LOCUS       NM_002851               8103 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type Z1
            (PTPRZ1), transcript variant 1, mRNA.
ACCESSION   NM_002851
VERSION     NM_002851.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8103)
  AUTHORS   Wang,Y., Suo,J., Wang,Z., Ran,K., Tian,Y., Han,W., Liu,Y. and
            Peng,X.
  TITLE     The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates
            tumor-associated macrophage polarization
  JOURNAL   Cell Signal 120, 111191 (2024)
   PUBMED   38685521
  REMARK    GeneRIF: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells
            modulates tumor-associated macrophage polarization.
REFERENCE   2  (bases 1 to 8103)
  AUTHORS   Nagai,K., Muto,Y., Miura,S., Takahashi,K., Naruse,Y., Hiruta,R.,
            Hashimoto,Y., Uzuki,M., Haga,Y., Fujii,R., Ueda,K., Kawaguchi,Y.,
            Fujii,M. and Kitazume,S.
  TITLE     Brain-specific glycosylation enzyme GnT-IX maintains levels of
            protein tyrosine phosphatase receptor PTPRZ, thereby mediating
            glioma growth
  JOURNAL   J Biol Chem 299 (9), 105128 (2023)
   PUBMED   37543361
  REMARK    GeneRIF: Brain-specific glycosylation enzyme GnT-IX maintains
            levels of protein tyrosine phosphatase receptor PTPRZ, thereby
            mediating glioma growth.
REFERENCE   3  (bases 1 to 8103)
  AUTHORS   Lacore,M.G., Delmas,C., Nicaise,Y., Kowalski-Chauvel,A.,
            Cohen-Jonathan-Moyal,E. and Seva,C.
  TITLE     The Glycoprotein M6a Is Associated with Invasiveness and
            Radioresistance of Glioblastoma Stem Cells
  JOURNAL   Cells 11 (14), 2128 (2022)
   PUBMED   35883571
  REMARK    GeneRIF: The Glycoprotein M6a Is Associated with Invasiveness and
            Radioresistance of Glioblastoma Stem Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8103)
  AUTHORS   Nagai,K., Fujii,M. and Kitazume,S.
  TITLE     Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous
            System Disease
  JOURNAL   Int J Mol Sci 23 (8), 4414 (2022)
   PUBMED   35457233
  REMARK    GeneRIF: Protein Tyrosine Phosphatase Receptor Type Z in Central
            Nervous System Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8103)
  AUTHORS   Huang,R., Liu,Y., Wang,K., Wang,Z., Zhang,C., Zhang,W., Zhao,Z.,
            Li,G., Huang,L., Chang,Y., Zeng,F., Jiang,T. and Hu,H.
  TITLE     High-sensitive clinical diagnostic method for PTPRZ1-MET and the
            characteristic protein structure contributing to ligand-independent
            MET activation
  JOURNAL   CNS Neurosci Ther 27 (5), 617-628 (2021)
   PUBMED   33645009
  REMARK    GeneRIF: High-sensitive clinical diagnostic method for PTPRZ1-MET
            and the characteristic protein structure contributing to
            ligand-independent MET activation.
REFERENCE   6  (bases 1 to 8103)
  AUTHORS   Ariyama,T., Hasegawa,K., Inazawa,J., Mizuno,K., Ogimoto,M.,
            Katagiri,T. and Yakura,H.
  TITLE     Assignment of the human protein tyrosine phosphatase,
            receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3
  JOURNAL   Cytogenet Cell Genet 70 (1-2), 52-54 (1995)
   PUBMED   7736789
REFERENCE   7  (bases 1 to 8103)
  AUTHORS   Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B.,
            Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et
            al.
  TITLE     The cloning of a receptor-type protein tyrosine phosphatase
            expressed in the central nervous system
  JOURNAL   J Biol Chem 268 (14), 10573-10581 (1993)
   PUBMED   8387522
REFERENCE   8  (bases 1 to 8103)
  AUTHORS   Krueger,N.X. and Saito,H.
  TITLE     A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
            expressed in brain and has an N-terminal receptor domain homologous
            to carbonic anhydrases
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7417-7421 (1992)
   PUBMED   1323835
REFERENCE   9  (bases 1 to 8103)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
REFERENCE   10 (bases 1 to 8103)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA454064.1, U88967.1, M93426.1,
            DA101746.1, CX872418.1 and CX868991.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002851.2.
