LOCUS       NM_007050              12622 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type T (PTPRT),
            transcript variant 2, mRNA.
ACCESSION   NM_007050
VERSION     NM_007050.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12622)
  AUTHORS   Chen,C., Liu,H., Li,Y., Xu,Q. and Liu,J.
  TITLE     Downregulation of PTPRT elevates the expression of survivin and
            promotes the proliferation, migration, and invasion of lung
            adenocarcinoma
  JOURNAL   BMC Cancer 24 (1), 63 (2024)
   PUBMED   38216925
  REMARK    GeneRIF: Downregulation of PTPRT elevates the expression of
            survivin and promotes the proliferation, migration, and invasion of
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12622)
  AUTHORS   Kan,H., Liu,H., Mu,Y., Li,Y., Zhang,M., Cao,Y., Dong,Y., Li,Y.,
            Wang,K., Li,Q., Hu,A. and Zheng,Y.
  TITLE     Novel genetic variants linked to prelabor rupture of membranes
            among Chinese pregnant women
  JOURNAL   Placenta 137, 14-22 (2023)
   PUBMED   37054626
  REMARK    GeneRIF: Novel genetic variants linked to prelabor rupture of
            membranes among Chinese pregnant women.
REFERENCE   3  (bases 1 to 12622)
  AUTHORS   Chen,C., Liu,H., Xu,Q., Zhang,X., Mu,F. and Liu,J.
  TITLE     Association of PTPRT Mutations with Cancer Metastasis in Multiple
            Cancer Types
  JOURNAL   Biomed Res Int 2022, 9386477 (2022)
   PUBMED   35789644
  REMARK    GeneRIF: Association of PTPRT Mutations with Cancer Metastasis in
            Multiple Cancer Types.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12622)
  AUTHORS   Li,L., Xu,F., Xie,P., Yuan,L. and Zhou,M.
  TITLE     PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for
            Breast Cancer
  JOURNAL   Biomed Res Int 2021, 3301402 (2021)
   PUBMED   34414233
  REMARK    GeneRIF: PTPRT Could Be a Treatment Predictive and Prognostic
            Biomarker for Breast Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12622)
  AUTHORS   Wang,Z., Shen,D., Parsons,D.W., Bardelli,A., Sager,J., Szabo,S.,
            Ptak,J., Silliman,N., Peters,B.A., van der Heijden,M.S.,
            Parmigiani,G., Yan,H., Wang,T.L., Riggins,G., Powell,S.M.,
            Willson,J.K., Markowitz,S., Kinzler,K.W., Vogelstein,B. and
            Velculescu,V.E.
  TITLE     Mutational analysis of the tyrosine phosphatome in colorectal
            cancers
  JOURNAL   Science 304 (5674), 1164-1166 (2004)
   PUBMED   15155950
REFERENCE   6  (bases 1 to 12622)
  AUTHORS   Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes: Correction
  JOURNAL   BMC Genomics 2, 5 (2001)
   PUBMED   11814386
  REMARK    Correction to:[BMC Genomics. 2001;2:1. doi: 10.1186/1471-2164-2-1..
            PMID: 11423001]
REFERENCE   7  (bases 1 to 12622)
  AUTHORS   Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes
  JOURNAL   BMC Genomics 2, 1 (2001)
   PUBMED   11423001
  REMARK    Erratum:[BMC Genomics. 2001;2:5. doi: 10.1186/1471-2164-2-5.. PMID:
            11814386]
REFERENCE   8  (bases 1 to 12622)
  AUTHORS   McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
  TITLE     Identification and characterization of RPTP rho, a novel RPTP
            mu/kappa-like receptor protein tyrosine phosphatase whose
            expression is restricted to the central nervous system
  JOURNAL   Brain Res Mol Brain Res 56 (1-2), 9-21 (1998)
   PUBMED   9602027
REFERENCE   9  (bases 1 to 12622)
  AUTHORS   McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
            Chiu,I.M., Burghes,A.H. and Rotter,A.
