LOCUS       NM_001105244            5595 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type M (PTPRM),
            transcript variant 1, mRNA.
ACCESSION   NM_001105244
VERSION     NM_001105244.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5595)
  AUTHORS   Chakraborty,S., Sharma,A., Pal,S., Sharma,A., Sihota,R.,
            Bhattacharjee,S. and Acharya,M.
  TITLE     A quantitative trait GWAS on lens thickness identifies novel risk
            loci on PTPRM in the narrow angle individuals susceptible to PACG
  JOURNAL   Eur J Ophthalmol 33 (5), 1922-1930 (2023)
   PUBMED   36927043
  REMARK    GeneRIF: A quantitative trait GWAS on lens thickness identifies
            novel risk loci on PTPRM in the narrow angle individuals
            susceptible to PACG.
REFERENCE   2  (bases 1 to 5595)
  AUTHORS   Hay,I.M., Shamin,M., Caroe,E.R., Mohammed,A.S.A., Svergun,D.I.,
            Jeffries,C.M., Graham,S.C., Sharpe,H.J. and Deane,J.E.
  TITLE     Determinants of receptor tyrosine phosphatase homophilic adhesion:
            Structural comparison of PTPRK and PTPRM extracellular domains
  JOURNAL   J Biol Chem 299 (1), 102750 (2023)
   PUBMED   36436563
  REMARK    GeneRIF: Determinants of receptor tyrosine phosphatase homophilic
            adhesion: Structural comparison of PTPRK and PTPRM extracellular
            domains.
REFERENCE   3  (bases 1 to 5595)
  AUTHORS   Song,J., Zhao,D., Sun,G., Yang,J., Lv,Z. and Jiao,B.
  TITLE     PTPRM methylation induced by FN1 promotes the development of
            glioblastoma by activating STAT3 signalling
  JOURNAL   Pharm Biol 59 (1), 904-911 (2021)
   PUBMED   34225581
  REMARK    GeneRIF: PTPRM methylation induced by FN1 promotes the development
            of glioblastoma by activating STAT3 signalling.
REFERENCE   4  (bases 1 to 5595)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
  REMARK    GeneRIF: PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic
            cancer progression.
REFERENCE   5  (bases 1 to 5595)
  AUTHORS   Liu,P., Zhang,C., Liao,Y., Liu,J., Huang,J., Xia,M., Chen,M.,
            Tan,H., He,W., Xu,M., Liu,T., Ooi,S., Du,Q., Qin,S., Zhu,Y.,
            Zou,Q., Wang,W. and Yao,S.
  TITLE     High expression of PTPRM predicts poor prognosis and promotes tumor
            growth and lymph node metastasis in cervical cancer
  JOURNAL   Cell Death Dis 11 (8), 687 (2020)
   PUBMED   32826853
  REMARK    GeneRIF: High expression of PTPRM predicts poor prognosis and
            promotes tumor growth and lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5595)
  AUTHORS   Brady-Kalnay,S.M., Rimm,D.L. and Tonks,N.K.
  TITLE     Receptor protein tyrosine phosphatase PTPmu associates with
            cadherins and catenins in vivo
  JOURNAL   J Cell Biol 130 (4), 977-986 (1995)
   PUBMED   7642713
REFERENCE   7  (bases 1 to 5595)
  AUTHORS   Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H.
            and Gebbink,M.F.
  TITLE     Homophilic interactions mediated by receptor tyrosine phosphatases
            mu and kappa. A critical role for the novel extracellular MAM
            domain
  JOURNAL   J Biol Chem 270 (24), 14247-14250 (1995)
   PUBMED   7782276
  REMARK    Erratum:[J Biol Chem 1995 Oct 13;270(41):24621]
REFERENCE   8  (bases 1 to 5595)
  AUTHORS   Brady-Kalnay,S.M. and Tonks,N.K.