            
            Summary: This gene encodes a member of the receptor protein
            tyrosine phosphatase family. Expression of this gene is restricted
            to the central nervous system (CNS), and it may be involved in the
            regulation of specific developmental processes in the CNS.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            May 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.37593.1,
                                           SRR1660807.67344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393386.7/ ENSP00000377047.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DA454064.1         57-122
            67-192              U88967.1           62-187
            193-4628            M93426.1           1-4436
            4629-4951           DA101746.1         226-548
            4952-7305           M93426.1           4757-7110
            7306-7788           CX872418.1         358-840
            7789-8103           CX868991.1         25-339              c
FEATURES             Location/Qualifiers
     source          1..8103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..8103
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /note="protein tyrosine phosphatase receptor type Z1"
                     /db_xref="GeneID:5803"
                     /db_xref="HGNC:HGNC:9685"
                     /db_xref="MIM:176891"
     exon            1..397
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..7287
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor-type,
                     zeta polypeptide 1; protein tyrosine phosphatase,
                     receptor-type, Z polypeptide 1; receptor-type tyrosine
                     phosphatase beta/zeta; protein-tyrosine phosphatase
                     receptor type Z polypeptide 2"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase zeta
                     isoform 1 precursor"
                     /protein_id="NP_002842.2"
                     /db_xref="CCDS:CCDS34740.1"
                     /db_xref="GeneID:5803"
                     /db_xref="HGNC:HGNC:9685"
                     /db_xref="MIM:176891"
                     /translation="MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGAL
                     NQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTV
                     EINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDA
                     DRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILL
                     NLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVM
                     LMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWER
                     PRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAIC
                     TNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSA
                     TNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVT
                     KLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT
                     EYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIP
                     ESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIR
                     VDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVST
                     VNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATP
                     VFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPL
                     HASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSD
                     AMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIP
                     KSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYT
                     TSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQET
                     SVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSA
                     NSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPS
                     DPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTI
                     SYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
                     EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITA
                     VSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDG
                     LSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDS
                     QTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSG
                     QGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFH
                     VSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQT
