LOCUS       NM_002841               9357 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type G (PTPRG),
            transcript variant 1, mRNA.
ACCESSION   NM_002841
VERSION     NM_002841.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9357)
  AUTHORS   Joshi,M.S., Stanoev,A., Huebinger,J., Soetje,B., Zorina,V.,
            Rossmannek,L., Michel,K., Muller,S.A. and Bastiaens,P.I.
  TITLE     The EGFR phosphatase RPTPgamma is a redox-regulated suppressor of
            promigratory signaling
  JOURNAL   EMBO J 42 (10), e111806 (2023)
   PUBMED   36988334
  REMARK    GeneRIF: The EGFR phosphatase RPTPgamma is a redox-regulated
            suppressor of promigratory signaling.
REFERENCE   2  (bases 1 to 9357)
  AUTHORS   Sloth,R.A., Axelsen,T.V., Espejo,M.S., Toft,N.J., Voss,N.C.S.,
            Burton,M., Thomassen,M., Vahl,P. and Boedtkjer,E.
  TITLE     Loss of RPTPgamma primes breast tissue for acid extrusion, promotes
            malignant transformation and results in early tumour recurrence and
            shortened survival
  JOURNAL   Br J Cancer 127 (7), 1226-1238 (2022)
   PUBMED   35821297
  REMARK    GeneRIF: Loss of RPTPgamma primes breast tissue for acid extrusion,
            promotes malignant transformation and results in early tumour
            recurrence and shortened survival.
REFERENCE   3  (bases 1 to 9357)
  AUTHORS   Lombardi,G., Latorre,R.V., Mosca,A., Calvanese,D., Tomasello,L.,
            Boni,C., Ferracin,M., Negrini,M., Dewik,N.A., Yassin,M.,
            Ismail,M.A., Carpentieri,B., Sorio,C. and Lecca,P.
  TITLE     Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells
            Overexpressing the Tumor Suppressor Gene PTPRG
  JOURNAL   Int J Mol Sci 23 (17), 9899 (2022)
   PUBMED   36077295
  REMARK    GeneRIF: Gene Expression Landscape of Chronic Myeloid Leukemia K562
            Cells Overexpressing the Tumor Suppressor Gene PTPRG.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9357)
  AUTHORS   Ismail,M.A., Nasrallah,G.K., Monne,M., AlSayab,A., Yassin,M.A.,
            Varadharaj,G., Younes,S., Sorio,C., Cook,R., Modjtahedi,H. and
            Al-Dewik,N.I.
  TITLE     Description of PTPRG genetic variants identified in a cohort of
            Chronic Myeloid Leukemia patients and their ability to influence
            response to Tyrosine kinase Inhibitors
  JOURNAL   Gene 813, 146101 (2022)
   PUBMED   34906644
  REMARK    GeneRIF: Description of PTPRG genetic variants identified in a
            cohort of Chronic Myeloid Leukemia patients and their ability to
            influence response to Tyrosine kinase Inhibitors.
REFERENCE   5  (bases 1 to 9357)
  AUTHORS   Boni,C., Laudanna,C. and Sorio,C.
  TITLE     A Comprehensive Review of Receptor-Type Tyrosine-Protein
            Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease
  JOURNAL   Biomolecules 12 (1), 84 (2022)
   PUBMED   35053232
  REMARK    GeneRIF: A Comprehensive Review of Receptor-Type Tyrosine-Protein
            Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic
            Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9357)
  AUTHORS   Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D.,
            D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al.
  TITLE     Identification of a carbonic anhydrase-like domain in the
            extracellular region of RPTP gamma defines a new subfamily of
            receptor tyrosine phosphatases
  JOURNAL   Mol Cell Biol 13 (3), 1497-1506 (1993)
   PUBMED   8382771
REFERENCE   7  (bases 1 to 9357)
  AUTHORS   Latif,F., Tory,K., Modi,W., Geil,L., LaForgia,S., Huebner,K.,
            Zbar,B. and Lerman,M.I.
  TITLE     A MspI polymorphism and linkage mapping of the human
            protein-tyrosine phosphatase G (PTPRG) gene
  JOURNAL   Hum Mol Genet 2 (1), 91 (1993)
   PUBMED   7683956
REFERENCE   8  (bases 1 to 9357)
  AUTHORS   LaForgia,S., Morse,B., Levy,J., Barnea,G., Cannizzaro,L.A., Li,F.,
            Nowell,P.C., Boghosian-Sell,L., Glick,J., Weston,A. et al.
