LOCUS       NM_133178               5573 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type U (PTPRU),
            transcript variant 1, mRNA.
ACCESSION   NM_133178
VERSION     NM_133178.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5573)
  AUTHORS   Rumman,M. and Dhawan,J.
  TITLE     PTPRU, a quiescence-induced receptor tyrosine phosphatase
            negatively regulates osteogenic differentiation of human
            mesenchymal stem cells
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 1), 41-49 (2022)
   PUBMED   36332481
  REMARK    GeneRIF: PTPRU, a quiescence-induced receptor tyrosine phosphatase
            negatively regulates osteogenic differentiation of human
            mesenchymal stem cells.
REFERENCE   2  (bases 1 to 5573)
  AUTHORS   Hay,I.M., Fearnley,G.W., Rios,P., Kohn,M., Sharpe,H.J. and
            Deane,J.E.
  TITLE     The receptor PTPRU is a redox sensitive pseudophosphatase
  JOURNAL   Nat Commun 11 (1), 3219 (2020)
   PUBMED   32591542
  REMARK    GeneRIF: The receptor PTPRU is a redox sensitive pseudophosphatase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5573)
  AUTHORS   Zhou,R., Zhou,X., Yin,Z., Guo,J., Hu,T., Jiang,S., Liu,L., Dong,X.,
            Zhang,S. and Wu,G.
  TITLE     MicroRNA-574-5p promotes metastasis of non-small cell lung cancer
            by targeting PTPRU
  JOURNAL   Sci Rep 6, 35714 (2016)
   PUBMED   27761023
  REMARK    GeneRIF: Transwell and wound-healing assays showed that miR-574-5p
            promotes the migration and invasion of NSCLC cells. Furthermore,
            miR-574-5p enhanced the tyrosine phosphorylation of beta-catenin by
            repressing PTPRU expression in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5573)
  AUTHORS   Liu,Y., Zhu,Z., Xiong,Z., Zheng,J., Hu,Z. and Qiu,J.
  TITLE     Knockdown of protein tyrosine phosphatase receptor U inhibits
            growth and motility of gastric cancer cells
  JOURNAL   Int J Clin Exp Pathol 7 (9), 5750-5761 (2014)
   PUBMED   25337216
  REMARK    GeneRIF: PTPRU is required for gastric cancer cell proliferation
            and migration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5573)
  AUTHORS   Zhu,Z., Liu,Y., Li,K., Liu,J., Wang,H., Sun,B., Xiong,Z., Jiang,H.,
            Zheng,J. and Hu,Z.
  TITLE     Protein tyrosine phosphatase receptor U (PTPRU) is required for
            glioma growth and motility
  JOURNAL   Carcinogenesis 35 (8), 1901-1910 (2014)
   PUBMED   24876153
  REMARK    GeneRIF: High PTPRU expression is associated with glioma growth and
            motility.
REFERENCE   6  (bases 1 to 5573)
  AUTHORS   Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S.,
            White,R.A., Painter,C., Steinberger,A.A. and Avraham,H.
  TITLE     Characterization and chromosomal localization of PTPRO, a novel
            receptor protein tyrosine phosphatase, expressed in hematopoietic
            stem cells
  JOURNAL   Gene 204 (1-2), 5-16 (1997)
   PUBMED   9434160
REFERENCE   7  (bases 1 to 5573)
  AUTHORS   Lin,B.Z., Pilch,P.F. and Kandror,K.V.
  TITLE     Sortilin is a major protein component of Glut4-containing vesicles
  JOURNAL   J Biol Chem 272 (39), 24145-24147 (1997)
   PUBMED   9305862
REFERENCE   8  (bases 1 to 5573)
  AUTHORS   Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K.
  TITLE     Molecular cloning and characterization of a novel human receptor
            protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene
            expression by PMA and calcium ionophore in Jurkat T lymphoma cells
  JOURNAL   Biochem Biophys Res Commun 231 (1), 77-81 (1997)
   PUBMED   9070223
REFERENCE   9  (bases 1 to 5573)
  AUTHORS   Crossland,S., Smith,P.D. and Crompton,M.R.
  TITLE     Molecular cloning and characterization of PTP pi, a novel
            receptor-like protein-tyrosine phosphatase
  JOURNAL   Biochem J 319 (Pt 1) (Pt 1), 249-254 (1996)
   PUBMED   8870675
REFERENCE   10 (bases 1 to 5573)
  AUTHORS   Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A.
