LOCUS       NM_002839              10389 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type D (PTPRD),
            transcript variant 1, mRNA.
ACCESSION   NM_002839
VERSION     NM_002839.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10389)
  AUTHORS   Chen,M., Dong,Y., Tian,L., Zhou,J., Zhu,E., Yuan,H., Li,X. and
            Wang,B.
  TITLE     Metastasis suppressor 1 interacts with protein tyrosine phosphatase
            receptor-delta to regulate adipogenesis
  JOURNAL   FASEB J 37 (4), e22857 (2023)
   PUBMED   36906292
  REMARK    GeneRIF: Metastasis suppressor 1 interacts with protein tyrosine
            phosphatase receptor-delta to regulate adipogenesis.
REFERENCE   2  (bases 1 to 10389)
  AUTHORS   Xu,J., Zhong,Y., Yin,H., Linneman,J., Luo,Y., Xia,S., Xia,Q.,
            Yang,L., Huang,X., Kang,K., Wang,J., Niu,Y., Li,L. and Gou,D.
  TITLE     Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis
  JOURNAL   J Hypertens 40 (9), 1795-1807 (2022)
   PUBMED   35848503
  REMARK    GeneRIF: Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis.
REFERENCE   3  (bases 1 to 10389)
  AUTHORS   Rautajoki,K.J., Jaatinen,S., Tiihonen,A.M., Annala,M.,
            Vuorinen,E.M., Kivinen,A., Rauhala,M.J., Maass,K.K., Pajtler,K.W.,
            Yli-Harja,O., Helen,P., Haapasalo,J., Haapasalo,H., Zhang,W. and
            Nykter,M.
  TITLE     PTPRD and CNTNAP2 as markers of tumor aggressiveness in
            oligodendrogliomas
  JOURNAL   Sci Rep 12 (1), 14083 (2022)
   PUBMED   35982066
  REMARK    GeneRIF: PTPRD and CNTNAP2 as markers of tumor aggressiveness in
            oligodendrogliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10389)
  AUTHORS   Ou,C., Peng,Q. and Zeng,C.
  TITLE     An integrative prognostic and immune analysis of PTPRD in cancer
  JOURNAL   Math Biosci Eng 19 (6), 5361-5379 (2022)
   PUBMED   35603359
  REMARK    GeneRIF: An integrative prognostic and immune analysis of PTPRD in
            cancer.
REFERENCE   5  (bases 1 to 10389)
  AUTHORS   Henderson,I.M., Zeng,F., Bhuiyan,N.H., Luo,D., Martinez,M.,
            Smoake,J., Bi,F., Perera,C., Johnson,D., Prisinzano,T.E., Wang,W.
            and Uhl,G.R.
  TITLE     Structure-activity studies of PTPRD phosphatase inhibitors identify
            a 7-cyclopentymethoxy illudalic acid analog candidate for
            development
  JOURNAL   Biochem Pharmacol 195, 114868 (2022)
   PUBMED   34863978
  REMARK    GeneRIF: Structure-activity studies of PTPRD phosphatase inhibitors
            identify a 7-cyclopentymethoxy illudalic acid analog candidate for
            development.
REFERENCE   6  (bases 1 to 10389)
  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
  TITLE     Intra- and intermolecular interactions between intracellular
            domains of receptor protein-tyrosine phosphatases
  JOURNAL   J Biol Chem 277 (49), 47263-47269 (2002)
   PUBMED   12376545
  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
            a common but specific mechanism that is likely to be regulated-
            domain2s and the wedge structures are crucial determinants of
            binding specificity, thus regulating cross-talk between RPTPs
REFERENCE   7  (bases 1 to 10389)
  AUTHORS   Wallace,M.J., Fladd,C., Batt,J. and Rotin,D.
