LOCUS       NM_001316676            5460 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type E (PTPRE),
            transcript variant 3, mRNA.
ACCESSION   NM_001316676
VERSION     NM_001316676.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5460)
  AUTHORS   Peng,C., Zhang,C., Yu,W., Li,L., Zhang,Z., Liu,T., Zhang,Y., Fan,G.
            and Huangfu,H.
  TITLE     Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an
            Oncogenic Role in Thyroid Carcinoma by Activating the AKT and
            ERK1/2 Signaling Pathway
  JOURNAL   Curr Cancer Drug Targets 23 (6), 471-481 (2023)
   PUBMED   36654463
  REMARK    GeneRIF: Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE)
            Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT
            and ERK1/2 Signaling Pathway.
REFERENCE   2  (bases 1 to 5460)
  AUTHORS   Lapointe,F., Turcotte,S., Roy,J., Bissonnette,E.,
            Rola-Pleszczynski,M. and Stankova,J.
  TITLE     RPTPepsilon promotes M2-polarized macrophage migration through
            ROCK2 signaling and podosome formation
  JOURNAL   J Cell Sci 133 (5) (2020)
   PUBMED   31722979
  REMARK    GeneRIF: RPTPepsilon promotes M2-polarized macrophage migration
            through ROCK2 signaling and podosome formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5460)
  AUTHORS   Bhattarai,N., McLinden,J.H., Xiang,J., Mathahs,M.M., Schmidt,W.N.,
            Kaufman,T.M. and Stapleton,J.T.
  TITLE     Hepatitis C virus infection inhibits a Src-kinase regulatory
            phosphatase and reduces T cell activation in vivo
  JOURNAL   PLoS Pathog 13 (2), e1006232 (2017)
   PUBMED   28235043
  REMARK    GeneRIF: these data demonstrate that HCV infection reduces PTPRE
            expression in the liver and peripheral blood mononuclear cell sof
            infected humans
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5460)
  AUTHORS   Vaughan,L.K., Wiener,H.W., Aslibekyan,S., Allison,D.B., Havel,P.J.,
            Stanhope,K.L., O'Brien,D.M., Hopkins,S.E., Lemas,D.J., Boyer,B.B.
            and Tiwari,H.K.
  TITLE     Linkage and association analysis of obesity traits reveals novel
            loci and interactions with dietary n-3 fatty acids in an Alaska
            Native (Yup'ik) population
  JOURNAL   Metabolism 64 (6), 689-697 (2015)
   PUBMED   25772781
REFERENCE   5  (bases 1 to 5460)
  AUTHORS   Kabir,N.N., Ronnstrand,L. and Kazi,J.U.
  TITLE     Deregulation of protein phosphatase expression in acute myeloid
            leukemia
  JOURNAL   Med Oncol 30 (2), 517 (2013)
   PUBMED   23440723
REFERENCE   6  (bases 1 to 5460)
  AUTHORS   Okubo,K., Itoh,K., Fukushima,A., Yoshii,J. and Matsubara,K.
  TITLE     Monitoring cell physiology by expression profiles and discovering
            cell type-specific genes by compiled expression profiles
  JOURNAL   Genomics 30 (2), 178-186 (1995)
   PUBMED   8586417
REFERENCE   7  (bases 1 to 5460)
  AUTHORS   van den Maagdenberg,A.M., van den Hurk,H.H., Weghuis,D.,
            Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
  TITLE     Assignment of the human protein tyrosine phosphatase epsilon
            (PTPRE) gene to chromosome 10q26 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 30 (1), 128-129 (1995)
   PUBMED   8595895
REFERENCE   8  (bases 1 to 5460)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 5460)
  AUTHORS   Murakawa,K., Matsubara,K., Fukushima,A., Yoshii,J. and Okubo,K.
