LOCUS       NM_002840               7720 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type F (PTPRF),
            transcript variant 1, mRNA.
ACCESSION   NM_002840
VERSION     NM_002840.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7720)
  AUTHORS   Nguyen,M.Q., Taniguchi,M., Yasumura,M., Iguchi,T. and Sato,M.
  TITLE     Cytoneme-like protrusion formation induced by LAR is promoted by
            receptor dimerization
  JOURNAL   Biol Open 11 (7) (2022)
   PUBMED   35735010
  REMARK    GeneRIF: Cytoneme-like protrusion formation induced by LAR is
            promoted by receptor dimerization.
REFERENCE   2  (bases 1 to 7720)
  AUTHORS   Ye,X., Qiu,R., He,X., Hu,Z., Zheng,F., Huang,X., Xie,X., Chen,F.,
            Ou,H. and Lin,G.
  TITLE     miR-647 inhibits hepatocellular carcinoma cell progression by
            targeting protein tyrosine phosphatase receptor type F
  JOURNAL   Bioengineered 13 (1), 1090-1102 (2022)
   PUBMED   34969357
  REMARK    GeneRIF: miR-647 inhibits hepatocellular carcinoma cell progression
            by targeting protein tyrosine phosphatase receptor type F.
REFERENCE   3  (bases 1 to 7720)
  AUTHORS   Gan,T., Stevens,A.T., Xiong,X., Wen,Y.A., Farmer,T.N., Li,A.T.,
            Stevens,P.D., Golshani,S., Weiss,H.L., Evers,B.M. and Gao,T.
  TITLE     Inhibition of protein tyrosine phosphatase receptor type F
            suppresses Wnt signaling in colorectal cancer
  JOURNAL   Oncogene 39 (44), 6789-6801 (2020)
   PUBMED   32973331
  REMARK    GeneRIF: Inhibition of protein tyrosine phosphatase receptor type F
            suppresses Wnt signaling in colorectal cancer.
REFERENCE   4  (bases 1 to 7720)
  AUTHORS   Vilstrup,J., Simonsen,A., Birkefeldt,T., Strandbygard,D.,
            Lyngso,J., Pedersen,J.S. and Thirup,S.
  TITLE     Crystal and solution structures of fragments of the human leucocyte
            common antigen-related protein
  JOURNAL   Acta Crystallogr D Struct Biol 76 (Pt 5), 406-417 (2020)
   PUBMED   32355037
  REMARK    GeneRIF: Crystal and solution structures of fragments of the human
            leucocyte common antigen-related protein.
REFERENCE   5  (bases 1 to 7720)
  AUTHORS   Xu,Y.Y., Liu,H., Su,L., Xu,N., Xu,D.H., Liu,H.Y., Spaner,D.,
            Bed-David,Y. and Li,Y.J.
  TITLE     PPARgamma inhibits breast cancer progression by upregulating PTPRF
            expression
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (22), 9965-9977 (2019)
   PUBMED   31799666
  REMARK    GeneRIF: PPARgamma inhibits breast cancer progression by
            upregulating PTPRF expression.
REFERENCE   6  (bases 1 to 7720)
  AUTHORS   Hashimoto,N., Feener,E.P., Zhang,W.R. and Goldstein,B.J.
  TITLE     Insulin receptor protein-tyrosine phosphatases. Leukocyte common
            antigen-related phosphatase rapidly deactivates the insulin
            receptor kinase by preferential dephosphorylation of the receptor
            regulatory domain
  JOURNAL   J Biol Chem 267 (20), 13811-13814 (1992)
   PUBMED   1321126
REFERENCE   7  (bases 1 to 7720)
  AUTHORS   Jirik,F.R., Harder,K.W., Melhado,I.G., Anderson,L.L. and
            Duncan,A.M.
  TITLE     The gene for leukocyte antigen-related tyrosine phosphatase (LAR)
            is localized to human chromosome 1p32, a region frequently deleted
            in tumors of neuroectodermal origin
  JOURNAL   Cytogenet Cell Genet 61 (4), 266-268 (1992)
   PUBMED   1486801
REFERENCE   8  (bases 1 to 7720)
  AUTHORS   Streuli,M., Krueger,N.X., Thai,T., Tang,M. and Saito,H.
  TITLE     Distinct functional roles of the two intracellular phosphatase like
            domains of the receptor-linked protein tyrosine phosphatases LCA
            and LAR
  JOURNAL   EMBO J 9 (8), 2399-2407 (1990)
   PUBMED   1695146
REFERENCE   9  (bases 1 to 7720)
  AUTHORS   Streuli,M., Krueger,N.X., Tsai,A.Y. and Saito,H.