  TITLE     Identification of the homophilic binding site of the receptor
            protein tyrosine phosphatase PTP mu
  JOURNAL   J Biol Chem 269 (45), 28472-28477 (1994)
   PUBMED   7961788
REFERENCE   9  (bases 1 to 5595)
  AUTHORS   Gebbink,M.F., Zondag,G.C., Wubbolts,R.W., Beijersbergen,R.L., van
            Etten,I. and Moolenaar,W.H.
  TITLE     Cell-cell adhesion mediated by a receptor-like protein tyrosine
            phosphatase
  JOURNAL   J Biol Chem 268 (22), 16101-16104 (1993)
   PUBMED   8393854
REFERENCE   10 (bases 1 to 5595)
  AUTHORS   Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R.,
            Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H.
  TITLE     Cloning, expression and chromosomal localization of a new putative
            receptor-like protein tyrosine phosphatase
  JOURNAL   FEBS Lett 290 (1-2), 123-130 (1991)
   PUBMED   1655529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001091.5, AP000897.6,
            AP005118.2, AP005900.1, AC006566.2, AP005227.3 and AP001094.6.
            
            On Jan 29, 2020 this sequence version replaced NM_001105244.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem catalytic
            domains, and thus represents a receptor-type PTP. The extracellular
            region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
            domain and four fibronectin type III-like repeats. This PTP has
            been shown to mediate cell-cell aggregation through the interaction
            with another molecule of this PTP on an adjacent cell. This PTP can
            interact with scaffolding protein RACK1/GNB2L1, which may be
            necessary for the downstream signaling in response to cell-cell
            adhesion. Alternative splicing results in multiple transcripts
            encoding distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580170.6/ ENSP00000463325.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AP001091.5         65140-65715
            577-699             AP000897.6         132820-132942
            700-971             AP005118.2         98062-98333
            972-1050            AP005118.2         116461-116539
            1051-1166           AP005118.2         136524-136639
            1167-1341           AP005118.2         159137-159311
            1342-1635           AP005118.2         165077-165370
            1636-1944           AP005900.1         162875-163183
            1945-2054           AP005900.1         169644-169753
            2055-2256           AP005900.1         178860-179061
            2257-2359           AP005900.1         181938-182040
            2360-2633           AP005900.1         206675-206948
            2634-2670           AP005900.1         207980-208016
            2671-2803           AC006566.2         80197-80329         c
            2804-2955           AP005227.3         56076-56227
            2956-3030           AP005227.3         59863-59937
            3031-3057           AP005227.3         60168-60194
            3058-3069           AP005227.3         64506-64517
            3070-3257           AP005227.3         65245-65432
            3258-3345           AP005227.3         108386-108473
            3346-3422           AP005227.3         126799-126875
            3423-3459           AP001094.6         27631-27667
            3460-3557           AP001094.6         51876-51973
            3558-3674           AP001094.6         79343-79459
            3675-3829           AP001094.6         84499-84653
            3830-3965           AP001094.6         84915-85050
            3966-4115           AP001094.6         86718-86867
            4116-4289           AP001094.6         87620-87793
            4290-4421           AP001094.6         88749-88880
            4422-4547           AP001094.6         93014-93139
            4548-4711           AP001094.6         95525-95688
            4712-4847           AP001094.6         102929-103064
            4848-5595           AP001094.6         114562-115309
FEATURES             Location/Qualifiers
