LOCUS       NM_001145026            8261 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type Q (PTPRQ),
            mRNA.
ACCESSION   NM_001145026 XM_001134446 XM_001714594 XM_001718294 XM_001718314
            XM_001718317 XM_940335
VERSION     NM_001145026.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8261)
  AUTHORS   Sakuma,N., Nishio,S.Y., Goto,S.I., Honkura,Y., Oda,K., Takeda,H.,
            Kobayashi,M., Kumakawa,K., Iwasaki,S., Takahashi,M., Ito,T.,
            Arai,Y., Isono,Y., Obara,N., Matsunobu,T., Okubo,K. and Usami,S.I.
  TITLE     Detailed Clinical Features of PTPRQ-Associated Hearing Loss
            Identified in a Large Japanese Hearing Loss Cohort
  JOURNAL   Genes (Basel) 15 (4), 489 (2024)
   PUBMED   38674423
  REMARK    GeneRIF: Detailed Clinical Features of PTPRQ-Associated Hearing
            Loss Identified in a Large Japanese Hearing Loss Cohort.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8261)
  AUTHORS   Qin,Y., Ma,Y., Zeng,Z., Zhong,Z., Qi,Y. and Liu,Y.
  TITLE     Delayed progressive sensorineural hearing loss due to a novel
            compound heterozygous PTPRQ mutation in a Chinese patient
  JOURNAL   J Clin Lab Anal 37 (7), e24886 (2023)
   PUBMED   37106574
  REMARK    GeneRIF: Delayed progressive sensorineural hearing loss due to a
            novel compound heterozygous PTPRQ mutation in a Chinese patient.
REFERENCE   3  (bases 1 to 8261)
  AUTHORS   Vanniya,S. P, Chandru,J., Jeffrey,J.M., Rabinowitz,T.,
            Brownstein,Z., Krishnamoorthy,M., Avraham,K.B., Cheng,L.,
            Shomron,N. and Srisailapathy,C.R.S.
  TITLE     PNPT1, MYO15A, PTPRQ, and SLC12A2-associated genetic and phenotypic
            heterogeneity among hearing impaired assortative mating families in
            Southern India
  JOURNAL   Ann Hum Genet 86 (1), 1-13 (2022)
   PUBMED   34374074
  REMARK    GeneRIF: PNPT1, MYO15A, PTPRQ, and SLC12A2-associated genetic and
            phenotypic heterogeneity among hearing impaired assortative mating
            families in Southern India.
REFERENCE   4  (bases 1 to 8261)
  AUTHORS   Zhang,W., Tang,Z., Fan,S., Yao,D., Zhang,Z., Guan,C., Deng,W. and
            Ying,Y.
  TITLE     Protein Tyrosine Phosphatase Receptor-type Q: Structure, Activity,
            and Implications in Human Disease
  JOURNAL   Protein Pept Lett 29 (7), 567-573 (2022)
   PUBMED   35546749
  REMARK    GeneRIF: Protein Tyrosine Phosphatase Receptor-type Q: Structure,
            Activity, and Implications in Human Disease.
            Review article
REFERENCE   5  (bases 1 to 8261)
  AUTHORS   Nakajima,M., Rauramaa,T., Makinen,P.M., Hiltunen,M., Herukka,S.K.,
            Kokki,M., Musialowicz,T., Jyrkkanen,H.K., Danner,N., Junkkari,A.,
            Koivisto,A.M., Jaaskelainen,J.E., Miyajima,M., Ogino,I., Furuta,A.,
            Akiba,C., Kawamura,K., Kamohara,C., Sugano,H., Tange,Y.,
            Karagiozov,K., Leinonen,V. and Arai,H.
  TITLE     Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid
            reflects ependymal cell dysfunction and is a potential biomarker
            for adult chronic hydrocephalus
  JOURNAL   Eur J Neurol 28 (2), 389-400 (2021)
   PUBMED   33035386
  REMARK    GeneRIF: Protein tyrosine phosphatase receptor type Q in
            cerebrospinal fluid reflects ependymal cell dysfunction and is a
            potential biomarker for adult chronic hydrocephalus.
