LOCUS       NM_002842               3923 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type H (PTPRH),
            transcript variant 1, mRNA.
ACCESSION   NM_002842
VERSION     NM_002842.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Wang,S., Cheng,Z., Cui,Y., Xu,S., Luan,Q., Jing,S., Du,B., Li,X.
            and Li,Y.
  TITLE     PTPRH promotes the progression of non-small cell lung cancer via
            glycolysis mediated by the PI3K/AKT/mTOR signaling pathway
  JOURNAL   J Transl Med 21 (1), 819 (2023)
   PUBMED   37974250
  REMARK    GeneRIF: PTPRH promotes the progression of non-small cell lung
            cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Swiatnicki,M.R., Rennhack,J.P., Ortiz,M.M.O., Hollern,D.P.,
            Perry,A.V., Kubiak,R., Riveria Riveria,S.M., O'Reilly,S. and
            Andrechek,E.R.
  TITLE     Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH
  JOURNAL   PLoS Genet 18 (9), e1010362 (2022)
   PUBMED   36054194
  REMARK    GeneRIF: Elevated phosphorylation of EGFR in NSCLC due to mutations
            in PTPRH.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Kim,M. and Ryu,S.E.
  TITLE     Crystal structure of the catalytic domain of human RPTPH
  JOURNAL   Acta Crystallogr F Struct Biol Commun 78 (Pt 7), 265-269 (2022)
   PUBMED   35787553
  REMARK    GeneRIF: Crystal structure of the catalytic domain of human RPTPH.
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Chen,A., Ding,S., Shen,X. and Lin,X.
  TITLE     The High Expression of PTPRH Is Associated with Poor Prognosis of
            Human Lung Adenocarcinoma
  JOURNAL   Comput Math Methods Med 2021, 9932088 (2021)
   PUBMED   34367321
  REMARK    GeneRIF: The High Expression of PTPRH Is Associated with Poor
            Prognosis of Human Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Dorofejeva,O. and Barr,A.J.
  TITLE     Defining the molecular basis of interaction between R3
            receptor-type protein tyrosine phosphatases and VE-cadherin
  JOURNAL   PLoS One 12 (9), e0184574 (2017)
   PUBMED   28926625
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Nagano,H., Noguchi,T., Inagaki,K., Yoon,S., Matozaki,T., Itoh,H.,
            Kasuga,M. and Hayashi,Y.
  TITLE     Downregulation of stomach cancer-associated protein tyrosine
            phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma
  JOURNAL   Oncogene 22 (30), 4656-4663 (2003)
   PUBMED   12879010
  REMARK    GeneRIF: SAP-1 expression is downregulated during the
            dedifferentiation of human hepatocellular carcinoma, which may play
            a causal role in disease progression
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Takada,T., Noguchi,T., Inagaki,K., Hosooka,T., Fukunaga,K.,
            Yamao,T., Ogawa,W., Matozaki,T. and Kasuga,M.
  TITLE     Induction of apoptosis by stomach cancer-associated
            protein-tyrosine phosphatase-1
  JOURNAL   J Biol Chem 277 (37), 34359-34366 (2002)
   PUBMED   12101188
  REMARK    GeneRIF: SAP-1 induces apoptotic cell death by inhibition of cell
            survival signaling mediated by PI 3-kinase, Akt, and ILK and
            activation of a caspase-dependent proapoptotic pathway.
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Noguchi,T., Tsuda,M., Takeda,H., Takada,T., Inagaki,K., Yamao,T.,
            Fukunaga,K., Matozaki,T. and Kasuga,M.
  TITLE     Inhibition of cell growth and spreading by stomach
            cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through
            dephosphorylation of p130cas
  JOURNAL   J Biol Chem 276 (18), 15216-15224 (2001)
   PUBMED   11278335
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Marneros,A.G., Mehenni,H., Reichenberger,E., Antonarakis,S.E.,
            Krieg,T. and Olsen,B.R.
  TITLE     Gene for the human transmembrane-type protein tyrosine phosphatase
            H (PTPRH): genomic structure, fine-mapping and its exclusion as a
            candidate for Peutz-Jeghers syndrome
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 213-216 (2001)
   PUBMED   11435690
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Matozaki,T., Suzuki,T., Uchida,T., Inazawa,J., Ariyama,T.,
            Matsuda,K., Horita,K., Noguchi,H., Mizuno,H., Sakamoto,C. et al.
