LOCUS       NM_002847               4860 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type N2
            (PTPRN2), transcript variant 1, mRNA.
ACCESSION   NM_002847
VERSION     NM_002847.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Wu,S., Wu,Z., Chen,M., Zhong,X., Gu,H., Du,W., Liu,W., Lang,L. and
            Wang,J.
  TITLE     Interactions of genetic variations in FAS, GJB2 and PTPRN2 are
            associated with noise-induced hearing loss: a case-control study in
            China
  JOURNAL   BMC Med Genomics 17 (1), 18 (2024)
   PUBMED   38212800
  REMARK    GeneRIF: Interactions of genetic variations in FAS, GJB2 and PTPRN2
            are associated with noise-induced hearing loss: a case-control
            study in China.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4860)
  AUTHORS   Lu,C., Zhao,Q., Wang,D., Feng,Y., Feng,L., Li,Z. and Shi,Q.
  TITLE     Rab35 regulates insulin secretion via phogrin in pancreatic beta
            cells
  JOURNAL   Clin Exp Pharmacol Physiol 49 (1), 104-112 (2022)
   PUBMED   34448213
  REMARK    GeneRIF: Rab35 regulates insulin secretion via phogrin in
            pancreatic beta cells.
REFERENCE   3  (bases 1 to 4860)
  AUTHORS   Yin,J. and Guo,Y.
  TITLE     HOXD13 promotes the malignant progression of colon cancer by
            upregulating PTPRN2
  JOURNAL   Cancer Med 10 (16), 5524-5533 (2021)
   PUBMED   34272834
  REMARK    GeneRIF: HOXD13 promotes the malignant progression of colon cancer
            by upregulating PTPRN2.
REFERENCE   4  (bases 1 to 4860)
  AUTHORS   Lee,S.
  TITLE     The association of genetically controlled CpG methylation
            (cg158269415) of protein tyrosine phosphatase, receptor type N2
            (PTPRN2) with childhood obesity
  JOURNAL   Sci Rep 9 (1), 4855 (2019)
   PUBMED   30890718
  REMARK    GeneRIF: The association of genetically controlled CpG methylation
            (cg158269415) of protein tyrosine phosphatase, receptor type N2
            (PTPRN2) with childhood obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4860)
  AUTHORS   Caromile,L.A., Oganesian,A., Coats,S.A., Seifert,R.A. and
            Bowen-Pope,D.F.
  TITLE     The neurosecretory vesicle protein phogrin functions as a
            phosphatidylinositol phosphatase to regulate insulin secretion
  JOURNAL   J Biol Chem 285 (14), 10487-10496 (2010)
   PUBMED   20097759
  REMARK    GeneRIF: While PTPRN2 shares sequence similarity with protein
            tyrosine phosphatases, this study in rat suggests that this protein
            instead functions as a membrane bound phosphatidylinositol
            phosphatase.
REFERENCE   6  (bases 1 to 4860)
  AUTHORS   Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C.,
            Maclaren,N.K., Notkins,A.L. and Lan,M.S.
  TITLE     Autoantigens in insulin-dependent diabetes mellitus: molecular
            cloning and characterization of human IA-2 beta
  JOURNAL   Proc Assoc Am Physicians 109 (4), 429-439 (1997)
   PUBMED   9220540
REFERENCE   7  (bases 1 to 4860)
  AUTHORS   Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and
            Crompton,M.R.
  TITLE     ICAAR, a novel member of a new family of transmembrane, tyrosine
            phosphatase-like proteins
  JOURNAL   Biochem Biophys Res Commun 229 (2), 402-411 (1996)
   PUBMED   8954911
REFERENCE   8  (bases 1 to 4860)
  AUTHORS   Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
  TITLE     Molecular cloning and characterization of the human transmembrane
            protein tyrosine phosphatase homologue, phogrin, an autoantigen of
            type 1 diabetes
  JOURNAL   Biochem Biophys Res Commun 227 (2), 440-447 (1996)
   PUBMED   8878534
REFERENCE   9  (bases 1 to 4860)
  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
  TITLE     Cloning and characterization of islet cell antigen-related
            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
            autoantigen in insulin-dependent diabetes
  JOURNAL   J Biol Chem 271 (40), 24817-24823 (1996)
   PUBMED   8798755
REFERENCE   10 (bases 1 to 4860)
  AUTHORS   Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.
