LOCUS       NM_004339               2600 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript
            variant 1, mRNA.
ACCESSION   NM_004339
VERSION     NM_004339.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2600)
  AUTHORS   Dai,X., Luo,S., Guo,S., Zhou,W. and Song,W.
  TITLE     Sp4 Regulates PTTG1IP Gene Transcription and Expression
  JOURNAL   DNA Cell Biol 41 (12), 1053-1062 (2022)
   PUBMED   36383136
  REMARK    GeneRIF: Sp4 Regulates PTTG1IP Gene Transcription and Expression.
REFERENCE   2  (bases 1 to 2600)
  AUTHORS   Yang,C., Liu,Q. and Jiang,Z.
  TITLE     CircPTTG1IP knockdown suppresses rheumatoid arthritis progression
            by targeting miR-431-5p/FSTL1 axis
  JOURNAL   Transpl Immunol 75, 101685 (2022)
   PUBMED   35933079
  REMARK    GeneRIF: CircPTTG1IP knockdown suppresses rheumatoid arthritis
            progression by targeting miR-431-5p/FSTL1 axis.
REFERENCE   3  (bases 1 to 2600)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2600)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2600)
  AUTHORS   Huang,S.Q., Wang,B., Liao,Q.J., Shen,C.X. and Li,W.B.
  TITLE     Pituitary tumor transforming gene binding factor (PBF) is required
            for androgen-induced prostate cancer proliferation and invasion
  JOURNAL   Neoplasma 66 (3), 327-335 (2019)
   PUBMED   30569723
  REMARK    GeneRIF: PBF is a novel AR target gene and plays a role in
            androgen-induced proliferation and metastatic functions
REFERENCE   6  (bases 1 to 2600)
  AUTHORS   Tfelt-Hansen,J., Yano,S., Bandyopadhyay,S., Carroll,R., Brown,E.M.
            and Chattopadhyay,N.
  TITLE     Expression of pituitary tumor transforming gene (PTTG) and its
            binding protein in human astrocytes and astrocytoma cells: function
            and regulation of PTTG in U87 astrocytoma cells
  JOURNAL   Endocrinology 145 (9), 4222-4231 (2004)
   PUBMED   15178645
  REMARK    GeneRIF: PTTG expression was higher in malignant cells than in
            primary astrocytes, whereas PTTG-binding factor was not in
            astrocytoma
REFERENCE   7  (bases 1 to 2600)
  AUTHORS   Stock,M., Schafer,H., Fliegauf,M. and Otto,F.
  TITLE     Identification of novel genes of the bone-specific transcription
            factor Runx2
  JOURNAL   J Bone Miner Res 19 (6), 959-972 (2004)
   PUBMED   15190888
REFERENCE   8  (bases 1 to 2600)
  AUTHORS   Boelaert,K., Tannahill,L.A., Bulmer,J.N., Kachilele,S., Chan,S.Y.,
            Kim,D., Gittoes,N.J., Franklyn,J.A., Kilby,M.D. and McCabe,C.J.
  TITLE     A potential role for PTTG/securin in the developing human fetal
            brain
  JOURNAL   FASEB J 17 (12), 1631-1639 (2003)
   PUBMED   12958169
REFERENCE   9  (bases 1 to 2600)
  AUTHORS   Chien,W. and Pei,L.
  TITLE     A novel binding factor facilitates nuclear translocation and
            transcriptional activation function of the pituitary
            tumor-transforming gene product
  JOURNAL   J Biol Chem 275 (25), 19422-19427 (2000)
   PUBMED   10781616
REFERENCE   10 (bases 1 to 2600)
  AUTHORS   Yaspo,M.L., Aaltonen,J., Horelli-Kuitunen,N., Peltonen,L. and
            Lehrach,H.
  TITLE     Cloning of a novel human putative type Ia integral membrane protein
            mapping to 21q22.3
  JOURNAL   Genomics 49 (1), 133-136 (1998)
   PUBMED   9570958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG721942.1 and BC019295.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004339.3.
            
            Summary: This gene encodes a single-pass type I integral membrane
            protein, which binds to pituitary tumor-transforming 1 protein
            (PTTG1), and facilitates translocation of PTTG1 into the nucleus.
