LOCUS       NM_002849               3427 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR),
            transcript variant 1, mRNA.
ACCESSION   NM_002849
VERSION     NM_002849.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3427)
  AUTHORS   Du,T., Hu,X., Hou,Z., Wang,W., You,S., Wang,M., Ji,M., Xue,N. and
            Chen,X.
  TITLE     Re-expression of epigenetically silenced PTPRR by histone
            acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2
            inhibition
  JOURNAL   Cell Mol Life Sci 81 (1), 64 (2024)
   PUBMED   38280930
  REMARK    GeneRIF: Re-expression of epigenetically silenced PTPRR by histone
            acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2
            inhibition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3427)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3427)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3427)
  AUTHORS   Wang,J.L., Wang,Y. and Ren,G.P.
  TITLE     Identification of PTPRR and JAG1 as key genes in
            castration-resistant prostate cancer by integrated bioinformatics
            methods
  JOURNAL   J Zhejiang Univ Sci B 21 (3), 246-255 (2020)
   PUBMED   32133801
  REMARK    GeneRIF: Identification of PTPRR and JAG1 as key genes in
            castration-resistant prostate cancer by integrated bioinformatics
            methods().
REFERENCE   5  (bases 1 to 3427)
  AUTHORS   Wang,Y., Cao,J., Liu,W., Zhang,J., Wang,Z., Zhang,Y., Hou,L.,
            Chen,S., Hao,P., Zhang,L., Zhuang,M., Yu,Y., Li,D. and Fan,G.
  TITLE     Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes
            the Wnt signaling pathway in ovarian cancer by dephosphorylating
            and inactivating beta-catenin
  JOURNAL   J Biol Chem 294 (48), 18306-18323 (2019)
   PUBMED   31653698
  REMARK    GeneRIF: Results suggest that protein tyrosine phosphatase receptor
            type R (PTPRR) expression might have utility as a prognostic marker
            for predicting overall survival.
REFERENCE   6  (bases 1 to 3427)
  AUTHORS   Ogata,M., Oh-hora,M., Kosugi,A. and Hamaoka,T.
  TITLE     Inactivation of mitogen-activated protein kinases by a mammalian
            tyrosine-specific phosphatase, PTPBR7
  JOURNAL   Biochem Biophys Res Commun 256 (1), 52-56 (1999)
   PUBMED   10066421
REFERENCE   7  (bases 1 to 3427)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   8  (bases 1 to 3427)
  AUTHORS   Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H.
  TITLE     Cloning and expression of PCPTP1 encoding protein tyrosine
            phosphatase
  JOURNAL   Gene 162 (2), 279-284 (1995)
   PUBMED   7557444
REFERENCE   9  (bases 1 to 3427)
  AUTHORS   Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.
  TITLE     cDNA cloning and characterization of a novel receptor-type protein
            tyrosine phosphatase expressed predominantly in the brain
  JOURNAL   J Biol Chem 270 (5), 2337-2343 (1995)
   PUBMED   7836467
REFERENCE   10 (bases 1 to 3427)
  AUTHORS   Sharma,E. and Lombroso,P.J.
  TITLE     A neuronal protein tyrosine phosphatase induced by nerve growth
            factor
  JOURNAL   J Biol Chem 270 (1), 49-53 (1995)
   PUBMED   7814416
  REMARK    Erratum:[J Biol Chem 1995 Sep 29;270(39):23234]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D64053.1, AC090676.11,
            AC083809.21 and CA435261.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002849.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and a single intracellular
            catalytic domain, and thus represents a receptor-type PTP.