  TITLE     A family of receptor-linked protein tyrosine phosphatases in humans
            and Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8698-8702 (1989)
   PUBMED   2554325
REFERENCE   10 (bases 1 to 7720)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y00815.1, BC048768.1,
            AC092815.2 and BU624266.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002840.4.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP possesses an extracellular
            region, a single transmembrane region, and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. The extracellular region contains three Ig-like
            domains, and nine non-Ig like domains similar to that of
            neural-cell adhesion molecule. This PTP was shown to function in
            the regulation of epithelial cell-cell contacts at adherents
            junctions, as well as in the control of beta-catenin signaling. An
            increased expression level of this protein was found in the
            insulin-responsive tissue of obese, insulin-resistant individuals,
            and may contribute to the pathogenesis of insulin resistance. Two
            alternatively spliced transcript variants of this gene, which
            encode distinct proteins, have been reported. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359947.9/ ENSP00000353030.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2009              Y00815.1           8-2016
            2010-2646           BC048768.1         2003-2639
            2647-3743           Y00815.1           2654-3750
            3744-4594           BC048768.1         3710-4560
            4595-4628           Y00815.1           4602-4635
            4629-6411           BC048768.1         4595-6377
            6412-7158           AC092815.2         61559-62305         c
            7159-7720           BU624266.1         24-585              c
FEATURES             Location/Qualifiers
     source          1..7720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..7720
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /note="protein tyrosine phosphatase receptor type F"
                     /db_xref="GeneID:5792"
                     /db_xref="HGNC:HGNC:9670"
                     /db_xref="MIM:179590"
     exon            1..208
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            209..288
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            289..424
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..6057
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte antigen-related (LAR) PTP receptor;
                     receptor-linked protein-tyrosine phosphatase LAR;
                     LCA-homolog; leukocyte antigen-related tyrosine
                     phosphatase; protein tyrosine phosphatase, receptor type,
                     F polypeptide; leukocyte common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     isoform 1 precursor"
                     /protein_id="NP_002831.2"
                     /db_xref="CCDS:CCDS489.2"
                     /db_xref="GeneID:5792"
                     /db_xref="HGNC:HGNC:9670"
                     /db_xref="MIM:179590"
                     /translation="MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSS
                     YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR
                     VSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ
                     IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVA
                     AYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQ
                     YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL
                     PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTR
                     FTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLL
                     SWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQ
                     HLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSM
                     LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKK
                     NYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEML
                     WVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