  TITLE     Characterization of PCP-2, a novel receptor protein tyrosine
            phosphatase of the MAM domain family
  JOURNAL   Oncogene 12 (12), 2555-2562 (1996)
   PUBMED   8700514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X97198.1, BC146655.1 and
            U73727.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_133178.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem intracellular
            catalytic domains, and thus represents a receptor-type PTP. The
            extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
            Ig-like and fibronectin type III-like repeats. This PTP was thought
            to play roles in cell-cell recognition and adhesion. Studies of the
            similar gene in mice suggested the role of this PTP in early neural
            development. The expression of this gene was reported to be
            regulated by phorbol myristate acetate (PMA) or calcium ionophore
            in Jurkat T lymphoma cells. Alternatively spliced transcript
            variants have been reported. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon compared to variant 3. The resulting isoform (1) has the same
            N- and C-termini but is 10 aa shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73727.1, X97198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373779.8/ ENSP00000362884.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                X97198.1           14-40
            28-116              BC146655.1         1-89
            117-2267            U73727.1           114-2264
            2268-2268           BC146655.1         2241-2241
            2269-3704           U73727.1           2266-3701
            3705-3705           BC146655.1         3669-3669
            3706-5313           U73727.1           3703-5310
            5314-5573           BC146655.1         5278-5537
FEATURES             Location/Qualifiers
     source          1..5573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..5573
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /note="protein tyrosine phosphatase receptor type U"
                     /db_xref="GeneID:10076"
                     /db_xref="HGNC:HGNC:9683"
                     /db_xref="MIM:602454"
     exon            1..196
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4434
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pi R-PTP-Psi; Receptor protein tyrosine
                     phosphatase hPTP-J; PTP pi; protein-tyrosine phosphatase
                     J; protein-tyrosine phosphatase pi; pancreatic carcinoma
                     phosphatase 2; protein-tyrosine phosphatase receptor
                     omicron; receptor-type protein-tyrosine phosphatase psi"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase U
                     isoform 1 precursor"
                     /protein_id="NP_573439.2"
                     /db_xref="CCDS:CCDS335.1"
                     /db_xref="GeneID:10076"
                     /db_xref="HGNC:HGNC:9683"
                     /db_xref="MIM:602454"
                     /translation="MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQA
                     QYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQF
                     SYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQV
                     LFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAE
                     AERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSN
                     FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEV
                     HAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAF
                     AEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
                     KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWE
                     EPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFS
                     VRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISV
                     YQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV
                     GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQ
                     RSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDR
                     SFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYH
                     TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPA
                     YDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCS
                     SIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR
                     HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVL
                     DVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE
                     FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLP
                     PDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTS
                     IVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQ
                     EGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSG
                     TFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLESR
                     "
     exon            197..328
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            329..600
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            601..682
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            683..798
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            799..973
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1267
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1576
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1686
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1888
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1991
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2265
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2302
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2441
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2599
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2790
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2866
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2943
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..2980
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3078
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3195
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3350
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3486
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3636
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3810
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3951
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4077
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4235
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4371
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     exon            4372..5573
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5550..5555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /note="hexamer: AATAAA"
     polyA_site      5573
                     /gene="PTPRU"
                     /gene_synonym="FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI;
                     PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgctc cgcgccgcgc cgctccgctc cggctcgggc tccggctcgc ctcgggctgg
       61 gctcgggctc cgggggcggc gtcccccgcg ccgggccccg ggacgggcgg cgacgctcca
      121 accatggccc gtgcccaggc gctcgtgctg gcactcacct tccagctctg cgcgccggag
      181 accgagactc cggcagctgg ctgcaccttc gaggaggcaa gtgacccagc agtgccctgc
      241 gagtacagcc aggcccagta cgatgacttc cagtgggagc aagtgcgaat ccaccctggc
      301 acccgggcac ctgcggacct gccccacggc tcctacttga tggtcaacac ttcccagcat
      361 gccccaggcc agcgagccca tgtcatcttc cagagcctga gcgagaatga tacccactgt
      421 gtgcagttca gctacttcct gtacagccgg gacgggcaca gcccgggcac cctgggcgtc
      481 tacgtgcgcg ttaatggggg ccccctgggc agtgctgtgt ggaatatgac tggatcccac
      541 ggccgtcagt ggcaccaggc tgagctggct gtcagcactt tctggcccaa tgaatatcag
      601 gtgctgtttg aggccctcat ctccccagac cgcaggggct acatgggcct agatgacatc
      661 ctgcttctca gctacccctg cgcaaaggcc ccacacttct cccgcctggg cgacgtggag
      721 gtcaacgcgg gccagaacgc gtcgttccag tgcatggccg cgggcagagc ggccgaggcc
      781 gaacgcttcc tcttgcaacg gcagagcggg gcgctggtgc cggcggcggg cgtgcggcac
      841 atcagccacc ggcgcttcct ggccactttc ccgctggctg ccgtgagccg cgccgagcag
      901 gacctgtacc gctgtgtgtc ccaggccccg cgcggcgcgg gcgtctctaa cttcgcggag
      961 ctcatcgtca aggagccccc aactcccatc gcgcccccac agctgctgcg tgctggcccc
     1021 acctacctca tcatccagct caacaccaac tccatcattg gcgacgggcc gatcgtgcgc
     1081 aaggagattg agtaccgcat ggcgcgcggg ccctgggctg aggtgcacgc cgtcagcctg
     1141 cagacctaca agctgtggca cctcgacccc gacacagagt atgagatcag cgtgctgctc
     1201 acgcgtcccg gagacggcgg cactggccgc cctgggccac ccctcatcag ccgcaccaaa
     1261 tgcgcagagc ccatgagggc ccccaaaggc ctggcttttg ctgagatcca ggcccgtcag
     1321 ctgaccctgc agtgggaacc actgggctac aacgtgacgc gttgccacac ctatactgtg
     1381 tcgctgtgct atcactacac cctgggcagc agccacaacc agaccatccg agagtgtgtg
     1441 aagacagagc aaggtgtcag ccgctacacc atcaagaacc tgctgcccta tcggaacgtt
     1501 cacgtgaggc ttgtcctcac taaccctgag gggcgcaaag agggcaagga ggtcactttc
     1561 cagacggatg aggatgtgcc cagtgggatt gcagccgagt ccctgacctt cactccactg
     1621 gaggacatga tcttcctcaa gtgggaggag ccccaggagc ccaatggtct catcacccag
     1681 tatgagatca gctaccagag catcgagtca tcagacccgg cagtgaacgt gccaggccca
     1741 cgacgtacca tctccaagct ccgcaatgag acctaccatg tcttctccaa cctgcaccca
