LOCUS       NM_002852               1884 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens pentraxin 3 (PTX3), mRNA.
ACCESSION   NM_002852
VERSION     NM_002852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Liu,D., Kuang,Y., Chen,S., Li,R., Su,F., Zhang,S., Qiu,Q., Lin,S.,
            Shen,C., Liu,Y., Liang,L., Wang,J., Xu,H. and Xiao,Y.
  TITLE     NAT10 promotes synovial aggression by increasing the stability and
            translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 83 (9), 1118-1131 (2024)
   PUBMED   38724075
  REMARK    GeneRIF: NAT10 promotes synovial aggression by increasing the
            stability and translation of N4-acetylated PTX3 mRNA in rheumatoid
            arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Weng,W.C., Hsieh,Y.H., Lin,C.Y., Liu,Y.F., Su,S.C., Wang,S.S. and
            Yang,S.F.
  TITLE     Functional variants of the pentraxin 3 gene are associated with the
            metastasis and progression of prostate cancer
  JOURNAL   J Cell Mol Med 28 (16), e70041 (2024)
   PUBMED   39187920
  REMARK    GeneRIF: Functional variants of the pentraxin 3 gene are associated
            with the metastasis and progression of prostate cancer.
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Li,Y., Chang,H.M., Zhu,H., Sun,Y.P. and Leung,P.C.K.
  TITLE     EGF-like growth factors upregulate pentraxin 3 expression in human
            granulosa-lutein cells
  JOURNAL   J Ovarian Res 17 (1), 97 (2024)
   PUBMED   38720330
  REMARK    GeneRIF: EGF-like growth factors upregulate pentraxin 3 expression
            in human granulosa-lutein cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Zhu,D., Chen,L., Meng,J., Wang,M., Ma,Y., Chen,X., Xiao,Y., Yi,D.,
            Shi,H., Sun,Y., Liu,H., Cheng,X., Su,Y., Ye,J., Chi,H., Zhou,Z.,
            Yang,C., Teng,J., Jia,J. and Hu,Q.
  TITLE     Neutrophil activation biomarker pentraxin 3 for diagnosis and
            monitoring of macrophage activation syndrome occurrence in
            adult-onset Still's disease
  JOURNAL   J Autoimmun 144, 103182 (2024)
   PUBMED   38460457
  REMARK    GeneRIF: Neutrophil activation biomarker pentraxin 3 for diagnosis
            and monitoring of macrophage activation syndrome occurrence in
            adult-onset Still's disease.
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Liu,J., Qiu,C., Zhou,Z., Li,J., Zhen,Y., Wang,R., Zhuang,Y. and
            Zhang,F.
  TITLE     Pentraxin 3 exacerbates psoriasiform dermatitis through regulation
            of macrophage polarization
  JOURNAL   Int Immunopharmacol 130, 111805 (2024)
   PUBMED   38457930
  REMARK    GeneRIF: Pentraxin 3 exacerbates psoriasiform dermatitis through
            regulation of macrophage polarization.
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Alles,V.V., Bottazzi,B., Peri,G., Golay,J., Introna,M. and
            Mantovani,A.
  TITLE     Inducible expression of PTX3, a new member of the pentraxin family,
            in human mononuclear phagocytes
  JOURNAL   Blood 84 (10), 3483-3493 (1994)
   PUBMED   7949102
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Lee,G.W., Goodman,A.R., Lee,T.H. and Vilcek,J.
  TITLE     Relationship of TSG-14 protein to the pentraxin family of major
            acute phase proteins
  JOURNAL   J Immunol 153 (8), 3700-3707 (1994)
   PUBMED   7523502
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Lee,G.W., Lee,T.H. and Vilcek,J.
  TITLE     TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a
            novel member of the pentaxin family of acute phase proteins
  JOURNAL   J Immunol 150 (5), 1804-1812 (1993)
   PUBMED   7679696
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Breviario,F., d'Aniello,E.M., Golay,J., Peri,G., Bottazzi,B.,
            Bairoch,A., Saccone,S., Marzella,R., Predazzi,V., Rocchi,M. et al.
  TITLE     Interleukin-1-inducible genes in endothelial cells. Cloning of a
            new gene related to C-reactive protein and serum amyloid P
            component
  JOURNAL   J Biol Chem 267 (31), 22190-22197 (1992)
   PUBMED   1429570
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Lee,T.H., Wisniewski,H.G. and Vilcek,J.
  TITLE     A novel secretory tumor necrosis factor-inducible protein (TSG-6)
            is a member of the family of hyaluronate binding proteins, closely
            related to the adhesion receptor CD44
  JOURNAL   J Cell Biol 116 (2), 545-557 (1992)
   PUBMED   1730767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA716533.1, BC039733.1,
            BQ010272.1 and AC020630.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002852.3.