  TITLE     Receptor protein-tyrosine phosphatase gamma is a candidate tumor
            suppressor gene at human chromosome region 3p21
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 5036-5040 (1991)
   PUBMED   1711217
REFERENCE   9  (bases 1 to 9357)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
REFERENCE   10 (bases 1 to 9357)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036018.1, BC140904.1 and
            AC092502.2.
            
            On Nov 22, 2018 this sequence version replaced NM_002841.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. The extracellular region of this PTP contains a
            carbonic anhydrase-like (CAH) domain, which is also found in the
            extracellular region of PTPRBETA/ZETA. This gene is located in a
            chromosomal region that is frequently deleted in renal cell
            carcinoma and lung carcinoma, thus is thought to be a candidate
            tumor suppressor gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209871.1, BC140904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000474889.6/ ENSP00000418112.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BC036018.1         3-342
            341-3164            BC140904.1         1-2824
            3165-3184           AC092502.2         13982-14001
            3185-5077           BC140904.1         2845-4737
            5078-6646           AC092502.2         63434-65002
            6647-9357           AC092502.2         65003-67713
FEATURES             Location/Qualifiers
     source          1..9357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     gene            1..9357
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /note="protein tyrosine phosphatase receptor type G"
                     /db_xref="GeneID:5793"
                     /db_xref="HGNC:HGNC:9671"
                     /db_xref="MIM:176886"
     exon            1..802
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             718..5055
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor type,
                     gamma polypeptide; receptor tyrosine phosphatase gamma;
                     receptor-type protein phosphatase gamma; protein tyrosine
                     phosphatase gamma; receptor-type tyrosine-protein
                     phosphatase gamma; H_RG317H01.1; receptor type protein
                     tyrosine phosphatase gamma"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase gamma
                     isoform 1 precursor"
                     /protein_id="NP_002832.3"
                     /db_xref="CCDS:CCDS2895.1"
                     /db_xref="GeneID:5793"
                     /db_xref="HGNC:HGNC:9671"
                     /db_xref="MIM:176886"
                     /translation="MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHG
                     SAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQEL
                     QLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAG
                     SEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPII
                     HGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPI
                     SYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFL
                     ENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNED
                     EKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQ
                     GTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVA
                     SVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDG
                     DSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPS
                     PTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATE
                     EQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIP
                     LIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTA
                     HFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQ
                     RCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDG
                     YNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE
                     YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMG
                     VPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNV
                     LGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGG
                     KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD
                     YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVY
                     WPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWP
                     NPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVD
                     VFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESD
                     PAESMESLV"
     exon            803..907
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1087
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1236
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1332
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1399
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1557
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1750
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1935
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2044
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2094
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2872
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3005
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3092
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3184
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3276
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3373
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3456
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3591
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3726
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3899
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4035
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4182
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4276
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4353
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4482
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4629
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4772
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4908
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..9357
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6025..6030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /note="hexamer: AATAAA"
     polyA_site      6043
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /note="major polyA site"
     regulatory      9335..9340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /note="hexamer: AATAAA"
     polyA_site      9357
                     /gene="PTPRG"
                     /gene_synonym="HPTPG; PTPG; R-PTP-GAMMA; RPTPG"
                     /note="major polyA site"
ORIGIN      
        1 atgttacttc ctgtatggag gcatggccag tttccagccc cgcgctcttc gttccttccc
       61 agcctgcgcc ggagccacaa ctttcaggag catggactga aggcgccctc gccccagcgc
      121 ccctctgaga tcctttgtgt tttcctccgt ttcctccggc cgtttctatt ttggggggct
      181 ctccgctccc cctgcctctc ccctcccctt cccctctcgc aaacatgcct ccttccttcc
      241 cggggccctg gaaggagctg cctgcctgaa gcccggagac gccgcgccgc gctcagcccc
      301 gccgccgccc gccggctctc gggctgtgct gcgctgccga ctcaagttgg ggatcctcgg
      361 ctgctcgccg ccgccgcccg cggtccctgc ctgccccagg cccggggcat cgccgccggc
