LOCUS       NM_014878               2187 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens pumilio RNA binding family member 3 (PUM3), mRNA.
ACCESSION   NM_014878
VERSION     NM_014878.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Lin,H.W., Lee,J.Y., Chou,N.L., Shih,T.W. and Chang,M.S.
  TITLE     Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A stability and
            cell proliferation
  JOURNAL   PLoS One 16 (8), e0256282 (2021)
   PUBMED   34407138
  REMARK    GeneRIF: Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A
            stability and cell proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Qiu,C., McCann,K.L., Wine,R.N., Baserga,S.J. and Hall,T.M.
  TITLE     A divergent Pumilio repeat protein family for pre-rRNA processing
            and mRNA localization
  JOURNAL   Proc Natl Acad Sci U S A 111 (52), 18554-18559 (2014)
   PUBMED   25512524
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Turpeinen,H., Ojala,P.J., Ojala,K., Miettinen,M., Volin,L. and
            Partanen,J.
  TITLE     Minor histocompatibility antigens as determinants for
            graft-versus-host disease after allogeneic haematopoietic stem cell
            transplantation
  JOURNAL   Int J Immunogenet 40 (6), 495-501 (2013)
   PUBMED   23480177
  REMARK    GeneRIF: Results indicate that mismatches in minor H antigens HA-8
            (KIAA0020) and ACC-1 (BCL2A1) predisposed to chronic
            graft-versus-host disease (GvHD).
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Bhatnagar,P., Barron-Casella,E., Bean,C.J., Milton,J.N.,
            Baldwin,C.T., Steinberg,M.H., Debaun,M., Casella,J.F. and
            Arking,D.E.
  TITLE     Genome-wide meta-analysis of systolic blood pressure in children
            with sickle cell disease
  JOURNAL   PLoS One 8 (9), e74193 (2013)
   PUBMED   24058526
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   7  (bases 1 to 2187)
  AUTHORS   Warren,E.H., Otterud,B.E., Linterman,R.W., Brickner,A.G.,
            Engelhard,V.H., Leppert,M.F., Martin,P.J. and Riddell,S.R.
  TITLE     Feasibility of using genetic linkage analysis to identify the genes
            encoding T cell-defined minor histocompatibility antigens
  JOURNAL   Tissue Antigens 59 (4), 293-303 (2002)
   PUBMED   12135428
REFERENCE   8  (bases 1 to 2187)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 2187)
  AUTHORS   Brickner,A.G., Warren,E.H., Caldwell,J.A., Akatsuka,Y.,
            Golovina,T.N., Zarling,A.L., Shabanowitz,J., Eisenlohr,L.C.,
            Hunt,D.F., Engelhard,V.H. and Riddell,S.R.
  TITLE     The immunogenicity of a new human minor histocompatibility antigen
            results from differential antigen processing
  JOURNAL   J Exp Med 193 (2), 195-206 (2001)
   PUBMED   11148223
REFERENCE   10 (bases 1 to 2187)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832239.1, AL832245.1 and BC016137.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014878.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225953.1, AL832239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397885.3/ ENSP00000380982.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-953               AL832239.1         2-954
            954-955             AL832245.1         948-949
            956-2175            AL832239.1         957-2176
            2176-2187           BC016137.2         2115-2126
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.2"
     gene            1..2187
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /note="pumilio RNA binding family member 3"
                     /db_xref="GeneID:9933"
                     /db_xref="HGNC:HGNC:29676"
                     /db_xref="MIM:609960"
     exon            1..51
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..143
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2008
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /note="penguin homolog; minor histocompatibility antigen
                     HA-8; protein 5 transactivated by hepatitis B virus X
                     antigen (HBxAg); HBV X-transactivated gene 5 protein; HBV
                     XAg-transactivated protein 5"
                     /codon_start=1
                     /product="pumilio homolog 3"
                     /protein_id="NP_055693.4"
                     /db_xref="CCDS:CCDS6448.2"
                     /db_xref="GeneID:9933"
                     /db_xref="HGNC:HGNC:29676"
                     /db_xref="MIM:609960"
                     /translation="MEVKGKKQFTGKSTKTAQEKNRFHKNSDSGSSKTFPTRKVAKEG
                     GPKVTSRNFEKSITKLGKKGVKQFKNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDE
                     SAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDCDKEKRVKLMS
