LOCUS       NM_004219                715 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens PTTG1 regulator of sister chromatid separation,
            securin (PTTG1), transcript variant 2, mRNA.
ACCESSION   NM_004219
VERSION     NM_004219.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 715)
  AUTHORS   Wang,Z., Zhang,J., Zuo,C., Chen,H., Wang,L., Xie,Y., Ma,H., Min,S.,
            Wang,X. and Lian,C.
  TITLE     Identification and validation of tryptophan-related gene signatures
            to predict prognosis and immunotherapy response in lung
            adenocarcinoma reveals a critical role for PTTG1
  JOURNAL   Front Immunol 15, 1386427 (2024)
   PUBMED   39144144
  REMARK    GeneRIF: Identification and validation of tryptophan-related gene
            signatures to predict prognosis and immunotherapy response in lung
            adenocarcinoma reveals a critical role for PTTG1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 715)
  AUTHORS   Wang,L. and Liu,X.
  TITLE     Multi-Omics Analysis of the Oncogenic Value of Pituitary
            Tumor-Transforming Gene 1 (PTTG1) in Human Cancers
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 87 (2024)
   PUBMED   38420810
  REMARK    GeneRIF: Multi-Omics Analysis of the Oncogenic Value of Pituitary
            Tumor-Transforming Gene 1 (PTTG1) in Human Cancers.
REFERENCE   3  (bases 1 to 715)
  AUTHORS   Hu,X., Yang,F. and Mei,H.
  TITLE     Pituitary tumor transforming gene 1 promotes proliferation and
            malignant phenotype in osteosarcoma via NF-kappaB signaling
  JOURNAL   J Orthop Sci 29 (1), 306-314 (2024)
   PUBMED   36414514
  REMARK    GeneRIF: Pituitary tumor transforming gene 1 promotes proliferation
            and malignant phenotype in osteosarcoma via NF-kappaB signaling.
REFERENCE   4  (bases 1 to 715)
  AUTHORS   Teveroni,E., Di Nicuolo,F., Vergani,E., Oliva,A., Vodola,E.P.,
            Bianchetti,G., Maulucci,G., De Spirito,M., Cenci,T., Pierconti,F.,
            Gulino,G., Iavarone,F., Urbani,A., Milardi,D., Pontecorvi,A. and
            Mancini,F.
  TITLE     SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its
            Oncogenic Activity in Human Seminoma
  JOURNAL   Int J Mol Sci 24 (23), 16891 (2023)
   PUBMED   38069214
  REMARK    GeneRIF: SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1,
            Impairing Its Oncogenic Activity in Human Seminoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 715)
  AUTHORS   Zhang,X., Wu,N., Huang,H., Li,S., Liu,S., Zhang,R., Huang,Y.,
            Lyu,H., Xiao,S., Ali,D.W., Michalak,M., Chen,X.Z., Zhou,C. and
            Tang,J.
  TITLE     Phosphorylated PTTG1 switches its subcellular distribution and
            promotes beta-catenin stabilization and subsequent transcription
            activity
  JOURNAL   Oncogene 42 (32), 2439-2455 (2023)
   PUBMED   37400529
  REMARK    GeneRIF: Phosphorylated PTTG1 switches its subcellular distribution
            and promotes beta-catenin stabilization and subsequent
            transcription activity.
REFERENCE   6  (bases 1 to 715)
  AUTHORS   Zhang,X., Horwitz,G.A., Heaney,A.P., Nakashima,M., Prezant,T.R.,
            Bronstein,M.D. and Melmed,S.
  TITLE     Pituitary tumor transforming gene (PTTG) expression in pituitary
            adenomas
  JOURNAL   J Clin Endocrinol Metab 84 (2), 761-767 (1999)
   PUBMED   10022450
REFERENCE   7  (bases 1 to 715)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
REFERENCE   8  (bases 1 to 715)
  AUTHORS   Zhang,X., Horwitz,G.A., Prezant,T.R., Valentini,A., Nakashima,M.,
            Bronstein,M.D. and Melmed,S.
  TITLE     Structure, expression, and function of human pituitary
            tumor-transforming gene (PTTG)
  JOURNAL   Mol Endocrinol 13 (1), 156-166 (1999)
   PUBMED   9892021
REFERENCE   9  (bases 1 to 715)
  AUTHORS   Dominguez,A., Ramos-Morales,F., Romero,F., Rios,R.M., Dreyfus,F.,
            Tortolero,M. and Pintor-Toro,J.A.