  TITLE     Molecular cloning and identification of a receptor-type protein
            tyrosine phosphatase, IA-2, from human insulinoma
  JOURNAL   DNA Cell Biol 13 (5), 505-514 (1994)
   PUBMED   8024693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093662.4, AC078942.7,
            AC019043.8, AC093856.3, AC011899.5, AC005481.3 and AC006372.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002847.4.
            
            Summary: This gene encodes a protein with sequence similarity to
            receptor-like protein tyrosine phosphatases. However, tyrosine
            phosphatase activity has not been experimentally validated for this
            protein. Studies of the rat ortholog suggest that the encoded
            protein may instead function as a phosphatidylinositol phosphatase
            with the ability to dephosphorylate phosphatidylinositol
            3-phosphate and phosphatidylinositol 4,5-diphosphate, and this
            function may be involved in the regulation of insulin secretion.
            This protein has been identified as an autoantigen in
            insulin-dependent diabetes mellitus. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4474950.1,
                                           SRR14038197.612418.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389418.9/ ENSP00000374069.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC093662.4         1323-1588           c
            267-317             AC078942.7         12561-12611         c
            318-431             AC019043.8         162243-162356
            432-534             AC093856.3         140994-141096       c
            535-703             AC093856.3         128150-128318       c
            704-1064            AC093856.3         102754-103114       c
            1065-1286           AC093856.3         74117-74338         c
            1287-1327           AC093856.3         72478-72518         c
            1328-1710           AC093856.3         69500-69882         c
            1711-1797           AC093856.3         46652-46738         c
            1798-1877           AC093856.3         17121-17200         c
            1878-1942           AC011899.5         78087-78151         c
            1943-2155           AC005481.3         103796-104008       c
            2156-2350           AC005481.3         77428-77622         c
            2351-2498           AC005481.3         42433-42580         c
            2499-2572           AC005481.3         25073-25146         c
            2573-2650           AC005481.3         16309-16386         c
            2651-2770           AC006372.2         189738-189857       c
            2771-2937           AC006372.2         188330-188496       c
            2938-2991           AC006372.2         183157-183210       c
            2992-3056           AC006372.2         180619-180683       c
            3057-3130           AC006372.2         160665-160738       c
            3131-4860           AC006372.2         150775-152504       c
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..4860
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /note="protein tyrosine phosphatase receptor type N2"
                     /db_xref="GeneID:5799"
                     /db_xref="HGNC:HGNC:9677"
                     /db_xref="MIM:601698"
     exon            1..266
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..3202
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tyrosine phosphatase IA-2 beta;
                     IAR/receptor-like protein-tyrosine phosphatase; protein
                     tyrosine phosphatase receptor pi; receptor-type
                     tyrosine-protein phosphatase N2; phogrin; islet cell
                     autoantigen-related protein; protein tyrosine phosphatase,
                     receptor type, N polypeptide 2"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase N2
                     isoform 1 precursor"
                     /protein_id="NP_002838.2"
                     /db_xref="CCDS:CCDS5947.1"
                     /db_xref="GeneID:5799"
                     /db_xref="HGNC:HGNC:9677"
                     /db_xref="MIM:601698"
                     /translation="MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEG
                     LCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQ
                     YVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEA
                     LSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLP
                     RTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMP
                     RPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAE
                     LMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEV
                     HRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQ
                     TYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEE
                     EARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVT
                     TEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLA
                     CILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRP
                     EGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLK
                     NKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHS
                     DYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQC
                     YHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDR
                     GVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEI
                     DIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ"
     exon            267..317
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..431
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..534
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..703
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1064
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1286
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1327
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1710
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1797
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1877
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1942
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2155
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2350
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2498
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2572
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2650
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2770
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2937
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..2991
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3056
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3130
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..4860
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4841..4846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /note="hexamer: ATTAAA"
     polyA_site      4860
                     /gene="PTPRN2"
                     /gene_synonym="IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2"
                     /note="major polyA site"
ORIGIN      
        1 gtccggtgct gaagctcggc ccggcgtcgc cgcaagagcg cgagaggcgc ggcgggagga
       61 gccggcggcg cgcgcctccc tgggcccgga ctcggccgcc tcccgccgcc tcccgcgcgg
      121 ccatggactg agcgccgccg gccaggccgc ggggatgggg ccgccgctcc cgctgctgct
      181 gctgctactg ctgctgctgc cgccacgcgt cctgcctgcc gccccttcgt ccgtcccccg
      241 cggccggcag ctcccggggc gtctgggctg cctgctcgag gagggcctct gcggagcgtc
      301 cgaggcctgt gtgaacgatg gagtgtttgg aaggtgccag aaggttccgg caatggactt
      361 ttaccgctac gaggtgtcgc ccgtggccct gcagcgcctg cgcgtggcgt tgcagaagct
      421 ttccggcaca ggtttcacgt ggcaggatga ctatactcag tatgtgatgg accaggaact
      481 tgcagacctc ccgaaaacct acctgaggcg tcctgaagca tccagcccag ccaggccctc
      541 aaaacacagc gttggcagcg agaggaggta cagtcgggag ggcggtgctg ccctggccaa
      601 cgccctccga cgccacctgc ccttcctgga ggccctgtcc caggccccag cctcagacgt
      661 gctcgccagg acccatacgg cgcaggacag accccccgct gagggtgatg accgcttctc
      721 cgagagcatc ctgacctatg tggcccacac gtctgcgctg acctaccctc ccgggtcccg
      781 gacccagctc cgcgaggacc tcctgccgcg gaccctcggc cagctccagc cagatgagct
      841 cagccctaag gtggacagtg gtgtggacag acaccatctg atggcggccc tcagtgccta
      901 tgctgcccag aggcccccag ctccccccgg ggagggcagc ctggagccac agtaccttct
      961 gcgtgcaccc tcaagaatgc ccaggccttt gctggcacca gccgcccccc agaagtggcc
     1021 ttcacctctg ggagattccg aagacccctc cagcacaggc gatggagcac ggattcatac
     1081 cctcctgaag gacctgcaga ggcagccggc tgaggtgagg ggcctgagtg gcctggagct
     1141 ggacggcatg gctgagctga tggctggcct gatgcaaggc gtggaccatg gagtagctcg
     1201 aggcagccct gggagagcgg ccctgggaga gtctggagaa caggcggatg gccccaaggc
     1261 caccctccgt ggagacagct ttccagatga cggagtgcag gacgacgatg atagacttta