            Silencing of this gene has been associated with colorectal cancer.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. This gene shares a symbol (PTPRQ) with another
            gene, protein tyrosine phosphatase, receptor type, Q (GeneID
            374462), which is also located on chromosome 12. [provided by
            RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1, also
            referred to as isoform alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64053.1, SRR1803613.205404.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283228.7/ ENSP00000283228.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1288              D64053.1           69-1356
            1289-1289           AC090676.11        70153-70153         c
            1290-1550           D64053.1           1358-1618
            1551-1551           AC090676.11        22610-22610         c
            1552-2240           D64053.1           1620-2308
            2241-2731           AC083809.21        99713-100203        c
            2732-3139           D64053.1           2800-3207
            3140-3427           CA435261.1         24-311              c
FEATURES             Location/Qualifiers
     source          1..3427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..3427
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /note="protein tyrosine phosphatase receptor type R"
                     /db_xref="GeneID:5801"
                     /db_xref="HGNC:HGNC:9680"
                     /db_xref="MIM:602853"
     exon            1..406
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..2322
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein-tyrosine phosphatase NC-PTPCOM1; Ch-1
                     PTPase; protein tyrosine phosphatase Cr1PTPase;
                     receptor-type tyrosine-protein phosphatase R; R-PTP-R;
                     ch-1PTPase; protein-tyrosine phosphatase PCPTP1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase R
                     isoform 1 precursor"
                     /protein_id="NP_002840.2"
                     /db_xref="CCDS:CCDS8998.1"
                     /db_xref="GeneID:5801"
                     /db_xref="HGNC:HGNC:9680"
                     /db_xref="MIM:602853"
                     /translation="MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIY
                     KHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQ
                     DLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKK
                     NSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHE
                     ADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITL
                     QPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQ
                     ERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHL
                     LQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINAN
                     YIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEK
                     RGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQ
                     LMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLR
                     MDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ"
     exon            407..705
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            706..819
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            820..975
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1086
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1355
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1542
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1627
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1707
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1845
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1956
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2114
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2228
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..3427
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /note="hexamer: AATAAA"
     polyA_site      3427
                     /gene="PTPRR"
                     /gene_synonym="EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ"
                     /note="major polyA site"
ORIGIN      
        1 atgctcagta gccgcggcgc tgctgctggg ctgctgggct ggcgcggagt ccaccctgcc