                     AHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKE
                     FYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYIN
                     ANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP
                     ADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWP
                     DMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT
                     VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPG
                     PAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG
                     TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF
                     VYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPK
                     WPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS
                     VDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGN
                     IAESLESLV"
     exon            398..463
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            464..643
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            644..795
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            796..891
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            892..958
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1116
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1267
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1452
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1579
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1626
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..5182
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5327
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5419
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5505
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5506..5526
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5527..5623
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5624..5706
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5841
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5842..5976
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5977..6140
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6141..6276
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6277..6423
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6424..6517
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6518..6591
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6592..6720
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6721..6867
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6868..7010
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            7011..7146
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            7147..8103
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8086..8091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /note="hexamer: TATAAA"
     polyA_site      8103
                     /gene="PTPRZ1"
                     /gene_synonym="HPTPZ; HPTPzeta; phosphacan; PTP-ZETA;
                     PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcggc cgccgcagcc ggcgaaagag gcaaagtccc gcacgccgga ggacatgcgc
       61 ctcggctagc ggccccgggc cccaccaccg tgcggctttc tccagattat tcctctctcg
      121 ctgtctctga ctgtctctct ctgtctctgt ctctgtctct ctctctctca cacacacaca
      181 cacacacaca aacacacata cgcacgcacg atctcacttc gatctataca ctggaggatt
      241 aaaacaaaca aacaaaaaaa acatttcctt cgctccccct ccctctccac tctgagaagc
      301 agaggagccg cacggcgagg ggccgcagac cgtctggaaa tgcgaatcct aaagcgtttc
      361 ctcgcttgca ttcagctcct ctgtgtttgc cgcctggatt gggctaatgg atactacaga
      421 caacagagaa aacttgttga agagattggc tggtcctata caggagcact gaatcaaaaa
      481 aattggggaa agaaatatcc aacatgtaat agcccaaaac aatctcctat caatattgat
      541 gaagatctta cacaagtaaa tgtgaatctt aagaaactta aatttcaggg ttgggataaa
      601 acatcattgg aaaacacatt cattcataac actgggaaaa cagtggaaat taatctcact
      661 aatgactacc gtgtcagcgg aggagtttca gaaatggtgt ttaaagcaag caagataact
      721 tttcactggg gaaaatgcaa tatgtcatct gatggatcag agcatagttt agaaggacaa
      781 aaatttccac ttgagatgca aatctactgc tttgatgcgg accgattttc aagttttgag
      841 gaagcagtca aaggaaaagg gaagttaaga gctttatcca ttttgtttga ggttgggaca
      901 gaagaaaatt tggatttcaa agcgattatt gatggagtcg aaagtgttag tcgttttggg
      961 aagcaggctg ctttagatcc attcatactg ttgaaccttc tgccaaactc aactgacaag
     1021 tattacattt acaatggctc attgacatct cctccctgca cagacacagt tgactggatt