      421 cgccgactcc gcgccctgcc cgatcggctc tctccttttt aaacggaaag cagcctttct
      481 ccgccgagag gatcgtcccc agcgtggctc tgcgttcccg gtcacttttt gagattttcc
      541 ggggggcgct cggcggcttc ccggattcca aggggactcg ggccgccgag cgcggggggc
      601 ccgtggagcg ggcgagccgg ggaagcgccc cggcttagcg gaggctcgca cggaggcaag
      661 aacttattca acaagtttac ctccctgctt tcctcttttc gatgtgcgtt ttcggacatg
      721 cggaggttac tggaaccgtg ttggtggatt ttgttcctga aaatcaccag ttccgtgctc
      781 cattatgtcg tgtgcttccc cgcgttgaca gaaggctacg ttggggccct gcacgagaat
      841 agacacggca gcgcagtgca gatccgcagg cgcaaggctt caggcgaccc gtactgggcc
      901 tactctggtg cctatggtcc tgagcactgg gtcacgtcta gtgtcagctg tgggggccgt
      961 caccagtctc ctattgacat tttagaccag tatgcgcgtg ttggggaaga ataccaggaa
     1021 ctgcaactcg atggcttcga caatgagtct tctaacaaaa cctggatgaa aaacacaggg
     1081 aaaacagtcg ccatccttct gaaagacgac tattttgtca gtggagctgg tctacctggc
     1141 agattcaaag ctgagaaggt ggaatttcac tggggccaca gcaatggctc agcgggctct
     1201 gaacacagca tcaatggcag gaggtttcct gttgagatgc agattttctt ttacaatcca
     1261 gatgactttg acagctttca aaccgcaatt tctgagaaca gaataatcgg agccatggcc
     1321 atattttttc aagtcagtcc gagggacaat tctgcactgg atcctattat ccacgggttg
     1381 aagggtgtcg tacatcatga gaaggagacc tttctggatc ctttcgtcct ccgggacctc
     1441 ctgcctgcat ccctgggcag ctattatcgg tacacaggtt ccttgaccac accaccgtgt
     1501 agcgaaatag tggagtggat agtcttccgg agacccgtcc ccatctctta ccatcagctt
     1561 gaggcttttt attccatctt caccacggag cagcaagacc atgtcaagtc ggtggagtat
     1621 ctgagaaata actttcgacc acagcagcgt ctgcatgaca gggtggtgtc caagtccgcc
     1681 gtccgtgact cctggaacca cgacatgaca gacttcttag aaaacccact ggggacagaa
     1741 gcctctaaag tttgcagctc tccacccatc cacatgaagg tgcagcctct gaaccagacg
     1801 gcactgcagg tgtcctggag ccagccggag actatctacc acccacccat catgaactac
     1861 atgatctcct acagctggac caagaatgag gacgagaagg agaagacgtt tacaaaggac
     1921 agcgacaaag acttgaaagc caccattagc catgtctcac ccgatagcct ttacctgttc
     1981 cgagtccagg ccgtgtgtcg gaacgacatg cgcagcgact ttagccagac gatgctgttt
     2041 caagctaata ccactcgaat attccaaggg accagaatag tgaaaacagg agtgcccaca
     2101 gcgtctcctg cctcttcagc cgacatggcc cccatcagct cggggtcttc tacctggacg
     2161 tcctctggca tcccattctc atttgtttcc atggcaactg ggatgggccc ctcctccagt
     2221 ggcagccagg ccacagtggc ctcggtggtc accagcacgc tgctcgccgg cctggggttc
     2281 ggcggtggtg gcatctcctc tttccccagc actgtgtggc ccacgcgcct cccgacggcc
     2341 gcctcagcca gcaagcaggc ggctaggcca gtcctagcca ccacagaggc cttggcttct
     2401 ccagggcccg atggtgattc gtcaccaacc aaggacggcg agggcaccga ggaaggagag
     2461 aaggatgaga aaagcgagag tgaggatggg gagcgggagc acgaggagga tggagagaag
     2521 gactccgaaa agaaggagaa gagtggggtg acccacgctg ccgaggagcg gaatcagacg
     2581 gagcccagcc ccacaccctc gtctcctaac aggactgccg agggagggca tcagactata
     2641 cctgggcatg agcaggatca cactgccgtc cccacagacc agacgggcgg aaggagggat
     2701 gccggcccag gcctggaccc cgacatggtc acctccaccc aagtgccccc caccgccaca
     2761 gaggagcagt atgcagggag tgatcccaag aggcccgaaa tgccatctaa aaagcctatg
     2821 tcccgcgggg accgattttc tgaagacagc agatttatca ctgttaatcc agcggaaaaa
     2881 aacacctctg gaatgataag ccgccctgct ccagggagga tggagtggat catccctctg
     2941 attgtggtat cagccttgac cttcgtgtgc ctcatccttc tcattgctgt gctcgtttac
     3001 tggagagggt gtaacaaaat aaagtccaag ggctttccca gacgtttccg tgaagtgcct
     3061 tcttctgggg agagaggaga gaaggggagc agaaaatgtt ttcagactgc tcatttctat
     3121 gtggaagaca gcagttcacc tcgagtggtc cctaatgaaa gtatccctat tattcctatt
     3181 ccggatgaca tggaagccat tcctgtcaaa cagtttgtca aacacatcgg tgagctctat
     3241 tctaataacc agcatgggtt ctctgaggat tttgaggaag tccagcgctg tactgctgat
     3301 atgaacatca ctgcagagca ttccaatcat ccagaaaaca agcacaaaaa cagatacatc
     3361 aacattttag catatgatca cagtagggtg aagttaagac ctttaccagg aaaagactct
