LOCUS       NM_006504               5289 bp    mRNA    linear   PRI 04-JUN-2023
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type E (PTPRE),
            transcript variant 1, mRNA.
ACCESSION   NM_006504 XM_005252690
VERSION     NM_006504.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5289)
  AUTHORS   Peng C, Zhang C, Yu W, Li L, Zhang Z, Liu T, Zhang Y, Fan G and
            Huangfu H.
  TITLE     Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an
            Oncogenic Role in Thyroid Carcinoma by Activating the AKT and
            ERK1/2 Signaling Pathway
  JOURNAL   Curr Cancer Drug Targets 23 (6), 471-481 (2023)
   PUBMED   36654463
  REMARK    GeneRIF: Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE)
            Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT
            and ERK1/2 Signaling Pathway.
REFERENCE   2  (bases 1 to 5289)
  AUTHORS   Lapointe F, Turcotte S, Roy J, Bissonnette E, Rola-Pleszczynski M
            and Stankova J.
  TITLE     RPTPepsilon promotes M2-polarized macrophage migration through
            ROCK2 signaling and podosome formation
  JOURNAL   J Cell Sci 133 (5) (2020)
   PUBMED   31722979
  REMARK    GeneRIF: RPTPepsilon promotes M2-polarized macrophage migration
            through ROCK2 signaling and podosome formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5289)
  AUTHORS   Bhattarai N, McLinden JH, Xiang J, Mathahs MM, Schmidt WN, Kaufman
            TM and Stapleton JT.
  TITLE     Hepatitis C virus infection inhibits a Src-kinase regulatory
            phosphatase and reduces T cell activation in vivo
  JOURNAL   PLoS Pathog 13 (2), e1006232 (2017)
   PUBMED   28235043
  REMARK    GeneRIF: these data demonstrate that HCV infection reduces PTPRE
            expression in the liver and peripheral blood mononuclear cell sof
            infected humans
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5289)
  AUTHORS   Vaughan LK, Wiener HW, Aslibekyan S, Allison DB, Havel PJ, Stanhope
            KL, O'Brien DM, Hopkins SE, Lemas DJ, Boyer BB and Tiwari HK.
  TITLE     Linkage and association analysis of obesity traits reveals novel
            loci and interactions with dietary n-3 fatty acids in an Alaska
            Native (Yup'ik) population
  JOURNAL   Metabolism 64 (6), 689-697 (2015)
   PUBMED   25772781
REFERENCE   5  (bases 1 to 5289)
  AUTHORS   Kabir NN, Ronnstrand L and Kazi JU.
  TITLE     Deregulation of protein phosphatase expression in acute myeloid
            leukemia
  JOURNAL   Med Oncol 30 (2), 517 (2013)
   PUBMED   23440723
REFERENCE   6  (bases 1 to 5289)
  AUTHORS   Okubo K, Itoh K, Fukushima A, Yoshii J and Matsubara K.
  TITLE     Monitoring cell physiology by expression profiles and discovering
            cell type-specific genes by compiled expression profiles
  JOURNAL   Genomics 30 (2), 178-186 (1995)
   PUBMED   8586417
REFERENCE   7  (bases 1 to 5289)
  AUTHORS   van den Maagdenberg AM, van den Hurk HH, Weghuis D, Wieringa B,
            Geurts van Kessel A and Hendriks WJ.
  TITLE     Assignment of the human protein tyrosine phosphatase epsilon
            (PTPRE) gene to chromosome 10q26 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 30 (1), 128-129 (1995)
   PUBMED   8595895
REFERENCE   8  (bases 1 to 5289)
  AUTHORS   Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee
            NH, Kirkness EF, Weinstock KG, Gocayne JD, White O et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 5289)
  AUTHORS   Murakawa K, Matsubara K, Fukushima A, Yoshii J and Okubo K.
