LOCUS       NM_001352926            5903 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens pumilio RNA binding family member 2 (PUM2), transcript
            variant 11, mRNA.
ACCESSION   NM_001352926
VERSION     NM_001352926.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5903)
  AUTHORS   Bai,T. and Liu,N.
  TITLE     RNA-binding protein PUM2 promotes T-cell acute lymphoblastic
            leukemia via competitively binding to RBM5 3'UTR with miR-28-5p
  JOURNAL   Eur J Haematol 110 (5), 498-509 (2023)
   PUBMED   36536516
  REMARK    GeneRIF: RNA-binding protein PUM2 promotes T-cell acute
            lymphoblastic leukemia via competitively binding to RBM5 3'UTR with
            miR-28-5p.
REFERENCE   2  (bases 1 to 5903)
  AUTHORS   Enwerem,I.I.I., Elrod,N.D., Chang,C.T., Lin,A., Ji,P., Bohn,J.A.,
            Levdansky,Y., Wagner,E.J., Valkov,E. and Goldstrohm,A.C.
  TITLE     Human Pumilio proteins directly bind the CCR4-NOT deadenylase
            complex to regulate the transcriptome
  JOURNAL   RNA 27 (4), 445-464 (2021)
   PUBMED   33397688
  REMARK    GeneRIF: Human Pumilio proteins directly bind the CCR4-NOT
            deadenylase complex to regulate the transcriptome.
REFERENCE   3  (bases 1 to 5903)
  AUTHORS   Zhang,T., Zhang,P. and Li,H.X.
  TITLE     CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of
            NSCLC Cells Through PUM2-Dependent Packaging
  JOURNAL   Int J Nanomedicine 16, 561-577 (2021)
   PUBMED   33542625
  REMARK    GeneRIF: CAFs-Derived Exosomal miRNA-130a Confers Cisplatin
            Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5903)
  AUTHORS   Wolfe,M.B., Schagat,T.L., Paulsen,M.T., Magnuson,B., Ljungman,M.,
            Park,D., Zhang,C., Campbell,Z.T., Goldstrohm,A.C. and
            Freddolino,P.L.
  TITLE     Principles of mRNA control by human PUM proteins elucidated from
            multimodal experiments and integrative data analysis
  JOURNAL   RNA 26 (11), 1680-1703 (2020)
   PUBMED   32753408
  REMARK    GeneRIF: Principles of mRNA control by human PUM proteins
            elucidated from multimodal experiments and integrative data
            analysis.
REFERENCE   5  (bases 1 to 5903)
  AUTHORS   Fox,M., Urano,J. and Reijo Pera,R.A.
  TITLE     Identification and characterization of RNA sequences to which human
            PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind
  JOURNAL   Genomics 85 (1), 92-105 (2005)
   PUBMED   15607425
  REMARK    GeneRIF: PUM2 and DAZL, are capable of binding the same mRNA
            sequences in the 3'UTR of human SDAD1 mRNA.
REFERENCE   6  (bases 1 to 5903)
  AUTHORS   Dazard,J.E., Gal,H., Amariglio,N., Rechavi,G., Domany,E. and
            Givol,D.
  TITLE     Genome-wide comparison of human keratinocyte and squamous cell
            carcinoma responses to UVB irradiation: implications for skin and
            epithelial cancer
  JOURNAL   Oncogene 22 (19), 2993-3006 (2003)
   PUBMED   12771951
REFERENCE   7  (bases 1 to 5903)
  AUTHORS   Jaruzelska,J., Kotecki,M., Kusz,K., Spik,A., Firpo,M. and Reijo
            Pera,R.A.
  TITLE     Conservation of a Pumilio-Nanos complex from Drosophila germ plasm
            to human germ cells
  JOURNAL   Dev Genes Evol 213 (3), 120-126 (2003)
   PUBMED   12690449
REFERENCE   8  (bases 1 to 5903)
  AUTHORS   Moore,F.L., Jaruzelska,J., Fox,M.S., Urano,J., Firpo,M.T.,
            Turek,P.J., Dorfman,D.M. and Pera,R.A.
  TITLE     Human Pumilio-2 is expressed in embryonic stem cells and germ cells
            and interacts with DAZ (Deleted in AZoospermia) and DAZ-like
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (2), 538-543 (2003)
   PUBMED   12511597
  REMARK    GeneRIF: PUM2 as a component of conserved cellular machinery that
            may be required for germ cell development.
REFERENCE   9  (bases 1 to 5903)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 5903)
  AUTHORS   Spassov,D.S. and Jurecic,R.
  TITLE     Cloning and comparative sequence analysis of PUM1 and PUM2 genes,
            human members of the Pumilio family of RNA-binding proteins
  JOURNAL   Gene 299 (1-2), 195-204 (2002)
   PUBMED   12459267
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007041.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001352926.1.