     1081 gtttttaaag atacagttag catctctgaa agccagttgg ctgttttttg tgaagttctt
     1141 acaatgcaac aatctggtta tgtcatgctg atggactact tacaaaacaa ttttcgagag
     1201 caacagtaca agttctctag acaggtgttt tcctcataca ctggaaagga agagattcat
     1261 gaagcagttt gtagttcaga accagaaaat gttcaggctg acccagagaa ttataccagc
     1321 cttcttgtta catgggaaag acctcgagtc gtttatgata ccatgattga gaagtttgca
     1381 gttttgtacc agcagttgga tggagaggac caaaccaagc atgaattttt gacagatggc
     1441 tatcaagact tgggtgctat tctcaataat ttgctaccca atatgagtta tgttcttcag
     1501 atagtagcca tatgcactaa tggcttatat ggaaaataca gcgaccaact gattgtcgac
     1561 atgcctactg ataatcctga acttgatctt ttccctgaat taattggaac tgaagaaata
     1621 atcaaggagg aggaagaggg aaaagacatt gaagaaggcg ctattgtgaa tcctggtaga
     1681 gacagtgcta caaaccaaat caggaaaaag gaaccccaga tttctaccac aacacactac
     1741 aatcgcatag ggacgaaata caatgaagcc aagactaacc gatccccaac aagaggaagt
     1801 gaattctctg gaaagggtga tgttcccaat acatctttaa attccacttc ccaaccagtc
     1861 actaaattag ccacagaaaa agatatttcc ttgacttctc agactgtgac tgaactgcca
     1921 cctcacactg tggaaggtac ttcagcctct ttaaatgatg gctctaaaac tgttcttaga
     1981 tctccacata tgaacttgtc ggggactgca gaatccttaa atacagtttc tataacagaa
     2041 tatgaggagg agagtttatt gaccagtttc aagcttgata ctggagctga agattcttca
     2101 ggctccagtc ccgcaacttc tgctatccca ttcatctctg agaacatatc ccaagggtat
     2161 atattttcct ccgaaaaccc agagacaata acatatgatg tccttatacc agaatctgct
     2221 agaaatgctt ccgaagattc aacttcatca ggttcagaag aatcactaaa ggatccttct
     2281 atggagggaa atgtgtggtt tcctagctct acagacataa cagcacagcc cgatgttgga
     2341 tcaggcagag agagctttct ccagactaat tacactgaga tacgtgttga tgaatctgag
     2401 aagacaacca agtccttttc tgcaggccca gtgatgtcac agggtccctc agttacagat
     2461 ctggaaatgc cacattattc tacctttgcc tacttcccaa ctgaggtaac acctcatgct
     2521 tttaccccat cctccagaca acaggatttg gtctccacgg tcaacgtggt atactcgcag
     2581 acaacccaac cggtatacaa tggtgagaca cctcttcaac cttcctacag tagtgaagtc
     2641 tttcctctag tcaccccttt gttgcttgac aatcagatcc tcaacactac ccctgctgct
     2701 tcaagtagtg attcggcctt gcatgctacg cctgtatttc ccagtgtcga tgtgtcattt
     2761 gaatccatcc tgtcttccta tgatggtgca cctttgcttc cattttcctc tgcttccttc
     2821 agtagtgaat tgtttcgcca tctgcataca gtttctcaaa tccttccaca agttacttca
     2881 gctaccgaga gtgataaggt gcccttgcat gcttctctgc cagtggctgg gggtgatttg
     2941 ctattagagc ccagccttgc tcagtattct gatgtgctgt ccactactca tgctgcttca
     3001 gagacgctgg aatttggtag tgaatctggt gttctttata aaacgcttat gttttctcaa
     3061 gttgaaccac ccagcagtga tgccatgatg catgcacgtt cttcagggcc tgaaccttct
     3121 tatgccttgt ctgataatga gggctcccaa cacatcttca ctgtttctta cagttctgca
     3181 atacctgtgc atgattctgt gggtgtaact tatcagggtt ccttatttag cggccctagc
     3241 catataccaa tacctaagtc ttcgttaata accccaactg catcattact gcagcctact
     3301 catgccctct ctggtgatgg ggaatggtct ggagcctctt ctgatagtga atttctttta
     3361 cctgacacag atgggctgac agcccttaac atttcttcac ctgtttctgt agctgaattt
     3421 acatatacaa catctgtgtt tggtgatgat aataaggcgc tttctaaaag tgaaataata
     3481 tatggaaatg agactgaact gcaaattcct tctttcaatg agatggttta cccttctgaa
     3541 agcacagtca tgcccaacat gtatgataat gtaaataagt tgaatgcgtc tttacaagaa
     3601 acctctgttt ccatttctag caccaagggc atgtttccag ggtcccttgc tcataccacc
     3661 actaaggttt ttgatcatga gattagtcaa gttccagaaa ataacttttc agttcaacct
     3721 acacatactg tctctcaagc atctggtgac acttcgctta aacctgtgct tagtgcaaac
     3781 tcagagccag catcctctga ccctgcttct agtgaaatgt tatctccttc aactcagctc
     3841 ttattttatg agacctcagc ttcttttagt actgaagtat tgctacaacc ttcctttcag
     3901 gcttctgatg ttgacacctt gcttaaaact gttcttccag ctgtgcccag tgatccaata
     3961 ttggttgaaa cccccaaagt tgataaaatt agttctacaa tgttgcatct cattgtatca
     4021 aattctgctt caagtgaaaa catgctgcac tctacatctg taccagtttt tgatgtgtcg
     4081 cctacttctc atatgcactc tgcttcactt caaggtttga ccatttccta tgcaagtgag
     4141 aaatatgaac cagttttgtt aaaaagtgaa agttcccacc aagtggtacc ttctttgtac
     4201 agtaatgatg agttgttcca aacggccaat ttggagatta accaggccca tcccccaaaa
     4261 ggaaggcatg tatttgctac acctgtttta tcaattgatg aaccattaaa tacactaata
     4321 aataagctta tacattccga tgaaatttta acctccacca aaagttctgt tactggtaag
     4381 gtatttgctg gtattccaac agttgcttct gatacatttg tatctactga tcattctgtt
     4441 cctataggaa atgggcatgt tgccattaca gctgtttctc cccacagaga tggttctgta
     4501 acctcaacaa agttgctgtt tccttctaag gcaacttctg agctgagtca tagtgccaaa
     4561 tctgatgccg gtttagtggg tggtggtgaa gatggtgaca ctgatgatga tggtgatgat
