LOCUS       NM_002844               6006 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type K (PTPRK),
            transcript variant 2, mRNA.
ACCESSION   NM_002844
VERSION     NM_002844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6006)
  AUTHORS   Hay,I.M., Shamin,M., Caroe,E.R., Mohammed,A.S.A., Svergun,D.I.,
            Jeffries,C.M., Graham,S.C., Sharpe,H.J. and Deane,J.E.
  TITLE     Determinants of receptor tyrosine phosphatase homophilic adhesion:
            Structural comparison of PTPRK and PTPRM extracellular domains
  JOURNAL   J Biol Chem 299 (1), 102750 (2023)
   PUBMED   36436563
  REMARK    GeneRIF: Determinants of receptor tyrosine phosphatase homophilic
            adhesion: Structural comparison of PTPRK and PTPRM extracellular
            domains.
REFERENCE   2  (bases 1 to 6006)
  AUTHORS   Nanayakkara,M., Bellomo,C., Furone,F., Maglio,M., Marano,A.,
            Lania,G., Porpora,M., Nicoletti,M., Auricchio,S. and Barone,M.V.
  TITLE     PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and
            Intestinal Organoids
  JOURNAL   Cells 12 (1), 115 (2022)
   PUBMED   36611909
  REMARK    GeneRIF: PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies
            and Intestinal Organoids.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6006)
  AUTHORS   Jeong,J.H., Yun,J.W., Kim,H.Y., Heo,C.Y. and Lee,S.
  TITLE     Investigation of cell signalings and therapeutic targets in
            PTPRK-RSPO3 fusion-positive colorectal cancer
  JOURNAL   PLoS One 17 (9), e0274555 (2022)
   PUBMED   36129915
  REMARK    GeneRIF: Investigation of cell signalings and therapeutic targets
            in PTPRK-RSPO3 fusion-positive colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6006)
  AUTHORS   Kim,M., Reinhard,C. and Niehrs,C.
  TITLE     A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt
            signaling
  JOURNAL   Elife 10, e70885 (2021)
   PUBMED   34590584
  REMARK    GeneRIF: A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and
            Wnt signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6006)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6006)
  AUTHORS   Yang,Y., Gil,M.C., Choi,E.Y., Park,S.H., Pyun,K.H. and Ha,H.
  TITLE     Molecular cloning and chromosomal localization of a human gene
            homologous to the murine R-PTP-kappa, a receptor-type protein
            tyrosine phosphatase
  JOURNAL   Gene 186 (1), 77-82 (1997)
   PUBMED   9047348
REFERENCE   7  (bases 1 to 6006)
  AUTHORS   Yang,Y., Gil,M., Byun,S.M., Choi,I., Pyun,K.H. and Ha,H.
  TITLE     Transforming growth factor-beta1 inhibits human keratinocyte
            proliferation by upregulation of a receptor-type tyrosine
            phosphatase R-PTP-kappa gene expression
  JOURNAL   Biochem Biophys Res Commun 228 (3), 807-812 (1996)
   PUBMED   8941358
REFERENCE   8  (bases 1 to 6006)
  AUTHORS   Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A.
  TITLE     Association of human protein-tyrosine phosphatase kappa with
            members of the armadillo family
  JOURNAL   J Biol Chem 271 (28), 16712-16719 (1996)
   PUBMED   8663237
REFERENCE   9  (bases 1 to 6006)
  AUTHORS   Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H.
            and Gebbink,M.F.
  TITLE     Homophilic interactions mediated by receptor tyrosine phosphatases
            mu and kappa. A critical role for the novel extracellular MAM
            domain
  JOURNAL   J Biol Chem 270 (24), 14247-14250 (1995)
   PUBMED   7782276
  REMARK    Erratum:[J Biol Chem 1995 Oct 13;270(41):24621]
REFERENCE   10 (bases 1 to 6006)
  AUTHORS   Sap,J., Jiang,Y.P., Friedlander,D., Grumet,M. and Schlessinger,J.