REFERENCE   6  (bases 1 to 8261)
  AUTHORS   Jung,H., Kim,W.K., Kim,D.H., Cho,Y.S., Kim,S.J., Park,S.G.,
            Park,B.C., Lim,H.M., Bae,K.H. and Lee,S.C.
  TITLE     Involvement of PTP-RQ in differentiation during adipogenesis of
            human mesenchymal stem cells
  JOURNAL   Biochem Biophys Res Commun 383 (2), 252-257 (2009)
   PUBMED   19351528
  REMARK    GeneRIF: Overexpression of PTP-RQ consistently led to reduced
            differentiation of mesenchymal stem cells into adipocytes via
            decreasing the phosphatidyl inositol phosphate level in cells, and
            consequently downregulating Akt/PKB phosphorylation.
REFERENCE   7  (bases 1 to 8261)
  AUTHORS   Seifert,R.A., Coats,S.A., Oganesian,A., Wright,M.B., Dishmon,M.,
            Booth,C.J., Johnson,R.J., Alpers,C.E. and Bowen-Pope,D.F.
  TITLE     PTPRQ is a novel phosphatidylinositol phosphatase that can be
            expressed as a cytoplasmic protein or as a subcellularly localized
            receptor-like protein
  JOURNAL   Exp Cell Res 287 (2), 374-386 (2003)
   PUBMED   12837292
REFERENCE   8  (bases 1 to 8261)
  AUTHORS   Oganesian,A., Poot,M., Daum,G., Coats,S.A., Wright,M.B.,
            Seifert,R.A. and Bowen-Pope,D.F.
  TITLE     Protein tyrosine phosphatase RQ is a phosphatidylinositol
            phosphatase that can regulate cell survival and proliferation
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7563-7568 (2003)
   PUBMED   12802008
REFERENCE   9  (bases 1 to 8261)
  AUTHORS   Wright,M.B., Hugo,C., Seifert,R., Disteche,C.M. and Bowen-Pope,D.F.
  TITLE     Proliferating and migrating mesangial cells responding to injury
            express a novel receptor protein-tyrosine phosphatase in
            experimental mesangial proliferative glomerulonephritis
  JOURNAL   J Biol Chem 273 (37), 23929-23937 (1998)
   PUBMED   9727007
REFERENCE   10 (bases 1 to 8261)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083812.24, ABBA01053496.1 and
            AC074031.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 22, 2018 this sequence version replaced NM_001145026.1.
            
            Summary: This locus encodes a member of the type III receptor-like
            protein-tyrosine phosphatase family. The encoded protein catalyzes
            the dephosphorylation of phosphotyrosine and phosphatidylinositol
            and plays roles in cellular proliferation and differentiation.