     1321 ccaagaggtc catcgtctga gtgccacact cgggggcctc ctgcaggacc acgggtctcg
     1381 actcttacct ggagccctcc cctttgcaag gcccctcgac atggagagga agaagtccga
     1441 gcaccctgag tcttccctgt cttcagaaga ggagactgcc ggagtggaga acgtcaagag
     1501 ccagacgtat tccaaagatc tgctggggca gcagccgcat tcggagcccg gggccgctgc
     1561 gtttggggag ctccaaaacc agatgcctgg gccctcgaag gaggagcaga gccttccagc
     1621 gggtgctcag gaggccctca gcgacggcct gcaattggag gtccagcctt ccgaggaaga
     1681 ggcgcggggc tacatcgtga cagacagaga ccccctgcgc cccgaggaag gaaggcggct
     1741 ggtggaggac gtcgcccgcc tcctgcaggt gcccagcagt gcgttcgctg acgtggaggt
     1801 tctcggacca gcagtgacct tcaaagtgag cgccaatgtc caaaacgtga ccactgagga
     1861 tgtggagaag gccacagttg acaacaaaga caaactggag gaaacctctg gactgaaaat
     1921 tcttcaaacc ggagtcgggt cgaaaagcaa actcaagttc ctgcctcctc aggcggagca
     1981 agaagactcc accaagttca tcgcgctcac cctggtctcc ctcgcctgca tcctgggcgt
     2041 cctcctggcc tctggcctca tctactgcct ccgccatagc tctcagcaca ggctgaagga
     2101 gaagctctcg ggactagggg gcgacccagg tgcagatgcc actgccgcct accaggagct
     2161 gtgccgccag cgtatggcca cgcggccacc agaccgacct gagggcccgc acacgtcacg
     2221 catcagcagc gtctcatccc agttcagcga cgggccgatc cccagcccct ccgcacgcag
     2281 cagcgcctca tcctggtccg aggagcctgt gcagtccaac atggacatct ccaccggcca
     2341 catgatcctg tcctacatgg aggaccacct gaagaacaag aaccggctgg agaaggagtg
     2401 ggaagcgctg tgcgcctacc aggcggagcc caacagctcg ttcgtggccc agagggagga
     2461 gaacgtgccc aagaaccgct ccctggccgt gctgacctat gaccactccc gggtcctgct
     2521 gaaggcggag aacagccaca gccactcaga ctacatcaac gctagcccca tcatggatca
     2581 cgacccgagg aaccccgcgt acatcgccac ccagggaccg ctgcccgcca ccgtggctga
     2641 cttttggcag atggtgtggg agagcggctg cgtggtgatc gtcatgctga cacccctcgc
     2701 ggagaacggc gtccggcagt gctaccacta ctggccggat gaaggctcca atctctacca
     2761 catctatgag gtgaacctgg tctccgagca catctggtgt gaggacttcc tggtgaggag
     2821 cttctatctg aagaacctgc agaccaacga gacgcgcacc gtgacgcagt tccacttcct
     2881 gagttggtat gaccgaggag tcccttcctc ctcaaggtcc ctcctggact tccgcagaaa
     2941 agtaaacaag tgctacaggg gccgttcttg tccaataatt gttcattgca gtgacggtgc
     3001 aggccggagc ggcacctacg tcctgatcga catggttctc aacaagatgg ccaaaggtgc
     3061 taaagagatt gatatcgcag cgaccctgga gcacttgagg gaccagagac ccggcatggt
     3121 ccagacgaag gagcagtttg agttcgcgct gacagccgtg gctgaggagg tgaacgccat
     3181 cctcaaggcc cttccccagt gagcggcagc ctcaggggcc tcaggggagc ccccacccca
     3241 cggatgttgt caggaatcat gatctgactt taattgtgtg tcttctatta taactgcata
     3301 gtaatagggc ccttagctct cccgtagtca gcgcagttta gcagttaaaa gtgtattttt
     3361 gtttaatcaa acaataataa agagagattt gtggaaaaat ccagttacgg gtggagggga
     3421 atcggttcat caattttcac ttgcttaaaa aaaatacttt ttcttaaagc acccgttcac
     3481 cttcttggtt gaagttgtgt taacaatgca gtagccagca cgttcgaggc ggtttccagg
     3541 aagagtgtgc ttgtcatctg ccactttcgg gagggtggat ccactgtgca ggagtggccg
     3601 gggaagctgg cagcactcag tgaggccgcc cggcacacaa ggcacgtttg gcatttctct
     3661 ttgagagagt ttatcattgg gagaagccgc agggacagaa ctgaacgtcc tgcagcttcg
     3721 gggcaagtga gacaatcaca gctcctcgct gcgtctccat caacactgcg ccgggtacca
     3781 tggacggccc cgtcagccac acctgtcagc ccaagcagag tgattcaggg gctccccggg
     3841 ggcagacacc tgtgcacccc atgagtagtg cccacttgag gctggcactc ccctgacctc
     3901 acctttgcaa agttacagat gcaccccaac attgagatgt gtttttaatg ttaaaatatt
     3961 gatttctacg ttatgaaaac agatgccccc gtgaatgctt acctgtgaga taaccacaac
     4021 caggaagaac aaatctgggc attgagcaag ctatgagggt ccccgggagc acacgaaccc
     4081 tgccaggccc ccgctggctc ctccaggcac gtcccggacc tgtggggccc cagagagggg
     4141 acatttccct cctgggagag aaggagatca gggcaactcg gagagggctg cgagcatttc
     4201 cctcccggga gaggagatca gggcgacctg cacgcactgc gtagagcctg gaagggaagt
     4261 gagaaaccag ccgaccggcc ctgcccctct tcccgggatc acttaatgaa ccacgtgttt
     4321 tgacatcatg taaacctaag cacgtagaga tgattcggat ttgacaaaat aacatttgag
     4381 tatccgattc gccatcaccc cctaccccag aaataggaca attcacttca ttgaccaaga
     4441 tgatcacatg gaaggcggca cagaggcagc tgtgtgggct gcagatttcc tgtgtggggt
     4501 tcagcgtaga aaacgcacct ccatcccgcc cttcccacag cattcctcca tcttagatag
     4561 atggtactct ccaaaggccc taccagaggg aacacggcct actgagcgga cagaatgatg
     4621 ccaaaatatt gcttatgtct ctacatggta ttgtaatgaa tatctgcttt aatatagcta
     4681 tcatttcttt tccaaaatta cttctctcta tctggaattt aattaatcga aatgaattta
     4741 tctgaatata ggaagcatat gcctacttgt aatttctaac tccttatgtt tgaagagaaa
     4801 cctccggtgt gagatataca aatatattta attgtgtcat attaaacttc tgatttcaca
//