  TITLE     hpttg, a human homologue of rat pttg, is overexpressed in
            hematopoietic neoplasms. Evidence for a transcriptional activation
            function of hPTTG
  JOURNAL   Oncogene 17 (17), 2187-2193 (1998)
   PUBMED   9811450
REFERENCE   10 (bases 1 to 715)
  AUTHORS   Kakar,S.S.
  TITLE     Assignment of the human tumor transforming gene TUTR1 to chromosome
            band 5q35.1 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 93-95 (1998)
   PUBMED   9925941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY006026.1, AF075242.1 and
            BM990391.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004219.3.
            
            Summary: The encoded protein is a homolog of yeast securin
            proteins, which prevent separins from promoting sister chromatid
            separation. It is an anaphase-promoting complex (APC) substrate
            that associates with a separin until activation of the APC. The
            gene product has transforming activity in vitro and tumorigenic
            activity in vivo, and the gene is highly expressed in various
            tumors. The gene product contains 2 PXXP motifs, which are required
            for its transforming and tumorigenic activities, as well as for its
            stimulation of basic fibroblast growth factor expression. It also
            contains a destruction box (D box) that is required for its
            degradation by the APC. The acidic C-terminal region of the encoded
            protein can act as a transactivation domain. The gene product is
            mainly a cytosolic protein, although it partially localizes in the
            nucleus. Three transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026003.1, BG777226.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352433.10/ ENSP00000344936.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                HY006026.1         50-77
            29-684              AF075242.1         1-656
            685-715             BM990391.1         24-54               c
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..715
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /note="PTTG1 regulator of sister chromatid separation,
                     securin"
                     /db_xref="GeneID:9232"
                     /db_xref="HGNC:HGNC:9690"
                     /db_xref="MIM:604147"
     exon            1..37
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            38..139
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..657
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /note="ESP1-associated protein 1; tumor-transforming
                     protein 1; pituitary tumor-transforming gene 1 protein;
                     pituitary tumor-transforming 1; endogenous cardiac
                     regeneration-associated regulator"
                     /codon_start=1
                     /product="securin"
                     /protein_id="NP_004210.1"
                     /db_xref="CCDS:CCDS4353.1"
                     /db_xref="GeneID:9232"
                     /db_xref="HGNC:HGNC:9690"
                     /db_xref="MIM:604147"
                     /translation="MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTP
                     RFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKS
                     SVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQ
                     LGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI"
     exon            140..324
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..418
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..577
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..715
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /note="hexamer: AATAAA"
     polyA_site      715
                     /gene="PTTG1"
                     /gene_synonym="EAP1; ECRAR; HPTTG; PTTG; TUTR1"
                     /note="major polyA site"
ORIGIN      
        1 accgcggcct cagatgaatg cggctgttaa gacctgcaat aatccagaat ggctactctg
       61 atctatgttg ataaggaaaa tggagaacca ggcacccgtg tggttgctaa ggatgggctg
      121 aagctggggt ctggaccttc aatcaaagcc ttagatggga gatctcaagt ttcaacacca
      181 cgttttggca aaacgttcga tgccccacca gccttaccta aagctactag aaaggctttg
      241 ggaactgtca acagagctac agaaaagtct gtaaagacca agggacccct caaacaaaaa
      301 cagccaagct tttctgccaa aaagatgact gagaagactg ttaaagcaaa aagctctgtt
      361 cctgcctcag atgatgccta tccagaaata gaaaaattct ttcccttcaa tcctctagac
      421 tttgagagtt ttgacctgcc tgaagagcac cagattgcgc acctcccctt gagtggagtg
      481 cctctcatga tccttgacga ggagagagag cttgaaaagc tgtttcagct gggcccccct
      541 tcacctgtga agatgccctc tccaccatgg gaatccaatc tgttgcagtc tccttcaagc
      601 attctgtcga ccctggatgt tgaattgcca cctgtttgct gtgacataga tatttaaatt
      661 tcttagtgct tcagagtttg tgtgtatttg tattaataaa gcattcttta acaga
//
