LOCUS       NM_006607                731 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pituitary tumor-transforming 2 (PTTG2), mRNA.
ACCESSION   NM_006607
VERSION     NM_006607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 731)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 731)
  AUTHORS   Liu,X.B., Li,F., Li,Y.Q. and Yang,F.
  TITLE     Pituitary tumor transforming gene PTTG2 induces psoriasis by
            regulating vimentin and E-cadherin expression
  JOURNAL   Int J Clin Exp Pathol 8 (9), 10887-10893 (2015)
   PUBMED   26617803
  REMARK    GeneRIF: PTTG2 induces psoriasis by regulating epidermal expression
            of vimentin and E-cadherin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 731)
  AUTHORS   Mendez-Vidal,C., Gamez-Del Estal,M.M., Moreno-Mateos,M.A.,
            Espina-Zambrano,A.G., Torres,B. and Pintor-Toro,J.A.
  TITLE     PTTG2 silencing results in induction of epithelial-to-mesenchymal
            transition and apoptosis
  JOURNAL   Cell Death Dis 4 (3), e530 (2013)
   PUBMED   23470537
  REMARK    GeneRIF: Knockdown of PTTG2 results in concomitant downregulation
            of E-cadherin and elevated vimentin levels, consistent with
            epithelial-to-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 731)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   5  (bases 1 to 731)
  AUTHORS   Chen,L., Puri,R., Lefkowitz,E.J. and Kakar,S.S.
  TITLE     Identification of the human pituitary tumor transforming gene
            (hPTTG) family: molecular structure, expression, and chromosomal
            localization
  JOURNAL   Gene 248 (1-2), 41-50 (2000)
   PUBMED   10806349
REFERENCE   6  (bases 1 to 731)
  AUTHORS   Prezant,T.R., Kadioglu,P. and Melmed,S.
  TITLE     An intronless homolog of human proto-oncogene hPTTG is expressed in
            pituitary tumors: evidence for hPTTG family
  JOURNAL   J Clin Endocrinol Metab 84 (3), 1149-1152 (1999)
   PUBMED   10084610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021106.6 and BC069114.1.
            
            On Nov 28, 2018 this sequence version replaced NM_006607.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504686.2/ ENSP00000424261.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC021106.6         126650-126686
            38-613              BC069114.1         1-576
            614-731             AC021106.6         127263-127380
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..731
                     /gene="PTTG2"
                     /note="pituitary tumor-transforming 2"
                     /db_xref="GeneID:10744"
                     /db_xref="HGNC:HGNC:9691"
                     /db_xref="MIM:604231"
     exon            1..731
                     /gene="PTTG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..613
                     /gene="PTTG2"
                     /note="pituitary tumor-transforming gene 2 protein"
                     /codon_start=1
                     /product="securin-2"
                     /protein_id="NP_006598.2"
                     /db_xref="CCDS:CCDS54755.1"
                     /db_xref="GeneID:10744"
                     /db_xref="HGNC:HGNC:9691"
                     /db_xref="MIM:604231"
                     /translation="MATLIYVDKEIGEPGTRVAAKDVLKLESRPSIKALDGISQVLTR
                     RFGKTYDAPSALPKATRKALGTVNRATEKSVKTNGPRKQKQPSFSAKKMTEKTVKTKS
                     SVPASDDAYPEIEKFFPFNLLDFESFDLPEERQIAHLPLSGVPLMILDEEGELEKLFQ
                     LGPPSPVKMPSPPWECNLFAVSFKHSVDPGC"
     regulatory      712..717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTTG2"
                     /note="hexamer: AATAAA"
     polyA_site      731
                     /gene="PTTG2"
                     /note="major polyA site"
ORIGIN      
        1 agatgaatgt ggctgttgag agcggcaata atccagaatg gctactctga tctacgttga
       61 taaggaaatt ggagaaccag gcacccgtgt ggctgccaag gatgtgctga agctggagtc
      121 tagaccttca atcaaagcat tagatgggat atctcaagtt ttaacacgac gttttggcaa
      181 aacatacgat gctccatcag ccttacctaa agctaccaga aaggctttgg gcactgtcaa
      241 cagagctaca gaaaagtcag taaagaccaa tggacccaga aaacaaaaac agccaagctt
      301 ttctgccaaa aagatgaccg agaagactgt taaaacaaaa agttctgttc ctgcctcaga
      361 tgacgcctat ccagaaatag aaaaattctt tcccttcaat cttctagact ttgagagttt
      421 tgacctgcct gaagagcgcc agattgcaca cctccccttg agtggagtgc ctctcatgat
      481 ccttgatgag gagggagagc ttgaaaagct gtttcagctg ggcccccctt cacctgtgaa
      541 aatgccctct ccaccatggg aatgcaatct gtttgcagtc tccttcaagc attctgtcga
      601 ccctggatgt tgaattgcca gctgtttgct atgacataga tatttaaatt tcttagtgct
      661 ttggagtttg tgtgtacttg tattaataaa gcattatttg tttaacaaca taataaatac
      721 ataaatataa a
//