  TITLE     Chromosomal assignments of 3'-directed partial cDNA sequences
            representing novel genes expressed in granulocytoid cells
  JOURNAL   Genomics 23 (2), 379-389 (1994)
   PUBMED   7835887
REFERENCE   10 (bases 1 to 5460)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC031078.1, AF406557.1,
            BC050062.1, X54134.1, BC071573.1, AL390236.21 and AK026334.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001316676.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. Several alternatively spliced transcript
            variants of this gene have been reported, at least two of which
            encode a receptor-type PTP that possesses a short extracellular
            domain, a single transmembrane region, and two tandem
            intracytoplasmic catalytic domains; another one encodes a PTP that
            contains a distinct hydrophilic N-terminus, and thus represents a
            nonreceptor-type isoform of this PTP. Studies of the similar gene
            in mice suggested the regulatory roles of this PTP in RAS related
            signal transduction pathways, cytokine-induced SATA signaling, as
            well as the activation of voltage-gated K+ channels. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (3) encodes isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050062.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BC031078.1         45-67
            24-196              AF406557.1         1-173
            197-1625            BC050062.1         147-1575
            1626-2517           X54134.1           1269-2160
            2518-3759           BC071573.1         1973-3214
            3760-3761           AL390236.21        98847-98848
            3762-5455           BC071573.1         3215-4908
            5456-5460           AK026334.1         1883-1887
FEATURES             Location/Qualifiers
     source          1..5460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..5460
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="protein tyrosine phosphatase receptor type E"
                     /db_xref="GeneID:5791"
                     /db_xref="HGNC:HGNC:9669"
                     /db_xref="MIM:600926"
     exon            1..207
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            208..378
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..2511
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein tyrosine phosphatase, receptor type, epsilon
                     polypeptide"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase
                     epsilon isoform 3"
                     /protein_id="NP_001303605.1"
                     /db_xref="GeneID:5791"
                     /db_xref="HGNC:HGNC:9669"
                     /db_xref="MIM:600926"
                     /translation="MTIAFTFPRSTMEPLCPLLLVGFSLPLARALRGNETTADSNETT
                     TTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGIL
                     EEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQG
                     TFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAA
                     QGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVED
                     CVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL
                     NPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTD
                     MQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIM
                     KENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFI
                     ATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEI
                     KNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAA
                     VQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPH
                     MVQTLEQYEFCYKVVQDFIDIFSDYANFK"
     exon            379..401
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            402..517
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            518..617
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            618..691
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            692..828