            Mutations at this locus have been linked to autosomal recessive
            deafness. [provided by RefSeq, Mar 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2144120
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000644991.3/ ENSP00000495607.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC083812.24        83935-84099         c
            166-274             AC083812.24        83485-83593         c
            275-501             AC083812.24        82617-82843         c
            502-571             ABBA01053496.1     25598-25667         c
            572-771             ABBA01053496.1     23759-23958         c
            772-1021            ABBA01053496.1     22340-22589         c
            1022-1150           AC083812.24        59497-59625         c
            1151-1297           AC083812.24        56084-56230         c
            1298-1470           AC083812.24        43730-43902         c
            1471-1651           AC083812.24        34880-35060         c
            1652-1813           AC083812.24        33241-33402         c
            1814-1993           AC083812.24        32964-33143         c
            1994-2101           AC083812.24        32229-32336         c
            2102-2383           AC083812.24        31804-32085         c
            2384-2566           AC083812.24        22129-22311         c
            2567-2668           AC083812.24        21665-21766         c
            2669-2789           AC083812.24        17892-18012         c
            2790-2950           AC074031.16        156072-156232       c
            2951-3096           AC074031.16        155210-155355       c
            3097-3265           AC074031.16        150303-150471       c
            3266-3556           AC074031.16        148402-148692       c
            3557-3832           AC074031.16        147883-148158       c
            3833-3984           AC074031.16        147366-147517       c
            3985-4126           AC074031.16        143550-143691       c
            4127-4396           AC074031.16        140513-140782       c
            4397-4720           AC074031.16        101795-102118       c
            4721-4842           AC074031.16        85067-85188         c
            4843-5029           AC074031.16        79622-79808         c
            5030-5274           AC074031.16        76411-76655         c
            5275-5341           AC074031.16        73981-74047         c
            5342-5500           AC074031.16        70705-70863         c
            5501-5723           AC074031.16        69871-70093         c
            5724-5797           AC074031.16        68113-68186         c
            5798-5897           AC074031.16        57956-58055         c
            5898-6026           AC074031.16        55174-55302         c
            6027-6053           AC074031.16        41324-41350         c
            6054-6135           AC074031.16        40578-40659         c
            6136-6226           AC074031.16        37413-37503         c
            6227-6303           AC074031.16        32186-32262         c
            6304-6438           AC074031.16        21106-21240         c
            6439-6564           AC074031.16        20783-20908         c
            6565-6713           AC074031.16        19755-19903         c
            6714-6849           AC074031.16        16943-17078         c
            6850-6973           AC074031.16        11522-11645         c
            6974-8261           AC074031.16        9974-11261          c
FEATURES             Location/Qualifiers
     source          1..8261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..8261
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /note="protein tyrosine phosphatase receptor type Q"
                     /db_xref="GeneID:374462"
                     /db_xref="HGNC:HGNC:9679"
                     /db_xref="MIM:603317"
     exon            1..165
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..7011
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /EC_number="3.1.3.67"
                     /EC_number="3.1.3.86"
                     /EC_number="3.1.3.95"
                     /note="protein-tyrosine phosphatase, receptor-type,
                     expressed by glomerular mesangial cells;