  TITLE     Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic
            binding
  JOURNAL   Mol Cell Biol 14 (1), 1-9 (1994)
   PUBMED   8264577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA790525.1, BC140775.1, AK295028.1, AF533875.1 and BQ018138.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002844.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem catalytic
            domains, and thus represents a receptor-type PTP. The extracellular
            region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
            domain and four fibronectin type III-like repeats. This PTP was
            shown to mediate homophilic intercellular interaction, possibly
            through the interaction with beta- and gamma-catenin at adherens
            junctions. Expression of this gene was found to be stimulated by
            TGF-beta 1, which may be important for the inhibition of
            keratinocyte proliferation. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks two alternate in-frame
            exons compared to variant 3. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749277.1, SRR1803612.280461.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368226.9/ ENSP00000357209.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               DA790525.1         127-249
            124-2262            BC140775.1         1-2139
            2263-2398           AK295028.1         2263-2398
            2399-4568           AF533875.1         2239-4408
            4569-5814           BC140775.1         4464-5709
            5815-6006           BQ018138.1         24-215              c
FEATURES             Location/Qualifiers
     source          1..6006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..6006
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /note="protein tyrosine phosphatase receptor type K"
                     /db_xref="GeneID:5796"
                     /db_xref="HGNC:HGNC:9674"
                     /db_xref="MIM:602545"
     exon            1..341
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..4564
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /EC_number="3.1.3.48"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; protein-tyrosine phosphatase, receptor type,
                     kappa; protein-tyrosine phosphatase kappa; receptor-type
                     tyrosine-protein phosphatase kappa; dJ480J14.2.1 (protein
                     tyrosine phosphatase, receptor type, K (R-PTP-KAPPA,
                     protein tyrosine phosphatase kappa, protein tyrosine
                     phosphatase kappa"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase kappa
                     isoform b precursor"
                     /protein_id="NP_002835.2"
                     /db_xref="CCDS:CCDS5137.1"
                     /db_xref="GeneID:5796"
                     /db_xref="HGNC:HGNC:9674"
                     /db_xref="MIM:602545"
                     /translation="MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGA
                     CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKEND
                     THCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFW
                     PNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIA
                     TGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSER
                     GSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTS
                     GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRT
                     PKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP
                     QHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF
                     LNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTT
                     YQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKG
                     APISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEP
                     APFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV
                     IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHM
                     VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTE
                     SPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAK
                     NRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWR
                     MIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTL
                     ERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG
                     RTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCG
                     ETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDK
                     NRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRL
                     VYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICN
                     LTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCL
                     NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
                     LESS"
     exon            342..464
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            465..736
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            737..818
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            819..934
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1109
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1403
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1706
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1816
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2018
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2124
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2398
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2435
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2574
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2735
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2920
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3008
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3085
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3122
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3220
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3337
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3492
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3628
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3778
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3952
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4084
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4210
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4374
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4510
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..6006
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /note="hexamer: AATAAA"
     polyA_site      6006
                     /gene="PTPRK"
                     /gene_synonym="R-PTP-kappa"
                     /note="major polyA site"
ORIGIN      
        1 actaacagga gcagcctccg ccgagcatgg agagctgccg ccgcggccgg ccggcgacgc
       61 tggcgacgct ttcgcccctg aggtagtttg gcgaccgcga agaaggaaaa agggcgggcg
      121 ggcggctgtc ctctcaccgt cctcaccccg cgaggcccgg cccgctcctc cgtcgtggat
      181 ttcgcggcga tccccccggc agctctttgc aaagctgctt gaaacttctc ccaaactcgg
      241 catggatacg actgcggcgg cggcgctgcc tgcttttgtg gcgctcttgc tcctctctcc
      301 ttggcctctc ctgggatcgg cccaaggcca gttctccgca ggtggctgta cttttgatga
      361 tggtccaggg gcctgtgatt accaccagga tctgtatgat gactttgaat gggtgcatgt
      421 tagtgctcaa gagcctcatt atctaccacc cgagatgccc caaggttcct atatgatagt
      481 ggactcttca gatcacgacc ctggagaaaa agccagactt cagctgccta caatgaagga
      541 gaacgacact cactgcattg atttcagtta cctattatat agccagaaag gactgaatcc
      601 tggcactttg aacatattag ttagggtgaa taaaggacct cttgccaatc caatttggaa
      661 tgtgactgga ttcacgggta gagattggct tcgggctgag ctagcagtga gcaccttttg
      721 gcccaatgaa tatcaggtaa tatttgaagc tgaagtctca ggagggagaa gtggttatat
      781 tgccattgat gacatccaag tactgagtta tccttgtgat aaatctcctc atttcctccg
      841 tctaggggat gtagaggtga atgcagggca aaacgctaca tttcagtgca ttgccacagg
      901 gagagatgct gtgcataaca agttatggct ccagagacga aatggagaag atataccagt
      961 agcccagact aagaacatca atcatagaag gtttgccgct tccttcagat tgcaagaagt
     1021 gacaaaaact gaccaggatt tgtatcgctg tgtaactcag tcagaacgag gttccggtgt
     1081 gtccaatttt gctcaactta ttgtgagaga accgccaaga cccattgctc ctcctcagct
     1141 tcttggtgtt gggcctacat atttgctgat ccaactaaat gccaactcga tcattggcga
     1201 tggtcctatc atcctgaaag aagtagagta ccgaatgaca tcaggatcct ggacagaaac
     1261 ccatgcagtc aatgctccaa cttacaaatt atggcattta gatccagata ccgaatatga
     1321 gatccgagtt ctacttacaa gacctggtga aggtggaacg gggctcccag gacctccact
     1381 aatcaccaga acaaaatgtg cagaacctat gagaacccca aagacattaa agattgctga
     1441 aatacaggca agacggattg ctgtggactg ggaatccttg ggttacaaca ttacgcgttg
     1501 ccacactttt aatgtcacta tctgctacca ttacttccgt ggtcacaacg agagcaaggc
     1561 agactgtttg gacatggacc ccaaagcccc tcagcatgtt gtgaaccatc tgccacctta
     1621 tacaaatgtc agcctcaaga tgatcctaac caatccagag ggaaggaagg agagtgaaga
     1681 gacaattatt caaactgatg aagatgtgcc tggtcccgta ccagtaaaat ctcttcaagg
     1741 aacatccttt gaaaataaga tcttcttgaa ctggaaagaa cctttggatc caaatggaat
     1801 catcactcaa tatgagatca gctatagcag tataagatca tttgatcctg cagttccagt
     1861 ggctggacct ccccagactg tatcaaattt atggaacagt acacaccatg tctttatgca
     1921 tctccaccct ggaaccacgt accagttttt cataagagcc agcacggtca aaggctttgg
     1981 tccagccaca gccatcaatg tcaccaccaa tatctcagct ccaactttac ctgactatga
     2041 aggagttgat gcctctctca atgaaactgc caccacaata actgtattgt tgagaccagc
     2101 acaagccaaa ggtgctccta tcagtgctta tcagattgtt gtggaagaac tgcacccaca
     2161 ccgaaccaag agagaagccg gagccatgga atgctaccag gttcctgtca cataccaaaa
