LOCUS       NM_002846               3612 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type N (PTPRN),
            transcript variant 1, mRNA.
ACCESSION   NM_002846
VERSION     NM_002846.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3612)
  AUTHORS   Kim,K.Y., Kim,M.S., Lee,Y.J., Lee,Y.A., Lee,S.Y., Shin,C.H. and
            Kim,J.H.
  TITLE     Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet
            Antigen-2 Positivity among Children and Adolescents with Diabetes
            in Korea
  JOURNAL   Diabetes Metab J 46 (6), 948-952 (2022)
   PUBMED   35263538
  REMARK    GeneRIF: Glutamic Acid Decarboxylase and Tyrosine
            Phosphatase-Related Islet Antigen-2 Positivity among Children and
            Adolescents with Diabetes in Korea.
REFERENCE   2  (bases 1 to 3612)
  AUTHORS   Garranzo-Asensio,M., Solis-Fernandez,G., Montero-Calle,A.,
            Garcia-Martinez,J.M., Fiuza,M.C., Pallares,P., Palacios-Garcia,N.,
            Garcia-Jimenez,C., Guzman-Aranguez,A. and Barderas,R.
  TITLE     Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2
            Diabetes and Colorectal Cancer and Identifies a Potential
            Diagnostic and Therapeutic Target
  JOURNAL   Diabetes 71 (3), 497-510 (2022)
   PUBMED   35040477
  REMARK    GeneRIF: Seroreactivity Against Tyrosine Phosphatase PTPRN Links
            Type 2 Diabetes and Colorectal Cancer and Identifies a Potential
            Diagnostic and Therapeutic Target.
REFERENCE   3  (bases 1 to 3612)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3612)
  AUTHORS   Ort,T., Maksimova,E., Dirkx,R., Kachinsky,A.M., Berghs,S.,
            Froehner,S.C. and Solimena,M.
  TITLE     The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ
            domains of beta2-syntrophin and nNOS in pancreatic beta-cells
  JOURNAL   Eur J Cell Biol 79 (9), 621-630 (2000)
   PUBMED   11043403
REFERENCE   5  (bases 1 to 3612)
  AUTHORS   Xie,J., Zhang,B., Lan,M.S. and Notkins,A.L.
  TITLE     Genomic structure and promoter sequence of the insulin-dependent
            diabetes mellitus autoantigen, IA-2 (PTPRN)
  JOURNAL   Genomics 54 (2), 338-343 (1998)
   PUBMED   9828138
REFERENCE   6  (bases 1 to 3612)
  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
  TITLE     Cloning and characterization of islet cell antigen-related
            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
            autoantigen in insulin-dependent diabetes
  JOURNAL   J Biol Chem 271 (40), 24817-24823 (1996)
   PUBMED   8798755
REFERENCE   7  (bases 1 to 3612)
  AUTHORS   Solimena,M., Dirkx,R. Jr., Hermel,J.M., Pleasic-Williams,S.,
            Shapiro,J.A., Caron,L. and Rabin,D.U.
  TITLE     ICA 512, an autoantigen of type I diabetes, is an intrinsic
            membrane protein of neurosecretory granules
  JOURNAL   EMBO J 15 (9), 2102-2114 (1996)
   PUBMED   8641276
REFERENCE   8  (bases 1 to 3612)
  AUTHORS   van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de
            Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
  TITLE     Assignment of the human gene for receptor-type protein tyrosine
            phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and
            identification of an intragenic genetic marker
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 145-148 (1996)
   PUBMED   8646884
REFERENCE   9  (bases 1 to 3612)
  AUTHORS   Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.
  TITLE     Molecular cloning and identification of a receptor-type protein
            tyrosine phosphatase, IA-2, from human insulinoma
  JOURNAL   DNA Cell Biol 13 (5), 505-514 (1994)
   PUBMED   8024693
REFERENCE   10 (bases 1 to 3612)
  AUTHORS   Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J.,
            Hicks,J.M., Goldstein,D.E. and Rae,P.M.