     source          1..5595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.23"
     gene            1..5595
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /note="protein tyrosine phosphatase receptor type M"
                     /db_xref="GeneID:5797"
                     /db_xref="HGNC:HGNC:9675"
                     /db_xref="MIM:176888"
     exon            1..576
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..4901
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor type, mu
                     polypeptide; protein tyrosine phosphatase mu;
                     receptor-type tyrosine-protein phosphatase mu"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase mu
                     isoform 1 precursor"
                     /protein_id="NP_001098714.1"
                     /db_xref="CCDS:CCDS58613.1"
                     /db_xref="GeneID:5797"
                     /db_xref="HGNC:HGNC:9675"
                     /db_xref="MIM:176888"
                     /translation="MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGD
                     DFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYF
                     VSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFE
                     VITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRL
                     WLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAEL
                     VVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVD
                     STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVK
                     SRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLS
                     PYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQ
                     TYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAS
                     TAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV
                     VEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNK
                     TYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHT
                     VKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQ
                     GTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPIND
                     ETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFK
                     EEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI
                     DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE
                     IYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLG
                     FVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSR
                     RVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFR
                     TLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMD
                     SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH
                     GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFL
                     KLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT
                     LRNNKPNMVDLLDQYKFCYEVALEYLNSG"
     exon            577..699
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            700..971
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1050
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1166
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1341
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1635
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1944
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2054
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2256
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2359
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2633
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2670
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2803
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2955
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3030
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3057
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3069
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3257
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3345