  TITLE     Molecular cloning of a human transmembrane-type protein tyrosine
            phosphatase and its expression in gastrointestinal cancers
  JOURNAL   J Biol Chem 269 (3), 2075-2081 (1994)
   PUBMED   8294459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010327.8 and KF456611.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002842.4.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and a single
            intracytoplasmic catalytic domain, and thus represents a
            receptor-type PTP. The extracellular region contains eight
            fibronectin type III-like repeats and multiple N-glycosylation
            sites. The gene was shown to be expressed primarily in brain and
            liver, and at a lower level in heart and stomach. It was also found
            to be expressed in several cancer cell lines, but not in the
            corresponding normal tissues. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D15049.2, BC111716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376350.8/ ENSP00000365528.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC010327.8         102829-102947       c
            120-153             AC010327.8         100612-100645       c
            154-420             AC010327.8         100135-100401       c
            421-687             AC010327.8         98772-99038         c
            688-954             AC010327.8         97228-97494         c
            955-1221            AC010327.8         95502-95768         c
            1222-1488           AC010327.8         93682-93948         c
            1489-1758           AC010327.8         92089-92358         c
            1759-2058           AC010327.8         90563-90862         c
            2059-2325           AC010327.8         89968-90234         c
            2326-2404           AC010327.8         85109-85187         c
            2405-2452           AC010327.8         84947-84994         c
            2453-2543           KF456611.1         92-182
            2544-2634           AC010327.8         80959-81049         c
            2635-2711           AC010327.8         79910-79986         c
            2712-2846           AC010327.8         79671-79805         c
            2847-2969           AC010327.8         79308-79430         c
            2970-3130           AC010327.8         78948-79108         c
            3131-3266           AC010327.8         75462-75597         c
            3267-3923           AC010327.8         74693-75349         c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3923
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /note="protein tyrosine phosphatase receptor type H"
                     /db_xref="GeneID:5794"
                     /db_xref="HGNC:HGNC:9672"
                     /db_xref="MIM:602510"
     exon            1..119
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..3416
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane-type protein-tyrosine phosphatase
                     type H; stomach cancer-associated protein tyrosine
                     phosphatase 1; receptor-type tyrosine-protein phosphatase
                     H"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase H
                     isoform 1 precursor"
                     /protein_id="NP_002833.4"
                     /db_xref="CCDS:CCDS33110.1"
                     /db_xref="GeneID:5794"
                     /db_xref="HGNC:HGNC:9672"
                     /db_xref="MIM:602510"
                     /translation="MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTS
                     SISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVE
                     KDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG
                     GRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEA
                     QTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCS
                     VWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEY
                     TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNL
                     HMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTL
                     YTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSY
                     WVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN
                     EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSR
                     TNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGV
                     NLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKV
                     VSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPG
                     DIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPY
                     DWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT
                     LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQK
                     TLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTL
                     IALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPA
                     EKEVPYEDVENLIYENVAAIQAHKLEV"
     exon            120..153
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..420
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..687
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..954
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1221
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1488
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1758
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..2058
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2325
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2404
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2452