  TITLE     Islet cell antigen 512 is a diabetes-specific islet autoantigen
            related to protein tyrosine phosphatases
  JOURNAL   J Immunol 152 (6), 3183-3188 (1994)
   PUBMED   8144912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L18983.1, X62899.2 and
            BC007713.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002846.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and a single catalytic
            domain, and thus represents a receptor-type PTP. This PTP was found
            to be an autoantigen that is reactive with insulin-dependent
            diabetes mellitus (IDDM) patient sera, and thus may be a potential
            target of autoimmunity in diabetes mellitus. Alternate splicing
            results in multiple transcript variants.[provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L18983.1, SRR1803611.253464.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295718.7/ ENSP00000295718.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               L18983.1           5-310
            307-3210            X62899.2           1-2904
            3211-3612           BC007713.2         2638-3039
FEATURES             Location/Qualifiers
     source          1..3612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..3612
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /note="protein tyrosine phosphatase receptor type N"
                     /db_xref="GeneID:5798"
                     /db_xref="HGNC:HGNC:9676"
                     /db_xref="MIM:601773"
     exon            1..184
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3009
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; islet cell antigen 512; islet cell autoantigen
                     3; protein tyrosine phosphatase-like N; islet cell antigen
                     2; ICA 512; PTP IA-2; insulinoma-associated
                     tyrosine-phosphatase-like protein"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase-like
                     N isoform 1 precursor"
                     /protein_id="NP_002837.1"
                     /db_xref="CCDS:CCDS2440.1"
                     /db_xref="GeneID:5798"
                     /db_xref="HGNC:HGNC:9676"
                     /db_xref="MIM:601773"
                     /translation="MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDR
                     RLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLT
                     QYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQP
                     PVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRD
                     GSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDS
                     GLLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAA
                     LQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGP
                     VEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSP
                     LGQSQPTVAGQPSARPAAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINIS
                     VVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQ
                     TAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDT
                     TFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEP
                     AQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRH
                     PDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMV
                     WESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYL
                     KNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAG
                     RTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
                     ILKALPQ"
     exon            185..235
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            236..349
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            350..446
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            447..708
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1063
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1195
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1230
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1505
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1592
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1672
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1737
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1956
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2157
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2305
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2379
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2457
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2577
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2744
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2798
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2863
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2937
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3612
