LOCUS       NM_002850               7356 bp    mRNA    linear   PRI 21-NOV-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type S (PTPRS),
            transcript variant 1, mRNA.
ACCESSION   NM_002850
VERSION     NM_002850.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7356)
  AUTHORS   Li,Y., Liu,J., Huang,J., Wei,C., Ge,L., Chung,M., Zhu,B., Guo,Z.,
            Zheng,T., Li,H., Gu,Y., Wang,W., Li,Q. and Wang,Z.
  TITLE     Reduced PTPRS expression promotes epithelial-mesenchymal transition
            of Schwann cells in NF1-related plexiform neurofibromas
  JOURNAL   Cancer Lett 599, 217151 (2024)
   PUBMED   39094827
  REMARK    GeneRIF: Reduced PTPRS expression promotes epithelial-mesenchymal
            transition of Schwann cells in NF1-related plexiform neurofibromas.
REFERENCE   2  (bases 1 to 7356)
  AUTHORS   Poirier,A., Picard,C., Labonte,A., Aubry,I., Auld,D.,
            Zetterberg,H., Blennow,K., Tremblay,M.L. and Poirier,J.
  CONSRTM   PREVENT-AD research group
  TITLE     PTPRS is a novel marker for early Tau pathology and synaptic
            integrity in Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 14718 (2024)
   PUBMED   38926456
  REMARK    GeneRIF: PTPRS is a novel marker for early Tau pathology and
            synaptic integrity in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7356)
  AUTHORS   Lertpanprom,M., Silsirivanit,A., Tippayawat,P., Proungvitaya,T.,
            Roytrakul,S. and Proungvitaya,S.
  TITLE     High expression of protein tyrosine phosphatase receptor S (PTPRS)
            is an independent prognostic marker for cholangiocarcinoma
  JOURNAL   Front Public Health 10, 835914 (2022)
   PUBMED   35991009
  REMARK    GeneRIF: High expression of protein tyrosine phosphatase receptor S
            (PTPRS) is an independent prognostic marker for cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7356)
  AUTHORS   Gong,Y., Abudureyimu,S., Kadomatsu,K. and Sakamoto,K.
  TITLE     Identification of PTPRsigma-interacting proteins by
            proximity-labelling assay
  JOURNAL   J Biochem 169 (2), 187-194 (2021)
   PUBMED   33313879
  REMARK    GeneRIF: Identification of PTPRsigma-interacting proteins by
            proximity-labelling assay.
REFERENCE   5  (bases 1 to 7356)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 7356)
  AUTHORS   Norris,K., Norris,F., Kono,D.H., Vestergaard,H., Pedersen,O.,
            Theofilopoulos,A.N. and Moller,N.P.
  TITLE     Expression of protein-tyrosine phosphatases in the major insulin
            target tissues
  JOURNAL   FEBS Lett 415 (3), 243-248 (1997)
   PUBMED   9357975
REFERENCE   7  (bases 1 to 7356)
  AUTHORS   Wagner,J., Gordon,L.A., Heng,H.H., Tremblay,M.L. and Olsen,A.S.
  TITLE     Physical mapping of receptor type protein tyrosine phosphatase
            sigma (PTPRS) to human chromosome 19p13.3
  JOURNAL   Genomics 38 (1), 76-78 (1996)
   PUBMED   8954782
REFERENCE   8  (bases 1 to 7356)
  AUTHORS   Endo,N., Rutledge,S.J., Opas,E.E., Vogel,R., Rodan,G.A. and
            Schmidt,A.
  TITLE     Human protein tyrosine phosphatase-sigma: alternative splicing and
            inhibition by bisphosphonates
  JOURNAL   J Bone Miner Res 11 (4), 535-543 (1996)
   PUBMED   8992885
REFERENCE   9  (bases 1 to 7356)
  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
            PTP sigma isoforms are expressed in a tissue-specific manner and
            associate with the LAR-interacting protein LIP.1
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11686-11690 (1995)
   PUBMED   8524829
REFERENCE   10 (bases 1 to 7356)
  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
            Imai,K. and Yachi,A.
  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
  JOURNAL   Cancer Res 52 (3), 737-740 (1992)
   PUBMED   1370651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005335.1, AB209333.1,
            BC029496.1, BC104812.1, U35234.1, U40317.1, CN413749.1, CN413752.1
            and AC118535.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002850.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            region, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. The extracellular region of this protein is
            composed of multiple Ig-like and fibronectin type III-like domains.