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            829..919
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            920..996
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1033
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1131
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1251
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1415
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1551
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1701
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1795
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1872
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2007
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2133
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2300
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2436
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..5460
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5437..5442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="hexamer: GATAAA"
     polyA_site      5460
                     /gene="PTPRE"
                     /gene_synonym="HPTPE; PTPE; R-PTP-EPSILON"
                     /note="major polyA site"
ORIGIN      
        1 ggacaaattt cctgctaggc tgcggacagc gggcggcagg agccggcgcg agcggcttca
       61 ggaacccacg gcctctgcgc gtccccgcga cccttcttcg cgcccggcga agacagccgg
      121 gcgccccgga gggcggcggg caggcgcccg ggagatgcgg agcctccgct gcagcgcgat
      181 ctgcgcgacc agaccggccc ccccgagtaa gcgcttgcag ccagttgtct agttgtcaga
      241 agccgagctc atcagcgggc tcctggtgtc ggcgttctgc tgctggaagg tcagggagtt
      301 ccctggaccc cacggaagaa gctgtctcca tgaaggacag ggaccgtgcc gtgaaccttt
      361 tattctccca ctgacatgac tatagccttc actttccctc ggtccaccat ggagcccttg
      421 tgtccactcc tgctggtggg ttttagcttg ccgctcgcca gggctctcag gggcaacgag
      481 accactgccg acagcaacga gacaaccacg acctcaggcc ctccggaccc gggcgcctcc
      541 cagccgctgc tggcctggct gctactgccg ctgctgctcc tcctcctcgt gctccttctc
      601 gccgcctact tcttcaggtt caggaagcag aggaaagctg tggtcagcac cagcgacaag
      661 aagatgccca acggaatctt ggaggagcaa gagcagcaaa gggtgatgct gctcagcagg
      721 tcaccctcag ggcccaagaa gtattttccc atccccgtgg agcacctgga ggaggagatc
      781 cgtatcagat ccgccgacga ctgcaagcag tttcgggagg agttcaactc attgccatct
      841 ggacacatac aaggaacttt tgaactggca aataaagaag aaaacagaga aaaaaacaga
      901 tatcccaaca tccttcccaa tgaccattct agggtgattc tgagccaact ggatggaatt
      961 ccctgttcag actacatcaa tgcttcctac atagatggtt acaaagagaa gaataaattc
     1021 atagcagctc aaggtcccaa acaggaaacg gttaacgact tctggagaat ggtctgggag
     1081 caaaagtctg cgaccatcgt catgttaaca aacttgaaag aaaggaaaga ggaaaagtgc
     1141 catcagtact ggcccgacca aggctgctgg acctatggaa acatccgggt gtgcgtggag
     1201 gactgcgtgg ttttggtcga ctacaccatc cggaagttct gcatacagcc acagctcccc
     1261 gacggctgca aagcccccag gctggtctca cagctgcact tcaccagctg gcccgacttc
     1321 ggagtgcctt ttacccccat tgggatgctg aagttcctca agaaagtaaa gacgctcaac
     1381 cccgtgcacg ctgggcccat cgtggtccac tgtagcgcgg gcgtgggccg gacgggcacc
     1441 ttcattgtga tcgatgccat gatggccatg atgcacgcgg agcagaaggt ggatgtgttt
     1501 gaatttgtgt ctcgaatccg taatcagcgc cctcagatgg ttcaaacgga tatgcagtac
     1561 acgttcatct accaagcctt actcgagtac tacctctacg gggacacaga gctggacgtg
     1621 tcctccctgg agaagcacct gcagaccatg cacggcacca ccacccactt cgacaagatc
     1681 gggctggagg aggagttcag gaaattgaca aatgtccgga tcatgaagga gaacatgagg
     1741 acgggcaact tgccggcaaa catgaagaag gccagggtca tccagatcat cccgtatgac
     1801 ttcaaccgag tgatcctttc catgaaaagg ggtcaagaat acacagacta catcaacgca
     1861 tccttcatag acggctaccg acagaaggac tatttcatcg ccacccaggg gccactggca
     1921 cacacggttg aggacttctg gaggatgatc tgggaatgga aatcccacac tatcgtgatg
     1981 ctgacggagg tgcaggagag agagcaggat aaatgctacc agtattggcc aaccgagggc
     2041 tcagttactc atggagaaat aacgattgag ataaagaatg ataccctttc agaagccatc
     2101 agtatacgag actttctggt cactctcaat cagccccagg cccgccagga ggagcaggtc
     2161 cgagtagtgc gccagtttca cttccacggc tggcctgaga tcgggattcc cgccgagggc
