LOCUS       NM_002843               7845 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type J (PTPRJ),
            transcript variant 1, mRNA.
ACCESSION   NM_002843
VERSION     NM_002843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7845)
  AUTHORS   Goob,G., Adrian,J., Cossu,C. and Hauck,C.R.
  TITLE     Phagocytosis mediated by the human granulocyte receptor CEACAM3 is
            limited by the receptor-type protein tyrosine phosphatase PTPRJ
  JOURNAL   J Biol Chem 298 (9), 102269 (2022)
   PUBMED   35850306
  REMARK    GeneRIF: Phagocytosis mediated by the human granulocyte receptor
            CEACAM3 is limited by the receptor-type protein tyrosine
            phosphatase PTPRJ.
REFERENCE   2  (bases 1 to 7845)
  AUTHORS   He,L., Takahashi,K., Pasic,L., Narui,C., Ellinger,P., Grundmann,M.
            and Takahashi,T.
  TITLE     The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid
            cancer cell proliferation and epidermal growth factor receptor
            signaling
  JOURNAL   Cancer Rep (Hoboken) 5 (9), e1566 (2022)
   PUBMED   34791835
  REMARK    GeneRIF: The effects of CD148 Q276P/R326Q polymorphisms in A431D
            epidermoid cancer cell proliferation and epidermal growth factor
            receptor signaling.
REFERENCE   3  (bases 1 to 7845)
  AUTHORS   Roychowdhury,A., Basu,M., Pal,D., Dutta,P., Samadder,S., Mondal,R.,
            Roy,A.K., Roychoudhury,S. and Panda,C.K.
  TITLE     PTPRJ is downregulated in cervical squamous cell carcinoma
  JOURNAL   J Genet 101 (2022)
   PUBMED   35791609
  REMARK    GeneRIF: PTPRJ is downregulated in cervical squamous cell
            carcinoma.
REFERENCE   4  (bases 1 to 7845)
  AUTHORS   Gautam,A., Sreedharanunni,S., Sachdeva,M.U.S., Rana,S., Kashyap,D.,
            Bose,P., Bal,A., Prakash,G., Malhotra,P., Das,R. and Varma,N.
  TITLE     The relative expression levels of CD148 and CD180 on clonal B cells
            and CD148/CD180 median fluorescence intensity ratios are useful in
            the characterization of mature B cell lymphoid neoplasms
            infiltrating blood and bone marrow - Results from a single centre
            pilot study
  JOURNAL   Int J Lab Hematol 43 (5), 1123-1131 (2021)
   PUBMED   33455071
  REMARK    GeneRIF: The relative expression levels of CD148 and CD180 on
            clonal B cells and CD148/CD180 median fluorescence intensity ratios
            are useful in the characterization of mature B cell lymphoid
            neoplasms infiltrating blood and bone marrow - Results from a
            single centre pilot study.
REFERENCE   5  (bases 1 to 7845)
  AUTHORS   Tsoyi,K., Liang,X., De Rossi,G., Ryter,S.W., Xiong,K., Chu,S.G.,
            Liu,X., Ith,B., Celada,L.J., Romero,F., Robertson,M.J.,
            Esposito,A.J., Poli,S., El-Chemaly,S., Perrella,M.A., Shi,Y.,
            Whiteford,J. and Rosas,I.O.
  TITLE     CD148 Deficiency in Fibroblasts Promotes the Development of
            Pulmonary Fibrosis
  JOURNAL   Am J Respir Crit Care Med 204 (3), 312-325 (2021)
   PUBMED   33784491
  REMARK    GeneRIF: CD148 Deficiency in Fibroblasts Promotes the Development
            of Pulmonary Fibrosis.
REFERENCE   6  (bases 1 to 7845)
  AUTHORS   Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and
            Aversa,G.