                     phosphotidylinositol phosphatase PTPRQ;
                     phosphatidylinositol phosphatase PTPRQ"
                     /codon_start=1
                     /product="phosphatidylinositol phosphatase PTPRQ
                     precursor"
                     /protein_id="NP_001138498.1"
                     /db_xref="CCDS:CCDS73501.1"
                     /db_xref="GeneID:374462"
                     /db_xref="HGNC:HGNC:9679"
                     /db_xref="MIM:603317"
                     /translation="MDFLIIFLLLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSP
                     VTRIVTTNVTKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQT
                     VYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVN
                     LTVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPE
                     CNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPY
                     TTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTG
                     KFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFT
                     PPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTLLTG
                     NNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAED
                     QTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQ
                     QVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF
                     LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEI
                     RLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRF
                     GHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK
                     RSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS
                     PPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLD
                     YNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPP
                     SKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTA
                     STSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYV
                     SLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTE
                     EDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYI
                     ILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLK
                     WSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK
                     VGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVE
                     RNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNI
                     AFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEA
                     HLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSP
                     FSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSV
                     VITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPS
                     QPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVN
                     SAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGP
                     IKNVQVLVTETGAQHDGNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIY
                     IIGADNACMIPGNEDKICNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLS
                     ERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI
                     TVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQD
                     LSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIA
                     TQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT
                     KLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA
                     HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQ
                     YIFLHQCILDLLSNKGSNQPICFVNYSALQKMDSLDAMEGDVELEWEETTM"
     exon            166..274
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            275..501
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            502..571
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            572..771
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1021
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1150
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1297
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1470
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1651
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1813
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1993