  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
            fibroblast growth factor (FGF-1) transcripts delineate a
            rostrocaudal boundary in the granule cell layer of the murine
            cerebellar cortex
  JOURNAL   J Comp Neurol 391 (4), 444-455 (1998)
   PUBMED   9486824
REFERENCE   10 (bases 1 to 12622)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021395.16, AL121763.25,
            AL136461.10, AL031656.10, AL022239.1, Z93942.1, AL035459.6,
            AL024473.1 and AL049812.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_007050.5.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem intracellular
            catalytic domains, and thus represents a receptor-type PTP. The
            extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
            Ig-like and fibronectin type III-like repeats. The protein domain
            structure and the expression pattern of the mouse counterpart of
            this PTP suggest its roles in both signal transduction and cellular
            adhesion in the central nervous system. Two alternatively spliced
            transcript variants of this gene, which encode distinct proteins,
            have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks a fragment within the
            coding region when compared to variant 1. The translation remains
            in-frame, and thus encodes a protein that lacks an internal
            segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC153300.1, AB006621.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373187.6/ ENSP00000362283.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AL021395.16        19423-19683         c
            262-387             AL121763.25        106792-106917       c
            388-659             AL121763.25        12180-12451         c
            660-741             AL121763.25        1203-1284           c
            742-857             AL136461.10        41180-41295         c
            858-1032            AL136461.10        26207-26381         c
            1033-1326           AL031656.10        59152-59445         c
            1327-1623           AL022239.1         85677-85973         c
            1624-1733           AL022239.1         61631-61740         c
            1734-1935           Z93942.1           109596-109797       c
            1936-2038           Z93942.1           108140-108242       c
            2039-2312           Z93942.1           73235-73508         c
            2313-2349           Z93942.1           40001-40037         c
            2350-2485           Z93942.1           6199-6334           c
            2486-2515           AL035459.6         43989-44018         c
            2516-2664           AL035459.6         7000-7148           c
            2665-2855           AL024473.1         76399-76589         c
            2856-2943           AL024473.1         56962-57049         c
            2944-3020           AL024473.1         43801-43877         c
            3021-3057           AL024473.1         34982-35018         c
            3058-3155           AL024473.1         33450-33547         c
            3156-3272           AL024473.1         30246-30362         c
            3273-3427           AL024473.1         25380-25534         c
            3428-3563           AL024473.1         21833-21968         c
            3564-3713           AL024473.1         19616-19765         c
            3714-3887           AL024473.1         17171-17344         c
            3888-4019           AL024473.1         13468-13599         c