     3421 aagcacagcg actacattaa tgcaaactat gttgatggtt acaacaaagc aaaagcctac
     3481 attgccaccc aaggaccttt gaagtctaca tttgaagatt tctggaggat gatttgggaa
     3541 caaaacactg gaatcattgt gatgattacg aaccttgtgg aaaaaggaag acgaaaatgt
     3601 gatcagtatt ggccaacaga gaacagtgag gaatatggaa acattattgt cacgctgaag
     3661 agcacaaaaa tacatgcctg ctacactgtt cgtcgttttt caatcagaaa tacaaaagtg
     3721 aaaaagggtc agaagggaaa tcccaagggt cgtcagaatg aaagggtagt gatccagtat
     3781 cactatacac agtggcctga catgggagtt cccgagtatg cccttccagt actgactttc
     3841 gtgaggagat cctcagcagc tcggatgcca gaaacgggcc ctgtgttggt gcactgcagt
     3901 gctggtgtgg gcagaacagg cacctatatt gtaatagaca gcatgctgca acagataaaa
     3961 gacaaaagca cagttaacgt cctgggattc ctgaagcata tcaggacaca gcgtaactac
     4021 ctcgtccaga ctgaggagca gtacattttc atccatgatg ccttgttgga agccattctt
     4081 ggaaaggaga ctgaagtatc ttcaaatcag ctgcacagct atgttaacag catccttata
     4141 ccaggagtag gaggaaagac acgactggaa aagcaattca agctggtcac acagtgtaat
     4201 gcaaaatatg tggaatgttt cagtgctcag aaagagtgta acaaagaaaa gaacagaaac
     4261 tcttcagttg tgccatctga gcgtgctcga gtgggtcttg caccattgcc tggaatgaaa
     4321 ggaacagatt acattaatgc ttcttatatc atgggctatt ataggagcaa tgaatttatt
     4381 ataactcagc atcctctgcc acatactacg aaagatttct ggcgaatgat ttgggatcat
     4441 aacgcacaga tcattgtcat gctgccagac aaccagagct tggcagaaga tgagtttgtg
     4501 tactggccaa gtcgagaaga atccatgaac tgtgaggcct ttaccgtcac ccttatcagc
     4561 aaagacagac tgtgcctctc taatgaagaa caaattatca tccatgactt tatccttgaa
     4621 gctacacagg atgactatgt cttagaagtt cggcactttc agtgtcccaa atggcctaac
     4681 ccagatgccc ccataagtag tacctttgaa cttatcaacg tcatcaagga agaggcctta
     4741 acaagggatg gtcccaccat tgttcatgat gagtatggag cagtttcagc aggaatgtta
     4801 tgtgccctta ccaccctgtc ccagcaactg gagaatgaaa atgctgtgga tgttttccag
     4861 gttgcaaaaa tgatcaatct tatgaggcct ggagtattca cagacattga acaataccag
     4921 ttcatctata aagcaatgct tagcttggtc agcactaaag aaaatggaaa tggtcccatg
     4981 acagtagaca aaaatggtgc tgttcttatt gcagatgaat cagaccctgc tgagagcatg
     5041 gagtccctag tgtgactgga atcctgaaag ggcacttaat ttgtaaactt ctgaagactg
     5101 agaacttttt tgaggccttt tttgccagac tctaggttat acaataaccc agttactttt
     5161 ttacactgat aaaagttttg atatttattt tttgccattt tatgtcttaa tggtatccta
     5221 ctgagcattt gcacctctgt tcatttcaca cagtgaaacg caattttacc tagtttgcac
     5281 tatatgatca gtgttactgc ctataatctt atacaacagc aaaccctgat gtgacattcc
     5341 atgacgacat acatgctact tttttttagt tcaatacagt gaaggtcttt gttatgacag
     5401 tgaatattgc ttttattatt attattgctg aagtggttgc attctactag caggcaatgc
     5461 tgtacttttc ttcagtcctc ctctcctttt tattttaggc actgttcaat actgtatgcc
     5521 ttctgtattt taatggagtg gatagcattg ttttctttta cagactagca ggctactggg
     5581 acctaaaaag gtctgttaat gtcatggcct tgaaacagtt ccatttatgc tggttaagag
     5641 atcccttaag aagttagaag gcttaagaac tgcttcatgt gaacatccct tattagttac
     5701 aaagttatat tcacagtttt ttaaaaatgt gtcaaaataa aggataactc tgtattacag
     5761 ctttcacagt agctatgtgg acaatgtgtt atttccattt tgactctcta aaatagctac
     5821 atcctaaaat cagggctatc tttaacaata gcaagatagc aatattatat acaactcagt
     5881 tatgagaccc tttagttatt ctccattaat gcttcttagt ttgtaatacc atacctcaca
     5941 gtaggtagaa gaatgaaaac ttctgcaggt gtgtaatttt gaaactagtc ctctaaaaat
     6001 tccctattac tcctatagca atctaataaa aactacctac atagttactg ttttctttcc
     6061 ttctttgcca aatgttttat aataaatctc ttaattacat acatttttct acttaagatt
     6121 aaattggaaa tactgtctta gcaaaagtct tgggactatc taaactccca cacatagata
     6181 aatctgattt ggagagagaa atttaaaata tttaattaaa ggtgataccc acattttcaa
     6241 gtttttaaaa gagggagatg gctttgtatg cttttgtgta gtttagaaca gatacacatt
     6301 agtaaaagat accaataatc attagagctc aaggaagtta ttaggtgcag cctctggagc