       61 gtctccgcct tggcttctgg gcgtccagaa ggccaggcat ttgccgcctc tgagcgcttc
      121 tgttcccctt acccgcaacc tcctactgct cttcctctct ccctctctta gggaggttga
      181 agctggtgct ggtttctgtc ggcgccacag actgactgct ctgcaaaccc cagccgagga
      241 cctgaatccc ggagactaga agacccttgg cggtggctct ttctaatagc actttacctg
      301 aagtggggtc gtggtggagt ttctcctcca cctctcaatg caaacactat gcggagagca
      361 gtctgcttcc ctgcgctgtg cctgctcctt aatcttcacg ctgcagggtg cttttcagga
      421 aacaatgatc attttttggc aattaatcag aagaagagtg ggaagccggt attcatttat
      481 aagcattcac aagacattga gaagagcctg gatatagccc cacaaaaaat ctacagacat
      541 agctaccatt cctcttccga agctcaagta agcaaacgcc accagattgt caattcagca
      601 tttcctagac ccgcatatga cccgtctctc aatctgctgg ccatggatgg tcaagatctt
      661 gaagtggaaa atctcccaat cccagcagca aatgtaattg tggtgacact gcaaatggat
      721 gtaaacaagc tgaacataac cttgcttcgg atcttccgcc aaggagtggc tgcagcttta
      781 ggactcttac cccagcaagt gcacatcaat cgcctcattg gaaagaagaa cagtattgaa
      841 ctgtttgtgt ctcccataaa ccgaaaaaca ggaatttctg atgctctgcc ctctgaggaa
      901 gttcttcgtt cacttaatat caatgttttg catcaaagtt tatcccagtt tggaattaca
      961 gaagtctctc ctgagaaaaa tgttttacaa gggcagcatg aagcggacaa aatctggagc
     1021 aaagaaggat tttatgctgt tgtcattttt ctcagcatct ttgttattat agtaacgtgt
     1081 ttgatgattc tttacagatt aaaagaaaga tttcagcttt ccttaagaca agacaaagag
     1141 aaaaaccagg agatccacct atcgcccatc acattacagc cagcactgtc cgaggcaaag
     1201 acagtccaca gcatggtcca acctgagcag gccccaaagg tactgaatgt tgtcgtggac
     1261 cctcaaggcc gaggtgctcc tgagatcaaa gctaccaccg ctacctctgt ttgcccttct
     1321 cctttcaaaa tgaagcccat aggacttcaa gagagaagag ggtccaacgt atctcttaca
     1381 ttggacatga gtagcttggg gaacattgaa ccctttgtgt ctataccaac accacgggag
     1441 aaggtagcaa tggagtatct gcagtcagcc agccgaattc tcacaaggtc tcagctgagg
     1501 gacgtcgtgg caagttcaca tttactccaa agtgaattca tggaaatacc aatgaacttt
     1561 gtggatccca aagaaattga tattccgcgt catggaacta aaaatcgcta taagaccatt
     1621 ttaccaaatc ccctcagcag agtgtgttta agaccaaaaa atgtaaccga ttcattgagc
     1681 acctacatta atgctaatta tattaggggc tacagtggca aggagaaagc cttcattgcc
     1741 acgcagggcc ccatgatcaa caccgtggat gatttctggc agatggtttg gcaggaagac
     1801 agccctgtga ttgttatgat cacaaaactc aaagaaaaaa atgagaaatg tgtgctatac
     1861 tggccggaaa agagagggat atatggaaaa gttgaggttc tggttatcag tgtaaatgaa
     1921 tgtgataact acaccattcg aaaccttgtc ttaaagcaag gaagccacac ccaacatgtg
     1981 aagcattact ggtacacctc atggcctgat cacaagactc cagacagtgc ccagcccctc
     2041 ctacagctca tgctggatgt agaagaagac agacttgctt cccagggccg agggcctgtg
     2101 gttgtccact gcagtgcagg aataggtaga acagggtgtt ttattgctac atccattggc
     2161 tgtcaacagc tgaaagaaga aggagttgtg gatgcactaa gcattgtctg ccagcttcgt
     2221 atggatagag gtggaatggt gcaaaccagt gagcagtatg aatttgtgca ccatgctctg
     2281 tgcctgtatg agagcagact ttcagcagag actgtccagt gagtcattga agacttgtca
     2341 gaccatcaat ctcttggggt gattaatcaa attacccacc caaggcttct agaaggagct
     2401 tcctgcaatg gaaggaagga gaagctctga agcccatgta tggcatggat tgtggaagac
     2461 tgggcaacat atttaagatt tccagctcct tgtgtatatg aatgcatttg taagcatccc
     2521 ccaaattatt ctgaaggttt tttgatgatg gaggtatgat aggtttatca cacagcctaa
     2581 ggcagatttt gttttgtctg tactgactct atctgccaca cagaatgtat gtatgtaata
     2641 ttcagtaata aatgtcatca ggtgatgact ggatgagctg ctgaagacat tcgtattatg
     2701 tgttagatgc tttaatgttt gcaaaatctg tcttgtgaat ggactgtcag ctgttaaact
     2761 gttcctgttt tgaagtgcta ttacctttct cagttaccag aatcttgctg ctaaagttgc
     2821 aagtgattga taatggattt ttaacagaga agtctttgtt tttgaaaaac aaaaatcaaa
     2881 aacagtaact attttatatg gaaatgtgtc ttgataatat tacctattaa atgtgtattt
     2941 atagtccctc ctatcaaaca attacagagc acaatgattg tcattgggta tatatgtatt
     3001 tactctctat tattgggcat aaaggtggct tctgctccag aactctatcc actgtatttc
     3061 cacatcgtga gtcattttac tttaaaaggg aaaaacaaat ttgtagcaac tctgaagtat
     3121 caagagtttt aactacttgt ctctcttttg ctaagaaggg atttttgaat atgctatcta
     3181 cctggaatct ctctctcaac aaaaggtata tgccttcagg aatgatataa tctgtcccat
     3241 tttcgaggct ccttataagg acatttccat gtatgtcctt acatttctga aagctttcaa
     3301 tcttcaagag acaaaaaaaa ttaaaataac taccctcagc aaacactagc tgttctgctc
     3361 atatatgaat ttttaatgca gcaatgttga ctttgtttca tactgccaat aaactcttaa
     3421 tactaaa
//