            Studies of the similar gene in mice suggested that this PTP may be
            involved in cell-cell interaction, primary axonogenesis, and axon
            guidance during embryogenesis. This PTP has been also implicated in
            the molecular control of adult nerve repair. Four alternatively
            spliced transcript variants, which encode distinct proteins, have
            been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The transcript 3'UTR sequence was derived from a
            genomic record (AC118535.1) based on a series of overlapping EST
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262963.11/ ENSP00000262963.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC005335.1         39083-39091         c
            10-149              AB209333.1         1-140
            150-503             BC029496.1         155-508
            504-811             BC104812.1         335-642
            812-2027            U35234.1           677-1892
            2028-2092           BC104812.1         1820-1884
            2093-2535           U40317.1           1836-2278
            2536-2545           U35234.1           2401-2410
            2546-2592           CN413749.1         536-582
            2593-2739           U35234.1           2458-2604
            2740-2971           U40317.1           2456-2687
            2972-3471           CN413752.1         143-642
            3472-4291           BC104812.1         2010-2829
            4292-4611           AB209333.1         2990-3309
            4612-4612           AC118535.1         27302-27302         c
            4613-4979           AB209333.1         3311-3677
            4980-6175           BC104812.1         3470-4665
            6176-7356           AC118535.1         18124-19304         c
FEATURES             Location/Qualifiers
     source          1..7356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..7356
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /note="protein tyrosine phosphatase receptor type S"
                     /db_xref="GeneID:5802"
                     /db_xref="HGNC:HGNC:9681"
                     /db_xref="MIM:601576"
     exon            1..149
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            150..334
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..6090
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase PTPsigma;
                     receptor-type tyrosine-protein phosphatase sigma"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase S
                     isoform 1 precursor"
                     /protein_id="NP_002841.3"
                     /db_xref="CCDS:CCDS45930.1"
                     /db_xref="GeneID:5802"
                     /db_xref="HGNC:HGNC:9681"
                     /db_xref="MIM:601576"
                     /translation="MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIG
                     VSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDE
                     NVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASG
                     NPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVA
                     TNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYV
                     KWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKA
                     PGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGL
                     SPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP
                     VEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG
                     DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHG
                     REVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQD
                     VKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQIL
                     LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVL
                     WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITN
                     LQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPA
                     GTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG
                     EEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREA
                     GALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTF
                     LRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITH
                     LKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ
                     SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEV
                     PRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPF
                     SDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR
                     TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADM
                     AEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ
                     PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLE
                     EKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF
                     TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIK
                     PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKL
                     AQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQP
                     IRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE
                     MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT
                     DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM
                     RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT"
     exon            335..480
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            481..622
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            623..811
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            812..820
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            821..838
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            839..949
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            950..961
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1231
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1813
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1947
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2092
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2398
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2592
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2619
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2737
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..3346
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3444
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3698
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3792
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..4008
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4166
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4178
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4291
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4292..4339
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4437
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4561
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4737
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4857
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5012
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5013..5298
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5477
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..5604
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5605..5730
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5731..5885
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5886..6021
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     exon            6022..7356
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7337..7342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /note="hexamer: ATTAAA"
     polyA_site      7356
                     /gene="PTPRS"
                     /gene_synonym="PTP-sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma"
                     /note="major polyA site"
ORIGIN      
        1 agtgagtgtc ctcgcgccgc ccgcccggca gcccggccgg cgcgcgcacg ccgcgagccg
       61 ctggcgctcg ggctccgctc ggatcccatg caacagccac gatgtgaagc ggggcagagc
      121 cgggggagcc cagcccagcc agcctccaga cgttgcccca tctgacgctc ggctcgaggc
      181 ctctctgtga gggaccgggg ggccatcccc ctccagggcg gagatcggag gtcgctgcca
      241 agcatggcgc ccacctgggg ccctggcatg gtgtctgtgg ttggtcccat gggcctcctt
      301 gtggtcctgc tcgttggagg ctgtgcagca gaagagcccc ccaggtttat caaagaaccc
      361 aaggaccaga tcggcgtgtc ggggggtgtg gcctctttcg tgtgtcaggc cacgggtgac
      421 cccaagccac gagtgacctg gaacaagaag ggcaagaagg tcaactctca gcgctttgag