            4020-4145           AL024473.1         775-900             c
            4146-4309           AL049812.14        105575-105738       c
            4310-4445           AL049812.14        102775-102910       c
            4446-12622          AL049812.14        93649-101825        c
FEATURES             Location/Qualifiers
     source          1..12622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q12-q13.11"
     gene            1..12622
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /note="protein tyrosine phosphatase receptor type T"
                     /db_xref="GeneID:11122"
                     /db_xref="HGNC:HGNC:9682"
                     /db_xref="MIM:608712"
     exon            1..261
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..4499
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor protein tyrosine phosphatase;
                     receptor-type tyrosine-protein phosphatase T;
                     receptor-type tyrosine-protein phosphatase rho"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase T
                     isoform 2 precursor"
                     /protein_id="NP_008981.4"
                     /db_xref="CCDS:CCDS42874.1"
                     /db_xref="GeneID:11122"
                     /db_xref="HGNC:HGNC:9682"
                     /db_xref="MIM:608712"
                     /translation="MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYS
                     VALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHC
                     IDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHF
                     YQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGK
                     WSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSG
                     VSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW
                     AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQN
                     VEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLR
                     GLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKP
                     PNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTI
                     KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVY
                     QLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVG
                     DNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQ
                     VDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREM
                     GPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPV
                     EMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRN
                     KNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFW
                     RMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFT
                     VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGA
                     GRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLC
                     GNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHD
                     KNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWR
                     LVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC
                     NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHC
                     LNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
                     YLSSF"
     exon            262..387
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            388..659
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            660..741