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2101
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2383
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2566
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2668
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2789
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2950
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3096
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3265
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3556
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3832
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3984
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4126
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4396
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4720
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4842
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..5029
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5274
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5341
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5342..5500
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5501..5723
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5724..5797
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5798..5897
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            5898..6026
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6027..6053
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6135
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6136..6226
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..6303
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6304..6438
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6439..6564
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6565..6713
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6714..6849
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6850..6973
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            6974..8261
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8078..8083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /note="hexamer: ATTAAA"
     polyA_site      8100
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
     regulatory      8240..8245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /note="hexamer: AATAAA"
     polyA_site      8261
                     /gene="PTPRQ"
                     /gene_synonym="DFNA73; DFNB84; DFNB84A; PTPGMC1; R-PTP-Q"
                     /note="major polyA site"
ORIGIN      
        1 gctcattaat tgtgtacttg ccagaaggat ctgtctttaa atcattaatg caggcaacat
       61 ttctctctag agccatcaat gtgattctac tggctgaaaa atgtaataaa gatggatttt
      121 cttatcattt ttcttttact ttttattggg acttcagaga cacaggttga tgtttccaat
      181 gtcgttcctg gtactaggta cgatataacc atctcttcaa tttctacaac atacacctca
      241 cctgttacta gaatagtgac aacaaatgta acaaaaccag ggcctccagt cttcctagcc
      301 ggggaaagag tcggatctgc tgggattctt ctgtcttgga atacaccacc taatccaaat
      361 ggaaggatta tatcttacat tgtcaaatat aaggaagttt gtccgtggat gcaaacagta
      421 tatacacaag tcagatcaaa gccagacagt ctggaagttc ttcttactaa tcttaatcct
      481 ggaacaacat atgaaattaa ggttgctgct gaaaacagtg ctggcattgg agtgtttagt
      541 gatccatttc tcttccaaac tgcagaaagt gctccaggaa aagtggtgaa tctcacagtt
      601 gaggcctaca acgcttcagc agttaagctg atttggtatt tacctcggca accaaatggc
      661 aaaattacca gcttcaagat tagtgtcaag catgccagaa gtgggatagt agtgaaagat
      721 gtctcaatca gagtagagga cattttgact gggaaattgc cagaatgcaa tgagaatagt
      781 gaatcttttt tatggagtac agccagccct tctccaaccc ttggtagagt tacacctcca
      841 tcgcgtacca cacattcatc aagcacgttg acacagaatg agatcagctc tgtgtggaaa
      901 gagcctatca gttttgtagt gacacacttg agaccttata caacatatct ttttgaagtt
      961 tcagctgcta caactgaagc aggttatatt gatagtacga ttgtcagaac accagaatca
     1021 gtgcctgaag gaccaccaca aaactgcgta acaggcaaca tcacaggaaa gtccttttca
     1081 attttatggg acccaccaac tatagtaaca gggaaattta gttatagagt tgaattatat
     1141 ggaccatcag gtcgcatttt ggataacagc acaaaagacc tcaagtttgc attcactaac
     1201 ctaacaccat ttacaatgta tgatgtctat attgcggctg aaaccagtgc agggactggg
     1261 cccaagtcaa atatttcagt attcactcca ccagatgttc caggggcagt gtttgattta
     1321 caacttgcag aggtagaatc cacgcaagta agaattactt ggaagaaacc acgacaacca
     1381 aatggaatta ttaaccaata ccgagtgaaa gtgctagttc cagagacagg aataattttg