      481 acgattgagt ttgatgagag tgcaggggca gtgctgagga tccagccgct gaggacaccg
      541 cgggatgaaa acgtgtacga gtgtgtggcc cagaactcgg ttggggagat cacagtccat
      601 gccaagctta ctgtcctccg agaggaccag ctgccctctg gcttccccaa catcgacatg
      661 ggcccacagt tgaaggtggt ggagcggaca cggacagcca ccatgctctg tgcagccagc
      721 ggcaaccctg accctgagat cacctggttc aaggacttcc tgcctgtgga tcctagtgcc
      781 agcaatggac gcatcaaaca gctgcgatca gaaacctttg aaagcactcc gattcgagga
      841 gccctgcaga ttgaaagcag tgaggaaacc gaccagggca aatatgagtg tgtggccacc
      901 aacagcgccg gcgtgcgcta ctcctcacct gccaacctct acgtgcgaga gcttcgagaa
      961 gtccgccgcg tggccccgcg cttctccatc ctgcccatga gccacgagat catgccaggg
     1021 ggcaacgtga acatcacctg cgtggccgtg ggctcgccca tgccatacgt gaagtggatg
     1081 cagggggccg aggacctgac ccccgaggat gacatgcccg tgggtcggaa cgtgctggaa
     1141 ctcacagatg tcaaggactc ggccaactac acctgcgtgg ccatgtccag cctgggcgtc
     1201 attgaggcgg ttgctcagat cacggtgaaa tctctcccca aagctcccgg gactcccatg
     1261 gtgactgaga acacagccac cagcatcacc atcacgtggg actcgggcaa cccagatcct
     1321 gtgtcctatt acgtcatcga atataaatcc aagagccaag acgggccgta tcagattaaa
     1381 gaggacatca ccaccacacg ttacagcatc ggcggcctga gccccaactc ggagtacgag
     1441 atctgggtgt cggccgtcaa ctccatcggc caggggcccc ccagcgagtc cgtggtcacc
     1501 cgcacaggcg agcaggcccc ggccagcgcg ccgcggaacg tgcaagcccg gatgctcagc
     1561 gcgaccacca tgattgtgca gtgggaggag ccggtggagc ccaacggcct gatccgcggc
     1621 taccgcgtct actacaccat ggaaccggag caccccgtgg gcaactggca gaagcacaac
     1681 gtggacgaca gcctgctgac caccgtgggc agcctgctgg aggacgagac ctacaccgtg
     1741 cgggtgctcg ccttcacctc cgtcggcgac gggcccctct cggaccccat ccaggtcaag
     1801 acgcagcagg gagtgccggg ccagcccatg aacctgcggg ccgaggccag gtcggagacc
     1861 agcatcacgc tgtcctggag ccccccgcgg caggagagta tcatcaagta cgagctcctc
     1921 ttccgggaag gcgaccatgg ccgggaggtg ggaaggacct tcgacccgac gacttcctac
     1981 gtggtggagg acctgaagcc caacacggag tacgccttcc gcctggcggc ccgctcgccg
     2041 cagggcctgg gcgccttcac ccccgtggtg cggcagcgca cgctgcagtc caaaccgtca
     2101 gccccccctc aagacgttaa atgtgtcagc gtgcgctcca cggccatttt ggtaagttgg
     2161 cgcccgccgc cgccggaaac gcacaacggg gccctggtgg gctacagcgt ccgctaccga
     2221 ccgctgggct cagaggaccc ggaacccaag gaggtgaacg gcatcccccc gaccaccact
     2281 cagatcctgc tggaggcctt ggagaagtgg acccagtacc gcatcacgac tgtcgctcac
     2341 acagaggtgg gaccagggcc cgagagctcg cccgtggtcg tccgcaccga cgaggatgtg
     2401 cccagcgcgc cgccgcggaa ggtggaggcg gaggcgctca acgccacggc catccgcgtg
     2461 ctgtggcgct cgcccgcgcc cggccggcag cacggccaga tccgcggcta ccaggtccac
     2521 tacgtgcgca tggagggcgc cgaggcccgc gggccgccgc gcatcaagga cgtcatgctg
     2581 gccgatgccc agtgggagac ggatgacacg gccgaatatg agatggtcat cacaaacttg
     2641 cagcctgaga ccgcgtactc catcacggta gccgcctaca ccatgaaggg cgatggcgct
     2701 cgcagcaaac ccaaggtggt tgtgaccaag ggagcagtgc tgggccgccc aaccctgtcg
     2761 gtgcagcaga cccccgaggg cagcctgctg gcacgctggg agcccccggc tggcaccgcg
     2821 gaggaccagg tgctgggcta ccgcctgcag tttggccgtg aggactcgac gcccctggcc
     2881 accctggagt tcccgccctc cgaggaccgc tacacggcat caggcgtgca caagggggcc
     2941 acgtatgtgt tccggcttgc ggcccggagc cgcggcggcc tgggcgagga ggcagccgag
     3001 gtcctgagca tcccggagga cacgccccgt ggccacccgc agattctgga ggcggccggc
     3061 aacgcctcgg ccgggaccgt ccttctccgc tggctgccac ccgtgcccgc cgagcgcaac
     3121 ggggccatcg tcaaatacac ggtggccgtg cgggaggccg gtgccctggg ccctgcccga
     3181 gagactgagc tgccggcagc ggctgagccg ggcgcggaga acgcgctcac gctgcagggc
     3241 ctgaagcccg acacggccta tgacctccaa gtgcgagccc acacgcgccg gggccctggc
     3301 cccttcagcc cccccgtccg ctaccggacg ttcctgcggg accaagtctc gcccaagaac
     3361 ttcaaggtga aaatgatcat gaagacatca gttctgctca gctgggagtt ccctgacaac
     3421 tacaactcac ccacacccta caagatccag tacaatgggc tcacactgga tgtggatggc
     3481 cgtaccacca agaagctcat cacgcacctc aagccccaca ccttctacaa ctttgtgctg
     3541 accaatcgcg gcagcagcct gggcggcctc cagcagacgg tcaccgcctg gactgccttc
     3601 aacctgctca acggcaagcc cagcgtcgcc cccaagcctg atgctgacgg cttcatcatg
     3661 gtgtatcttc ctgacggcca gagccccgtg cctgtccaga gctatttcat tgtgatggtg
     3721 ccactgcgca agtctcgtgg aggccaattc ctgaccccgc tgggtagccc agaggacatg
     3781 gatctggaag agctcatcca ggacatctca cggctacaga ggcgcagcct gcggcactcg
     3841 cgtcagctgg aggtgccccg gccctatatt gcagctcgct tctctgtgct gccacccacg