            
            Summary: This gene encodes a protein that belongs to a family of
            RNA-binding proteins. The encoded protein functions as a
            translational repressor during embryonic development and cell
            differentiation. This protein is also thought to be a positive
            regulator of cell proliferation in adipose-derived stem cells.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1361886.1,
                                           SRR1660803.144419.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC007041.3         114554-114632       c
            80-148              AC007041.3         90958-91026         c
            149-257             AC007041.3         82185-82293         c
            258-445             AC007041.3         75884-76071         c
            446-615             AC007041.3         75142-75311         c
            616-886             AC007041.3         71962-72232         c
            887-980             AC007041.3         71626-71719         c
            981-1106            AC007041.3         61201-61326         c
            1107-1249           AC007041.3         58024-58166         c
            1250-1388           AC007041.3         54300-54438         c
            1389-1532           AC007041.3         46991-47134         c
            1533-1817           AC007041.3         46595-46879         c
            1818-2085           AC007041.3         26841-27108         c
            2086-2215           AC007041.3         23985-24114         c
            2216-2344           AC007041.3         21891-22019         c
            2345-2482           AC007041.3         19681-19818         c
            2483-2608           AC007041.3         18864-18989         c
            2609-2730           AC007041.3         18511-18632         c
            2731-2923           AC007041.3         17470-17662         c
            2924-5903           AC007041.3         12385-15364         c
FEATURES             Location/Qualifiers
     source          1..5903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..5903
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /note="pumilio RNA binding family member 2"
                     /db_xref="GeneID:23369"
                     /db_xref="HGNC:HGNC:14958"
                     /db_xref="MIM:607205"
     exon            1..79
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..148
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3055
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /note="isoform 3 is encoded by transcript variant 11;
                     pumilio-2; pumilio homolog 2"
                     /codon_start=1
                     /product="pumilio homolog 2 isoform 3"
                     /protein_id="NP_001339855.1"
                     /db_xref="GeneID:23369"
                     /db_xref="HGNC:HGNC:14958"
                     /db_xref="MIM:607205"
                     /translation="MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDE
                     WRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSS
                     PADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRG
                     LPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSN
                     PETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQL
                     TAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAAT
                     LAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQ
                     RPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
                     PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQ
                     QQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSA
                     LSGFGSSGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIM
                     PSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFN
                     EILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKA
                     LESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFV
                     LSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPED
                     KSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTM
                     MKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSP
                     DLGPIGGPPNGML"
     exon            149..257