  TITLE     CD148: a receptor-type protein tyrosine phosphatase involved in the
            regulation of human T cell activation
  JOURNAL   J Immunol 161 (7), 3249-3255 (1998)
   PUBMED   9759839
REFERENCE   7  (bases 1 to 7845)
  AUTHORS   de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,
            Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.
  TITLE     CD148 is a membrane protein tyrosine phosphatase present in all
            hematopoietic lineages and is involved in signal transduction on
            lymphocytes
  JOURNAL   Blood 91 (8), 2800-2809 (1998)
   PUBMED   9531590
REFERENCE   8  (bases 1 to 7845)
  AUTHORS   Jallal,B., Mossie,K., Vasiloudis,G., Knyazev,P., Zachwieja,J.,
            Clairvoyant,F., Schilling,J. and Ullrich,A.
  TITLE     The receptor-like protein-tyrosine phosphatase DEP-1 is
            constitutively associated with a 64-kDa protein serine/threonine
            kinase
  JOURNAL   J Biol Chem 272 (18), 12158-12163 (1997)
   PUBMED   9115287
REFERENCE   9  (bases 1 to 7845)
  AUTHORS   Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of a novel protein-tyrosine phosphatase, HPTP eta
  JOURNAL   Blood 84 (12), 4186-4194 (1994)
   PUBMED   7994032
REFERENCE   10 (bases 1 to 7845)
  AUTHORS   Ostman,A., Yang,Q. and Tonks,N.K.
  TITLE     Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,
            is enhanced with increasing cell density
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9680-9684 (1994)
   PUBMED   7937872
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR007037.1, AL359057.1,
            AC026975.5, U10886.1 and AI218139.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002843.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes,
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region containing five fibronectin type III repeats, a single
            transmembrane region, and a single intracytoplasmic catalytic
            domain, and thus represents a receptor-type PTP. This protein is
            present in all hematopoietic lineages, and was shown to negatively
            regulate T cell receptor signaling possibly through interfering
            with the phosphorylation of Phospholipase C Gamma 1 and Linker for
            Activation of T Cells. This protein can also dephosphorylate the
            PDGF beta receptor, and may be involved in UV-induced signal
            transduction. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000418331.7/
                                                ENSP00000400010.2
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               DR007037.1         9-523
            516-971             AL359057.1         341-796
            972-972             AC026975.5         54631-54631
            973-1630            AL359057.1         798-1455
            1631-2969           U10886.1           1626-2964
            2970-2970           AC026975.5         75732-75732
            2971-4619           U10886.1           2966-4614
            4620-7453           AC026975.5         98631-101464
            7454-7775           AI218139.1         80-401              c
            7776-7845           AI218139.1         9-78                c
FEATURES             Location/Qualifiers
     source          1..7845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..7845
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /note="protein tyrosine phosphatase receptor type J"
                     /db_xref="GeneID:5795"
                     /db_xref="HGNC:HGNC:9673"