                     YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPK
                     NRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWR
                     MVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA
                     LHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGV
                     GRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
                     GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKN
                     RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM
                     LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV
                     TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG
                     VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
                     SFDHYAT"
     exon            425..570
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            571..712
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            713..901
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1012
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1282
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1864
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2001
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2146
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2452
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2646
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2673
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2791
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..3370
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3468
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3722
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3816
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..4035
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4190
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4306
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4404
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4528
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4704
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4824
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4979
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5265
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5266..5444
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5445..5571
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5697
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5698..5852
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5853..5988
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     exon            5989..7720
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7700..7705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /note="hexamer: AATAAT"
     polyA_site      7720
                     /gene="PTPRF"
                     /gene_synonym="BNAH2; LAR"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggagcg gtggcggcgg cagaggcggc ggctccagct tcggctccgg ctcgggctcg
       61 ggctccggct ccggctccgg ctccggctcc agctcgggtg gcggtggcgg gagcgggacc
      121 aggtggaggc ggcggcggca gaggagtggg agcagcggcc ctagcggctt gcggggggac
      181 atgcggaccg acggcccctg gataggcgga aggagtggag gccctggtgc ccggcccttg
      241 gtgctgagta tccagcaaga gtgaccgggg tgaagaagca aagactcggt tgattgtcct
      301 gggctgtggc tggctgtgga gctagagccc tggatggccc ctgagccagc cccagggagg
      361 acgatggtgc cccttgtgcc tgcactggtg atgcttggtt tggtggcagg cgcccatggt
      421 gacagcaaac ctgtcttcat taaagtccct gaggaccaga ctgggctgtc aggaggggta
      481 gcctccttcg tgtgccaagc tacaggagaa cccaagccgc gcatcacatg gatgaagaag
      541 gggaagaaag tcagctccca gcgcttcgag gtcattgagt ttgatgatgg ggcagggtca
      601 gtgcttcgga tccagccatt gcgggtgcag cgagatgaag ccatctatga gtgtacagct
      661 actaacagcc tgggtgagat caacactagt gccaagctct cagtgctcga agaggaacag
      721 ctgccccctg ggttcccttc catcgacatg gggcctcagc tgaaggtggt ggagaaggca
      781 cgcacagcca ccatgctatg tgccgcaggc ggaaatccag accctgagat ttcttggttc
      841 aaggacttcc ttcctgtaga ccctgccacg agcaacggcc gcatcaagca gctgcgttca
      901 ggtgccttgc agatagagag cagtgaggaa tccgaccaag gcaagtacga gtgtgtggcg
      961 accaactcgg caggcacacg ttactcagcc cctgcgaacc tgtatgtgcg agtgcgccgc