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            742..857
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1032
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1326
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1623
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1733
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1935
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2038
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2312
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2349
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2485
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2515
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2664
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2855
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2943
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3020
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3057
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3155
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3272
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3427
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3563
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3713
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3887
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4019
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4145
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4309
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4445
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..12622
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12587..12592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /note="hexamer: AATAAA"
     polyA_site      12622
                     /gene="PTPRT"
                     /gene_synonym="R-PTP-T; RPTP-rho; RPTPrho"
                     /note="major polyA site"
ORIGIN      
        1 agttcgcgcc gcgcctcggc ttggaacgca ggagcgccgg ctccgggagc ccgagcggag
       61 ccagccgcgc gcacagccag cggccgcgcc ggcgatgcgg ggccaccccg cgcccgcccc
      121 agtcccggcc ccggcccccg cgggaagggg ctgagctgcc cgccgccgcc cggatggcga
      181 gcctcgccgc gctcgccctc agcctgctcc tgaggctgca gctgccgcca ctgcccggcg
      241 cccgggctca gagcgccgca ggtggctgtt cctttgatga gcactacagc aactgtggtt
      301 atagtgtggc tctagggacc aatgggttca cctgggagca gattaacaca tgggagaaac
      361 caatgctgga ccaggcagtg cccacaggat ctttcatgat ggtgaacagc tctgggagag
      421 cctctggcca gaaggcccac cttctcctgc caaccctgaa ggagaatgac acccactgca
      481 tcgacttcca ttactacttc tccagccgtg acaggtccag cccaggggcc ttgaacgtct
      541 acgtgaaggt gaatggtggc ccccaaggga accctgtgtg gaatgtgtcc ggggtcgtca
      601 ctgagggctg ggtgaaggca gagctcgcca tcagcacttt ctggccacat ttctatcagg
      661 tgatatttga atccgtctca ttgaagggtc atcctggcta catcgccgtg gacgaggtcc
      721 gggtccttgc tcatccatgc agaaaagcac ctcattttct gcgactccaa aacgtggagg
      781 tgaatgtggg gcagaatgcc acatttcagt gcattgctgg tgggaagtgg tctcagcatg
      841 acaagctttg gctccagcaa tggaatggca gggacacggc cctgatggtc acccgtgtgg
      901 tcaaccacag gcgcttctca gccacagtca gtgtggcaga cactgcccag cggagcgtca
      961 gcaagtaccg ctgtgtgatc cgctctgatg gtgggtctgg tgtgtccaac tacgcggagc
     1021 tgatcgtgaa agagcctccc acgcccattg ctcccccaga gctgctggct gtgggggcca
     1081 catacctgtg gatcaagcca aatgccaact ccatcatcgg ggatggcccc atcatcctga
     1141 aggaagtgga atatcgcacc accacaggca cgtgggcaga gacccacata gtcgactctc
     1201 ccaactataa gctgtggcat ctggaccccg atgttgagta tgagatccga gtgctcctca
     1261 cacgaccagg tgaggggggt acgggaccgc cagggcctcc cctcaccacc aggaccaagt