     1801 ggcaccacct acctgttctc cgtgcgggcc cgcacaggca aaggcttcgg ccaggcggca
     1861 ctcactgaga taaccactaa catctctgct cccagctttg attatgccga catgccgtca
     1921 cccctgggcg agtctgagaa caccatcacc gtgctgctga ggccggcaca gggccgcggt
     1981 gcgcccatca gtgtgtacca ggtgattgtg gaggaggagc gggcgcggag gctgcggcgg
     2041 gagccaggtg gacaggactg cttcccagtg ccattgacct tcgaggcggc gctggcccga
     2101 ggcctggtgc actacttcgg ggccgaactg gcggccagca gtctacctga ggccatgccc
     2161 tttaccgtgg gtgacaacca gacctaccga ggcttctgga acccaccact tgagcctagg
     2221 aaggcctatc tcatctactt ccaggcagca agccacctga agggggagac ccggctgaat
     2281 tgcatccgca ttgccaggaa agctgcctgc aaggaaagca agcggcccct ggaggtgtcc
     2341 cagagatcgg aggagatggg gcttatcctg ggcatctgtg caggggggct tgctgtcctc
     2401 atccttctcc tgggtgccat cattgtcatc atccgcaaag ggaagccggt gaacatgacc
     2461 aaggccaccg tcaactaccg ccaggagaag acacacatga tgagcgccgt ggaccgcagc
     2521 ttcacagacc agagcaccct gcaggaggac gagcggctgg gcctgtcctt catggacacc
     2581 catggctaca gcacccgggg agaccagcgc agcggtgggg tcactgaggc cagcagcctc
     2641 ctggggggct ccccgaggcg tccctgtggc cggaagggct ccccatacca cacggggcag
     2701 ctgcaccctg cggtgcgtgt cgcagacctt ctgcagcaca tcaaccagat gaagacggcc
     2761 gagggttacg gcttcaagca ggagtatgag agcttctttg aaggctggga cgccacaaag
     2821 aagaaagaca aggtcaaggg cagccggcag gagccaatgc ctgcctatga tcggcaccga
     2881 gtgaaactgc acccgatgct gggagacccc aatgccgact acattaatgc caactacata
     2941 gatggttacc acaggtcaaa ccacttcata gccactcaag ggccgaagcc tgagatggtc
     3001 tatgacttct ggcgtatggt gtggcaggag cactgttcca gcatcgtcat gatcaccaag
     3061 ctggtcgagg tgggcagggt gaaatgctca cggtactggc cggaggactc agacacctac
     3121 ggggacatca agattatgct ggtgaagaca gagaccctgg ctgagtatgt cgtgcgcact
     3181 tttgccctgg agcggagagg ctactctgcc cggcacgagg tccgccagtt ccacttcaca
     3241 gcgtggccag agcatggcgt cccctaccat gccacggggc tgctggcttt catccggcgc
     3301 gtgaaggcct ccaccccacc tgatgccggg cccattgtca tccactgcag cgcgggcacc
     3361 ggccgcacag gttgctatat cgtcctggat gtgatgctgg acatggcaga gtgtgagggc
     3421 gtcgtggaca tttacaactg tgtgaagact ctctgctccc ggcgtgtcaa catgatccag
     3481 actgaggagc agtacatctt cattcatgat gcaatcctgg aggcctgcct gtgtggggag
     3541 accaccatcc ctgtcagtga gttcaaggcc acctacaagg agatgatccg cattgatcct
     3601 cagagtaatt cctcccagct gcgggaagag ttccagacgc tgaactcggt caccccgccg
     3661 ctggacgtgg aggagtgcag catcgccctg ttgccccgga accgcgacaa gaaccgcagc
     3721 atggacgtcc tgccgcccga ccgctgcctg cccttcctca tctccactga tggggactcc
     3781 aacaactaca ttaatgcagc cctgactgac agctacacac ggagtgcggc cttcatcgtg
     3841 accctgcacc cgctgcagag caccacgccc gacttctggc ggctggtcta cgattacggg
     3901 tgcacctcca tcgtcatgct caaccagctg aaccagtcca actccgcctg gccctgcctg
     3961 cagtactggc cagagccagg ccggcagcaa tatggcctca tggaggtgga gtttatgtcg
     4021 ggcacagctg atgaagactt agtggctcga gtcttccggg tgcagaacat ctctcggttg
     4081 caggaggggc acctgctggt gcggcacttc cagttcctgc gctggtctgc ataccgggac
     4141 acacctgact ccaagaaggc cttcttgcac ctgctggctg aggtggacaa gtggcaggcc
     4201 gagagtgggg atgggcgcac catcgtgcac tgcctaaacg ggggaggacg cagcggcacc
     4261 ttctgcgcct gcgccacggt cctggagatg atccgctgcc acaacttggt ggacgttttc
     4321 tttgctgcca aaaccctccg gaactacaaa cccaacatgg tggagaccat ggatcagtac
     4381 cacttttgct acgatgtggc cctggagtac ttggaggggc tggagtcaag atagcggggc
     4441 cctggcctgg ggcacccact gcacactcag ggccagaccc accatcctgg actggcgagg
     4501 aagatcagtg cctcctgctc tgcccaaaca cactcccatg gggcaagcac tggagtggat
     4561 gctgggctat cttgctcccc cttccactgt gggcagggcc tttcgcttgt cccatgggcg
     4621 ggtggtgggc caaggaggag cttagcaagt ctgcagccca gccccacctc catagggtcc
     4681 tgcaggcctg tgctgagagg cctggtgctg cctggcagag tgacaaaggc tcaggacggc
     4741 tggctctggg ggactcaggc caagcccctt ggcaccatcc tggcttttgg cagggatgag
     4801 tgaggccctg cagagagcat cccaggccaa ggttcccact cagcctgccc cctctgcatg
     4861 tgggtagagg atgtactggg acttggcatt taggattcca tctggcccag cccctgaagg
     4921 tcctggggaa gcaggtctca attctgaata gccagtgggg cacactgact gtcctcccca
     4981 ggggaactgc agcgccctcc tccccactgc cccctgcagc ccctgagata ttttgctcac
     5041 tatccctccc cacttgcttc cctgatatgt gctctgagct tccctgaacc aggatctgcc
     5101 tattactgct gtgccccatg gggggctcct tccctgcctg acccactgtt gcagaatgaa
     5161 gtcacctcgc ccccctcttc ctttaatctt caggcctcac tggcctgtcc tgctcagctt
     5221 gggccagtga caatctgcaa ggctgaacaa cagcccctgg ggttgaggcc cctgtggctc
     5281 ctggtcaggc tgcccgttgt ggggaggggc agtgttagag cagggctggt cataccctct
     5341 ggagttcaga ggaagaggta ggaccagtgc ttttttgttt cttttgttat ttttggttgg
     5401 gtgggtggga aggtctcttt aaaatggggc aggccacacc cccattccgt gcctcaattt
     5461 ccccatctgt aaactgtaga tatgactact gacctacctc gcagggggct gtggggaggc
     5521 ataagctgat gtttgtaaag cgctttgtaa ataaacgtgc tctctgaatg cca
//