     1021 gtggctcctc gtttctccat ccctcccagc agccaggagg tgatgccagg cggcagcgtg
     1081 aacctgacat gcgtggcagt gggtgcaccc atgccctacg tgaagtggat gatgggggcc
     1141 gaggagctca ccaaggagga tgagatgcca gttggccgca acgtcctgga gctcagcaat
     1201 gtcgtacgct ctgccaacta cacctgtgtg gccatctcct cgctgggcat gatcgaggcc
     1261 acagcccagg tcacagtgaa agctcttcca aagcctccga ttgatcttgt ggtgacagag
     1321 acaactgcca ccagtgtcac cctcacctgg gactctggga actcggagcc tgtaacctac
     1381 tatggcatcc agtaccgcgc agcgggcacg gagggcccct ttcaggaggt ggatggtgtg
     1441 gccaccaccc gctacagcat tggcggcctc agccctttct cggaatatgc cttccgcgtg
     1501 ctggcggtga acagcatcgg gcgagggccg cccagcgagg cagtgcgggc acgcacggga
     1561 gaacaggcgc cctccagccc accgcgccgc gtgcaggcac gcatgctgag cgccagcacc
     1621 atgctggtgc agtgggagcc tcccgaggag cccaacggcc tggtgcgggg ataccgcgtc
     1681 tactatactc cggactcccg ccgccccccg aacgcctggc acaagcacaa caccgacgcg
     1741 gggctcctca cgaccgtggg cagcctgctg cctggcatca cctacagcct gcgcgtgctt
     1801 gccttcaccg ccgtgggcga tggccctccc agccccacca tccaggtcaa gacgcagcag
     1861 ggagtgcctg cccagcccgc ggacttccag gccgaggtgg agtcggacac caggatccag
     1921 ctctcgtggc tgctgccccc tcaggagcgg atcatcatgt atgaactggt gtactgggcg
     1981 gcagaggacg aagaccaaca gcacaaggtg accttcgacc caacctcctc ctacacacta
     2041 gaggacctga agcctgacac actctaccgc ttccagctgg ctgcacgctc ggatatgggg
     2101 gtgggcgtct tcacccccac cattgaggcc cgcacagccc agtccacccc ctccgcccct
     2161 ccccagaagg tgatgtgtgt gagcatgggc tccaccacgg tccgggtaag ttgggtcccg
     2221 ccgcctgccg acagccgcaa cggcgttatc acccagtact ccgtggccta cgaggcggtg
     2281 gacggcgagg accgcgggcg gcatgtggtg gatggcatca gccgtgagca ctccagctgg
     2341 gacctggtgg gcctggagaa gtggacggag taccgggtgt gggtgcgggc acacacagac
     2401 gtgggccccg gccccgagag cagcccggtg ctggtgcgca ccgatgagga cgtgcccagc
     2461 gggcctccgc ggaaggtgga ggtggagcca ctgaactcca ctgctgtgca tgtctactgg
     2521 aagctgcctg tccccagcaa gcagcatggc cagatccgcg gctaccaggt cacctacgtg
     2581 cggctggaga atggcgagcc ccgtggactc cccatcatcc aagacgtcat gctagccgag
     2641 gcccagtggc ggccagagga gtccgaggac tatgaaacca ctatcagcgg cctgaccccg
     2701 gagaccacct actccgttac tgttgctgcc tataccacca agggggatgg tgcccgcagc
     2761 aagcccaaaa ttgtcactac aacaggtgca gtcccaggcc ggcccaccat gatgatcagc
     2821 accacggcca tgaacactgc gctgctccag tggcacccac ccaaggaact gcctggcgag
     2881 ctgctgggct accggctgca gtactgccgg gccgacgagg cgcggcccaa caccatagat
     2941 ttcggcaagg atgaccagca cttcacagtc accggcctgc acaaggggac cacctacatc
     3001 ttccggcttg ctgccaagaa ccgggctggc ttgggtgagg agttcgagaa ggagatcagg
     3061 acccccgagg acctgcccag cggcttcccc caaaacctgc atgtgacagg actgaccacg
     3121 tctaccacag aactggcctg ggacccgcca gtgctggcgg agaggaacgg gcgcatcatc
     3181 agctacaccg tggtgttccg agacatcaac agccaacagg agctgcagaa catcacgaca
     3241 gacacccgct ttacccttac tggcctcaag ccagacacca cttacgacat caaggtccgc
     3301 gcatggacca gcaaaggctc tggcccactc agccccagca tccagtcccg gaccatgccg
     3361 gtggagcaag tgtttgccaa gaacttccgg gtggcggctg caatgaagac gtctgtgctg
     3421 ctcagctggg aggttcccga ctcctataag tcagctgtgc cctttaagat tctgtacaat
     3481 gggcagagtg tggaggtgga cgggcactcg atgcggaagc tgatcgcaga cctgcagccc
     3541 aacacagagt actcgtttgt gctgatgaac cgtggcagca gcgcaggggg cctgcagcac
     3601 ctggtgtcca tccgcacagc ccccgacctc ctgcctcaca agccgctgcc tgcctctgcc
     3661 tacatagagg acggccgctt cgatctctcc atgccccatg tgcaagaccc ctcgcttgtc
     3721 aggtggttct acattgttgt ggtgcccatt gaccgtgtgg gcgggagcat gctgacgcca
     3781 aggtggagca cacccgagga actggagctg gacgagcttc tagaagccat cgagcaaggc
     3841 ggagaggagc agcggcggcg gcggcggcag gcagaacgtc tgaagccata tgtggctgct
     3901 caactggatg tgctcccgga gacctttacc ttgggggaca agaagaacta ccggggcttc
     3961 tacaaccggc ccctgtctcc ggacttgagc taccagtgct ttgtgcttgc ctccttgaag
     4021 gaacccatgg accagaagcg ctatgcctcc agcccctact cggatgagat cgtggtccag
     4081 gtgacaccag cccagcagca ggaggagccg gagatgctgt gggtgacggg tcccgtgctg
     4141 gcagtcatcc tcatcatcct cattgtcatc gccatcctct tgttcaaaag gaaaaggacc
     4201 cactctccgt cctctaagga tgagcagtcg atcggactga aggactcctt gctggcccac
     4261 tcctctgacc ctgtggagat gcggaggctc aactaccaga ccccaggtat gcgagaccac
     4321 ccacccatcc ccatcaccga cctggcggac aacatcgagc gcctcaaagc caacgatggc