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2543
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2634
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2711
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2846
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2969
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3130
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3266
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3923
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3901..3906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3923
                     /gene="PTPRH"
                     /gene_synonym="R-PTP-H; SAP1"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtaaag tccagcaggt ggaaggacta ggcctgggac tcctgggtcc ccggcagtgt
       61 ctggaggcat ggctggggct ggcgggggcc tcggggtctg ggggaacctg gtgctgctgg
      121 gcctgtgcag ctggacaggg gccagggcgc ctgcccccaa cccagggagg aacctgacag
      181 tggagactca gaccaccagc tccatctccc tgagctggga ggtccccgat ggcctagact
      241 cacagaactc caactactgg gttcagtgta ctggagacgg cggcacaaca gagactcgaa
      301 acacaacagc caccaacgtc accgtggatg gccttggacc cgggtcattg tatacgtgtt
      361 ctgtgtgggt ggagaaagac ggagtaaata gctctgtggg gactgtcact actgccacag
      421 ctcccaaccc agtgaggaac ctgagagtgg aggctcagac caacagctcc atcgccctga
      481 cctgggaggt ccccgacggc ccagacccac agaactccac ctacggggtt gagtacactg
      541 gagatggtgg cagagcaggg actcgaagca cagcacacac taacatcacc gtggatggac
      601 ttgaacccgg gtgtttgtat gcgttttcca tgtgggtggg aaagaatgga atcaacagct
      661 cccgggagac tcgaaatgcc accacagctc acaacccagt gaggaacctg agagtggagg
      721 ctcagaccac cagctccatc tccctgagct gggaggtccc cgatggcaca gacccacaga
      781 actcgaccta ctgcgttcag tgcactggag atggtggcag aacagagact cgaaacacaa
      841 cagacaccag agtcaccgtg gatggccttg gacccgggtc attgtatacg tgttctgtgt
      901 gggtggagaa agacggagta aatagctctg tggagattgt cactagtgcc acagctccca
      961 acccagtgag aaacctgaca gtggaggctc agaccaacag ctccatcgcc ctgacctggg
     1021 aggtccccga tggcccagac ccacagaact ccacctacgg ggttgagtac actggagatg
     1081 gtggcagagc agggactcga agcacagcac acaccaacat caccgtggat agacttgaac
     1141 ccgggtgttt gtatgtgttt tccgtgtggg tggggaagaa tggaatcaac agctcccggg
     1201 agactcgaaa tgccaccaca gcccccaacc cagtgagaaa cctccatatg gagactcaga
     1261 ccaacagctc catcgcccta tgctgggaag tccccgatgg cccataccct caggactaca
     1321 cctactgggt agagtacact ggagacggtg gtggcacaga gacccgaaac acaacaaata
     1381 ccagtgtgac agctgagaga cttgagcccg gaaccttgta cacattctct gtatgggcag
     1441 aaaaaaatgg agcacgtggc tccaggcaga atgtcagcat ctccacagtc cccaacgcag
     1501 tgacaagcct cagcaagcag gactggacca acagcaccat tgctttgcgc tggacagctc
     1561 cccagggccc aggccagtct tcctacagct actgggtctc atgggtcagg gaaggcatga
     1621 ctgaccccag gacccaaagc acctcaggta ctgacatcac cctaaaggaa ctggaagctg
     1681 gcagcctgta ccacctcacc gtctgggccg agaggaatga ggtcagaggc tataacagca
     1741 ccctcactgc agccactgct cccaatgagg tcacagatct ccagaatgaa actcagacta
     1801 agaactcagt catgctgtgg tggaaggccc ctggagaccc ccactctcag ttgtacgtat
     1861 actgggtcca gtgggccagc aagggacatc cccggagggg gcaagatccc caagcgaatt
     1921 gggtcaacca gaccagcagg accaatgaga cgtggtacaa agtggaggcc ctggaacccg
     1981 ggacgttgta caatttcacc gtgtgggcag agaggaatga cgtagccagt tccacgcaga
     2041 gcctctgtgc gtccacatac ccagacacag tcaccatcac ttcctgtgtc agcacctcag
     2101 cgggctatgg agtcaacttg atctggtcct gcccccaggg aggctacgag gcctttgagt
     2161 tggaggtggg aggacagcgg ggctcccagg acagatcttc atgtggggag gctgtgtctg
     2221 tgttgggtct cgggccggct cggtcctacc cagccaccat cacgaccatc tgggacggaa
     2281 tgaaggtcgt gtctcactct gtggtctgcc acaccgagag tgcaggggtc attgccggag
     2341 cctttgtggg catcctcctg tttctcatcc tcgtgggcct gctgattttc ttcctgaaga
     2401 ggaggaataa gaagaagcag cagaaaccag aactcaggga tctggtcttt agctccccag
     2461 gggacatccc agctgaagac ttcgctgacc acgtcaggaa gaatgagagg gacagcaact
     2521 gtggttttgc agacgagtac cagcaactct ccctggtggg ccacagccag tctcagatgg
     2581 tggcttcggc ttcagagaac aacgccaaga accgctacag aaatgtgctg ccctatgact
     2641 ggtcccgggt gcccctgaag cccatccatg aggagccagg ctctgactac atcaatgcca
     2701 gcttcatgcc cggtctctgg agcccccagg agttcattgc aacccagggt cccctgccac
     2761 agacagtggg tgacttctgg cgcctggtgt gggaacagca gagccacacc ctggtcatgc
     2821 tgaccaactg catggaggcc ggccgggtga agtgtgagca ttactggcct ctggactcgc
     2881 agccctgcac ccatgggcac ctgcgggtaa ccctggtagg tgaggaagtg atggagaact
     2941 ggacggtgcg ggaactgctg ctcctccagg tggaggagca gaagacactg tctgtgcgcc
     3001 aattccacta ccaggcctgg ccggatcacg gcgttccctc ctccccagac accttgctgg
     3061 ctttctggag gatgcttcgg cagtggctgg atcagaccat ggagggaggc ccacccattg
     3121 tgcactgcag tgctggcgtg ggtcgcacag gaaccctcat tgccctggac gtcctgctcc
     3181 ggcagctgca gtccgagggt ctccttgggc ccttcagctt tgtaaggaag atgagagaga
     3241 gtcggccgtt gatggtgcag actgaggctc agtacgtatt cctgcatcag tgcatcctgc
     3301 ggttcctcca acagtcagcc caggccccag ccgagaagga agtcccgtat gaggatgtcg
     3361 aaaacctcat ctacgagaac gtggccgcca tccaggccca caagttggag gtctaagtga
     3421 cgagggggct gggtcggcag cccaggcatc ctcaagctct ggacacccac ttgagcccag
     3481 attcctggaa gagcagaggg ctgggctccc agactcctgg gtgctgtggg aggagggggc
     3541 tggtatccca aactctggtt tccccaggag agagtggtct ggtgggcttc agatgagtcc
     3601 tatgggagct ggggatctgg attcctggtt ccctgaagga ggagagggat gatagcttgg
     3661 attccctagg tctttccagg atgcagaaag aaacaggctg gggcctggat tctgaggcag
     3721 gaaggaattt gggtctggag ttctggctac ttgaggacca aaggcaggaa ggatcctgcc
     3781 ttgattttac ttcagaaacc aaatcagtct tctataatct ggggtcggag ggagtccctg
     3841 tgcccaaggt ctctctgcac cccaccatcc acatgtattt ttccttctat cccataattt
     3901 attaaatcac tgttctcccc aga
//
