaaactatg caaattatta
     4921 aataagtgta aattaggatt caattaaaga tagttgatta tattgcaatc agatggcatt
     4981 cacaaactta actggagcat atacaaatat attagtctaa gttttgtatg ctaacagaaa
     5041 gatataattt agctacctat tctaaaaatg gtgaatatta ttaatattgt ataataggag
     5101 tgggaagact gcctcctttt ttgaagagag agattaagga tttttataat tgtttttcat
     5161 caaattttaa tatttttgtc aaatttttag gtatttaatt tgtaaaacag tttgctttgt
     5221 actggcatac agaaaatagg gtattgattt taaacttttt gaagccaagt gatcaagtac
     5281 atttgtaata aaagtcaatg gatctatatc agttgtactc actgttttca tttcttatta
     5341 atatagggat gctgtacttt ttcttaagga aaactgaatt aaatttgggt ggaagggagg
     5401 gggaaaagat aaatccgttg ataatgagaa tctgggtggg tatcatggcc caagcacttt
     5461 atatcatttt ttaagtcagt taagatttga tatattttaa aagatactat gtcaactttt
     5521 ttcttcctat tttcttatgt aacttgacgt ttggggggat tatctcattc atttttgttt
     5581 gtgtgctttt aacattttgt gttttggccc tgttcaaact ttctaaacac atttttcttt
     5641 tatgacattt tgggttatct gctagacctg gtgaccccac catatgggca tgattatttt
     5701 tatcttccac acatggttca ccttcttgtc tacaatattc ccactcattt tttcaggtta
     5761 tatatacaca cacatttcca gataatttta gaatggggct atctgaaatt gatggtctag
     5821 tagctttcat agctccacaa ttcattttat tttacatgtg aacataattt taagattttc
     5881 ttcaccataa aaagtgagat accaagtcta atgacttttt tcccttttta aaatcttttg
     5941 agtatcagaa tgagaccttg ctatctatgt aaaaggatgc taaaacaagg gcatctgtag
     6001 caacttaggt ttggaatagt tggtgatgac tctgagtata acatttatag tttattatcc
     6061 ctaaatttga atatcttcat aatttggaga gagatgtata cacacacata cacatatata
     6121 tgtatatata cattgtgtgt gtgtatatgt atatagatac acacatctcc ttgagagtgg
     6181 aataagtagg agagataatt tattggaatt gcttacatag ataaattcac caaagttatt
     6241 tgtgtagatt tgttaaagtg tatcaatttt taaatcacaa tatttctgtt ttcttcattg
     6301 catattaacc aaattttggc cattcataag tatgctataa aactaaagtg atcactgcta
     6361 ttcacgaatt attatagaat cttctttgca gattttgtga tatattaaga aaagctgatt
     6421 ttaatattaa tatttaagaa gttatttgat cctgaaaacc taaatttaag gtataggcca
     6481 tttgacacgt cctttttgaa cagaaatttc attacaggct aagtgaaaat aagccagaat
     6541 tagcatgagt caggtagaat ttcatgataa aagaacaacc agatgaaata agaaataatg
     6601 attggtttca agccaatgaa tctgctaagc taactaccaa gttttgatgt tgaatggtcc
     6661 aggcaattta tgtctttagg aaagctgagt gtggcaaagg tcacttgtta acatttttct
     6721 taacaagaat gtcataacta ctcattcatt tttattttgt ccccacgttt ggtatttgtt
     6781 ttgttttgtg tttttccttc ctgatgtcct ttgcttttgt ggaagattgt cctgttgata
     6841 ggcagaaaca tggtggtgat cctctatgta aaatatagtt gcttcttaca catcagaagt
     6901 atttcactca ttttggaatc acaggatttt catgttttca taaatacaca cattgttttg
     6961 ataattatta gcaattagct tattttgtag cattagatgg aaaaatgttt aagctaaaga
     7021 gtttaatttt cttgattttg gttccacttt aataattcaa gaggcctcca agttcaagga