                     /db_xref="MIM:600925"
     exon            1..450
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..4368
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase eta;
                     susceptibility to colon cancer 1, mouse, homolog of; human
                     density enhanced phosphatase-1; CD148 antigen; protein
                     tyrosine phosphatase, receptor type, J polypeptide;
                     density-enhanced phosphatase 1; protein-tyrosine
                     phosphatase eta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform 1 precursor"
                     /protein_id="NP_002834.3"
                     /db_xref="CCDS:CCDS7945.1"
                     /db_xref="GeneID:5795"
                     /db_xref="HGNC:HGNC:9673"
                     /db_xref="MIM:600925"
                     /translation="MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIP
                     DPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQG
                     SNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE
                     KTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALT
                     GVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQ
                     SNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVG
                     LEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNE
                     SSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQV
                     HTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGG
                     LFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGA
                     SEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYT
                     RPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDA
                     TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKW
                     TCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSC
                     GKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTT
                     GEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTT
                     LGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGV
                     ICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYF
                     KKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT
                     HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR
                     TKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWP
                     DHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENE
                     NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
                     ENLAPVTTFGKTNGYIA"
     exon            451..469
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            470..706
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            707..970
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1228
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1447
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1711
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1969
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2227
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2506
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2797
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2929
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3140
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3265
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3353
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3395