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..445
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..615
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..886
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..980
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1106
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1249
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1388
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1532
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1817
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2085
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2215
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2344
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2482
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2608
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2730
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2923
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..5903
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5868..5873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /note="hexamer: AATGAA"
     polyA_site      5903
                     /gene="PUM2"
                     /gene_synonym="PUMH2; PUML2"
                     /note="major polyA site"
ORIGIN      
        1 gcacgcgcag ggcgcccccg gcccgcgcgg cggcagcgcg ggagcaggga cgcaaggcat
       61 taaaaggagc cgcgccttgg tttgatctgt ggatgaaatg aatcatgatt ttcaagctct
      121 tgcattagaa tctcggggaa tgggagagct tttgcctacc aaaaagtttt gggaacctga
      181 tgattcaaca aaagatggac aaaaaggcat atttcttggg gatgatgaat ggagagagac
      241 tgcatgggga gcttctcacc attcaatgtc ccagcctatt atggtacaga gaagatctgg
      301 acagggtttt catggaaaca gtgaagtaaa tgcaatactg tctccgcgat cagaaagtgg
      361 aggccttggt gtgagcatgg tagaatatgt attaagttct tctcctgctg ataaattgga
      421 ttctcgattt aggaagggaa attttggcac tagagatgct gaaacagatg gacctgagaa
      481 aggagatcaa aaaggcaagg cttctccatt tgaggaggac caaaacagag atcttaaaca
      541 aggagatgat gatgattcta aaataaatgg cagaggtttg ccaaatggaa tggatgccga
      601 ttgcaaagat tttaatcgta ctcctggaag tcgtcaagcc tctccaactg aagtagttga
      661 gcgcttgggc cccaatacta atccctcaga aggactgggg cctcttccta atcctacagc
      721 taataaacca cttgttgaag aattttcaaa tcctgaaact cagaatctgg atgccatgga
      781 acaagttggt ctggaatcct tacagtttga ctatcctggt aatcaggtac caatggactc
      841 ttcaggagct actgtaggcc tttttgacta caattcccag cagcagctct ttcagaggac
      901 taatgcacta acagttcaac agttaactgc agctcaacag cagcaatatg cattagcagc
      961 agctcagcag ccacatatag ctggtgtatt ctcagcaggc cttgctccag ctgcatttgt
     1021 gccaaatcca tacattatta gtgctgctcc tccagggacc gatccgtata ctgcagcagg
     1081 attggctgca gcagctacat tagcaggtcc agcagtggtt ccacctcagt attacggcgt
     1141 tccatggggg gtgtatccag ccaacttatt tcagcagcaa gctgcagctg cggcaaataa
     1201 cacagccagt cagcaagcag catcacaagc tcagcctgga cagcaacagg ttctccgtgc
     1261 tggagcaggt cagcgtcctc ttactcccaa tcagggtcag caagggcagc aagcagaatc
     1321 acttgcggca gctgcagcag caaatccaac attggctttt ggtcagggtc ttgctactgg
     1381 catgccaggc tatcaagtac tagctccaac tgcctattat gatcagactg gtgccttagt
     1441 ggttggccct ggagcaagga ctggccttgg agctccagtt cggttaatgg ctccaacacc
     1501 tgttttaatt agttcagcag cagcacaagc tgcagcagca gcagcagctg gaggaactgc
     1561 aagtagcctt acaggcagca caaatggtct gtttcggcca attggcactc agccaccaca
     1621 gcagcagcaa cagcagccaa gcactaatct gcaatctaat tcattttatg gaagcagttc
     1681 tttgactaat agctcccaga gtagttcttt attttctcat ggacctggtc aacctggaag
     1741 tacatctctt ggctttggaa gtggtaactc tttgggtgct gctataggct cagccctcag
     1801 tggatttggt tcatcaggag gactgacaaa tggtagtggt cgatatatct ctgcagcacc
     1861 tggagcagaa gcaaaatatc gaagtgcttc aagcacttcc agtctattta gctccagcag
     1921 ccagctcttt cctccttccc ggcttcggta taataggtct gatattatgc cttctggccg
     1981 cagtagatta ttggaagatt tcagaaacaa ccgcttccca aaccttcagc ttagagactt
     2041 gattggacat atagttgagt tttctcaaga ccagcatggt tctagattca tacagcaaaa
     2101 actagagaga gctactccag ctgagcgaca gatggtattt aatgaaattc tgcaagcagc
     2161 ctatcaatta atgactgatg tttttggcaa ctatgttata cagaagtttt ttgagtttgg
     2221 gagtctggat caaaaattag ccctggctac tcgtattcgt ggtcatgttc tacccttagc
     2281 cttgcagatg tatggctgcc gcgttattca gaaagcatta gaatctattt cttctgacca
     2341 gcagagtgaa atggtaaagg agctggatgg tcatgtgctc aaatgtgtga aagatcagaa
     2401 tggaaaccat gttgtacaaa aatgtatcga atgtgttcag ccacagtcac tacagttcat