     1321 gtgcagatcc ggtacatggc ccacagaacg tggaaatcgt agacatcaga gcccggcagc
     1381 tgaccctgca gtgggagccc ttcggctacg cggtgacccg ctgccatagc tacaacctca
     1441 ccgtgcagta ccagtatgtg ttcaaccagc agcagtacga ggccgaggag gtcatccaga
     1501 cctcctccca ctacaccctg cgaggcctgc gccccttcat gaccatccgg ctgcgactct
     1561 tgctgtctaa ccccgagggc cgaatggaga gcgaggagct ggtggtgcag actgaggaag
     1621 acgttccagg agctgttcct ctagaatcca tccaaggggg gccctttgag gagaagatct
     1681 acatccagtg gaaacctccc aatgagacca atggggtcat cacgctctac gagatcaact
     1741 acaaggctgt cggctcgctg gacccaagtg ctgacctctc gagccagagg gggaaagtgt
     1801 tcaagctccg gaatgaaacc caccacctct ttgtgggtct gtacccaggg accacctatt
     1861 ccttcaccat caaggccagc acagcaaagg gctttgggcc ccctgtcacc actcggattg
     1921 ccaccaaaat ttcagctcca tccatgcctg agtacgacac agacacccca ttgaatgaga
     1981 cagacacgac catcacagtg atgctgaaac ccgctcagtc ccggggagct cctgtcagtg
     2041 tttatcagct ggttgtcaag gaggagcgac ttcagaagtc acggagggca gctgacatta
     2101 ttgagtgctt ttcggtgccc gtgagctatc ggaatgcctc cagcctcgat tctctacact
     2161 actttgctgc tgagttgaag cctgccaacc tgcctgtcac ccagccattt acagtgggtg
     2221 acaataagac atacaatggc tactggaacc ctcctctctc tcccctgaaa agctacagca
     2281 tctacttcca ggcactcagc aaagccaatg gagagaccaa aatcaactgt gttcgtctgg
     2341 ctacaaaagg tgcctccacc cagaattcta acactgtgga gccagagaag caggtggaca
     2401 acaccgtgaa gatggctggc gtgatcgctg gcctcctcat gttcatcatc attctcctgg
     2461 gcgtgatgct caccatcaaa aggagaagaa atgcttattc ctactcctat tacttgaagc
     2521 tggccaagaa gcagaaggag acccagagtg gagcccagag ggagatgggg cctgtggcct
     2581 ctgccgacaa acccaccacc aagctcagcg ccagccgcaa tgatgaaggc ttctcttcta
     2641 gttctcagga cgtcaacgga ttcacagatg gcagccgcgg ggagctttcc cagcccaccc
     2701 tcacgatcca gactcatccc taccgcacct gtgaccctgt ggagatgagc tacccccggg
     2761 accagttcca acccgccatc cgggtggctg acttgctgca gcacatcacg cagatgaaga
     2821 gaggccaggg ctacgggttc aaggaggaat acgaggcctt accagagggg cagacagctt
     2881 cgtgggacac agccaaggag gatgaaaacc gcaataagaa tcgatatggg aacatcatat
     2941 cctacgacca ttcccgggtg aggctgctgg tgctggatgg agacccgcac tctgactaca
     3001 tcaatgccaa ctacattgac ggataccatc gacctcggca ctacattgcg actcaaggtc
     3061 cgatgcagga gactgtaaag gacttttgga gaatgatctg gcaggagaac tccgccagca
     3121 tcgtcatggt cacaaacctg gtggaagtgg gcagggtgaa atgtgtgcga tactggccag
     3181 atgacacgga ggtctacgga gacattaaag tcaccctgat tgaaacagag cccctggcag
     3241 aatacgtcat acgcaccttc acagtccaga agaaaggcta ccatgagatc cgggagctcc
     3301 gcctcttcca cttcaccagc tggcctgacc acggcgttcc ctgctatgcc actggccttc
     3361 tgggcttcgt ccgccaggtc aagttcctca accccccgga agctgggccc atagtggtcc
     3421 actgcagtgc tggggctggg cggactggct gcttcattgc cattgacacc atgcttgaca
     3481 tggccgagaa tgaaggggtg gtggacatct tcaactgcgt gcgtgagctc cgggcccaaa
     3541 gggtcaacct ggtacagaca gaggagcaat atgtgtttgt gcacgatgcc atcctggaag
     3601 cgtgcctctg tggcaacact gccatccctg tgtgtgagtt ccgttctctc tactacaata
     3661 tcagcaggct ggacccccag acaaactcca gccaaatcaa agatgaattt cagaccctca
     3721 acattgtgac accccgtgtg cggcccgagg actgcagcat tgggctcctg ccccggaacc
     3781 atgataagaa tcgaagtatg gacgtgctgc ctctggaccg ctgcctgccc ttccttatct
     3841 cagtggacgg agaatccagc aattacatca acgcagcact gatggatagc cacaagcagc
     3901 ctgccgcctt cgtggtcacc cagcaccctc tacccaacac cgtggcagac ttctggaggc
     3961 tggtgttcga ttacaactgc tcctctgtgg tgatgctgaa tgagatggac actgcccagt
     4021 tctgtatgca gtactggcct gagaagacct ccgggtgcta tgggcccatc caggtggagt
     4081 tcgtctccgc agacatcgac gaggacatca tccacagaat attccgcatc tgtaacatgg