  TITLE     The second catalytic domain of protein tyrosine phosphatase delta
            (PTP delta) binds to and inhibits the first catalytic domain of PTP
            sigma
  JOURNAL   Mol Cell Biol 18 (5), 2608-2616 (1998)
   PUBMED   9566880
REFERENCE   8  (bases 1 to 10389)
  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
            PTP sigma isoforms are expressed in a tissue-specific manner and
            associate with the LAR-interacting protein LIP.1
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11686-11690 (1995)
   PUBMED   8524829
REFERENCE   9  (bases 1 to 10389)
  AUTHORS   Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
  TITLE     Molecular characterization of the human transmembrane
            protein-tyrosine phosphatase delta. Evidence for tissue-specific
            expression of alternative human transmembrane protein-tyrosine
            phosphatase delta isoforms
  JOURNAL   J Biol Chem 270 (12), 6722-6728 (1995)
   PUBMED   7896816
REFERENCE   10 (bases 1 to 10389)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135790.7, BC028038.1,
            AL390723.21, AB211400.1, AL356584.21, AL445926.5 and BM680342.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002839.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            region, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. The extracellular region of this protein is
            composed of three Ig-like and eight fibronectin type III-like
            domains. Studies of the similar genes in chicken and fly suggest
            the role of this PTP is in promoting neurite growth, and regulating
            neurons axon guidance. Multiple alternatively spliced transcript
            variants of this gene have been reported. A related pseudogene has
            been identified on chromosome 5. [provided by RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381196.9/ ENSP00000370593.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AL135790.7         135837-136115       c
            280-494             BC028038.1         1-215
            495-495             AL390723.21        23944-23944         c
            496-1982            AB211400.1         185-1671
            1983-1983           AL356584.21        20392-20392         c
            1984-6936           AB211400.1         1673-6625
            6937-9750           AL445926.5         119217-122030       c
            9751-10389          BM680342.1         18-656              c
FEATURES             Location/Qualifiers
     source          1..10389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1-p23"
     gene            1..10389
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /note="protein tyrosine phosphatase receptor type D"
                     /db_xref="GeneID:5789"
                     /db_xref="HGNC:HGNC:9668"
                     /db_xref="MIM:601598"
     exon            1..315
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            316..423
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            424..478
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            479..551
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            552..655
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            656..697
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            698..736
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            737..786
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            787..820
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            821..880
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            881..919
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1086