     2461 cattgatgct ttcaagggac aagtatttgt gctttcaact catccttatg gctgcagagt
     2521 aattcagcgc atcctagagc attgcactgc agaacagacc ttacctatct tagaagaact
     2581 ccaccaacat acagagcagt tggtacagga tcagtatggc aattatgtta ttcagcatgt
     2641 actggaacac ggtcgacctg aagacaagag caaaattgtt tccgaaatca ggggaaaggt
     2701 tttagccctg agtcaacaca aatttgccag caatgtagta gaaaagtgtg ttactcatgc
     2761 ctcccgtgct gagagagctt tactgattga cgaggtttgc tgccagaatg atggtcctca
     2821 cagtgcctta tacaccatga tgaaggacca gtatgccaat tacgtggttc aaaagatgat
     2881 tgatatggct gaacctgctc agagaaagat aatcatgcac aagattcgac ctcacattac
     2941 tactttgcgc aaatacacat acgggaagca tatactggcc aagttggaaa agtattattt
     3001 gaagaatagc ccggacctag gacctattgg aggaccacca aatggaatgc tgtaaattac
     3061 aggagcaaga gaaagaagat aatttaacca tgtgaaaaga atttttttgt gtgtgaatta
     3121 tcaaaacaca actcaactat gaatcttcaa ttttttttta aagcaaaact atttattgac
     3181 tttattcatc catttgtaaa ttttttaagg ttcttgtgta tatttggggg gtgggggatg
     3241 aattataaat tatattcagc cctgagtgga gacctatcag attggattgc tggcaaagca
     3301 cagaatgcct gtatatgatg taactgtatc aaaaataaaa agctgtcaca tattttgtaa
     3361 atttttacct tgtaaagtca caaaaatagt ttttaaagga aaaagtacag tattctttta
     3421 ataaactggc tcacagtctg gtaggtctac aaccccatag cacaacaggt ttatagagat
     3481 gtatatagaa ttatagtcct tatttttttc ctttgcgtga aaccttttat aacagattaa
     3541 caatcaactg cataaatatt attaatattt taaaaagagt taagttgtat tttgataatt
     3601 cacaaactat catgcaaata acgagtaagt agacaagaat aaagtggttt gagatgaaaa
     3661 gaacctaaca ttatttacag tagatgtggt tttaatacaa ttactgccct aaaatgtctc
     3721 tggcaatgta cagaaatatt gtatatactt acatatgtaa ttgttgtaag agttaaatac
     3781 aaaatcatgg tgacacttcc aattaagtgc actaaatgaa aagttaagtc acttattaac
     3841 ttttcagttt ggtttgcaat gagaaagagt ggaaatttgt attttgtttt gcttatagaa
     3901 ttacagacat gttgaggaag tgttgagctt tattttgctt tttcatagag gcagaaagta
     3961 ggaaccagat agagatgaaa aggggccact gaaaagtgaa tttgatagct cagcatttaa
     4021 gcatgattac atattcagat agctcttttt gctttctata aatatatgca ttgtgtgtgt
     4081 agtaatagat gtaagtttac actttgaaag gaaatcttgt ttcaatgttt attataaaag
     4141 ccttgctaat ttagtagtga tgctttcctt ggttgtacag gtgtacattt gtaaaccttc
     4201 atgctgtaaa tggaatttgt tttatctctt tgggatacat ttgcatttta gtgtacattt
     4261 acgtccctgc cctctttgac ctggcaatat agtgttgtat aatgtaaatt tatttctcca
     4321 aatcgagagt gattttttaa aaatttttta tctttatatg gtttcagaag tatgaaccag
     4381 ctttcttttt attattgtga gatcattttg ttttataaca tagttgttga ctgttaatat
     4441 ggacctgcta gaatttggat cactttcaat tgaagtcagg gtattgtgca taatagaaag
     4501 tattggactg agatatttgg ttaccatgga ggccaatgct tttttcatct tattaaatgt
     4561 gatgtgactt ttttctttgt acagaagagt actgtatttt tgaatagcct actcccaagt
     4621 aagagcaaat ctgtatgata acattttttc ctctggacat aagacataac agtaacacga
     4681 tgtacattta caagcggcct tatgtacatt tcccaacaat ctttttaagg caaaattgtg
     4741 accatatgtg tataattaaa atcgttttta atcctttgcc tatgaaaata ttttggaaaa
     4801 aaacttgctg tgtatattca gtttctgaaa gataaagaaa gtgctttgta ttttgttgaa
     4861 gtcagtattt tgtataaaca tttatgttga cccacttatg ttcagtgctg aaaactaaaa
     4921 tgaacatgct attctgtcag ctgaatatgg aagagatctt tttttactag agatctgcag
     4981 aagaaacgca atcttctgag cacaatatgg aatctaaagg ttttatcact tagttgttca
     5041 tattatgaac ctaaaaataa tggcataaag tttggggatg ccaggcatac tttttcatgt
     5101 ttggtgttga gttattttac ttttctaacc caacattcct tggtgagacc attaaatcca
     5161 aacacttgtc accgttcctt ctcatagtca ctctgggtca tcagcatgtc ccagtcactg
     5221 cagcaacgcc ttgtgtttgt ttcatttttt taaaacccac acaaagccgc tgtctcactt
     5281 tttcctactt taccaacctc agagtatttc ggcccgtatc gaacttttgt tctcagtatc
     5341 agcccatggt ttcaggatca aagctgtcat gttggagatt ggtaatggct ttcctgtctt
     5401 tgtacagttg aattcctagt cttccttcat ccttgccctc tgttggcaca ggcattatct
     5461 ctgcaatttt agaaaatgac aagtagagaa tactacattg agaaactaaa ccctcttctt
     5521 ggggtcctga tactcattcc catttgtccc agtgctgaca acccaatctt cccaatactt
     5581 tcaggcctgc tctacaaaag tacctgttct tgtagaaatt ttacagtctg ccattttggg
     5641 tgcccacccc aatttttacc ttttagtaag ttggcatgaa attttggtaa aatctgaaaa
     5701 tcacatttca gaataaaaca attgggcaaa actacctagg ctttactctt gagtgtctcc
     5761 ttttgatagg gattgtttct ggaccagttt gtctaagtcc tggctcttat tggttcatat
     5821 gaaataatgt taacttcact tctttgtata ttatgtataa attagaaaat gaaaaatgtg
     5881 tgaataacat tgtatgaaat aaa
//