     7081 ccaagtcctt ctattttaga attgtgaaaa acatggaaat actcttgtta gtgtgtgttt
     7141 tggtctaagg tagattatta acacagaagg atcctaggag gatttaagaa aatatgtcct
     7201 tatcgtgaag tggcagttaa agttatggga caggtgaatt acctattcat cttgactagc
     7261 tcaaacaatg atagccatca gctaatgact tatcagacac atgttgagtt tgggtcaaac
     7321 tcccattcag ctggagtgga ttggcaattt taaatgcagg tagttggtgg tggtacttga
     7381 cctacctcct taccatgtac atctggcatc ttctctctcc tatccttttt ctttgtttct
     7441 ctctccactt ttactcttgc tgtaggccta ccagtggcac tcaagcttac ttcttcagag
     7501 agaagtaaag aaatttctga ctcctgcctt agaacatagc taactgatga tccagaacaa
     7561 tttcagtatt atgaggtaac tgggcagttt ttttctgatt gctattttcc ccatagtctt
     7621 aagctggcag tttgaaggta tctaaattaa tgttaagaaa cttgtgaact gaagagagta
     7681 agaagtatgt gtattttagg taagttactg ggaactgaga cttactggtt tggaaattgg
     7741 agagtaggac gaggagagct gtttaatgtg tttgtggatg ggggtttgag aggtatatag
     7801 agaatggttt ggaaataaag tgagaggaat ttttactaga ggtaggaaaa ggtactatga
     7861 tggagtccga atgagagtta tttgctaagg aaatgaagtt gatcttcact aaggaagttt
     7921 caataaagcc agagaaaatg ggtccctcat tgattatgag aaagctgtta gttactatag
     7981 ctagagttat gataatgatc atgcattata caagtctgtt ttcatgtata ggatgtctgc
     8041 ttttctggga caaattagca caattgtgga atgacagctt ttctggtcaa ggcaagtgga
     8101 tgctggggag ttattatttt gaggaaaaga aaatttcaag cttttcacca ttattctttt
     8161 taaactatca gaaatattta tcacacatac tatctatttt cttgggctct tgttacaatg
     8221 tagtttacct ttacttttca aatggtcctt agatcaaatt atttgatttt gtactccaca
     8281 aagacacata ttattccttg cttttataga attttgagac tttggcccac acaaatttct
     8341 tagaagacaa taaaccaggt aaaaacacta acttgcaatt ttaggtgtct tttttatttc
     8401 ttttacattt gcatccgtag caaccattta accttgtaga ccttatgagg ccctcaataa
     8461 tactgtattt ctaaaattag acaacatacc ccccaaactc atgtttctgt ttccctactt
     8521 tctctcttac tttaaaattg tagtattccc aagagttcag tggtggcaaa tgttaataaa
     8581 ataagttagt acattttgga ggttcttata tcctttgtag ggtaagctga tagtgtttag
     8641 atttctgttc ccattattcc agtagtgttt taaattattt aagataaata attactgtaa
     8701 tgtttgtttt taagttacat aattcaagta tgtttggatt aactctttgt tgtcaaattt
     8761 agtatggatt tattcctggt gatttggaca gattactttg aagtttcatt ttactcacat
     8821 ctctatatat tagtgataaa aatctctttt aaaaatagca aaaaagtggt tctgattttg
     8881 tactttgaag gtaatttttc ttttttacga atgtcaggtt cattaacaat agcaggatta
     8941 tttttactat agcttatttt gtagagttgg cactttagta taattttcac attttattgt
     9001 gtcagatttt aaattataat agttatatac tataactcat ttaagtcaat gcaaagcctt
     9061 cttaaatagc ccctccctta gaaatttgtt taaaaagaag tgaattccca aacctgtgtc
     9121 aagaacttgt gatttaaatg actgtgagac aagtccttga aaggcttaag tctagtcagt
     9181 ggagataaat gatagcccat ttccatgctg catatagttg ttagggttta taaagttgtc
     9241 aatgtgtaaa agtgcaaaag caggaaagac taaagttgcc tgtaaaattt ctagttttca