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             1023..6761
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor type,
                     delta polypeptide; rceptor-type tyrosine-protein
                     phosphatase delta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase delta
                     isoform 1 precursor"
                     /protein_id="NP_002830.1"
                     /db_xref="CCDS:CCDS43786.1"
                     /db_xref="GeneID:5789"
                     /db_xref="HGNC:HGNC:9668"
                     /db_xref="MIM:601598"
                     /translation="MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFI
                     CQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASN
                     NVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWF
                     KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYS
                     APANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL
                     TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTES
                     TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFR
                     VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQG
                     YRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ
                     VITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEP
                     GTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
                     SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTE
                     YRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ
                     HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSL
                     TVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY
                     RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIP
                     EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI
                     VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVM
                     KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNR
                     GNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVP
                     LKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFT
                     LGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITD
                     EEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
                     LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE
                     VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF
                     GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYC
                     VRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
                     CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
                     EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC
                     NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
                     DFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL
                     REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV
                     HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
                     LEYLGSFDHYAT"
     exon            1087..1232
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1374
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1563
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1572
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1590
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1701
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1713
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1983
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2565
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2699
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2844
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3150
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3344
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3371
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3489
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..4077
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4175
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4435
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4526
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4736
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4737..4897
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..5010
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5011..5108
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5109..5232
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5233..5408
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5409..5528
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5683
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5684..5969
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            5970..6148
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6149..6275
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6276..6401
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6402..6556
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6557..6692
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            6693..10389
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10367..10372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /note="hexamer: AATAAA"
     polyA_site      10389
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; R-PTP-delta;
                     RPTPDELTA"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgagc gagacgagga gggagcgcca gcgagcgagc gagcgagtgc gggagcggcc
       61 gcctcggctc cccgcccagc cgcgcccgca gccggcggcc ggagcgcgtg ggggcagcgc
      121 ctcgccccga cagagcctcg cctcctcctt gccgtctcgg ctgcttctcc gaggagccgg
      181 gagccgctca tcggcctccc caaccctgcg ctcccctccc agcccgagtc ctcccgctgc
      241 tctttctcct cctcctcccg agcctcctcc cctccggcgc ggcgccgcca gccagcctcg
      301 gcggggagag tgcagtttat tctgggcctg tgtggaatag aaagacaatt ctttatttga
      361 ctggtaggaa agaaaagaga agactcctca gggtttccaa ggaggactgg agcggctgct
      421 ttagtgaaga agtgaagaat caaggaagta aaggacctgt ctcaaagtca cacaactagg
      481 aaatcttgag gagtctgata cttttcatcc tccagctata aaatcatctt gtagggggaa
      541 gctgtacatt ggtggaaaat aaaaggcaag cagttcctgg cccgtgatat tccagttaga
      601 ggtgtctgac tgacagcatg ttggcaccga gggaagcgat gggcttcggc tccaggtttc
      661 tgtcctgaga ccacagcaga atgtgccttg gacaaaggct tggactcctt gatcttctgg
      721 taacttcaaa aatctggtct cagggtggtg aactttttct tcgaattcct aacctgtgag
      781 cttacgatga tggtgcctgt ccattaactg aacaactgtg gttttgaact tcttgaggcc
      841 agggactgtg tctgaaaaca ccgacggtgg ctaactcaag ggagacgtct ggtgaacacc
      901 cgtgggatct aaagaacaag ctctgaaagt gttccagctg aaatttcaga tcggacagac
      961 tcgctgcggc tccggaggca gtgattccaa gctgctcgcg cacgctgctg ccaagctgca
     1021 ggatggtgca cgtagccagg ctgctgctgc tgctcctcac tttcttcctc cgcacggatg
     1081 ctgagacacc tccaaggttt acacgaacac ccgttgatca gacaggggtc tctggcggag
     1141 ttgcctcttt catctgccaa gctacgggag acccaagacc taaaattgtc tggaacaaaa
     1201 aaggaaagaa agtcagcaat cagagatttg aggtaataga gtttgacgat gggtctggat
     1261 cagttctcag aatacaaccc ttacggactc cgagggatga ggccatttat gaatgtgtgg
     1321 cctcaaataa tgtgggagaa ataagtgtat ccaccagact cacagttttg cgggaagatc
     1381 aaattcccag gggcttccct accattgaca tgggcccaca gttgaaggtg gttgagcgta
     1441 ctcgcacggc caccatgctt tgtgcagcca gtggtaatcc ggatccagaa atcacttggt
     1501 ttaaagattt cttacctgtg gacacaagca acaacaatgg tcgtattaag cagttacgat