     2221 tgccatgagt gggggtgcac cgtattactt tgctgcagaa ctccccccgg gaaacctacc
     2281 tgagcctgcc ccgttcactg tgggtgacaa tcggacctac caaggctttt ggaaccctcc
     2341 tttggctccg cgcaaaggat acaacatcta tttccaggcg atgagcagtg tggagaagga
     2401 aactaaaacc cagtgcgtac gcattgctac aaaagcagca gcaacagaag aaccagaagt
     2461 gatcccagat cccgccaagc agacagacag agtggtgaaa atagcaggaa ttagtgctgg
     2521 aattttggtg ttcatcctcc ttctcctagt tgtcatatta attgtaaaaa agagcaaact
     2581 tgctaaaaaa cgcaaagatg ccatggggaa tacccggcag gagatgactc acatggtgaa
     2641 tgcaatggat cgaagttatg ctgatcagag cactctgcat gcagaagatc ctctttccat
     2701 caccttcatg gaccaacata actttagtcc aagatatgag aaccacagtg ctacagcaga
     2761 gtccagtcgc cttctagacg tacctcgcta cctctgtgag gggacggaat ccccttacca
     2821 gacaggacag ctgcatccag ccatcagggt agctgattta ctgcagcaca ttaatctcat
     2881 gaagacatca gacagctatg ggttcaaaga ggaatatgag agcttttttg aaggacagtc
     2941 agcatcttgg gatgtagcta aaaaagatca aaatagagca aaaaaccgat atggaaacat
     3001 tatagcatat gatcactcca gagtgatttt gcaacccgta gaggatgatc cttcctcaga
     3061 ttatattaat gccaactata ttgatggcta ccagagacca agtcattaca ttgcaaccca
     3121 aggtcccgtt catgaaacag tgtatgattt ctggaggatg atttggcaag aacaatctgc
     3181 ttgcattgtg atggttacaa atttagttga ggttggccgg gttaaatgct ataaatattg
     3241 gcctgatgat actgaagttt atggtgactt caaagtaacg tgtgtagaaa tggaaccact
     3301 tgctgaatat gtagttagga cattcaccct ggaaaggagg gggtacaatg aaatccgtga
     3361 agttaaacag ttccatttca cgggctggcc tgaccatgga gtgccctacc atgctacagg
     3421 gctgctttcc tttatccggc gagtcaagtt atcaaaccct cccagtgctg gccccatcgt
     3481 tgtacattgc agtgctggtg ctggacgaac tggctgctac attgtgattg acatcatgct
     3541 agacatggct gaaagagagg gtgttgttga tatttacaat tgtgtcaaag ccttaagatc
     3601 tcggcgtatt aatatggtcc agacagagga acagtacatt tttattcatg atgccatttt
     3661 agaagcctgc ttatgtggag aaactgccat acctgtctgt gaatttaaag ctgcatattt
     3721 tgatatgatt agaatagact cccagactaa ctcttcacat ctcaaggatg aatttcagac
     3781 tctgaattca gtcacccctc gactacaagc tgaagactgc agtatagcgt gcctgccaag
     3841 gaaccatgac aagaaccgtt tcatggacat gctgccacct gacagatgtc tgcctttttt
     3901 aattacaatt gatggggaga gcagtaacta catcaatgct gctcttatgg acagctacag
     3961 gcaaccagct gctttcatcg tcacacaata ccctctgcca aacactgtaa aagacttctg
     4021 gagattagtg tatgattatg gctgtacctc cattgtgatg ttaaacgaag tcgacttgtc
     4081 ccagggctgc cctcagtact ggccagagga agggatgcta cgatatggcc ccatccaagt
     4141 ggaatgtatg tcttgttcaa tggactgtga tgtgatcaac cggattttta ggatatgcaa
     4201 tctaacaaga ccacaggaag gttatctgat ggtgcaacag tttcagtacc taggatgggc
     4261 ttctcatcga gaagtgcctg gatccaaaag gtcattcttg aaactgatac ttcaggtgga
     4321 aaagtggcag gaggaatgcg aggaagggga aggccggacg attatccact gcctaaatgg
     4381 tggcgggcga agtggcatgt tctgtgctat aggcatcgtt gttgaaatgg tgaaacggca
     4441 aaatgttgtc gatgttttcc atgcagtaaa gacactgagg aacagcaagc caaacatggt
     4501 ggaagccccg gagcaatacc gtttctgcta tgatgtagct ttggagtacc tggaatcatc
     4561 ttagttgggt gagactcttt aaagtgcatc catgaagaaa cctgtccatc tattgagcca
     4621 gcagctgttg tacctgttac acttgtgcag aaagatttta atgtgggggg tgggagactt
     4681 ttacatttga gaggtaaaag tatttttttt atgaagttgt gtatcttaat aaaaaggact
     4741 gaattagttt ttattactat attaaagcat caacatttca tgccacataa attatattta
     4801 ataagaacca gattgaaatg agaacgtatt ggtgtttgta cagtgaacat gccacctttt
     4861 ttctcatggt ttcagtagag cagctaccac atgttgcatg agttcatact ttctacgtgg
     4921 catttttctc cctttctaaa atgaaagctg atgaatctta aaaggaagaa gaaaagaaaa
     4981 gctgtgcaaa ttcatagtaa agttcgtttt ttatatgttt ccagtgtagc agatctctat
     5041 ataaatatat aaatatatat aactggctta ttttctttta atgtgcaatg atggctggat
     5101 catttaaagt tctttttaga aaataacata agccaaagac tcaagtgtaa atatgtctat
     5161 atggagaaag cacattatat ttattggtta cttacattcc ttttttgatg gctaaaatac
     5221 taccaccaca caatcatctt ttttttcctg aagaaagctt tttctttagc taaaatcaat
     5281 tgtaaacgat ttttgtagat tattttttgt atgttttagt gtaagtagaa gataaacttt
     5341 ttattcataa accaggaagc aatgttcttt atagtgattc tcttgtgtac atgcttgtga
     5401 attaaatttg tgtaaaatcc cttggcaatt gggtctttta atataggacc aaattaaaac
     5461 attttgctga atatgtatag tttttcacaa tttcattagg taaataatgg tttggtgatc
     5521 atacatgaga aatgtacaca ttaaaaggcc ttgctgacaa cttgcacaat gttgaacata
     5581 gcctttaagc atcatttaaa ttttaaagga atggagtttt tcagcctgtg gcccagcact
     5641 ggtcaagaaa acaagatggc aacatatatg ctttcagggt caaatttgag caaactgtaa
     5701 actgtcaggg tgataaaatg tttctcttga tgtttacatg cacaagcttt gcgttctgac
     5761 tataaaaagt gtgaacaaat caatgccaga ttcctgtttt gcgcattgtc atgggattct
     5821 taagtgaacc tttctaaatg tggtcttgtt cacatgctcc acgtagctgt aacttcacat
     5881 catcagcttg cagtttgtaa ttgactaaag cattccagtg tcctctttct agattgccag
     5941 ctcatgacat ggtgcttata aagatttaat taaagtaaga atgaaataaa gtttttataa
     6001 ttataa
//