     9301 ttatttgcac tatttatctt tgcacttgat tttttgaaag ttaaggctag tcactttcac
     9361 ttttgtttct agtcttttct aatttcttgc agaattgtgt tttcaatatt ccacccaaag
     9421 caaaaattat atgcaattaa aaatatttta taaggccaag aaaatatttc ttaatgttag
     9481 ctgtataaaa caaaaatttg ttctgataaa atttttaata tgggccttta tttgccaata
     9541 aaatcctttg taaatgtgag ctttattaaa ctgtttaaat agacaaagtt aaagcttagg
     9601 atagggaata tatatgtatg tgtatatgaa atgatgtctt cgagttttaa cttccagcct
     9661 gagatggcct agatttggtg tgttagtttg tttcactgaa gtcagtgaga taggagtcta
     9721 gctgggtaca tgcttaaaaa gctggaagtg aagtgggtgg caagtggcag ctccctcttt
     9781 catgtagttt tccataatgt tcatatagtt tccttatggt ctaagtgtta caactggttt
     9841 tcaagttgtt atattgaata ttcctttttg gaattcaggg ttgaatcact ttgaggggga
     9901 agggaagcaa gggcaagaga ctttatttta accagatgcg gtcttatgac ctcaaagatg
     9961 tgctctagaa agaaaataac aaaaagtgta cctgtgaaca tattttttgt cttggtgata
    10021 ttatgcaaca cagtgttcag aattgcaaaa aaatttaaaa attgatagtt ttatcaatgg
    10081 aacagagaga tgtgtttttg gctaaaatta ttttttgtaa gttatttggt tatttcattt
    10141 tatattccct ttcccatagc tttgtacaca cctcatactt aaaaccaagt gagaggcctc
    10201 ttttcagatc tggtttattt ttggaatgcc tgagtgtgtt tccagattgg ggggggagag
    10261 gtggtgtttt actttttgac atgctcttag catgttttgc tagtcattct ggatcttatg
    10321 tttgcaaatt ctgttgaaca ttcagtgatg tatttgaaat gagaaagtcc tttataacat
    10381 agtgtgaatg tttgtggcca attcaattgt ggaatcttat ggctttgttt ttactttggg
    10441 tagaagttta acttccattg ttcagatttt aggtttatct agtgaaattg tgccaggtag
    10501 ttgtctaaat atggaccaat tttgggaaat gaagattaat aagtgtatat ttgattctag
    10561 ataatccttt actcaaaatc ataagttaaa gattcacatc attaagagtt atctaacttt
    10621 tatgttgtca aatctttaaa tgtggatgat attcagcatt ctatctatga atttccttta
    10681 ggaaaagaga aaaattcagt ctccaaacct tttcttggag acaaaattta ccacatatcg
    10741 aaaatgaaaa aaatttagaa agcgatttga ttatttttta atggagttta accagcttaa
    10801 ttaatgattt ttccagtttg aagcacttat tttcccaatg tgaataaagg gaaaagatca
    10861 gcaatttgtc cctggccttt ttcgaggcca tttttagttt tctgccccca tttcccagtc
    10921 ctggtataaa atgaattacg ggtatccctc taagtcccta taaccctttt tgggggtcac
    10981 agatatcttt gataatctga tgacagtgtg atggatcctc tacccaagaa aaaaaaaatg
    11041 cccatccctg gataattttg catacaactt caggggcatc acacatcttc tgaaacccaa
    11101 gttaaagatc tctgctctaa gtaaattgta gagaatttta gtgcaaatcg ttgataaaat
    11161 taggaaccaa ctattggctt aaaacctttc atattggaat tattgttaga tggtggcccc
    11221 tactagcaaa atgtgacatt gcaaccagct tcgttagaca ttataacaac cagagagaag
    11281 ggaaaaaagc aaagttctga aagctattta taaggagtca gggcatctct agacatggga
    11341 gccttcctgg ttcaaggcag gggtcagggt gcctgacaat ttctagcagg gtagagtttg
    11401 ataaaccaca atgctcagga tgccaagggg ttagccatta tcttaacccc ttcctcacca
    11461 aaagatttta gttttgtctg ttgggaaaca agatgtcact agggaaaaaa a
//