  TITLE     Chromosomal assignments of 3'-directed partial cDNA sequences
            representing novel genes expressed in granulocytoid cells
  JOURNAL   Genomics 23 (2), 379-389 (1994)
   PUBMED   7835887
REFERENCE   10 (bases 1 to 5289)
  AUTHORS   Krueger NX, Streuli M and Saito H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC031078.1, AF406557.1,
            X54134.1, BC071573.1, AL390236.21 and AK026334.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_006504.5.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. Several alternatively spliced transcript
            variants of this gene have been reported, at least two of which
            encode a receptor-type PTP that possesses a short extracellular
            domain, a single transmembrane region, and two tandem
            intracytoplasmic catalytic domains; another one encodes a PTP that
            contains a distinct hydrophilic N-terminus, and thus represents a
            nonreceptor-type isoform of this PTP. Studies of the similar gene
            in mice suggested the regulatory roles of this PTP in RAS related
            signal transduction pathways, cytokine-induced SATA signaling, as
            well as the activation of voltage-gated K+ channels. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) lacks a 5' exon compared to
            variant 3. The resulting isoform (1) is shorter at the N-terminus
            compared to isoform 3. The encoded protein is a receptor type
            isoform of this PTP. Variants 1, 4, and 5 all encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.86543.1,
                                           SRR1803617.230654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254667.8/ ENSP00000254667.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BC031078.1         45-67
            24-702              AF406557.1         1-679
            703-2346            X54134.1           517-2160
            2347-3588           BC071573.1         1973-3214
            3589-3590           AL390236.21        98847-98848
            3591-5284           BC071573.1         3215-4908
            5285-5289           AK026334.1         1883-1887
FEATURES             Location/Qualifiers
     source          1..5289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..5289
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="protein tyrosine phosphatase receptor type E"
                     /db_xref="GeneID:5791"
                     /db_xref="HGNC:HGNC:9669"
                     /db_xref="MIM:600926"
     exon            1..207
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            208..230
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            231..346
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2340
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor type,
                     epsilon polypeptide"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase
                     epsilon isoform 1 precursor"
                     /protein_id="NP_006495.1"
                     /db_xref="CCDS:CCDS7657.1"
                     /db_xref="GeneID:5791"
                     /db_xref="HGNC:HGNC:9669"
                     /db_xref="MIM:600926"
                     /translation="MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGAS
                     QPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL
                     SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENR
                     EKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDF
                     WRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRK
                     FCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVH
                     CSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALL
                     EYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPA
                     NMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVE
                     DFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISI
                     RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNH
                     PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFC
                     YKVVQDFIDIFSDYANFK"
     exon            347..446
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            447..520
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            521..657
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            658..748
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            749..825
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            826..862
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            863..960
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1080
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1244
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1380
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1530
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1624
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1701
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1836
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1962
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2129
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2265
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..5289
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5266..5271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="hexamer: GATAAA"
     polyA_site      5289
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="major polyA site"
ORIGIN      
        1 ggacaaattt cctgctaggc tgcggacagc gggcggcagg agccggcgcg agcggcttca
       61 ggaacccacg gcctctgcgc gtccccgcga cccttcttcg cgcccggcga agacagccgg
      121 gcgccccgga gggcggcggg caggcgcccg ggagatgcgg agcctccgct gcagcgcgat
      181 ctgcgcgacc agaccggccc ccccgagact atagccttca ctttccctcg gtccaccatg
      241 gagcccttgt gtccactcct gctggtgggt tttagcttgc cgctcgccag ggctctcagg
      301 ggcaacgaga ccactgccga cagcaacgag acaaccacga cctcaggccc tccggacccg
      361 ggcgcctccc agccgctgct ggcctggctg ctactgccgc tgctgctcct cctcctcgtg
      421 ctccttctcg ccgcctactt cttcaggttc aggaagcaga ggaaagctgt ggtcagcacc
      481 agcgacaaga agatgcccaa cggaatcttg gaggagcaag agcagcaaag ggtgatgctg
      541 ctcagcaggt caccctcagg gcccaagaag tattttccca tccccgtgga gcacctggag
      601 gaggagatcc gtatcagatc cgccgacgac tgcaagcagt ttcgggagga gttcaactca
      661 ttgccatctg gacacataca aggaactttt gaactggcaa ataaagaaga aaacagagaa
      721 aaaaacagat atcccaacat ccttcccaat gaccattcta gggtgattct gagccaactg
      781 gatggaattc cctgttcaga ctacatcaat gcttcctaca tagatggtta caaagagaag
      841 aataaattca tagcagctca aggtcccaaa caggaaacgg ttaacgactt ctggagaatg
      901 gtctgggagc aaaagtctgc gaccatcgtc atgttaacaa acttgaaaga aaggaaagag
      961 gaaaagtgcc atcagtactg gcccgaccaa ggctgctgga cctatggaaa catccgggtg
     1021 tgcgtggagg actgcgtggt tttggtcgac tacaccatcc ggaagttctg catacagcca
     1081 cagctccccg acggctgcaa agcccccagg ctggtctcac agctgcactt caccagctgg
     1141 cccgacttcg gagtgccttt tacccccatt gggatgctga agttcctcaa gaaagtaaag
     1201 acgctcaacc ccgtgcacgc tgggcccatc gtggtccact gtagcgcggg cgtgggccgg
     1261 acgggcacct tcattgtgat cgatgccatg atggccatga tgcacgcgga gcagaaggtg
     1321 gatgtgtttg aatttgtgtc tcgaatccgt aatcagcgcc ctcagatggt tcaaacggat
     1381 atgcagtaca cgttcatcta ccaagcctta ctcgagtact acctctacgg ggacacagag
     1441 ctggacgtgt cctccctgga gaagcacctg cagaccatgc acggcaccac cacccacttc
     1501 gacaagatcg ggctggagga ggagttcagg aaattgacaa atgtccggat catgaaggag
     1561 aacatgagga cgggcaactt gccggcaaac atgaagaagg ccagggtcat ccagatcatc
     1621 ccgtatgact tcaaccgagt gatcctttcc atgaaaaggg gtcaagaata cacagactac
     1681 atcaacgcat ccttcataga cggctaccga cagaaggact atttcatcgc cacccagggg
     1741 ccactggcac acacggttga ggacttctgg aggatgatct gggaatggaa atcccacact
     1801 atcgtgatgc tgacggaggt gcaggagaga gagcaggata aatgctacca gtattggcca
     1861 accgagggct cagttactca tggagaaata acgattgaga taaagaatga taccctttca
     1921 gaagccatca gtatacgaga ctttctggtc actctcaatc agccccaggc ccgccaggag
     1981 gagcaggtcc gagtagtgcg ccagtttcac ttccacggct ggcctgagat cgggattccc