     4381 ctcaagttct cccaggagta tgagtccatc gaccctggac agcagttcac gtgggagaat
     4441 tcaaacctgg aggtgaacaa gcccaagaac cgctatgcga atgtcatcgc ctacgaccac
     4501 tctcgagtca tccttacctc tatcgatggc gtccccggga gtgactacat caatgccaac
     4561 tacatcgatg gctaccgcaa gcagaatgcc tacatcgcca cgcagggccc cctgcccgag
     4621 accatgggtg atttctggag gatggtgtgg gaacagcgca cggccactgt ggtcatgatg
     4681 acacggctgg aggagaagtc ccgggtaaaa tgtgatcagt actggccagc ccgtggcacc
     4741 gagacctgtg gccttattca ggtgaccctg ttggacacag tggagctggc cacatacact
     4801 gtgcgcacct tcgcactcca caagagtggc tccagtgaga agcgcgagct gcgtcagttt
     4861 cagttcatgg cctggccaga ccatggagtt cctgagtacc caactcccat cctggccttc
     4921 ctacgacggg tcaaggcctg caacccccta gacgcagggc ccatggtggt gcactgcagc
     4981 gcgggcgtgg gccgcaccgg ctgcttcatc gtgattgatg ccatgttgga gcggatgaag
     5041 cacgagaaga cggtggacat ctatggccac gtgacctgca tgcgatcaca gaggaactac
     5101 atggtgcaga cggaggacca gtacgtgttc atccatgagg cgctgctgga ggctgccacg
     5161 tgcggccaca cagaggtgcc tgcccgcaac ctgtatgccc acatccagaa gctgggccaa
     5221 gtgcctccag gggagagtgt gaccgccatg gagctcgagt tcaagttgct ggccagctcc
     5281 aaggcccaca cgtcccgctt catcagcgcc aacctgccct gcaacaagtt caagaaccgg
     5341 ctggtgaaca tcatgcccta cgaattgacc cgtgtgtgtc tgcagcccat ccgtggtgtg
     5401 gagggctctg actacatcaa tgccagcttc ctggatggtt atagacagca gaaggcctac
     5461 atagctacac aggggcctct ggcagagagc accgaggact tctggcgcat gctatgggag
     5521 cacaattcca ccatcatcgt catgctgacc aagcttcggg agatgggcag ggagaaatgc
     5581 caccagtact ggccagcaga gcgctctgct cgctaccagt actttgttgt tgacccgatg
     5641 gctgagtaca acatgcccca gtatatcctg cgtgagttca aggtcacgga tgcccgggat
     5701 gggcagtcaa ggacaatccg gcagttccag ttcacagact ggccagagca gggcgtgccc
     5761 aagacaggcg agggattcat tgacttcatc gggcaggtgc ataagaccaa ggagcagttt
     5821 ggacaggatg ggcctatcac ggtgcactgc agtgctggcg tgggccgcac cggggtgttc
     5881 atcactctga gcatcgtcct ggagcgcatg cgctacgagg gcgtggtcga catgtttcag
     5941 accgtgaaga ccctgcgtac acagcgtcct gccatggtgc agacagagga ccagtatcag
     6001 ctgtgctacc gtgcggccct ggagtacctc ggcagctttg accactatgc aacgtaacta
     6061 ccgctcccct ctcctccgcc acccccgccg tggggctccg gaggggaccc agctcctctg
     6121 agccataccg accatcgtcc agccctccta cgcagatgct gtcactggca gagcacagcc
     6181 cacggggatc acagcgtttc aggaacgttg ccacaccaat cagagagcct agaacatccc
     6241 tgggcaagtg gatggcccag caggcaggca ctgtggccct tctgtccacc agacccacct
     6301 ggagcccgct tcaagctctc tgttgcgctc ccgcatttct catgcttctt ctcatggggt
     6361 ggggttgggg caaagcctcc tttttaatac attaagtggg gtagactgag ggattttagc
     6421 ctcttccctc tgatttttcc tttcgcgaat ccgtatctgc agaatgggcc actgtagggg
     6481 ttggggttta ttttgttttg tttttttttt tcttgagttc actttggatc cttattttgt
     6541 atgacttctg ctgaaggaca gaacattgcc ttcctcgtgc agagctgggg ctgccagcct
     6601 gagcggaggc tcggccgtgg gccgggaggc agtgctgatc cggctgctcc tccagccctt
     6661 cagacgagat cctgtttcag ctaaatgcag ggaaactcaa tgttttttta agttttgttt
     6721 tccctttaaa gccttttttt aggccacatt gacagtggtg ggcggggaga agatagggaa
     6781 cactcatccc tggtcgtcta tcccagtgtg tgtttaacat tcacagccca gaaccacaga
     6841 tgtgtctggg agagcctggc aaggcattcc tcatcaccat cgtgtttgca aaggttaaaa
     6901 caaaaacaaa aaaccacaaa aataaaaaac aaaaaaaaca aaaaacccaa gaaaaaaaaa
     6961 aagagtcagc ccttggcttc tgcttcaaac cctcaagagg ggaagcaact ccgtgtgcct
     7021 ggggttcccg agggagctgc tggctgacct gggcccacag agcctggctt tggtccccag
     7081 cattgcagta tggtgtggtg tttgtaggct gtggggtctg gctgtgtggc caaggtgaat
     7141 agcacaggtt agggtgtgtg ccacacccca tgcacctcag ggccaagcgg gggcgtggct
     7201 ggcctttcag gtccaggcca gtgggcctgg tagcacatgt ctgtcctcag agcaggggcc
     7261 agatgatttt cctccctggt ttgcagctgt tttcaaagcc cccgataatc gctcttttcc
     7321 actccaagat gccctcataa accaatgtgg caagactact ggacttctat caatggtact
     7381 ctaatcagtc cttattatcc cagcttgctg aggggcaggg agagcgcctc ttcctctggg
     7441 cagcgctatc tagataggta agtgggggcg gggaagggtg catagctgtt ttagctgagg
     7501 gacgtggtgc cgacgtcccc aaacctagct aggctaagtc aagatcaaca ttccagggtt
     7561 ggtaatgttg gatgatgaaa cattcatttt taccttgtgg atgctagtgc tgtagagttc
     7621 actgttgtac acagtctgtt ttctatttgt taagaaaaac tacagcatca ttgcataatt
     7681 cttgatggta ataaatttga ataatcagat ttcttacaaa
//