                     DLQKLIQGKIKTIAFAHDSTRVIQCYIQYGNEEQRKQAFEELRDDLVELSKAKYSRNI
                     VKKFLMYGSKPQIAEIIRSFKGHVRKMLRHAEASAIVEYAYNDKAILEQRNMLTEELY
                     GNTFQLYKSADHRTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLD
                     FFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVE
                     KVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIISSLPSIVNDKYGRKVLLYLLSPRD
                     PAHTVREIIEVLQKGDGNAHSKKDTEVRRRELLESISPALLSYLQEHAQEVVLDKSAC
                     VLVSDILGSATGDVQPTMNAIASLAATGLHPGGKDGELHIAEHPAGHLVLKWLIEQDK
                     KMKENGREGCFAKTLVEHVGMKNLKSWASVNRGAIILSSLLQSCDLEVANKVKAALKS
                     LIPTLEKTKSTSKGIEILLEKLST"
     exon            144..365
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            366..501
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            502..577
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            578..671
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            672..738
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            739..913
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1017
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1096
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1195
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1249
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1330
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1473
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1696
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1784
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1875
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2187
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2153..2158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /note="hexamer: TATAAA"
     polyA_site      2187
                     /gene="PUM3"
                     /gene_synonym="HA-8; HLA-HA8; KIAA0020; PEN; PUF-A; PUF6;
                     XTP5"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggcgg tcgggatccg ctgcgcgagc tgtctcggtc ccacgtgtgc gagttgctac
       61 gatggaagtt aaagggaaaa agcaattcac aggaaagagt acaaagacag cacaagaaaa
      121 aaacagattt cataaaaata gtgattctgg ttcttcaaag acatttccaa caaggaaagt
      181 tgctaaagaa ggtggaccta aagtcacatc taggaacttt gagaaaagta tcacaaaact
      241 tgggaaaaag ggtgtaaagc agttcaagaa taagcagcaa ggggacaaat caccaaagaa
      301 caaattccag ccggcaaata aattcaacaa gaagagaaaa ttccagccag atggtagaag
      361 cgatgaatca gcagccaaga agcccaaatg ggatgacttc aaaaagaaga agaaagaact
      421 gaagcaaagc agacaactca gtgataaaac caactatgac attgttgttc gggcaaagca
      481 gatgtgggag attttaagaa gaaaagactg tgacaaagaa aaaagagtaa agttaatgag
      541 tgatttgcag aagttgattc aagggaaaat taaaactatt gcatttgcac acgattcaac
      601 tcgtgtgatc cagtgttaca ttcagtatgg taatgaagaa cagagaaaac aggcttttga
      661 agaattgcga gatgatttgg ttgagttaag taaagccaaa tattcgagaa atattgttaa
      721 gaaatttctc atgtatggaa gtaaaccaca gattgcagag ataatcagaa gttttaaagg
      781 ccacgtgagg aagatgctgc ggcatgcgga agcatcagcc atcgtggagt acgcatacaa
      841 tgacaaagcc attttggagc agaggaacat gctgacggaa gagctctatg ggaacacatt
      901 tcagctttac aagtcagcag atcaccgaac tctggacaaa gtgttagagg tacagccaga
      961 aaaattagaa cttattatgg atgaaatgaa acagattcta actccaatgg cccaaaagga
     1021 agctgtgatt aagcactcat tggtgcataa agtattcttg gactttttta cctatgcacc
     1081 ccccaaactc agatcagaaa tgattgaagc catccgcgaa gcggtggtct acctggcaca
     1141 cacacacgat ggcgccagag tggccatgca ctgcctgtgg catggcacgc ccaaggacag
     1201 gaaagtgatt gtgaaaacaa tgaagactta tgttgaaaag gtggctaatg gccaatactc
     1261 ccatttggtt ttactggcgg catttgattg tattgatgat actaagcttg tgaagcagat
     1321 aatcatatca gaaattatca gttcattgcc tagcatagta aatgacaaat atggaaggaa
     1381 ggtcctattg tacttactaa gccccagaga tcctgcacat acagtacgag aaatcattga
     1441 agttctgcaa aaaggagatg gaaatgcaca cagtaagaaa gatacagagg tccgcagacg
     1501 ggagctccta gaatccattt ctccagcttt gttaagctac ctgcaagaac acgcccaaga
     1561 agtggtgcta gataagtctg cgtgtgtgtt ggtgtctgac attctgggat ctgccactgg
     1621 agacgttcag cctaccatga atgccatcgc cagcttggca gcaacaggac tgcatcctgg
     1681 tggcaaggac ggagagcttc acattgcaga acatcctgca ggacatctag ttctgaagtg
     1741 gttaatagag caagataaaa agatgaaaga aaatgggaga gaaggttgtt ttgcaaaaac
     1801 acttgtagag catgttggta tgaagaacct gaagtcctgg gctagtgtaa atcgaggtgc
     1861 cattattctt tctagcctcc tccagagttg tgacctggaa gttgcaaaca aagtcaaagc
     1921 tgcactgaaa agcttgattc ctacattgga aaaaaccaaa agcaccagca aaggaataga
     1981 aattctactt gaaaaactga gcacataggt ggaaagagtt aagagcaaga tggaatgatt
     2041 ttttctgttc tctgttctgt ttcccaatgc agaaaagaag gggtagggtc caccatactg
     2101 gtaattgggg tactctgtat atgtgtttct tctttgtata cgaatctatt tatataaatt
     2161 gtttttttaa atggtctttt ttaaaaa
//