     4141 cccggccaca ggatggttat cgtatagtcc agcacctcca gtacattggc tggcctgcct
     4201 accgggacac gcccccctcc aagcgctctc tgctcaaagt ggtccgacga ctggagaagt
     4261 ggcaggagca gtatgacggg agggagggac gtactgtggt ccactgccta aatgggggag
     4321 gccgtagtgg aaccttctgt gccatctgca gtgtgtgtga gatgatccag cagcaaaaca
     4381 tcattgacgt gttccacatc gtgaaaacac tgcgtaacaa caaatccaac atggtggaga
     4441 ccctggaaca gtataaattt gtatacgagg tggcactgga atatttaagc tccttttagc
     4501 tcaatgggat ggggaacctg ccggagtcca gaggctgctg tgaccaagcc cccttttgtg
     4561 tgaatggcag taactgggct caggagctct gaggtggcac cctgcctgac tccaaggaga
     4621 agactggtgg ccctgtgttc cacggggggc tctgcacctt ctgaggggtc tcctgttgcc
     4681 gtgggagatg ctgctccaaa aggcccaggc ttccttttca acctaaccag ccacagccaa
     4741 gggcccaagc agaagtacac ccacaagcaa ggccttggat ttctggctcc cagaccacct
     4801 gcttttgttc tgagtttgtg gatctcttgg caagccaact gtgcaggtgc tggggagtgg
     4861 gaggctcccc tgccctcctt ctccttagga gtggaggaga tgtgtgttct gctcctctac
     4921 gtcatggaaa agattgaggc tcttgggggt cactgctctg ctgccccctg caacctcctt
     4981 caggggcctc tggcaccaga catttgcagt ctggaccagt gtgaccttac gatgttccct
     5041 aggccacaag agaggccccc catcctcaca cctaacctgc atggggcttc gcccacaacc
     5101 attctgtacc ccttccccag cctgggcctt gaccgtccag cattcactgg ccggccagct
     5161 gtgtccacag cagtttttga taaaggtgtt ctttgctttt ttgtgtggtc agtgggaggg
     5221 ggtggaactg cagggaactt ctctgctcct ccttgtcttt gtaaaaaggg accacctccc
     5281 tggggcaggg cttgggctga cctgtaggat gtaacccctg tgtttctttg gtggtagctt
     5341 tctttggaag agacaaacaa gataagattt gattattttc caaagtgtat gtgaaaagaa
     5401 actttctttt ggagggtgta aaatcttagt ctcttatgtc aaaaagaagg gggcggggga
     5461 gtttgagtat gtacctctaa gacaaatctc tcgggccttt tattttttcc tggcaatgtc
     5521 cttaaaagct cccaccctgg gacagcatgc cactgagcaa ggagagatgg gtgagcctga
     5581 agatggtccc tttggtttct ggggcaaata gagcaccagc tttgtgcata atttggatgt
     5641 ccaaatttga actccttcct aaagaaaccc agcagccacc ttgaaaaagg ccattgtgga
     5701 gcccattata ctttgattta aaataggcca agagaatcag gcctggagat ctagggtctt
     5761 gtccaaagtg tgagtgagtc aatgagaggg aaccaacatt tgctaagtct ctactgtatg
     5821 ccagggatca tgcttggcac tttccatagg acatttcaca cagtccttag aacccccagg
     5881 agagagctac tgacttgtta tcatctccat ttgatcatct cctccaatga ggaaacccac
     5941 gcaccttcct tagtaatgaa atcctgggtt ccaaaggggc aggtaatggc aatgagactt
     6001 ctccgtgctg ttttcttcat cttctctaag ccaagcaatt attttatgga gggaaaataa
     6061 ggccagaaac ttctgagcag ataactccac aaatggaaat ttagtacttt cttcctgatg
     6121 ccagttcttc tgggaagcgc agaatttcag atatatttta gtaacacatt cccagctccc
     6181 caggaaagcc agtctcatct aatttcttag tcagtaaaaa caattccctg ttccttcagg
     6241 ctatgaatgg accagccagg gaaactctcg accttgatct ctagccagtg cttaggccca
     6301 atatctgaca gcctcaggtg ggctgggacc taggaagctc catcttgaag gctggtctag
     6361 ccccagacag ggcatgaggg gcagagaatt caagaaggta cagctttggc cctcaagagc
     6421 ccactgtatg ctggggaaat ggaaccatgg tgcagtagtg tggagtggat gagtgttcca
     6481 tgagcctagg agcaagaaag tctcttcggc ctcgggcttc ctggagaagg ggacgtccat
     6541 tcctgctggg tcttaacaag cataaaaagg aaaaaaagga aactcaggca aagggatcca
     6601 tatgtgcaat ggcaaagaaa tgtgaaaagg cattgggaga agcagtctgg gggaggccag
     6661 cccagtgcgg gcacagcaca acacggggag cagcaagaga tgagccaggg tccaggagac
     6721 agatgcccat cgcgagtaca gactttgtcc tattggcaac aaggagtcca tggagcttta
     6781 gagagatgca ctcagcttcg tgttggccaa gactccttct gggccaatgg ggctgcctct
     6841 tttcctttca tcagacactg tgaaaacatt cccttaagcg tgcacttttt aatatcacat
     6901 ctatttgtct gtctgctcat tgttttgttg ctggaactaa atatgcaatg gatcatgaga