     2041 gccgagggca aaggcatgat tgacctcatc gcagccgtgc agaagcagca gcagcagaca
     2101 ggcaaccacc ccatcaccgt gcactgcagt gccggagctg ggcgaacagg tacattcata
     2161 gccctcagca acattttgga gcgagtaaaa gccgagggac ttttagatgt atttcaagct
     2221 gtgaagagtt tacgacttca gagaccacat atggtgcaaa ccctggaaca gtatgaattc
     2281 tgctacaaag tggtacaaga ttttattgat atattttctg attatgctaa tttcaaatga
     2341 agattcctgc cttaaaatat tttttaattt aatggtcagt atattttgta aaaatcatgt
     2401 taatttattt catagttgac attaatatct tccctaattt ctttgtatat attttgttat
     2461 gccttaaagg ccacctgcta tacagttgtt aaatcttaaa tatgcttttt aaaaattgga
     2521 ataatgtatt aaggtcaaat aatatcccat aaaatatata tttctgctaa tattagtaaa
     2581 tatcttaatt tttcattaga ttcatatcat ttaatttcac atattcaaca cctttaaatg
     2641 ttgtaatctt aatatgcgaa gtgtgcctct gcaagatact aacacaaagc tcatgttaag
     2701 aaaacagttg aggactcaga agtcagttcg aaaatgcact ttcctaacag tgaattcaca
     2761 accctgaaca gcagcatttt tggaaggcaa actgttcgtg atggtacaat gtaaatgggg
     2821 acttctgtaa agttctcagt ttcggtccat gtggtttatc tttacatttt aaagatcaaa
     2881 gaagtcttta caacctgaat ccaggtctaa aacacactag agtagctggt gactataaat
     2941 aatattttaa aatgctgtgt ctacaccatc aagactgtgt ctacactatc ttggctgaac
     3001 gagaagagat gtaaatgctg ggtggtcccg ttgacccacg gcgttgggta caacaaaacc
     3061 agccatcgga gttacacccc aaagcaccat ttgctgtcca gctgcctgtc gtttggccca
     3121 gaccaccctc agaaaaaaac cagctgcctc tcccattctc ccctcccgtt ctgccacagc
     3181 ggcctgggct ggtccagtgc tatgcctgga ggctcaacac aaaacttccc atccaaacat
     3241 tcagatgaac tgagcgtctt acacacgcag tacagaggag cacacattag gatagaaaca
     3301 gtagaataac cacgggcaat taaactttaa attttctgag cagcattttg gtatttaaac
     3361 atttcttgta aaaagctgag acagtttgta agaaaagaat ccttaaaatc tagatttata
     3421 ccatttttta aagtcccacc tttcaatgtt taataaaaca aaaagagaaa tccttaatct
     3481 aaaagctaaa ttatttttga atggaaatac tactgagacc attgacactg gataacagta
     3541 atgatcccat taccagataa gattgactga cggggaaaaa aaaaaaaaaa gaatggggtg
     3601 tgaatgtacc aacactgaat cttacagcag ttatctttct atggccatta ggtacctagc
     3661 agatgtgcac aatataaaca aaaagatatc tggcctacct tactactaaa agcatttaac
     3721 acgtgcattt ttggtacttt tttttttgtt ttctaaaagc tacataaagg ccttatttga
     3781 cattttcact gataactgat cgcaccctca tgttgcagtg ttcgtcccct attcattaac
     3841 agtgtgtgca aatgcaaccc caggacacat tattgttctg atagatgctc acagggaatc
     3901 aagcttctcg cccactccac ggctctgagc cccatccaag ggcaagactt ggtgcccagc
     3961 tggaaggacg aaagcacact ttgtgaccgc catcctcacc agctgcatgc ctgggctgca
     4021 cactgctgaa cgtgctcctc tctccttctc tgtacaatga ttcagcatct cggcggaaga
     4081 ggaaaatgga gctttttgag gctcgccagg tcccttttgt tttcaccatt aaaattccaa
     4141 acccaaagcc tttgtttgac tgaaggagaa gagagggaag taagcttctg ttcagcacct
     4201 gaaccctaga aaaagagcca gtttgctacg atgaaggtga catttctctg gtcatttatt
     4261 tgagagttcg aagtcaaagt cgaggggcac cggctttggt tcatgtctag gagccctctg
     4321 tcagaatcct tgaagccctt taatggtcta actggcatct cttgtatcaa gaagtacctt
     4381 taaggtagac cttttcaggg tgccctcagg aaagggccct gctcatgttt ttttcctgtc
     4441 cccttagacc aaccccaggt gtccactgca ggggttctgc ctgttcccaa actttttcca
     4501 ttccaggaac aaaggagaag ccactttccc caggacgcaa gactctcccc tccactgtcc
     4561 gggacagcgt tcgcccttta gcggggaggt cattacagcc tcatggcctc taccaaggcc
     4621 ccagatcaca ggatctcctg ggccttggag cacctcacgc tgggggaatc aatccctgag
     4681 ggactcagaa tcttctccgt gcaacctgga aagttcatct cttgtttcct tcagtcaaag
     4741 aaagtccatt gtacataaca aaacagcccc caaacagccc agtgccgaca ccattgttcc
     4801 tttcacactt tcctttgttg catgcagttg ggttcaaatg ccaaatagtg attagaagac
     4861 gaccattctg atctgtgtgt gatctggtca ctatgtgact gcctttacgg tttctctcca
     4921 tgtgctatat gaatgaagaa tgcataccag tgttttaaaa ggtattttta tgtgttttta
     4981 aacacttttt taaatgagcc tgacacctgt gtttcagcat ttggagacat ccccatgtta
     5041 ttcttttaag tgtataatta ctgatacttt tttgtttgtt tgtttaacta agttgtgttt
     5101 aacttatgtg cagtctttat aatgtatgta tgttattaca gtttcaacta tcatattttc
     5161 tttgattaca tttataattt gatcttgctc tgattataat gccagtgaat gttgctgaac
     5221 tctttgtata tgcaaattgc aagatttaaa ccattctgat gcaaggataa acctttactt
     5281 tgactacca
//