     1561 cagaatctat tggtggtaca ccaataagag gagcccttca gattgagcag agtgaagagt
     1621 ctgaccaagg aaaatatgag tgtgttgcca ccaacagcgc gggcactcgc tattccgctc
     1681 ctgccaattt atatgtcaga gagctgcgag aagttcgccg tgtcccacca agattctcta
     1741 tcccacccac taatcatgaa atcatgccag gcggaagcgt taatatcacc tgtgtggccg
     1801 tggggtcacc aatgccttat gtaaagtgga tgttgggggc agaagatctg acacctgaag
     1861 atgatatgcc aataggaaga aatgtgctag aactgaatga tgtaagacag tcagcaaatt
     1921 acacctgtgt tgctatgtca acactgggtg tcattgaagc aatagcacag atcactgtca
     1981 aagccttacc caaacctcca ggaactcctg tagtgaccga gagcacagct acaagcatca
     2041 cactgacgtg ggactctggg aaccctgagc ctgtttctta ttacataatt cagcataaac
     2101 ctaaaaactc tgaggaactt tacaaagaaa ttgatggggt ggcgaccaca cgctacagtg
     2161 tcgctggact aagtccctac tcggattatg aattcagggt tgttgctgtc aataacattg
     2221 ggcgggggcc tcccagcgaa cctgtgctaa cacaaacctc agagcaagca ccatccagtg
     2281 ccccgaggga tgtccaggca cgaatgttga gttcgaccac cattttggta cagtggaagg
     2341 aacctgaaga gccaaatgga cagatccaag gatatagagt ttattataca atggatccca
     2401 ctcaacatgt caacaactgg atgaaacaca atgtagctga cagccaaatc actactattg
     2461 gcaacttagt gccccagaaa acatattctg tcaaagtcct ggcttttacc tcaattggag
     2521 atggtcccct ttcaagtgac atacaagtca tcactcagac aggagtacca gggcagccac
     2581 taaacttcaa agcagaacct gagtctgaaa caagtatttt gctctcttgg acacctccac
     2641 gttcagatac cattgccaac tatgaactgg tctacaaaga tggggagcat ggagaggagc
     2701 aacgaattac cattgagcca gggacatcat ataggctgca aggactgaaa ccaaacagct
     2761 tatactattt ccgtctggct gcacgctccc ctcaaggcct gggtgcttct actgcagaaa
     2821 tatcagctag aaccatgcag tcaaagccgt cagctcctcc tcaagacatt agttgcacca
     2881 gcccaagttc cactagtatt ttggtaagtt ggcaacctcc accagtggaa aaacagaatg
     2941 gcattatcac tgaatactcc atcaagtaca ctgcagtgga tggggaagat gacaagcctc
     3001 acgagatttt gggaattcct tcggacacta ccaaatacct tttggaacag ctggaaaaat
     3061 ggactgaata ccggatcact gtgacagccc atacagatgt cggccctggc cctgagagct
     3121 tgtccgtgtt gattcgaacc aatgaagatg ttcctagtgg tcctcctcgc aaagtcgagg
     3181 tagaggctgt caactcaaca tctgttaaag tctcatggcg ctcacccgtg cccaataaac
     3241 agcatggcca gataagagga tatcaggtgc attatgtgag gatggaaaat ggtgagccca
     3301 agggccagcc catgctgaaa gatgtcatgc tggctgatgc acagtgggaa tttgatgata
     3361 ctactgaaca tgacatgatc atttctgggc tccagcctga aacttcctac tccctcaccg
     3421 tcacagccta cacaaccaaa ggagatggtg ctcgcagcaa gcccaaactg gtgtccacca
     3481 ctggggcagt tccagggaaa cctcggcttg tgattaacca cactcagatg aatactgctc
     3541 ttattcagtg gcaccctccg gtggacacat ttggacctct tcagggctac cgtctaaaat
     3601 ttggccgcaa ggatatggag ccacttacta ctcttgagtt ctctgaaaaa gaagatcact
     3661 ttacagctac agacatccac aagggagcat catacgtctt caggctctca gccagaaaca
     3721 aagtgggctt tggggaggag atggtgaagg agatttccat tccagaagaa gtaccaactg
     3781 gattccctca aaaccttcac tcagaaggca ccacttcaac ctccgtccag ttatcttggc
     3841 aaccacctgt cctggcagag agaaatggca ttatcaccaa gtataccctt ctttataggg
     3901 atatcaacat cccccttctc ccgatggagc agcttattgt tccagctgac accactatga
     3961 cactcactgg cttaaaacca gataccacat acgatgtaaa agtacgtgct catacgagca
     4021 aagggcccgg gccatatagt cccagtgtcc agttcaggac actgcctgtg gatcaagtgt
     4081 ttgcaaaaaa ttttcatgtc aaagcagtaa tgaagacttc cgtgttgctg tcttgggaga
     4141 ttccagagaa ttataactcc gccatgcctt tcaaaattct ttatgatgat gggaaaatgg
     4201 tagaagaagt ggatggccga gccacacaga agttaattgt caacctgaag cctgagaaat
     4261 catattcatt tgtgctgaca aatcgtggaa acagtgctgg tgggctgcag cacagggtca
     4321 cggcaaagac tgcaccagat gtattacgta ccaagcctgc cttcattggg aagaccaact
     4381 tggatggcat gattactgtg caactgcctg aagtacctgc aaatgagaat ataaaaggtt
     4441 actacataat aattgtgcct ttgaagaaat ctcgcgggaa atttatcaag ccatgggaga