            Coexpression of this protein and PTTG1 induces transcriptional
            activation of basic fibroblast growth factor. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.172735.1,
                                           SRR1660807.105466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330938.8/ ENSP00000328325.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BG721942.1         153-192
            41-2600             BC019295.1         1-2560
FEATURES             Location/Qualifiers
     source          1..2600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2600
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /note="PTTG1 interacting protein"
                     /db_xref="GeneID:754"
                     /db_xref="HGNC:HGNC:13524"
                     /db_xref="MIM:603784"
     exon            1..189
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..617
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pituitary tumor-transforming gene 1
                     protein-interacting protein; PTTG-binding factor;
                     pituitary tumor-transforming gene protein-binding factor;
                     pituitary tumor-transforming 1 interacting protein"
                     /codon_start=1
                     /product="pituitary tumor-transforming gene 1
                     protein-interacting protein isoform 1 precursor"
                     /protein_id="NP_004330.1"
                     /db_xref="CCDS:CCDS13715.1"
                     /db_xref="GeneID:754"
                     /db_xref="HGNC:HGNC:13524"
                     /db_xref="MIM:603784"
                     /translation="MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNT
                     NKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITM
                     SVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDE
                     IRKKYGLFKEENPYARFENN"
     exon            190..242
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..351
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..523
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..570
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..2600
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /note="hexamer: AATAAA"
     polyA_site      2600
                     /gene="PTTG1IP"
                     /gene_synonym="C21orf1; C21orf3; PBF; PTTG1IP1"
                     /note="major polyA site"
ORIGIN      
        1 gttccgggcg gagaccgctt gtgctggagt cggagttgta acgctccact gactgataga
       61 gcgaccggcc gaccatggcg cccggagtgg cccgcgggcc gacgccgtac tggaggttgc
      121 gcctcggtgg cgccgcgctg ctcctgctgc tcatcccggt ggccgccgcg caggagcctc
      181 ccggagctgc ttgttctcag aacacaaaca aaacctgtga agagtgcctg aagaacgtct
      241 cctgtctttg gtgcaacact aacaaggctt gtctggacta cccagttaca agcgtcttgc
      301 caccggcttc cctttgtaaa ttgagctctg cacgctgggg agtttgttgg gtgaactttg
      361 aggcgctgat catcaccatg tcggtagtcg ggggaaccct cctcctgggc attgccatct
      421 gctgctgctg ctgctgcagg aggaagagga gccggaagcc ggacaggagt gaggagaagg
      481 ccatgcgtga gcgggaggag aggcggatac ggcaggagga acggagagca gagatgaaga
      541 caagacatga tgaaatcaga aaaaaatatg gcctgtttaa agaagaaaac ccgtatgcta
      601 gatttgaaaa caactaaagc gctccagcac atcagtcccg acgcttcctg tgaggtgcac
      661 gctccgcagc ccagcccagc cgggagacca cgtggccatt gcggtctcct gaccttggcc
      721 agtgaacctg ccagccttcc aggacaggcg gccggagagc tgcccctgaa ggacagtcct
      781 ctcgtcttgc agactggtga ccttctattc cctgttcatc tctgtttcta gatttagtca
      841 cttgaaataa gaaatctttg gggtttgggc ttttttatac tcttctcagt ttgtgaaacg
      901 ctaactgcac acgaagccgc ctgacggcac ccagcgctgt ggctgtcatt ctcccagggc
      961 agaaccctgc gtttctctct gtccactaac aagcttcaca cgcaacacag ggaagtcggt
     1021 ttgacttttg tcatgaggag aactgaccag ccctcatcat tccccataaa accacggaca
     1081 gcgtctgtgt gcgcatcttg agtcttcaca cctgttgact cacacggctt ttgctgatga
     1141 cacggggctc cagtacacag tctgataagg acttaacgtc ctaacctcaa ttgtattaaa
     1201 tagcattggg gaatagctaa acctttttaa aaaaatttat tggattttcc tccctgctta
     1261 aaagatttca ccagaaaacc ttcatataaa aattcaggcc ctttttggac aatttttaaa
     1321 atttgtatct ttactagaac atgagaatct ttttcccttg gaagcttgaa ttataaatgt
     1381 ggtgtttggc ctgcctcagc agcaccagtt gactgctcgt gtgccagcgg tgtggggagg
     1441 acggggcagg acgctgcagc tctctccagc cctgttggca tcctcagtgc ctgcaggcct
     1501 ctcgctgcct gttgggctgt ctggggggtg gccatttagg gatcgtgggg acggggtcca
     1561 ccccaagaag aaagaaaggc ccgtccacag gcccggctct gggccacgtg ccccggaagc
     1621 aggtgtgtcc agagtcagct gagggctctc cccacaccac ccagcaggcg ctggtgctcc
     1681 ttctgcctca tgggaccagt ccagcttcca gccgctctgg ctcgagggtg gtctgaccac
     1741 ttccttctga gtgggcttct ctgggagctc tccagtggca ctgctggacc tgcccacgtt
     1801 tctgtaaaat caggatacgt ggctttagta agcagaccaa gcgcttcgtg gcagggaaag
     1861 cagcgtgcgg ggaagtcact gaaaagtgct gcctaaggaa gtttggaaat agtccctgtt
     1921 ccagattgcc ttgaatttta aaacattttg ctttgggaaa gtaggtcagc agcacctaag
     1981 atcaaggatg cgttccattt tcacacttca cagtcatgaa aactgagaag actgtcttca
     2041 gcgtgaacta aagttcacag gcagatcact gatccagaac acttcaagaa ctcgtcaaac
     2101 agctcgataa gcctttttga ctgtgtacat ctgtaccggg aataacattc ctaggctgaa
     2161 atttccacaa agaatagaac ctgtacccag ttcttcaggc tgatttccct gacctcttgg
     2221 gcatttgtat ttgtagtaaa gtattgcaga gattcctaag tattttatag cagccatcaa
     2281 aattggactt tgtattgttt attcataaaa gacacttggt aatagacttc agtgaactct
     2341 gtatgaatgc agtagtgtgt gtgcaaaatc cgcttcctga gcgtagggtg ctgagctggc
     2401 gctagggctc ggttgtgaaa tacagcgtag tcagcccttg cgctcagtgt agaaacccac
     2461 gtctgtaagg tcggtcttcg tccatctgct tttttctgaa atacactaag agcagccaca
     2521 aaactgtaac ctcaaggaaa ccataaagct tggagtgcct taatttttaa ccagtttcca
     2581 ataaaacggt ttactacctg
//