     2221 aaaggcatga ttgacctcat cgcagccgtg cagaagcagc agcagcagac aggcaaccac
     2281 cccatcaccg tgcactgcag tgccggagct gggcgaacag gtacattcat agccctcagc
     2341 aacattttgg agcgagtaaa agccgaggga cttttagatg tatttcaagc tgtgaagagt
     2401 ttacgacttc agagaccaca tatggtgcaa accctggaac agtatgaatt ctgctacaaa
     2461 gtggtacaag attttattga tatattttct gattatgcta atttcaaatg aagattcctg
     2521 ccttaaaata ttttttaatt taatggtcag tatattttgt aaaaatcatg ttaatttatt
     2581 tcatagttga cattaatatc ttccctaatt tctttgtata tattttgtta tgccttaaag
     2641 gccacctgct atacagttgt taaatcttaa atatgctttt taaaaattgg aataatgtat
     2701 taaggtcaaa taatatccca taaaatatat atttctgcta atattagtaa atatcttaat
     2761 ttttcattag attcatatca tttaatttca catattcaac acctttaaat gttgtaatct
     2821 taatatgcga agtgtgcctc tgcaagatac taacacaaag ctcatgttaa gaaaacagtt
     2881 gaggactcag aagtcagttc gaaaatgcac tttcctaaca gtgaattcac aaccctgaac
     2941 agcagcattt ttggaaggca aactgttcgt gatggtacaa tgtaaatggg gacttctgta
     3001 aagttctcag tttcggtcca tgtggtttat ctttacattt taaagatcaa agaagtcttt
     3061 acaacctgaa tccaggtcta aaacacacta gagtagctgg tgactataaa taatatttta
     3121 aaatgctgtg tctacaccat caagactgtg tctacactat cttggctgaa cgagaagaga
     3181 tgtaaatgct gggtggtccc gttgacccac ggcgttgggt acaacaaaac cagccatcgg
     3241 agttacaccc caaagcacca tttgctgtcc agctgcctgt cgtttggccc agaccaccct
     3301 cagaaaaaaa ccagctgcct ctcccattct cccctcccgt tctgccacag cggcctgggc
     3361 tggtccagtg ctatgcctgg aggctcaaca caaaacttcc catccaaaca ttcagatgaa
     3421 ctgagcgtct tacacacgca gtacagagga gcacacatta ggatagaaac agtagaataa
     3481 ccacgggcaa ttaaacttta aattttctga gcagcatttt ggtatttaaa catttcttgt
     3541 aaaaagctga gacagtttgt aagaaaagaa tccttaaaat ctagatttat accatttttt
     3601 aaagtcccac ctttcaatgt ttaataaaac aaaaagagaa atccttaatc taaaagctaa
     3661 attatttttg aatggaaata ctactgagac cattgacact ggataacagt aatgatccca
     3721 ttaccagata agattgactg acggggaaaa aaaaaaaaaa agaatggggt gtgaatgtac
     3781 caacactgaa tcttacagca gttatctttc tatggccatt aggtacctag cagatgtgca
     3841 caatataaac aaaaagatat ctggcctacc ttactactaa aagcatttaa cacgtgcatt
     3901 tttggtactt ttttttttgt tttctaaaag ctacataaag gccttatttg acattttcac
     3961 tgataactga tcgcaccctc atgttgcagt gttcgtcccc tattcattaa cagtgtgtgc
     4021 aaatgcaacc ccaggacaca ttattgttct gatagatgct cacagggaat caagcttctc
     4081 gcccactcca cggctctgag ccccatccaa gggcaagact tggtgcccag ctggaaggac
     4141 gaaagcacac tttgtgaccg ccatcctcac cagctgcatg cctgggctgc acactgctga
     4201 acgtgctcct ctctccttct ctgtacaatg attcagcatc tcggcggaag aggaaaatgg
     4261 agctttttga ggctcgccag gtcccttttg ttttcaccat taaaattcca aacccaaagc
     4321 ctttgtttga ctgaaggaga agagagggaa gtaagcttct gttcagcacc tgaaccctag
     4381 aaaaagagcc agtttgctac gatgaaggtg acatttctct ggtcatttat ttgagagttc
     4441 gaagtcaaag tcgaggggca ccggctttgg ttcatgtcta ggagccctct gtcagaatcc
     4501 ttgaagccct ttaatggtct aactggcatc tcttgtatca agaagtacct ttaaggtaga
     4561 ccttttcagg gtgccctcag gaaagggccc tgctcatgtt tttttcctgt ccccttagac
     4621 caaccccagg tgtccactgc aggggttctg cctgttccca aactttttcc attccaggaa
     4681 caaaggagaa gccactttcc ccaggacgca agactctccc ctccactgtc cgggacagcg
     4741 ttcgcccttt agcggggagg tcattacagc ctcatggcct ctaccaaggc cccagatcac
     4801 aggatctcct gggccttgga gcacctcacg ctgggggaat caatccctga gggactcaga
     4861 atcttctccg tgcaacctgg aaagttcatc tcttgtttcc ttcagtcaaa gaaagtccat
     4921 tgtacataac aaaacagccc ccaaacagcc cagtgccgac accattgttc ctttcacact
     4981 ttcctttgtt gcatgcagtt gggttcaaat gccaaatagt gattagaaga cgaccattct
     5041 gatctgtgtg tgatctggtc actatgtgac tgcctttacg gtttctctcc atgtgctata
     5101 tgaatgaaga atgcatacca gtgttttaaa aggtattttt atgtgttttt aaacactttt
     5161 ttaaatgagc ctgacacctg tgtttcagca tttggagaca tccccatgtt attcttttaa
     5221 gtgtataatt actgatactt ttttgtttgt ttgtttaact aagttgtgtt taacttatgt
     5281 gcagtcttta taatgtatgt atgttattac agtttcaact atcatatttt ctttgattac
     5341 atttataatt tgatcttgct ctgattataa tgccagtgaa tgttgctgaa ctctttgtat
     5401 atgcaaattg caagatttaa accattctga tgcaaggata aacctttact ttgactacca
//