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3404
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3492
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3583
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3657
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3792
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3912
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4073
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4209
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..7845
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7826..7831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /note="hexamer: TATAAA"
     polyA_site      7845
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /note="major polyA site"
ORIGIN      
        1 agccccagcc gcatgacgcg cggaggaggc agcgggagca gccgcgggag ccgggaccgg
       61 gtagccgcgc gctgggggtg ggcgccgctc gctccgcccc gcgaagcccc tgcgcgctca
      121 gggacgcggc ccccccgcgg cagccgcgct aggctccggc gtgtggccgc ggccgccgcc
      181 gccgctgcca tgtctccggg gaagcccggg gcgggcggag cggggacgag gcggaccggc
      241 tggcggagga ggaggcgaag gagacggcag gaggcggcga cgacggtgcc cgggctcggg
      301 cgcacggcgg ggcccgattc gcgcgtccgg ggcacgttcc agggcgcgcg gggcatgaag
      361 ccggcggcgc gggaggcgcg gctgcctccg cgctcgcccg ggctgcgctg ggcgctgccg
      421 ctgctgctgc tgctgctgcg cctgggccag atcctgtgcg caggtggcac ccctagtcca
      481 attcctgacc cttcagtagc aactgttgcc acaggggaaa atggcataac gcagatcagc
      541 agtacagcag aatcctttca taaacagaat ggaactggaa cacctcaggt ggaaacaaac
      601 accagtgagg atggtgaaag ctctggagcc aacgatagtt taagaacacc tgaacaagga
      661 tctaatggga ctgatggggc atctcaaaaa actcccagta gcactgggcc cagtcctgtg
      721 tttgacatta aagctgtttc catcagtcca accaatgtga tcttaacttg gaaaagtaat
      781 gacacagctg cttctgagta caagtatgta gtaaagcata agatggaaaa tgagaagaca
      841 attactgttg tgcatcaacc atggtgtaac atcacaggct tacgtccagc gacttcatat
      901 gtattctcca tcactccagg aataggcaat gagacttggg gagatcccag agtcataaaa
      961 gtcatcacag agccgatccc agtttctgat ctccgtgttg ccctcacggg tgtgaggaag
     1021 gctgctctct cctggagcaa tggcaatggc actgcctcct gccgggttct tcttgaaagc
     1081 attggaagcc atgaggagtt gactcaagac tcaagacttc aggtcaatat ctcgggcctg
     1141 aagccagggg ttcaatacaa catcaacccg tatcttctac aatcaaataa gacaaaggga
     1201 gaccccttgg gcacagaagg tggcttggat gccagcaata cagagagaag ccgggcaggg
     1261 agccccaccg cccctgtgca tgatgagtcc ctcgtgggac ctgtggaccc atcctccggc
     1321 cagcagtccc gagacacgga agtcctgctt gtcgggttag agcctggcac ccgatacaat
     1381 gccaccgttt attcccaagc agcgaatggc acagaaggac agccccaggc catagagttc
     1441 aggacaaatg ctattcaggt ttttgacgtc accgctgtga acatcagtgc cacaagcctg
     1501 accctgatct ggaaagtcag cgataacgag tcgtcatcta actataccta caagatacat
     1561 gtggcggggg agacagattc ttccaatctc aacgtcagtg agcctcgcgc tgtcatcccc
     1621 ggactccgct ccagcacctt ctacaacatc acagtgtgtc ctgtcctagg tgacatcgag
     1681 ggcacgccgg gcttcctcca agtgcacacc ccccctgttc cagtttctga cttccgagtg
     1741 acagtggtca gcacgacgga gatcggctta gcatggagca gccatgatgc agaatcattt
     1801 cagatgcata tcacacagga gggagctggc aattctcggg tagaaataac caccaaccaa
     1861 agtattatca ttggtggctt gttccctgga accaagtatt gctttgaaat agttccaaaa
     1921 ggaccaaatg ggactgaagg ggcatctcgg acagtttgca atagaactgt tcccagtgca
     1981 gtgtttgaca tccacgtggt ctacgtcacc accacggaga tgtggctgga ctggaagagc
     2041 cctgacggtg cttccgagta tgtctaccat ttagtcatag agtccaagca tggctctaac
     2101 cacacaagca cgtatgacaa agcgattact ctccagggcc tgattccggg caccttatat
     2161 aacatcacca tctctccaga agtggaccac gtctgggggg accccaactc cactgcacag