     6961 ctcagattct atgagaaacc cagggtctct gctttaccac ggagcagggt caccaaccca
     7021 gatctccagg cccatgagga tggaacatga aaggagccga caaaagttgc ttccattggc
     7081 atgggctctg gagctgtcca gaagtccagg gacaccagac ttgatcaagg aagggctgtc
     7141 actttagagg ttcaaaagga agtgcctcaa agcaaaggca agcaaaggaa ccccacgatg
     7201 aacttgctct tttcctttga tgagcctctc cccaggtgta tttcagcaga ccccggggac
     7261 ccacccccac tgggcctgct ggcctccctc ggctccagcc caatgcccca gctggccttc
     7321 cccagcctgc aaggagcctg tagcatggca aatctgcctg ctgtatgcta ttttcttaga
     7381 tcttggtaca tccagacagg atgagggtgg agggagagct atttaacaca aatcctaaga
     7441 tttttttctg ctcaggaagg ggtgaaatag ctggcagata caaaagacag tggcttttat
     7501 cattttaaat ggtaggaatt taaggtgtga cttcagggag aaacaaactt gcaaaaaaaa
     7561 aaaatctcag gccatgttgg ggtaacccag caagggccag tgatgatttc ccccagctca
     7621 tccccttatt ttcccacaac ccaaccattc tctaaagcag gacagtgaat aggtcttagg
     7681 ccagtgcaca caggaagaaa ttgaggctta tggatgggga tgacttccct aagatcccat
     7741 gggacaagga tgtggcaagg cttggatgag atggggcacc agtgcccagg aatttgaaca
     7801 ttttccttta cccaggaaat ctccggagcc aacaccacca cccccagggg gtctccccac
     7861 cccaccccat ttacagggtg agctcagcct gtcatgagca gaggaaaata ttattaatgc
     7921 tctctgagtc tttacaacag gagctcttac ctcatagatg tgggctctgt ttggggaaga
     7981 tgcaaggaag taatgagaag cccaggaaat ttctccacct gtgtttatgg cctaaatagc
     8041 ttcaggatgt atcttagctg cactccaaca ttgcatcctt tctggggtga agaatctggg
     8101 ccaaccaggg gtccttgggc ctctagaagg ccacagtagg cctctctttg tgggaatgga
     8161 aggggacagt ttgcttttag tgctggccct ctctgtgggt gtggcctgca aaggaaccaa
     8221 cagaccctat gctggggact ctaacatgtg agctcattaa attcttccag cattctaaag
     8281 gagggtttgt gattgtcacc atttactgat gaggaaacta aggctcctag gggagaaatc
     8341 acttgcccac agttccacag ctagtgagtg aatgaaccag gatttaaacc ggttttttct
     8401 cactacagag acaatatttt tccaccattg tatctcacat ttttcccagg aggttaccca
     8461 taacagaaga gactagagtg gaacagatac gtcagtggat aaagctcaaa gcaaacaaca
     8521 gtaagcttaa aattccttca tagtctcatg ttttacgttc acaattcatg caaaatttgc
     8581 attccacttt ctgatttagc cttgttggtt ttaatatgac tctatgaata tttcaaaaaa
     8641 aaatgtgctc tgttcctcat gttgttctgt tctgttcacc ccgctatgac ggaccctagg
     8701 tcagctggtc ttcagcttga ccctagaatt gactctagga gcagtgaccc tgctgcctcc
     8761 cagagccagt tataggctca agatcaagac caactgacct tctcctaggc agctcctttg
     8821 gtgtgtgggt gctctgacct cactgttcat gaggggacct caactaaggc atcttccagt
     8881 tgggtgctgg aaggaaccca ttaactcaca ctagaatgat gaggatttgc tcatctggcg
     8941 tggagaagga tgagcccaca aaaccctaaa gggaaaagag aagctggaca cagctgtact
     9001 cagcagattc ctgaatgcta ggctggaaag tggtgcctgt tgtccaagtg gagtcacatg
     9061 gttgctaatg tgggcaagtc tgaggacaca cttcatgagc agctggggtc tggaaggctc
     9121 ctcactttac cctagccaca cataattact gggtgcctac agcacctagc accttggagg
     9181 gggcactatt aggaaatcga gattactatg gcacaattaa ttcctgggta aggcatgggg
     9241 ttgtggtgga cagagctcag tctttagttt gaacgaaaac atacatacat gaaaaacata
     9301 catgaaaaaa ggaccctcat caacattaga aggggtagat ttggagcact ttaggcagga
     9361 aaacaggaac gcaaggccag gaaactggaa cccagtgaat actcagaacc gaggatgcag
     9421 atgacttatt tagcaaaatg gtcacttctg tgacatagct ggagaaagga tgggtaacag
     9481 cttgccagag ccacttggaa caagggcaaa tctcagtgtc tggggcaaaa gatgatgcat
     9541 ttccctctga cccatcatgt ttattcatcc tccactcccc attgccacac tagctcttgc
     9601 tgtaagtcct caccaggatc tacatttcct cgtcgctggt gggaacccct tagagtacat
     9661 agaggtatca gtccagtaag actgctctac acaacagaag tgaggcccag ggagtagcag
     9721 ccaggccctt atcctgttac ctctgcagga gtgactgccc aacccagatc cagagacatt
