LOCUS       NM_001002913             962 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens peptidyl-tRNA hydrolase 1 homolog (PTRH1), transcript
            variant 1, mRNA.
ACCESSION   NM_001002913 XM_059972
VERSION     NM_001002913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Kuroha,K., Zinoviev,A., Hellen,C.U.T. and Pestova,T.V.
  TITLE     Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from
            Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1
  JOURNAL   Mol Cell 72 (2), 286-302 (2018)
   PUBMED   30244831
REFERENCE   4  (bases 1 to 962)
  AUTHORS   De Pereda,J.M., Waas,W.F., Jan,Y., Ruoslahti,E., Schimmel,P. and
            Pascual,J.
  TITLE     Crystal structure of a human peptidyl-tRNA hydrolase reveals a new
            fold and suggests basis for a bifunctional activity
  JOURNAL   J Biol Chem 279 (9), 8111-8115 (2004)
   PUBMED   14660562
  REMARK    GeneRIF: arrangement of secondary structure elements generates a
            fold not previously reported for peptidyl-trna hydrolase and
            intermolecular contacts in the crystal asymmetric unit cell suggest
            a likely surface for protein-protein interactions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB141384.1, BC047012.1 and BQ045289.1.
            
            On Jul 10, 2019 this sequence version replaced NM_001002913.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047012.1, BX399486.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543175.5/ ENSP00000439469.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DB141384.1         14-19
            7-821               BC047012.1         1-815
            822-962             BQ045289.1         163-303             c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..962
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /note="peptidyl-tRNA hydrolase 1 homolog"
                     /db_xref="GeneID:138428"
                     /db_xref="HGNC:HGNC:27039"
                     /db_xref="MIM:621047"
     exon            1..120
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..669
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /EC_number="3.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable peptidyl-tRNA hydrolase; PTH"
                     /codon_start=1
                     /product="peptidyl-tRNA hydrolase isoform 1"
                     /protein_id="NP_001002913.1"
                     /db_xref="CCDS:CCDS35147.1"
                     /db_xref="GeneID:138428"
                     /db_xref="HGNC:HGNC:27039"
                     /db_xref="MIM:621047"
                     /translation="MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGT
                     RHSVGMAVLGQLARRLGVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSV
                     ARAAELFGLTAEEVYLVHDELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLR
                     VGIGRPAHPEAVQAHVLGCFSPAEQELLPLLLDRATDLILDHIRERSQGPSLGP"
     exon            121..340
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..440
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..486
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..962
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      800..805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /note="hexamer: ATTAAA"
     polyA_site      821
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /note="major polyA site"
     regulatory      943..948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
                     /note="hexamer: ATTAAA"
     polyA_site      962
                     /gene="PTRH1"
                     /gene_synonym="C9orf115; PTH1"
ORIGIN      
        1 ggtgtcggag tgaatggggg cagcatgagg ccgggcggct ttttgggcgc cggacagcgg
       61 ctgagtagag ccatgagccg atgtgttttg gagcctcgcc ccccggggaa gcggtggatg
      121 gtggctggcc tggggaatcc cggactgccc ggcacgcgac acagcgtggg catggcggtg
      181 ctggggcagc tggcgcggcg gctgggtgtg gcggagagtt ggacgcgcga ccggcactgt
      241 gccgccgacc tcgccctggc cccgctgggg gatgcccaac tggtcctgct ccggccacgg
      301 cggcttatga acgccaacgg gcgcagcgtg gcccgggctg cggagctgtt tgggctgact
      361 gccgaggaag tctacctggt gcatgatgag ctggacaagc ccctggggag actggctctg
      421 aagctggggg gcagtgccag gggccacaat ggagtccgtt cctgcattag ctgcctcaac
      481 tccaatgcaa tgccaaggct gcgggtgggt atcgggcgcc cggcgcaccc tgaggcggtt
      541 caggcccatg tgctgggctg cttctcccct gctgagcagg agctgctgcc tctgttgctg
      601 gatcgagcca ccgacctgat cttggaccac atccgtgagc gaagccaggg gccctcactg
      661 gggccgtgac actagtggcc atggctgcct gcctgactgt agtgcccacc aacccagcca
      721 ctgccacaga gctgccacgc cagccttggt atctactttt tatacaaatc tcctctagac
      781 tgttccaggc tgcctgcgga ttaaagtggg ggtgactgtg actggaccag tccatttctg
      841 gagtaggttc ttctctctgt gtcctacttg ggacgtaggg gaacttcagg aagactaaac
      901 ttttcaagcc tttttagaga accaggggca cgcatctgta agattaaaga tgctggcttg
      961 ga
//