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3422
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3459
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3557
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3674
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3829
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3965
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4115
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4116..4289
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4421
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4547
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4711
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4712..4847
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     exon            4848..5595
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5575..5580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /note="hexamer: ATTAAA"
     polyA_site      5595
                     /gene="PTPRM"
                     /gene_synonym="hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtcgg ggagcaagag ccccgcgcgc agccggcgcg ggctcggtca tcggcgcgcc
       61 gccgcccggg gctgggcttg gggctgcctg tggagaggcg gcgggcggaa cgcgcgcggc
      121 cacggccacg gccaccgcca cggccacggc cggcagctcg ggtcccgggt cccgggcagg
      181 ggaaggggag aggcggcgag ctcagcaacc ggaaccgagg gaagattttg gctccgcggg
      241 ctcgccctcc gctccctctg ccagcggcgc cagacgccga gtggggccag ggacagggga
      301 ggaggaccca ggaccctgtg cccgcgcccc tggagccgct ggagttcgga cttctgcaac
      361 tgttggcact ttgggggctt ggcttagcgc tctgctgttt acccgtctct cctcgctgcc
      421 tcggaaccaa agctcccggc cccctccgcc ctcgcgcgcc cacccaccgc cgccggggag
      481 cggcccggcc cgcactcagc accatgaggg gacttgggac ttgcctggcg actttggccg
      541 gacttttgct aactgcggcg ggcgagacgt tctcaggtgg ctgcctcttt gatgagccgt
      601 atagcacatg tggatatagt caatctgaag gtgatgactt caattgggag caagtgaaca
      661 ccttgactaa accgacttct gatccatgga tgccatcagg ttctttcatg ctggtgaatg
      721 cctctgggag acctgagggg cagagagccc acctgctctt accccaactt aaagaaaatg
      781 acacccactg catcgatttt cactattttg tgtccagcaa gagtaattct cctccggggt
      841 tactcaatgt ctacgtgaag gtcaataacg ggccactggg gaatcctatc tggaatatat
      901 ctggagaccc aacacgtaca tggaacaggg cagaactggc cattagtact ttctggccta
      961 acttttatca ggtgattttt gaagtgataa cttctggaca tcaaggctat ctcgctatcg
     1021 atgaggtgaa ggtgttagga catccatgta ccaggactcc tcacttcctg cggattcaga
     1081 atgtggaagt taatgctggc cagtttgcta ccttccagtg cagtgccatc ggcaggaccg
     1141 tggcaggaga caggctctgg ttacagggca ttgatgtgcg agatgctcct ctgaaggaaa
     1201 tcaaggtgac cagctcccga cgcttcattg cttcatttaa tgttgtgaat accaccaaac
     1261 gagatgctgg aaagtaccgc tgcatgattc gcactgaagg aggtgttgga atatcaaact
     1321 atgcagagtt ggtagttaaa gaaccacccg ttcctattgc cccacctcag ctcgcctctg
     1381 taggagccac ctacctgtgg atacagctca acgccaactc catcaatggg gatgggccca
     1441 ttgtggcccg agaggtggag tactgcacgg ccagtgggag ctggaatgac cggcagccag
     1501 tcgattccac gagctataaa attggacacc ttgacccaga tacagaatat gagattagtg
     1561 tgctcctgac caggccaggg gagggtggca ctggctctcc tggtccagct ctcaggacaa
     1621 gaacaaagtg tgctgatccc atgcgaggcc caagaaaact agaagtagtg gaggtcaaat
     1681 ctcggcaaat cactatccgc tgggagccat ttggatataa tgtaactcgt tgccacagtt
     1741 ataatctcac tgtccactac tgttaccaag ttggaggaca agaacaagtg cgagaagaag
     1801 taagctggga tacagaaaac tcacaccctc aacacacgat cactaacctg tcaccataca
     1861 ccaatgtcag tgtgaaactg atcctcatga acccagaggg ccggaaggaa agccaagaac
     1921 tcatagtgca gacagatgaa gacctcccag gtgctgttcc cactgaatcc atacaaggaa
     1981 gtacctttga agagaagata tttcttcagt ggagagaacc aactcaaaca tatggtgtaa
     2041 tcactttata tgagatcacc tacaaagcag tcagttcctt tgacccagaa atagatttat
     2101 ccaatcagag tggaagagtt tcaaagctgg gaaatgaaac ccattttctg ttttttggac
     2161 tgtatccggg gaccacatac tcctttacca tccgagctag cacagctaag ggttttgggc
     2221 ctccagcaac aaaccagttc accaccaaaa tatcagcacc ctctatgcca gcttatgaac
     2281 ttgagacacc tttgaatcaa actgacaata ccgtgacagt catgctgaaa cctgcccaca
     2341 gcagaggagc acctgtcagt gtctatcaaa tagttgttga ggaagaacgt cctcgaagaa