     9781 gaaggaaatg ataattcctt ggtacctcac tgccttggga caaaatgaag aaagccaccc
     9841 ttccttaggc tgcagcttgc cactcctggg ctgggtaaac aggtcatcag caccaagctc
     9901 aaccaggagt aacactctgg aagacatggg tgagcccaag aggaagcatg aacaggacgc
     9961 tgttcctaag tcatgtcaac aggttgtgct gggccaggat ccccagggaa aaaaatggtc
    10021 aacccaactg gagggtaggt tagaagaaaa aaaacataaa cgtggatagt catgtcatct
    10081 caaatccctg acttggcttc cccattactt aacagtctga gctccttctt agcctgtgac
    10141 cagcttcaaa tcacagccaa gtaaaacaag gaaataggaa aagtaaatcc aactagaaga
    10201 gacaagctga gattcagatt tgtttactcc tcccatgcaa agtttccctg ttggaggttt
    10261 tccatgtata catgtctaga agtgatagaa tgcaaggcct tggctttgtc ttgcagggat
    10321 ctgcctttga ggtcatagac tgaacagcag ggagagaggt tagtggtgga gtgtgggggg
    10381 agctgttcta gctccagttt cttctgacac atttttcagg atcatggatc tgatcctccg
    10441 aagcacagca gagatatcta agccatattt gtgcacatga gcagactctt ctagtttttt
    10501 agtaaccagg gatgggcttt tgcatggcac tgactataga gatgtcttgt agagatcaag
    10561 ccagtctttt gcatcccacc tgcccacctc cagaagagat gggaaaaggt catcaaaggg
    10621 cattcaccaa ctgaaatcca ctcatgaatg ttaggtctct aaaaggaggc atcaacactc
    10681 acaatggtag cctccaaacc tagcatccca cctatctaag agctcagggg tggtccactg
    10741 gggcagatac aagggaagtg caagggctca ggatgaaaga aaatctattg ggaagagttt
    10801 taggggcttg atcattatgg ggcttccttc tatatctgag aactgctctg ggtggtgaga
    10861 tgtggactct gatccttaat tggaatgttc ggagaatgag tgtctggtgg ccttgaagtg
    10921 ttggacagaa aagtatcagt ataaaagcct ggagctcagg gtaattaatg tagttcatgg
    10981 ttccttagtg agcaggactc ttggatgtgg aggagaaagg gtcataggaa gtaaaccacc
    11041 aaaattacaa aattgagtct ctgtacaatt acttcagtgc ctttgggctt atgaatacaa
    11101 atcagtgggc cttctctatg atggtccaac aaactctcag tgtccaccct gtccctgtat
    11161 ctcccatgga agatgaataa tgtcaggtgt tctttgggtc aaaggcccca gggcagtctg
    11221 gaggcttaga gggcagagtg gtgtcattcc atgtaaagtt aggcttctga ggggtcaggc
    11281 agaatatggt gtccatatct tccatagctc tgcagattct tggatgaagt caagcacagt
    11341 ttgctagacc caggtcactc ctctgagtat aactaggacc catgagtgaa acttaatagc
    11401 tgtaaggaag aacctgctgt ctgccagaga ggataagctg cccatctcag cagctgtcta
    11461 aaagaaggca ggtgtctctt taaagggaag agaagcattg gtgaaatgga tttcaggtca
    11521 cttccattcc agatgggtga gatcttgtgg agctgggatc atgtttgaac tcattcatac
    11581 ctgtagagca cgaatccaag tagattgtgt ttggtctgta caggctgaag ccccctgctc
    11641 tcccacccaa gtgcccccac tgagcaggcc aacatgctgt tgtggccaca tatactgggc
    11701 tgatccaggc tggttatcac caaacagcaa accataggga acagctgctt tgccatagac
    11761 ccaataccca tgtagatctc tcatgagagc agccataact cagacccact gaccaacagg
    11821 gccatgagtg acagccagaa ccagtgaagg tccaagtagg acacagagca gggcttttct
    11881 taccatacac attatctcca gaggttattt ctaccccact ccctattcaa ggcctgttgg
    11941 agcacactgc aaaagcaaaa gcacagtaac tcaatttaca catgattata atcatttcca
    12001 gtgcacacat ttcatcacca ggtggatcct gagctagccc atgtaaatcc gggttaaccc
    12061 atattggtaa tcatactcaa aagcactttt caccctacat tctactagcc aatcaaagac
    12121 aaagagttgt ggcctctacc attgccttgg cttctggaca ccctcacaag ctatcccaag
    12181 gttcccgctc aactccaggg aggctgacat cttcacatcc actgggcata taatattgca
    12241 tgagaccaaa gtctccacac tctttgcagc ctcctccatg aatcccaatg gcctgcactt
    12301 gtacagtttg ggtgtttgat agataaagca cgtatgagaa gagaaaacaa aataaatcaa
    12361 ctttttaaaa aagccagcac tgtgctgtca atgttttttt tttcttttca attctagctc
    12421 agaaaagcag aaggtaaata atgtcaggtc aatgaatatc agatatattt tttgactgta
    12481 cattacagtg aagtgtaatc tttttacacc tgcaagtcca tcttatttat tcttgtaaat
    12541 gttccctgac aatgtttgta acatggctgt gttaaaaaat ctatacaata aagctgtgac
    12601 cctgagattc atgttttcct aa
//