            
            Summary: This gene encodes a member of the pentraxin protein
            family. The expression of this protein is induced by inflammatory
            cytokines in response to inflammatory stimuli in several
            mesenchymal and epithelial cell types, particularly endothelial
            cells and mononuclear phagocytes. The protein promotes fibrocyte
            differentiation and is involved in regulating inflammation and
            complement activation. It also plays a role in angiogenesis and
            tissue remodeling. The protein serves as a biomarker for several
            inflammatory conditions. [provided by RefSeq, Jun 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039733.1, X63613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295927.4/ ENSP00000295927.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               DA716533.1         63-506
            445-1660            BC039733.1         477-1692
            1661-1879           BQ010272.1         18-236              c
            1880-1884           AC020630.21        71253-71257
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.32"
     gene            1..1884
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /note="pentraxin 3"
                     /db_xref="GeneID:5806"
                     /db_xref="HGNC:HGNC:9692"
                     /db_xref="MIM:602492"
     exon            1..214
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1230
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /note="pentraxin-related protein PTX3; tumor necrosis
                     factor-inducible protein TSG-14; TNF alpha-induced protein
                     5; tumor necrosis factor alpha-induced protein 5; tumor
                     necrosis factor-inducible gene 14 protein; long pentraxin
                     3"
                     /codon_start=1
                     /product="pentraxin-related protein PTX3 precursor"
                     /protein_id="NP_002843.2"
                     /db_xref="CCDS:CCDS3180.1"
                     /db_xref="GeneID:5806"
                     /db_xref="HGNC:HGNC:9692"
                     /db_xref="MIM:602492"
                     /translation="MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDP
                     TPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARP
                     CAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTR
                     ADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDV
                     LNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNS
                     EEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLT
                     GFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS"
     exon            215..616
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1884
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /note="hexamer: AATAAA"
     polyA_site      1839
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /note="major polyA site"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
                     /note="hexamer: TATAAA"
     polyA_site      1884
                     /gene="PTX3"
                     /gene_synonym="TNFAIP5; TSG-14"
ORIGIN      
        1 actctcactc tcctccgctc aaactcagct cacttgagag tctcctcccg ccagctgtgg
       61 aaagaacttt gcgtctctcc agcaatgcat ctccttgcga ttctgttttg tgctctctgg
      121 tctgcagtgt tggccgagaa ctcggatgat tatgatctca tgtatgtgaa tttggacaac
      181 gaaatagaca atggactcca tcccactgag gaccccacgc cgtgcgcctg cggtcaggag
      241 cactcggaat gggacaagct cttcatcatg ctggagaact cgcagatgag agagcgcatg
      301 ctgctgcaag ccacggacga cgtcctgcgg ggcgagctgc agaggctgcg ggaggagctg
      361 ggccggctcg cggaaagcct ggcgaggccg tgcgcgccgg gggctcccgc agaggccagg
      421 ctgaccagtg ctctggacga gctgctgcag gcgacccgcg acgcgggccg caggctggcg
      481 cgtatggagg gcgcggaggc gcagcgccca gaggaggcgg ggcgcgccct ggccgcggtg
      541 ctagaggagc tgcggcagac gcgagccgac ctgcacgcgg tgcagggctg ggctgcccgg
      601 agctggctgc cggcaggttg tgaaacagct attttattcc caatgcgttc caagaagatt
      661 tttggaagcg tgcatccagt gagaccaatg aggcttgagt cttttagtgc ctgcatttgg
      721 gtcaaagcca cagatgtatt aaacaaaacc atcctgtttt cctatggcac aaagaggaat
      781 ccatatgaaa tccagctgta tctcagctac caatccatag tgtttgtggt gggtggagag
      841 gagaacaaac tggttgctga agccatggtt tccctgggaa ggtggaccca cctgtgcggc
      901 acctggaatt cagaggaagg gctcacatcc ttgtgggtaa atggtgaact ggcggctacc
      961 actgttgaga tggccacagg tcacattgtt cctgagggag gaatcctgca gattggccaa
     1021 gaaaagaatg gctgctgtgt gggtggtggc tttgatgaaa cattagcctt ctctgggaga
     1081 ctcacaggct tcaatatctg ggatagtgtt cttagcaatg aagagataag agagaccgga
     1141 ggagcagagt cttgtcacat ccgggggaat attgttgggt ggggagtcac agagatccag
     1201 ccacatggag gagctcagta tgtttcataa atgttgtgaa actccacttg aagccaaaga
     1261 aagaaactca cacttaaaac acatgccagt tgggaaggtc tgaaaactca gtgcataata
     1321 ggaacacttg agactaatga aagagagagt tgagaccaat ctttatttgt actggccaaa
     1381 tactgaataa acagttgaag gaaagacatt ggaaaaagct tttgaggata atgttactag
     1441 actttatgcc atggtgcttt cagtttaatg ctgtgtctct gtcagataaa ctctcaaata
     1501 attaaaaagg actgtattgt tgaacagagg gacaattgtt ttacttttct ttggttaatt
     1561 ttgttttggc cagagatgaa ttttacattg gaagaataac aaaataagat ttgttgtcca
     1621 ttgttcattg ttattggtat gtaccttatt acaaaaaaaa gatgaaaaca tatttatact
     1681 acaaggtgac ttaacaacta taaatgtagt ttatgtgtta taatcgaatg tcacgttttt
     1741 gagaagatag tcatataagt tatattgcaa aagggatttg tattaattta agactatttt
     1801 tgtaaagctc tactgtaaat aaaatatttt ataaaactag ctcacgtcat ttaattataa
     1861 atttaagaga tgttttggag caaa
//