     4621 gatgatgatg acagaggtag tgatggctta tccattcata agtgtatgtc atgctcatcc
     4681 tatagagaat cacaggaaaa ggtaatgaat gattcagaca cccacgaaaa cagtcttatg
     4741 gatcagaata atccaatctc atactcacta tctgagaatt ctgaagaaga taatagagtc
     4801 acaagtgtat cctcagacag tcaaactggt atggacagaa gtcctggtaa atcaccatca
     4861 gcaaatgggc tatcccaaaa gcacaatgat ggaaaagagg aaaatgacat tcagactggt
     4921 agtgctctgc ttcctctcag ccctgaatct aaagcatggg cagttctgac aagtgatgaa
     4981 gaaagtggat cagggcaagg tacctcagat agccttaatg agaatgagac ttccacagat
     5041 ttcagttttg cagacactaa tgaaaaagat gctgatggga tcctggcagc aggtgactca
     5101 gaaataactc ctggattccc acagtcccca acatcatctg ttactagcga gaactcagaa
     5161 gtgttccacg tttcagaggc agaggccagt aatagtagcc atgagtctcg tattggtcta
     5221 gctgaggggt tggaatccga gaagaaggca gttatacccc ttgtgatcgt gtcagccctg
     5281 acttttatct gtctagtggt tcttgtgggt attctcatct actggaggaa atgcttccag
     5341 actgcacact tttacttaga ggacagtaca tcccctagag ttatatccac acctccaaca
     5401 cctatctttc caatttcaga tgatgtcgga gcaattccaa taaagcactt tccaaagcat
     5461 gttgcagatt tacatgcaag tagtgggttt actgaagaat ttgagacact gaaagagttt
     5521 taccaggaag tgcagagctg tactgttgac ttaggtatta cagcagacag ctccaaccac
     5581 ccagacaaca agcacaagaa tcgatacata aatatcgttg cctatgatca tagcagggtt
     5641 aagctagcac agcttgctga aaaggatggc aaactgactg attatatcaa tgccaattat
     5701 gttgatggct acaacagacc aaaagcttat attgctgccc aaggcccact gaaatccaca
     5761 gctgaagatt tctggagaat gatatgggaa cataatgtgg aagttattgt catgataaca
     5821 aacctcgtgg agaaaggaag gagaaaatgt gatcagtact ggcctgccga tgggagtgag
     5881 gagtacggga actttctggt cactcagaag agtgtgcaag tgcttgccta ttatactgtg
     5941 aggaatttta ctctaagaaa cacaaaaata aaaaagggct cccagaaagg aagacccagt
     6001 ggacgtgtgg tcacacagta tcactacacg cagtggcctg acatgggagt accagagtac
     6061 tccctgccag tgctgacctt tgtgagaaag gcagcctatg ccaagcgcca tgcagtgggg
     6121 cctgttgtcg tccactgcag tgctggagtt ggaagaacag gcacatatat tgtgctagac
     6181 agtatgttgc agcagattca acacgaagga actgtcaaca tatttggctt cttaaaacac
     6241 atccgttcac aaagaaatta tttggtacaa actgaggagc aatatgtctt cattcatgat
     6301 acactggttg aggccatact tagtaaagaa actgaggtgc tggacagtca tattcatgcc
     6361 tatgttaatg cactcctcat tcctggacca gcaggcaaaa caaagctaga gaaacaattc
     6421 cagctcctga gccagtcaaa tatacagcag agtgactatt ctgcagccct aaagcaatgc
     6481 aacagggaaa agaatcgaac ttcttctatc atccctgtgg aaagatcaag ggttggcatt
     6541 tcatccctga gtggagaagg cacagactac atcaatgcct cctatatcat gggctattac
     6601 cagagcaatg aattcatcat tacccagcac cctctccttc ataccatcaa ggatttctgg
     6661 aggatgatat gggaccataa tgcccaactg gtggttatga ttcctgatgg ccaaaacatg
     6721 gcagaagatg aatttgttta ctggccaaat aaagatgagc ctataaattg tgagagcttt
     6781 aaggtcactc ttatggctga agaacacaaa tgtctatcta atgaggaaaa acttataatt
     6841 caggacttta tcttagaagc tacacaggat gattatgtac ttgaagtgag gcactttcag
     6901 tgtcctaaat ggccaaatcc agatagcccc attagtaaaa cttttgaact tataagtgtt
     6961 ataaaagaag aagctgccaa tagggatggg cctatgattg ttcatgatga gcatggagga
     7021 gtgacggcag gaactttctg tgctctgaca acccttatgc accaactaga aaaagaaaat
     7081 tccgtggatg tttaccaggt agccaagatg atcaatctga tgaggccagg agtctttgct
     7141 gacattgagc agtatcagtt tctctacaaa gtgatcctca gccttgtgag cacaaggcag
     7201 gaagagaatc catccacctc tctggacagt aatggtgcag cattgcctga tggaaatata
     7261 gctgagagct tagagtcttt agtttaacac agaaaggggt gggggaactc acatctgagc
     7321 attgttttcc tcttcctaaa attaggcagg aaaatcagtc tagttctgtt atctgttgat
     7381 ttcccatcac ctgacagtaa ctttcatgac ataggattct gccgccaaat ttatatcatt
     7441 aacaatgtgt gcctttttgc aagacttgta atttacttat tatgtttgaa ctaaaatgat
     7501 tgaattttac agtatttcta agaatggaat tgtggtattt ttttctgtat tgattttaac
     7561 agaaaatttc aatttataga ggttaggaat tccaaactac agaaaatgtt tgtttttagt
     7621 gtcaaatttt tagctgtatt tgtagcaatt atcaggtttg ctagaaatat aacttttaat
     7681 acagtagcct gtaaataaaa cactcttcca tatgatattc aacattttac aactgcagta
     7741 ttcacctaaa gtagaaataa tctgttactt attgtaaata ctgccctagt gtctccatgg
     7801 accaaattta tatttataat tgtagatttt tatattttac tactgagtca agttttctag
     7861 ttctgtgtaa ttgtttagtt taatgacgta gttcattagc tggtcttact ctaccagttt
     7921 tctgacattg tattgtgtta cctaagtcat taactttgtt tcagcatgta attttaactt
     7981 ttgtggaaaa tagaaatacc ttcattttga aagaagtttt tatgagaata acaccttacc
     8041 aaacattgtt caaatggttt ttatccaagg aattgcaaaa ataaatataa atattgccat
     8101 taa
//