     4501 gtccagatga aatggaatta gatgagctgc ttaaggagat atctaggaag cgcagaagca
     4561 tccgttatgg gagagaagtt gaattaaagc catatattgc cgctcacttt gatgtccttc
     4621 ccactgagtt caccctgggg gatgacaagc attatggtgg atttacaaac aagcaactcc
     4681 aaagtggtca agaatatgtc ttctttgtgt tagcagtaat ggaacatgca gagtctaaga
     4741 tgtatgcaac cagcccttac tccgaccccg tggtgtcaat ggatctggat ccgcagccaa
     4801 tcacggatga agaagaaggc ttgatctggg ttgtaggtcc tgtccttgca gtggtcttta
     4861 tcatctgcat tgtcattgct attcttcttt ataaaaggaa gagggcagag tccgactcta
     4921 gaaaaagcag cataccgaac aataaggaga tcccttcaca ccacccaaca gaccctgtag
     4981 aactgaggcg ccttaacttt caaacaccgg gtatggctag ccatcctcca atacccatct
     5041 tggaacttgc agaccacatt gaaagattga aagcaaatga caacttgaag ttttcccagg
     5101 aatatgagtc aattgaccct ggccagcagt tcacttggga acattcaaac ttggaagtaa
     5161 acaaaccaaa gaatagatac gcgaatgtaa tcgcatatga tcattcccgg gttctcctat
     5221 cagctataga agggatccca ggaagtgact atgtgaatgc caactacata gatgggtata
     5281 ggaagcaaaa tgcctatatt gcaacacagg gatctctccc cgaaacattt ggggactttt
     5341 ggagaatgat atgggaacaa cggagtgcca cagttgtcat gatgacaaaa ctagaagaaa
     5401 gatcaagggt gaagtgtgac cagtattggc ctagcagagg cacagaaacc cacggactcg
     5461 ttcaagtaac gctgcttgat actgtggagc tggccacata ttgtgttcga acatttgcac
     5521 tttacaagaa tggttcaagt gagaagagag aagtgagaca attccagttc accgcctggc
     5581 ctgatcatgg tgttccagaa caccctacac cttttctagc tttcttacgt agagtcaaaa
     5641 cctgtaaccc tcccgatgct ggtccgatgg ttgtgcactg cagtgcggga gttggccgga
     5701 ctggttgctt catcgtcata gatgccatgt tagaaagaat aaagcatgaa aaaactgtag
     5761 atatttatgg ccatgtaact ttaatgagag cccagaggaa ctatatggtt caaacagaag
     5821 accaatacat ctttatccat gatgcactgt tagaagcagt gacttgtgga aataccgaag
     5881 tgccagctag aaacttgtat gcctacattc agaagctgac acaaatagaa acgggagaga
     5941 atgtcacagg aatggagctc gaatttaagc gtctagccag ctcaaaagct cacacctcaa
     6001 ggtttatcag tgccaatctt ccatgtaata aattcaaaaa tcgccttgtt aatattatgc
     6061 catatgaatc cacaagggta tgcctgcagc ctatccgtgg agtagaagga tctgattaca
     6121 tcaatgccag ttttattgat ggatacagac aacagaaagc ctacatcgct acccaggggc
     6181 ccttggcaga gaccactgaa gacttctggc ggatgctctg ggaacacaat tccaccatag
     6241 ttgtgatgct caccaagctg cgtgaaatgg gcagagagaa atgtcaccaa tactggccag
     6301 cagaacggtc tgcaagatac cagtactttg ttgtagatcc catggctgag tacaacatgc
     6361 cacagtatat cctaagggaa ttcaaggtca cagatgccag ggacggccag tcccgaacag
     6421 taaggcagtt ccagttcact gactggccag agcaaggagt gccaaagtcc ggagaaggat
     6481 ttattgactt catcggccaa gtccataaaa caaaagaaca gtttggccaa gatggaccca
     6541 tttcagtcca ttgcagcgcg ggcgttggaa gaactggagt cttcataacg ctaagcattg
     6601 ttttggaaag aatgagatat gaaggagttg tagatatctt ccagactgtc aaaatgttaa
     6661 gaacacaacg accagctatg gtacagacag aggatcaata tcagttttcc tatcgtgccg
     6721 cactagagta cctgggcagc tttgaccact atgcaacgta gaaacccctg acccattctg
     6781 gatttttact acaggccctt caatatccat ggagtctctt ctgagccata cagggcactt
     6841 gagaagtcct tcttaacttc tagctaacaa ctacttagtg ggactattac acacaaaaca
     6901 aattaaaaac aaattattcc aggtggacca agaattcaca gtttaataat ctaacctgaa
     6961 aaataatgaa gagaatcctg actgatgagg catctgaagg attttattta cagatacctc
     7021 aaggattcaa aatcaaggga agaagaaatc acagcaaaga accaccatct tattcaggat
     7081 tgcttgaaag gtgcaaggag aaattgccag aatgctgcag ttcagcacaa gatatgtgct
     7141 ggtgtggctt ctcacaatga aacggactct gctttgacat cgccccttcc caccatactg
     7201 ctcataataa cattttaggg ggaaagggga gggaatgttt aaaaagaaag tccttgattt
     7261 agttttttag tattgtaaag atactgctga cctgtgcttc atttctaact gtgtaaactt
     7321 ttttttaaca aaatgtatca ttcgataaag tgaattttaa aaaagttaca taactcttca
     7381 tttttttatt tccaaatcgt aggttttttt aagctgtaga actgttatct gtaatatctt