     2221 tacacacggc ccagcaatgt gtccaacatt gatgtaagta ccaacaccac agcagcaact
     2281 ttaagttggc agaactttga tgacgcctct cccacgtact cctactgcct tcttattgag
     2341 aaggctggaa attccagcaa cgcaacacaa gtagtcacgg acattggaat tactgacgct
     2401 acagtcactg aattaatacc tggctcatca tacacagtgg agatctttgc acaagtaggg
     2461 gatgggatca agtcactgga acctggccgg aagtcattct gtacagatcc tgcgtccatg
     2521 gcctccttcg actgcgaagt ggtccccaaa gagccagccc tggttctcaa atggacctgc
     2581 cctcctggcg ccaatgcagg ctttgagctg gaggtcagca gtggagcctg gaacaatgcg
     2641 acccacctgg agagctgctc ctctgagaat ggcactgagt atagaacgga agtcacgtat
     2701 ttgaattttt ctacctcgta caacatcagc atcaccactg tgtcctgtgg aaagatggca
     2761 gcccccaccc ggaacacctg cactactggc atcacagatc cccctcctcc agatggatcc
     2821 cctaatatta catctgtcag tcacaattca gtaaaggtca agttcagtgg atttgaagcc
     2881 agccacggac ccatcaaagc ctatgctgtc attctcacca ccggggaagc tggtcaccct
     2941 tctgcagatg tcctgaaata cacgtatgag gatttcaaaa agggagcctc agatacttat
     3001 gtgacatacc tcataagaac agaagaaaag ggacgttctc agagcttgtc tgaagttttg
     3061 aaatatgaaa ttgacgttgg gaatgagtca accacacttg gttattacaa tgggaagctg
     3121 gaacctctgg gctcctaccg ggcttgtgtg gctggcttca ccaacattac cttccaccct
     3181 caaaacaagg ggctcattga tggggctgag agctatgtgt ccttcagtcg ctactcagat
     3241 gctgtttcct tgccccagga tccaggtgtc atctgtggag cggtttttgg ctgtatcttt
     3301 ggtgccctgg ttattgtgac tgtgggaggc ttcatcttct ggagaaagaa gaggaaagat
     3361 gcaaagaata atgaagtgtc cttttctcaa attaaaccta aaaaatctaa gttaatcaga
     3421 gtggagaatt ttgaggccta cttcaagaag cagcaagctg actccaactg tgggttcgca
     3481 gaggaatacg aagatctgaa gcttgttgga attagtcaac ctaaatatgc agcagaactg
     3541 gctgagaata gaggaaagaa tcgctataat aatgttctgc cctatgatat ttcccgtgtc
     3601 aaactttcgg tccagaccca ttcaacggat gactacatca atgccaacta catgcctggc
     3661 taccactcca agaaagattt tattgccaca caaggacctt taccgaacac tttgaaagat
     3721 ttttggcgta tggtttggga gaaaaatgta tatgccatca ttatgttgac taaatgtgtt
     3781 gaacagggaa gaaccaaatg tgaggagtat tggccctcca agcaggctca ggactatgga
     3841 gacataactg tggcaatgac atcagaaatt gttcttccgg aatggaccat cagagatttc
     3901 acagtgaaaa atatccagac aagtgagagt caccctctga gacagttcca tttcacctcc
     3961 tggccagacc acggtgttcc cgacaccact gacctgctca tcaacttccg gtacctcgtt
     4021 cgtgactaca tgaagcagag tcctcccgaa tcgccgattc tggtgcattg cagtgctggg
     4081 gtcggaagga cgggcacttt cattgccatt gatcgtctca tctaccagat agagaatgag
     4141 aacaccgtgg atgtgtatgg gattgtgtat gaccttcgaa tgcataggcc tttaatggtg
     4201 cagacagagg accagtatgt tttcctcaat cagtgtgttt tggatattgt cagatcccag
     4261 aaagactcaa aagtagatct tatctaccag aacacaactg caatgacaat ctatgaaaac
     4321 cttgcgcccg tgaccacatt tggaaagacc aatggttaca tcgcctaatt ccaaaggaat
     4381 aacctttctg gagtgaacca gaccgtcgca cccacagcga aggcacatgc cccgatgtcg
     4441 acatgttttt atatgtctaa tatcttaatt ctttgttctg ttttgtgaga actaattttg
     4501 agggcatgaa gctgcatatg atagatgaca aattggggct gtcgggggct gtggatgggt
     4561 ggggagcaaa tcatctgcat tcctgatgac caatgggatg aggtcacttt tttttttttt
     4621 cccccttgag gattgtggaa aaccaggaaa agggagctat gatttttttt tccaaaacaa
     4681 tttctttttt aaaaaagact attttatatg attcacatgc taaagccagg attgtgttgg
     4741 gttgaatata ttttaagtat cagaggtcta tttttaccta ctgtgtcttg gaatctagcc
     4801 gatggaaaat acctaattgt ggatgatgat tgcgcaggga ggggtacgtg gcacctcttc
     4861 cgaatgggtt ttctatttga acatgtgcct tttctgaatt atgcttccac aggcaaaact
     4921 cagtagagat ctatattttt gtactgaatc tcataattgg aatatacgga atatttaaac
     4981 agtagcttag catcagaggt ttgcttcctc agtaacattt ctgttctcat ttgatcaggg