     6361 catactcacg ctgcagtgca taatgggaaa attaggagca ttaataagaa atttcagtag
     6421 tgtttgtaag gaaaataagc tacttactga gatctgtttc ttctattgca tgtttgcttt
     6481 tgagggacag cttctgtcaa aagtgaaatc atcaccagaa ctgggcctgt taggaagaat
     6541 agggttttat ttacttttta tgtcaattaa cttcaacaaa aaggccacgc tggctgctgt
     6601 catgccatct gggtatgcat taaacattaa tgatgatcag cactgaggtt ctatttatct
     6661 tgatttggct ttcataaagt ttgtcagaat ggtgctggag gaccagaagt gctaaggaga
     6721 aagaagctat gggccaagtt aaagaatttg aatgcaaagg ccaggtcaat ggagttttca
     6781 taaactacat aatttaccag ggtttatctc atcttctcaa tacatagatt taacaacatg
     6841 gaatactctg cttttcaaga gctgcgtaag ctagtcctga gataagatgt tcaagagagc
     6901 atgctaagtt gcatgtgcta gatgagagac acctttacag cccctccgct ccaaccagag
     6961 gtgacacagg aagctctgta aagttcaagt aaagcttgaa cacaggaaca ctacaactgc
     7021 cagatgctga ggagaatcag gaaagcaatg agctagactc tttttttagt caattaagtg
     7081 ggttgtttta gatgtataga gtattgatat gagttaacac tttttagtag atggcaaagt
     7141 gggcttgatg ttcaaaagta atgttcgagt tagggttcat ggtccctttc tcagtaattt
     7201 tttcttaata aaagtaaaca ctggttcaaa gacaaatagc aagtattccc tcctgtgcta
     7261 tttatagagg gctcaattcg tagaaaggca taccctccaa tgcaattctg tggctgtccc
     7321 ttacagtggt ttcagaatca cgaaaaaaca gctagtaaat aggatagaaa caataaaaga
     7381 aagagtttag aagttccctg tgagcaatct gtgtgtcttc agcgagcttg aaccaaagtc
     7441 ttcatatcct gacccactga attataagca attgctactt gcccatcttg ccaaagtagt
     7501 ccaaacacac ttcaatgagg acagttatat ttagcaggtc ctcacccctg caagagacag
     7561 catatcctca ctattattat tcatgtgtta ttggcaaaaa catagcttgc atctttccag
     7621 aggcagagtt tcaaagacag ggttttcttt gagacataag cacattgctt aagtacataa
     7681 caaggttatt aacacttgca ctcaggggaa aggaaatagc tattgcaaat taatgtgtgc
     7741 aacttaataa aataagctgt ttgtgtatat gaatttagct ctaggtaagc aaaatgcaca
     7801 catcatataa aaataaattg caatgatcag accaagtggc tgtgctggac atcaaagaaa
     7861 agacatgctg ttgccatcag gagaactctt tcttatatgc gatagccaag atatcttctt
     7921 taatatgaaa aaagttaatt tctgaatttc aaaaagagta agattagcta attggtcttc
     7981 ctaattttta tgcctttaga gtttttagtc tattcaagta gaagagtcca gcgaggccaa
     8041 agaagggtta cggtgttcaa gttctggttg ttggagtttt tagcccagag tgacatactg
     8101 aaatcagtaa ataattattt tataatgaca cagcacaact gccttgttat gaatttttct
     8161 taaatgcata tatactgtat ttaaaattaa aatatagata ccaatttacc aaagatacat
     8221 attactaatt ctaagcaaaa ctaaaaaaaa aacccaactc atcataattt aagaatcaaa
     8281 atgtagtttg tcttaagaat ttagtggtta tactggaaat gcattttcaa ctcctatgtt
     8341 ctaaagttta tgttcaaatg gtgccagtga atttttatat gaagggaaaa tgcctgcttt
     8401 tttttttttt ttaacagatg taatttcact taaccctttg cgctttccct tagttgtcat
     8461 ttaacataca atactggctt tacttatctc tagaaagaag aaggcatgct acaaatagga
     8521 aggaattgta ataatgatat ttggcctcta ctttgtctta gctgttaaac tgtttttagt
     8581 atttttgtta aatatttgca aagggaagca ttttctacag aggataatta atttcaagaa
     8641 aaatatcttg agttttaaga aataaacatc tccagaaaag gagaaagtcg attttataaa
     8701 atgtcgcaac tctccaacat ttggggtagt gactcctttt ttgttaggac atttgaaact
     8761 agcaagcagc cattgtttct aaagaattct ggcttcacat tgactcatgt ttctttcact
     8821 ccattttgaa atagctaaaa atcattaaaa ctgtaaatat tttgttgctt gggtaagcat
     8881 cttctgggaa ctttgtatct atggtatata atcatagaat tttatatttt catataaagc
     8941 taattttttt ctagtttcaa ctccgtcata gttttttttc ctttttgtgg tggatatgtg
     9001 aattcaactt tctgtgtatt gaagtagcaa aaaccatctt tacattccaa aagaatccaa
     9061 catgtgttat ttctttgagg cagtgattgt gaaagttggg ttttcttttt aattccattg
     9121 accatttgtg caataggaat tagacataat tagtcactga aaacattcgt cacattgacc
     9181 catttggaaa aagtgtgctt tttttttttt tttaaatttg ttcaggggga ggggttttgt
     9241 aacctgaaat ttttcccttt ttcttctgtt taaactatat caaatcattc tattatagtg
     9301 ttatttaata tgtaaattgt attgctatac ataaaataaa gtatggtttt tgatgta
//