     2401 ctaaaaagac gacagaaatc ttaaagtgct acccagtgcc aattcacttc cagaatgctt
     2461 ctctgctgaa ctcacagtac tactttgctg cagaatttcc tgcagacagc ctccaagctg
     2521 cgcagccttt tacaattggt gataataaga catataatgg atactggaac actccccttc
     2581 tcccctataa aagctacaga atttatttcc aagctgctag tagagccaat ggggaaacca
     2641 aaatagactg tgtccaagtg gccacaaaag gagctgccac tccgaaacca gtcccagaac
     2701 ccgagaaaca gacagaccat acagttaaaa ttgctggagt catcgcgggc atcttgctgt
     2761 tcgtgattat atttcttgga gttgtgttgg taatgaagaa aaggaaactg gccaagaagc
     2821 ggaaagagac catgagcagc acccgacagg agatgactgt gatggtgaac tcaatggaca
     2881 agagctatgc tgagcagggc acaaactgcg acgaggcttt ctcattcatg gacacgcaca
     2941 atctgaatgg gagatctgtg tcttcaccat cgtccttcac aatgaaaaca aatacactga
     3001 gcacatcggt gcctaattcc tattacccag acccatttgt gccaactgca attttagtgc
     3061 caataaatga tgaaacccac acaatggcca gcgataccag cagcctggtg cagtcccata
     3121 cttacaagaa gcgagagccg gccgacgtgc cctatcagac tgggcagctc caccccgcca
     3181 tccgggtggc agacctcctt cagcacatca cacagatgaa gtgtgcggag ggctacggct
     3241 tcaaggagga atacgagagc ttctttgaag ggcagtctgc accatgggac tcggctaaga
     3301 aagatgagaa cagaatgaag aacagatacg ggaatatcat tgcatacgat cattcccgag
     3361 tgaggctgca gacaatagaa ggagacacaa actcagacta tatcaatggc aattatatcg
     3421 atggttatca tcgacccaat cattacattg ctacccaagg gccaatgcag gaaaccatct
     3481 atgacttctg gaggatggtg tggcacgaaa acactgcaag tatcatcatg gtgaccaatc
     3541 ttgtggaagt gggaagggtc aaatgctgca aatactggcc agatgacaca gagatatata
     3601 aagacattaa agttacccta atagaaacag aactactggc agaatatgtg ataagaacat
     3661 ttgctgttga aaagagaggt gtgcatgaaa tccgagagat cagacagttt cacttcactg
     3721 gctggccgga tcatggggtc ccctaccatg ccaccggcct gctgggattc gtgcggcaag
     3781 tcaagtccaa gagcccgccc agtgcaggcc cactggtggt gcactgcagt gctggtgcag
     3841 ggaggactgg ctgtttcatc gtcattgata tcatgttgga catggccgaa agggaagggg
     3901 tcgtagacat ctacaactgc gtcagggagc tgcggtcacg gagggtgaac atggtgcaaa
     3961 cagaggagca gtatgtgttt atccacgatg cgatcctgga agcctgtctt tgtggggaca
     4021 cctctgtgcc tgcttcccaa gttaggtctc tgtattatga catgaacaaa ctggatccac
     4081 agacaaactc aagccagatt aaagaggaat tccggacgct aaacatggtg acaccaacgc
     4141 tgcgagtaga ggactgcagc atcgcactgt tgccccggaa ccatgagaaa aaccggtgca
     4201 tggacatcct gcccccagac cgctgcctgc ccttcctcat caccatcgat ggggagagca
     4261 gcaactacat caatgctgcc ctcatggaca gctataaaca gccttcagct tttatagtca
     4321 cccagcatcc tttgccaaac acagtgaaag acttttggag actggtcctg gattatcact
     4381 gcacatccgt agttatgcta aatgatgtgg atcctgccca gttgtgtcca cagtactggc
     4441 cagaaaacgg agtacacaga cacggcccca tccaggtgga atttgtctct gctgacctgg
     4501 aagaggacat catcagcagg atattccgca tttacaatgc cgccagaccc caagatggat
     4561 atcggatggt gcagcaattc cagttcctgg gctggccgat gtacagggac acaccagtgt
     4621 ctaagcgctc cttcttgaag ctcattcgcc aggtggacaa gtggcaagag gagtacaatg
     4681 gcggggaagg ccgcacggtt gtgcactgct tgaacggggg aggccgcagt gggacgttct
     4741 gcgccatcag catcgtatgt gagatgctcc ggcaccagag aaccgtggat gtctttcacg
     4801 ctgtgaagac actgaggaac aacaagccca acatggtcga cctcctggat cagtacaagt
     4861 tctgctacga ggtggccctg gaatacttga attctggctg atggtgtaaa cagctctgca
     4921 aacaatccct ttcataccac aaagccaaga cgttccatgg tatttgtgca aaagagatga
     4981 agacttctca atatgcttat tttgctttgc ataattggct ctttttaaga gcccaagaaa
     5041 gtgtttctaa aattgcttgc actgcccaat cccagtaatg ctgctgcctg acagaaacac
     5101 acacacagcc acagttgcca aatcccgtac tccttgccac cggcttccta gagcagcgta
     5161 gacagctggt aaactgaaga gcacaactat attcttatga aggaatttgt acctttgggg
     5221 tattattttg tggcccgtga ccctcgttat tgttacagct gagtgtatgt ttttgttctg
     5281 tggagaatgc tatctggcat tatggtaata tattatttta ggtaatattt gtactttaac
     5341 atgttgcata atatatgctt atgtagcttt ccaggactaa cagataaatg tgtaatgaac
     5401 aaagatatgt tgtatgagtc gtcgtttctg tcagatttgt attgtttcca agggaaaagc
     5461 ttgggggagg actcagttca caaaatgcaa aactcaacga tcagattcac ggacccagag
     5521 cttttccatg tgtttatatt gtaaatattt ttgatttcat caaattattt attcattaaa
     5581 agaaattttt gtgaa
//