     5041 gaggcctctt tgccccgact ccgcttcccc tgccccctgt acatttgtgc tccatttttt
     5101 cttccctttt ccctcccagt tttctccaaa gactcttctg ttggcaacat tttcaaccca
     5161 ttggttgggt gagaatggcg actcaaatat caccttgaga atttctgtgg gtgggaatgg
     5221 gagaagcaga ggaatcctac agtggcagaa atccttttct tgtccctgta ttatcctttt
     5281 tctcatgtct gtatttggta tgaaggatta tttaaaggtg caatatgtga attagtgatt
     5341 catgatgttc taggttttta gtaacgtttt actcaggttg gcattttatg tgtctgtgtc
     5401 tgtatgtgtg tgtgtatgtt cagaagcgtg gcaatctgtg aacacttcag cgtgaattca
     5461 gtgtcagatt aatccctcct tccccaaagt ccactggctt tcgtctctct ctgccgtgac
     5521 acatatcgga atctactgtg tatatatata tatatatata tatatatata tatatatata
     5581 tatatataca ctaagctctc aaaaacagtc attcctatga attgaggtgt acaaagtttg
     5641 aatttgtatc aaagatgtaa ttattatttt taaaaccttt tcactatact gctgctgtaa
     5701 ttactttgat ttttaaaatg tagattaatt tttttttttt tgcttcaggt gtgtatccac
     5761 caagaatttc aaatttatgt ggatttattt tattggtaca taatctgtaa acttcttaag
     5821 gcattaacat gaaaagattt tttcttttta ttttatattg tggctcaggt tatattttga
     5881 agatgttttg agtttatcct ccaataggca atgaagttga caaggtttta tgaaggaata
     5941 accaagtccc tggagtcctg tggctgttgc cacagtaatg tgtcctgctg taaacaggac
     6001 aggtgtgtcc tgttgagaat gtgagcgggc tcttccagcc tcctggtccc tcctgactct
     6061 gccacgcccc tcacctcact ggcacttcga taactgactg gacgtgttaa tgggtctttt
     6121 agggttctaa agggtgaacc acacttttaa agccccggct gtggttcgga gggttagtgc
     6181 tgtatgcctt ttatttccct ttccctttga ggtactgaaa ggatgaaaag gtggtgtcat
     6241 gttttgggga gaatcttact tctcaaatgg aaattgcact ttttgctgaa tcctttgcat
     6301 ttttttggta gtaagcagtt cattgagtat caggtcctca aaggaatgag ttggcccggc
     6361 tagggtgggc cctcttgacc taacttcaga gggggccttg gctcagtagg tgtgaatcag
     6421 ggaagccaca ttgtcctcag ggtgctgtat gaagctgggt gtgggcggat tcctcccaca
     6481 ccttcacact ggcctgcctc caactcatac agatctcgga gcggtcggta cttcattcat
     6541 aggtccctgt tcaggcagca gttctgtggg ctgtggccct ctcccctcca atatgtccga
     6601 aaccattgtg atgggtggca aatcccaggg agctcctaag ccctgctctg cccacatcac
     6661 tgccacagag aagtcagagg aagggacttg ttgctaaaaa atcctttaaa aggttaaata
     6721 ctttaaaaga ttaaagcaac ataactgtaa acatattgta taaaaatgaa aaacacagga
     6781 accctcttcc cttccgcctg gtgtgggctt gggaaatggg caagcggccc cagcaatcat
     6841 gggaggaact cttgcggggg agcggtctgg gattccaaat gggcaggtca cacgaaggtc
     6901 acgatgcttc tctgcatcct gaaaagggct ggggacaggg ccagtggggg tggtaagggt
     6961 atttatagca cagtgcttga aaagggaaga ttaatgtgta aatataaagg acacacaggc
     7021 tgggggttgg tcagaggcaa gaggagggtg cctctgagct tcaacccctc ccaggaacaa
     7081 tgagctcaaa ttggaagagt ccagtggaat cggggggatg gtgtgagcac ccctgttcag
     7141 tctttgacaa ttgcatacag aaaagcagct ggtatgggtt tgggtgtcaa tgaaagggcc
     7201 aaagactggt ggccagctgg tttgggggat ttgggccatt gatagcatct cccaggaaca
     7261 acgacttttt gcctccaaag ttggatctag tgatgatcag caccagcagg aaatgacatt
     7321 tggtgtctgc ccactgcagc catactgtga cctccagcca gacttccgcc taattgactc
     7381 cactggattt gtgctctgtt gagtcagagg ctcccggggg ttggggatcg aggggcgggg
     7441 gtcagctatg cagcccatca cgtgtgtttt tcatctggga tgaaaaagcc tggttctctt
     7501 ttgaaatgct tgattgtact tattgagcta aacaagtctt ggtgactgtt gttgatttgc
     7561 ctcaaaagtt ttaagtcctg ggttttcaga ctactgtgta gcagctgtgt gtttaacata
     7621 ctgtagcttt ttctcccttg ggggcacata caaataggat gtgttgatgt ggactctaaa
     7681 ctgtaatttt cctgtaacta ttttggaatg atgcatattt ctaatgtttg ttatacttgt
     7741 acagagtatt gctgttggtt gctttttttt tttttaagga aaaaatggcc tgaaaacatt
     7801 tttttaaaga cttacaaata ccaaatataa aaaaatgtca atgca
//