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3580..3585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /note="hexamer: AATAAA"
     polyA_site      3612
                     /gene="PTPRN"
                     /gene_synonym="IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N"
                     /note="major polyA site"
ORIGIN      
        1 ccctctggca ggctcccgcc agcgtcgctg cggctccggc ccgggagcga gcgcccggag
       61 ctcggaaaga tgcggcgccc gcggcggcct gggggtctcg ggggatccgg gggtctccgg
      121 ctgctcctct gcctcctgct gctgagcagc cgcccggggg gctgcagcgc cgttagtgcc
      181 cacggctgtc tatttgaccg caggctctgc tctcacctgg aagtctgtat tcaggatggc
      241 ttgtttgggc agtgccaggt gggagtgggg caggcccggc cccttttgca agtcacctcc
      301 ccagttctcc aacgcttaca aggtgtgctc cgacaactca tgtcccaagg attgtcctgg
      361 cacgatgacc tcacccagta tgtgatctct caggagatgg agcgcatccc caggcttcgc
      421 cccccagagc cccgtccaag ggacaggtct ggcttggcac ccaagagacc tggtcctgct
      481 ggagagctgc ttttacagga catccccact ggctccgccc ctgctgccca gcatcggctt
      541 ccacaaccac cagtgggcaa aggtggagct ggggccagct cctctctgtc ccctctgcag
      601 gctgagctgc tcccgcctct cttggagcac ctgctgctgc ccccacagcc tccccaccct
      661 tcactgagtt acgaacctgc cttgctgcag ccctacctgt tccaccagtt tggctcccgt
      721 gatggctcca gggtctcaga gggctcccca gggatggtca gtgtcggccc cctgcccaag
      781 gctgaagccc ctgccctctt cagcagaact gcctccaagg gcatatttgg ggaccaccct
      841 ggccactcct acggggacct tccagggcct tcacctgccc agctttttca agactctggg
      901 ctgctctatc tggcccagga gttgccagca cccagcaggg ccagggtgcc aaggctgcca
      961 gagcaaggga gcagcagccg ggcagaggac tccccagagg gctatgagaa ggaaggacta
     1021 ggggatcgtg gagagaagcc tgcttcccca gctgtgcagc cagatgcggc tctgcagagg
     1081 ctggccgctg tgctggcggg ctatggggta gagctgcgtc agctgacccc tgagcagctc
     1141 tccacactcc tgaccctgct gcagctactg cccaagggtg caggaagaaa tccgggaggg
     1201 gttgtaaatg ttggagctga tatcaagaaa acaatggagg ggccggtgga gggcagagac
     1261 acagcagagc ttccagcccg cacatccccc atgcctggac accccactgc cagccctacc
     1321 tccagtgaag tccagcaggt gccaagccct gtctcctctg agcctcccaa agctgccaga
     1381 ccccctgtga cacctgtcct gctagagaag aaaagcccac tgggccagag ccagcccacg
     1441 gtggcaggac agccctcagc ccgcccagca gcagaggaat atggctacat cgtcactgat
     1501 cagaagcccc tgagcctggc tgcaggagtg aagctgctgg agatcctggc tgagcatgtg
     1561 cacatgtcct caggcagctt catcaacatc agtgtggtgg gaccagccct caccttccgc
     1621 atccggcaca atgagcagaa cctgtctttg gctgatgtga cccaacaagc agggctggtg
     1681 aagtctgaac tggaagcaca gacagggctc caaatcttgc agacaggagt gggacagagg
     1741 gaggaggcag ctgcagtcct tccccaaact gcgcacagca cctcacccat gcgctcagtg
     1801 ctgctcactc tggtggccct ggcaggtgtg gctgggctgc tggtggctct ggctgtggct
     1861 ctgtgtgtgc ggcagcatgc gcggcagcaa gacaaggagc gcctggcagc cctggggcct
     1921 gagggggccc atggtgacac tacctttgag taccaggacc tgtgccgcca gcacatggcc
     1981 acgaagtcct tgttcaaccg ggcagagggt ccaccggagc cttcacgggt gagcagtgtg
     2041 tcctcccagt tcagcgacgc agcccaggcc agccccagct cccacagcag caccccgtcc
     2101 tggtgcgagg agccggccca agccaacatg gacatctcca cgggacacat gattctggca
     2161 tacatggagg atcacctgcg gaaccgggac cgccttgcca aggagtggca ggccctctgt
     2221 gcctaccaag cagagccaaa cacctgtgcc accgcgcagg gggagggcaa catcaaaaag
     2281 aaccggcatc ctgacttcct gccctatgac catgcccgca taaaactgaa ggtggagagc
     2341 agcccttctc ggagcgatta catcaacgcc agccccatta ttgagcatga ccctcggatg
     2401 ccagcctaca tagccacgca gggcccgctg tcccatacca tcgcagactt ctggcagatg
     2461 gtgtgggaga gcggctgcac cgtcatcgtc atgctgaccc cgctggtgga ggatggtgtc
     2521 aagcagtgtg accgctactg gccagatgag ggtgcctccc tctaccacgt atatgaggtg
     2581 aacctggtgt cggagcacat ctggtgcgag gactttctgg tgcggagctt ctacctgaag
     2641 aacgtgcaga cccaggagac gcgcacgctc acgcagttcc acttcctcag ctggccggca
     2701 gagggcacac cggcctccac gcggcccctg ctggacttcc gcaggaaggt gaacaagtgc
     2761 taccggggcc gctcctgccc catcatcgtg cactgcagtg atggtgcggg gaggaccggc
     2821 acctacatcc tcatcgacat ggtcctgaac cgcatggcaa aaggagtgaa ggagattgac
     2881 atcgctgcca ccctggagca tgtccgtgac cagcggcctg gccttgtccg ctctaaggac
     2941 cagtttgaat ttgccctgac agccgtggcg gaggaagtga atgccatcct caaggccctg
     3001 ccccagtgag accctggggc cccttggcgg gcagcccagc ctctgtccct ctttgcctgt
     3061 gtgagcatct ctgtgtaccc actcctcact gccccaccag ccacctcttg ggcatgctca
     3121 gcccttccta gaagagtcag gaagggaaag ccagaagggg cacgcctgcc cagcctcgca
     3181 tgccagagcc tggggcatcc cagagcccag ggcatcccat gggggtgctg cagccaggag
     3241 gagaggaaag gacatgggta gcaattctac ccagagcctt ctcctgccta cattccctgg
     3301 cctggctctc ctgtagctct cctggggttc tgggagttcc ctgaacatct gtgtgtgtcc
     3361 ccctatgctc cagtatggaa gaatggggtg gagggtcgcc acacccggct ccccctgctt
     3421 ctcagccccg ggcctgcctc tgactcacac ttgggcgctc tgccctccct ggcctcacgc
     3481 ccagcctcct cccaccaccc tcccaccatg cgctgctcaa cctctctcct tctggcgcaa
     3541 gagaacattt ctagaaaaaa ctacttttgt accagtgtga ataaagttag tgtgttgtct
     3601 gtgcagctgc aa
//