     7441 gctgtagaaa tatcaaatca tttgaaaatt tgcacatttt tgtgcaaaac tcaatctaca
     7501 gtatcagtct cgtcagatat attaatttta cacttcagtt ttgattggtg agaaagtacc
     7561 cattctcttc aaataatcaa agataattat tattttgttt tgtttttgga atcaacaggg
     7621 aggcgcaaag tataaagttg ctgctaacat atatacatat atatccatat tttataaggg
     7681 tgtctatgta tatatagaca gtgtgtccac acaaaaaata gatacagtta tcagtcagtc
     7741 agttcttcca tgatttagtt tttttaaacg tagaaaagct attgtaaaca tctctttcca
     7801 tttattctta attttttgac atattggtat ttctttaaag ggaaatgagg aatgcacatc
     7861 agtgattgat tgtcaaacct caccccctga tttcctacct aatctacccc cacctaacca
     7921 atcaatcaca tccacaaatt gttttgtttg tttgttagtc aggcttccaa caaagttcaa
     7981 tatttctaac actctagtgc aataaaaatt attattaaat agctaagagg tgtgcatgtg
     8041 ggaaaggtca gtgcatatcc ctttaggagg ggagaatgtt gtaatatatc agctatcgag
     8101 ttgtttaaaa aaagtgtatt caatcgtata ttgtctatag tatgtgctat gaaatttgca
     8161 tttatgatat gtaacagggg caaagccaaa ttcatgttac tctgttcagt cagaaacatt
     8221 ttgtggcata cagcattcct gggaagtgct gtactttgtt tcgttttggt tttagttttg
     8281 catttagagt gccttataat tgatgcctat tttaatagca tttcttttta gcttttggtt
     8341 cgtatttcca ttcactgttc gtatctgtta ctttctatta aagcattatc tgtttaccac
     8401 atgtacaaaa actctttgaa taatatgcat tcctagtttt cagccaagtc ggggatgtta
     8461 gtgattgtac cagcccaaag cacttggata atcagggccc ttcttccttt tataatcaat
     8521 catcaacatc agaaaaagct acttgtttta tttatattcc cttccaaatc cgctctggaa
     8581 catgcagtaa ctgcaccaaa cttattttag taacaaatat cattggcaac tttggaatat
     8641 atttgatatt ccattaggat ttttctaaaa ggggaaataa actatatata tatatgtatc
     8701 ttacccccaa ttcttccaac agaatttcta taggaagcca tggatgatgg cataagtttg
     8761 ccacatatta catgatttta aataatcctc aaaataccca aggaactctt aaagagtttt
     8821 ggtatgagta tactactttg gtttaatttt agcttcatgg atgttctgca tggaaggatt
     8881 tttgttttcc acattttccc attgctagca gagtgaaatc caagagacca aacatttgca
     8941 agcattgtat ttgagcactt ttgtaaaaaa caaagaaaaa gaaaaaaaag aaaatatata
     9001 taatactaaa aaaaagtatc tagaaggcta cctcagaatg agactctcta acctacatca
     9061 gaaccagaga agaatgtgca ctatgtgggt ctgttatcat tattttcttt tagtttgtat
     9121 ctttttggag atttatccaa gtgccagatt actcagtgct ataattttct tttagttaaa
     9181 caaagggggt cagacagaca ttgcatcatc cagacatgcc ttgttggaca tgtagaatcc
     9241 gatggagcac tgcacaccag aatgattggc caatgagcag cttctctccc tgaaacaata
     9301 actgcccatt tggcaaaggg aaagatgaca ataatcagaa gaagaaaatg aatgggatgc
     9361 ataccataga cgaacgaggc ggagactatt gcgggaatct tactgttcag gagctgttcc
     9421 tagaactaac tcccttactg tcattgatgt gcattccact ctgtgctttt ctgtacaacc
     9481 attcaagttt taatttccca ggtgaaccat ctttatctgc cattaccaca agctttcaag
     9541 tttccagtta ttttcatcat cataaccagt acggtgctat tatttaccta tgtacgtgta
     9601 gttatgtata attttgtaat tagttacaat ggtaaaaaaa atcaaaatat ataaaaagtg
     9661 atttgtacag aactttattt tagctctttt ttaaaaatga tttgcatggt tagaaaacgg
     9721 cgaggacagc caggggaggg aagggcctct agggaacttt gcactttcta tacctttgta
     9781 ctatgcactg ccctattgat tctacaccca ataatgatat tacttgaacc catctgtaag
     9841 aaactgcttc ggaaattcat ttgtgtgtat gtaaataaca caacatagaa acaggaaggg
     9901 aaaaaagtct gcagtaatgc acgtattttt tttctttcct gtttattttc ggttttgctt
     9961 taagtccttt tatttttaat tccctttttg tttttctttt tgggttttgg ttccttttgg
    10021 gtttatgggt gccctgatac tccagcagag atcagaaggc tacagatcca ttctatccat
    10081 ccgttatgtg gctttgccat cccagcttgg agtgtcttta caaagataat aacagttgtg
    10141 ttctttgctc tcgttttgga tgcatagact gaaaaattaa aacaaataac ttgtaaaatg
    10201 gcttgttaaa aaatacaatt acctctaatt agtagtacgc gtaaatgttt tacagaatga
    10261 aaggcgtgct ttttattttc ttacttcgtt acattggtgg cgaaagaagt ctgtatgaaa
    10321 atcagttctt tgctgacaca agttccattt gttacaaatg aattctaata aaaatgtcag
    10381 tgttatgca
//