     1441 gaaaatactt tgctcactgg aaataatgag tatataaatg accccatggc tccagaaatt
     1501 gtgaacatag tagagccaat ggtaggatta tatgagggtt cagcagagat gtcgtctgac
     1561 cttcactcac ttgctacatt tatatataac agccatccag ataaaaactt tcctgcaagg
     1621 aatagagctg aagaccagac ttcaccagtt gtaactacaa ggaatcagta tattactgac
     1681 attgcagctg aacagctgtc ttatgttatc aggagacttg tacctttcac tgagcacatg
     1741 attagtgtat ctgctttcac catcatggga gaaggaccac caacagttct cagtgttagg
     1801 acacgtcagc aagtgccaag ctccattaaa attataaact ataaaaatat tagttcttca
     1861 tctattttgt tatattggga tcctccagaa tatcccaatg gaaaaataac tcactatacg
     1921 atttatgcaa tggaattgga tacaaacaga gcattccaga taactaccat agataacagc
     1981 tttctcataa cagggttaaa gaaatacaca aaatacaaaa tgagagtggc agcctcaacc
     2041 cacgttggag aaagttcttt gtctgaagaa aatgacatct ttgtgagaac ttcagaagat
     2101 gaaccggaat catcacctca agatgtcgaa gtaattgatg ttaccgcaga tgaaataagg
     2161 ttgaagtggt caccacccga aaagcccaat gggatcatta ttgcttatga agtgctatat
     2221 aaaaatatag atactttata tatgaagaac acatcaacaa cagacataat attaaggaac
     2281 ttaagacctc acaccctcta taacatttct gtaaggtctt acaccagatt tggtcatggc
     2341 aatcaggtat cttctttact ctctgtaagg acttcggaga ctgtgcctga tagtgcacca
     2401 gaaaatatca cttacaaaaa tatttcttct ggagagattg agctatcatt ccttccccca
     2461 agtagtccca atggaatcat acaaaaatat acaatttatc tcaagagaag taatggaaat
     2521 gaggaaagaa ctataaatac aacctcttta acccaaaaca ttaaagtact gaagaaatat
     2581 acccaatata tcattgaggt gtctgctagt acactcaaag gtgaaggagt tcggagtgct
     2641 cccataagta tactgacgga ggaagatgct cctgattctc cccctcaaga cttctctgta
     2701 aaacagttgt ctggtgtcac ggtgaagttg tcatggcaac cacccctgga gccaaatgga
     2761 attatccttt attacacagt ttatgtctgg aatagatcat cattaaaaac tattaatgtc
     2821 actgaaacat cattggagtt atcagatttg gattataatg ttgaatacag tgcttatgta
     2881 acagctagca ccagatttgg tgatgggaaa acaagaagca atatcattag ctttcaaaca
     2941 ccagagggag caccaagcga tcctcccaaa gatgtttatt atgcaaacct cagttcttca
     3001 tcaataattc ttttctggac acctccttca aaacctaatg ggattataca atattactct
     3061 gtttattaca gaaatacttc aggtactttt atgcagaatt ttacactcca tgaagtaacc
     3121 aatgactttg acaatatgac tgtatccaca attatagata aactgacaat attcagctac
     3181 tatacatttt ggttaacagc aagtacttca gttggaaatg ggaataaaag cagtgacatc
     3241 attgaagtat acacagatca agacatacct gaagggtttg ttggaaacct gacttacgaa
     3301 tccatttcgt caactgcaat aaatgtaagc tgggtcccac cggctcaacc aaacggtcta
     3361 gtcttctact atgtttcact gatcttacag cagactcctc gccatgtgag accacctctt
     3421 gttacatatg agagaagcat atattttgat aatctggaaa aatacactga ttatatatta
     3481 aaaattactc catcaacaga aaagggattc tctgatacct atactgccca gctatacatc
     3541 aagactgaag aagatgtccc agaaacttca ccaataatca acacttttaa aaacctttcc
     3601 tctacctcag ttctcttatc atgggatccc ccagtaaagc caaatggtgc aataataagt
     3661 tatgatttaa ctttacaagg accaaatgaa aattattctt tcattacttc tgataattac
     3721 ataatattgg aagagctttc accatttaca ttatatagct tttttgctgc cgcaagaact
     3781 agaaaaggac ttggtccttc cagtattctt ttcttttaca cagatgagtc agtgccgtta
     3841 gcacctccac aaaatttgac tttaatcaac tgtacttcag actttgtatg gctgaaatgg
     3901 agcccaagtc ctcttccagg tggtattgtt aaagtatata gttttaaaat tcatgaacat
     3961 gaaactgaca ctatatatta taagaatata tcaggattta aaactgaagc caaacttgtt
     4021 ggactggaac cagtcagcac ctactctatc cgtgtatctg cgttcaccaa agttggaaat
     4081 ggcaatcaat ttagtaatgt agtaaaattc acaacccaag aatcagttcc agatgtcgtg
     4141 cagaatatgc agtgcatggc aactagctgg cagtcagttt tagtgaaatg ggatccaccc
     4201 aaaaaggcaa atggaataat aacgcagtat atggtaacag ttgaaaggaa ttctacaaaa
     4261 gtttctcccc aagatcacat gtacactttc ataaagcttc ttgccaatac ctcatatgtc
     4321 tttaaagtaa gagcttcaac ctcagctggt gaaggtgatg aaagcacatg ccatgtcagc
     4381 acactacctg aaacagttcc cagtgttccc acaaatattg ctttttctga tgttcagtca
     4441 actagtgcaa cattgacatg gataagacct gacactatcc ttggctactt tcaaaattac
     4501 aaaattacca ctcaacttcg tgctcaaaaa tgcaaagaat gggaatccga agaatgtgtt
     4561 gaatatcaaa aaattcaata cctctatgaa gctcacttaa ctgaagagac agtatatgga
     4621 ttaaagaaat ttagatggta tagattccaa gtggctgcca gcaccaatgc tggctatggc
     4681 aatgcttcaa actggatttc tacaaaaact ctgcctggcc ctccagatgg tcctcctgaa
     4741 aatgttcatg tagtagcaac atcacctttt agcatcagca taagctggag tgaacctgct
     4801 gtcattactg gaccaacatg ttatctgatt gatgtcaaat cggtagataa tgatgaattt