     3901 ttccatcccg gcgaccagaa gcagtatggc ggcttcgata accggggcct ggagcccggc
     3961 caccgctatg tcctcttcgt gcttgccgtg cttcagaaga gcgagcctac ctttgcagcc
     4021 agtcccttct cagacccctt ccagctggat aacccggacc cccagcccat cgtggatggc
     4081 gaggaggggc ttatctgggt gatcgggcct gtgctggccg tggtcttcat aatctgcatt
     4141 gtcattgcta tcctgctcta caagaacaaa cccgacagta aacgcaagga ctcagaaccc
     4201 cgcaccaaat gcctcctgaa caatgccgac ctcgcccctc accaccccaa ggaccctgtg
     4261 gaaatgagac gcattaactt ccagactcca gattcaggcc tcaggagccc cctcagggag
     4321 ccggggtttc actttgaaag catgcttagc cacccgccaa ttcccatcgc agacatggcg
     4381 gagcacacgg agcggctcaa ggccaacgac agcctcaagc tctcccagga gtatgagtcc
     4441 atcgaccctg gacagcagtt cacatgggaa cattccaacc tggaagtgaa caagccgaag
     4501 aaccgctatg ccaacgtcat cgcctatgac cactcccgtg tcatcctcca gcccattgaa
     4561 ggcatcatgg gcagtgatta catcaatgcc aactacgtgg acggctaccg gtgtcagaac
     4621 gcgtacattg ccacgcaggg gccgctgcct gagacctttg gggacttctg gcgtatggtg
     4681 tgggagcagc ggtcggcgac catcgtcatg atgacgcggc tggaggagaa gtcacggatc
     4741 aagtgtgatc agtattggcc caacagaggc acggagacct acggcttcat ccaggtcacg
     4801 ttgctagata ccatcgagct ggccacattc tgcgtcagga cattctctct gcacaagaat
     4861 ggctccagtg agaaacgcga ggtccgccag ttccagttta cggcgtggcc ggaccatggc
     4921 gtgcccgaat acccaacgcc cttcctggct ttcctgcgga gagtcaagac ctgcaacccg
     4981 ccagatgccg gccccatcgt ggttcactgc agtgccggtg tgggccgcac aggctgcttt
     5041 atcgtcatcg acgccatgct tgagcggatc aagccagaga agacagtcga tgtctatggc
     5101 cacgtgacgc tcatgaggtc ccagcgcaac tacatggtgc agacggagga ccagtacagc
     5161 ttcatccacg aggccctgct ggaggccgtg ggctgtggca acacagaagt gcccgcacgc
     5221 agcctctatg cctacatcca gaagctggcc caggtggagc ctggcgaaca cgtcactggc
     5281 atggaactcg agttcaagcg gctggctaac tccaaggccc acacgtcacg cttcatcagt
     5341 gccaatctgc cttgtaacaa gttcaagaac cgcctggtga acatcatgcc ctatgagagc
     5401 acacgggtct gtctgcaacc catccggggt gtggagggct ctgactacat caacgccagc
     5461 ttcattgatg gctacaggca gcagaaggcc tacatcgcga cacaggggcc gctggcggag
     5521 accacggaag acttctggcg catgctgtgg gagaacaatt cgacgatcgt ggtgatgctg
     5581 accaagctgc gggagatggg ccgggagaag tgtcaccagt actggccggc cgagcgctct
     5641 gcccgctacc agtactttgt ggtagatccg atggcagaat acaacatgcc tcagtatatc
     5701 ctgcgagagt tcaaggtcac agatgcccgg gatggccagt cccggactgt ccggcagttc
     5761 cagttcacag actggccgga acagggtgtg ccaaagtcgg gggagggctt catcgacttc
     5821 attggccaag tgcataagac taaggagcag tttggccagg acggccccat ctctgtccac
     5881 tgcagtgccg gcgtgggcag gacgggcgtc ttcatcacgc ttagcatcgt gctggagcgg
     5941 atgcggtatg aaggcgtggt ggacatcttt cagacggtga agatgctacg aacccagcgg
     6001 ccggccatgg tgcagacaga ggatgagtac cagttctgtt accaggcggc actggagtac
     6061 ctcggaagct ttgaccacta tgcaacctaa agccatggtt ccccccaggc ccgacaccac
     6121 tggccccgga tgcctctgcc cctcccgggc ggacctcctg aggcctggac ccccagtggg
     6181 cagggcagga ggtggcagcg gcagcagctg tgtttctgca ccatttccga ggacgacgca
     6241 gcccctcgag cccccccacc ggccccggcc gccccagcga cctccctggc accggccgcc
     6301 gccttcaaat acttggcaca ttcctccttt ccttccaatt ccaaaaccag attccggggt
     6361 ggggggtggg gggatggtga gcaaatagga gtgctcccca gaaccagagg agggtggggc
     6421 acagaccata gacggacccc tcgtcctccc ccagcggtgg tagggggacc cggggggctc
     6481 ctccccgctc tgcagcctgg ggacactggg ctgggaccag aatccagctt tcttttaaaa
     6541 ctctcagtgt aactgtatcc cgtgacattt catttttttt aaatagtgta tttttttttc
     6601 catttttttt tttaagagaa acaaacaaaa gactcgccag tcaatgactt tcaaagagaa
     6661 ctaactttgg cttattcata ttctgttcaa agacagtcta ttttttcact gtagaaagcg
     6721 tccttgtgtg atagttacgt tcgcaaacgc gcacgccagg cccatggctg taccttggct
     6781 tttttttttt tttttttttt tttaattttt cctaccatca gaaagtgtgc tttgctcaca
     6841 gaagaatggg atgtcctttt ttctttcttg gctttttttt tccccctttt tgtttcattt
     6901 ttataaatta aattttcaga catatcaaat acagttctga gggtaaggtc atgggggagc
     6961 tcggacccag tggcgttggg tgcggttgag ggggacgctg ctgtaagagg agagagatga
     7021 cagtggtcct cctctgagag cctgagctgt ctccccgtct cccgccccca aggagacaga
     7081 gaggatccta cttcttcggg gacagtggct gtatggctgt gctgccccac atcagggacc
     7141 ctttccccct gggactgtgg ggcagtttgg gagcaaaacc agaaggacag gcccccctct
     7201 acccgcctac cctgagcaag cgagttgttc ctctttgtac aagggcaggt ctgcggttac
     7261 tttcaacact gtttattcca gcggaagcag ccgggtggtt ttcccacccc cgtgtatgta
     7321 gatatatcga ctttgtatta aaggaagatc gtctga
//