     4861 aatatatcct tcatcaagtc aaatgaagaa aataaaacca tagaaattaa agatttagaa
     4921 atattcacaa ggtattctgt agtgatcact gcatttactg ggaacattag tgctgcatat
     4981 gtagaaggga agtcaagtgc tgaaatgatt gttactactt tagaatcagc cccaaaggac
     5041 ccacctaaca acatgacatt tcagaagata ccagatgaag ttacaaaatt tcaattaacg
     5101 ttccttcctc cttctcaacc taatggaaat atccaagtat atcaagctct ggtttaccga
     5161 gaagatgatc ctactgctgt ccagattcac aacctcagta ttatacagaa aaccaacaca
     5221 ttcgtcattg caatgctaga aggactaaaa ggtggacata catacaatat cagtgtttac
     5281 gcagtcaata gtgctggtgc aggtccaaag gttccgatga gaataaccat ggatatcaaa
     5341 gctccagcac gaccaaaaac caaaccaacc cctatttatg atgccacagg aaaactgctt
     5401 gtgacttcaa caacaattac aatcagaatg ccaatatgtt actacagtga tgatcatgga
     5461 ccaataaaaa atgtacaagt gcttgtgaca gaaacaggag ctcagcatga tggaaatgta
     5521 acaaagtggt atgatgcata ttttaataaa gcaaggccat attttacaaa tgaaggcttt
     5581 cctaaccctc catgtacaga aggaaagaca aagtttagtg gcaatgaaga aatctacatc
     5641 ataggtgctg ataatgcatg catgattcct ggcaatgaag acaaaatttg caatggacca
     5701 ctgaaaccaa aaaagcaata cttatttaaa tttagagcta caaatattat gggacaattt
     5761 actgactctg attattctga ccctgttaag actttagggg aaggactttc agaaagaacc
     5821 gtagagatca ttctttccgt cactttgtgt atcctttcaa taattctcct tggaacagct
     5881 atttttgcat ttgcaagaat tcgacagaag cagaaagaag gtggcacata ctctcctcag
     5941 gatgcagaaa ttattgacac taaattgaag ctggatcagc tcatcacagt ggcagacctg
     6001 gaactgaagg acgagagatt aacgcggtta cttagttata gaaaatccat caagccaata
     6061 agcaagaaat ccttcctgca acatgttgaa gagctttgca caaacaacaa cctaaagttt
     6121 caagaagaat tttcggaatt accaaaattt cttcaggatc tttcttcaac tgatgctgat
     6181 ctgccttgga atagagcaaa aaaccgcttc ccaaacataa aaccatataa taataacaga
     6241 gtaaagctga tagctgacgc tagtgttcca ggttcggatt atattaatgc cagctatatt
     6301 tctggttatt tatgtccaaa tgaatttatt gctactcaag gtccactacc aggaacagtt
     6361 ggagattttt ggagaatggt gtgggaaacc agagcaaaaa cattagtaat gctaacacag
     6421 tgttttgaaa aaggacggat cagatgccat cagtattggc cagaggacaa caagccagtt
     6481 actgtctttg gagatatagt gattacaaag ctaatggagg atgttcaaat agattggact
     6541 atcagggatc tgaaaattga aaggcatggg gattgcatga ctgttcgaca gtgtaacttt
     6601 actgcctggc cagagcatgg ggttcctgag aacagcgccc ctctaattca ctttgtgaag
     6661 ttggttcgag caagcagggc acatgacacc acacctatga ttgttcactg cagtgctgga
     6721 gttggaagaa ctggagtttt tattgctctg gaccatttaa cacaacatat aaatgaccat
     6781 gattttgtgg atatatatgg actagtagct gaactgagaa gtgaaagaat gtgcatggtg
     6841 cagaatctgg cacagtatat ctttttacac cagtgcattc tggatctctt atcaaataag
     6901 ggaagtaatc agcccatctg ttttgttaac tattcagcac ttcagaagat ggactctttg
     6961 gacgccatgg aaggtgatgt tgagcttgaa tgggaagaaa ccactatgta aatattcaga
     7021 ccaaaggata caattggaag agatttttaa atcccagggg ccaaagttac cccctcattc
     7081 ttccgaattg aaatgtgcaa ccttaaagaa atatctatgc ttctctcact gtgcctttcc
     7141 aaacggattg aacattttaa gactagttct tgaaaatagc taatacagaa taattatttg
     7201 ttttgtacag aataaatatt atgcatttta aatgcttaag aaaagacatc ccatatgttt
     7261 ttgaagtcct ccatattttg gaataagcca aatagaaaat tattattata ttagcattaa
     7321 tgtttcaatg tgaattttcc ctatgtattg gatttaattt tgagcaaaag ttgtaaatgt
     7381 tgattcagta gtgttgtttt ggcttacagg gtattgatgt ttcttgtgga taatttccag
     7441 gactgtcata atgatctgta cttccatgta cacccctgtg ttttgaatcc tctgttttat
     7501 gagtgctgag atatcatctc atgatcccga acagctgaac agtaaccccc tgacactgca
     7561 gggattactt ggcctttata caacacacag tagctcttca gggacactta gggctattta
     7621 atttgcattg tgatcttcag tttgagaacc ttaaaagaaa aattaaaagt gcaattgcac
     7681 acatgaaatt acagagtacc attctagcaa acctacattt gtaaacttta aaacacaagt
     7741 tttaccccct gtattgtata ttcaaatata tagtaaatgt atcagagtat ttgcccatta
     7801 gatatagtca acctaatatt aacaattctg aagagtttct tcagcaaaaa tgtatcaaaa
     7861 gagtaataaa aacactgtgc gtgtttcaag cttgtaaacc aatgatgtgc tgctgtggtg
     7921 ccaacagaga cttccaaatg gattatgtta aatggccgtc atttcatttc ccaaggttga
     7981 ttttgagcag tatacttggt ggaactgaaa acaaagaaat taaccatgta tagcaaattc
     8041 aaggtttctt tatagaaaat ctttcagcct ccatcttatt aaatagtgac aatgtggtaa
     8101 gttttgaatt acatgaactc attttgtcat agatttcaat taagagtaat aaatagtatt
     8161 aattattctc ttctatgata agaagtatat cttatgctta tttccgctgg aacatatata
     8221 tataagaaat gctatggcca ataaaattga attttaatga a
//
