LOCUS       NM_005608                907 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type C
            associated protein (PTPRCAP), mRNA.
ACCESSION   NM_005608
VERSION     NM_005608.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 907)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 907)
  AUTHORS   Tsoy,T.D., Kruglova,N.A. and Filatov,A.V.
  TITLE     Lymphocyte Phosphatase-Associated Phosphoprotein Is a Substrate of
            Protein Kinase CK2
  JOURNAL   Biochemistry (Mosc) 83 (11), 1380-1387 (2018)
   PUBMED   30482149
  REMARK    GeneRIF: LPAP is a substrate for protein kinase CK2 that
            phosphorylates it at Ser153, presumably ensuring LPAP resistance to
            degradation.
REFERENCE   3  (bases 1 to 907)
  AUTHORS   Kruglova,N.A., Meshkova,T.D., Kopylov,A.T., Mazurov,D.V. and
            Filatov,A.V.
  TITLE     Constitutive and activation-dependent phosphorylation of lymphocyte
            phosphatase-associated phosphoprotein (LPAP)
  JOURNAL   PLoS One 12 (8), e0182468 (2017)
   PUBMED   28827793
  REMARK    GeneRIF: results support the model: following phorbol 12-myristate
            13-acetate (PMA) or TCR/CD3 activation of T cells, LPAP is rapidly
            dephosphorylated at Ser-99 and Ser-172 and slowly phosphorylated at
            Ser-163. Ser-153 exhibited a high basal level of phosphorylation in
            both resting and activated cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 907)
  AUTHORS   Ju,H., Lim,B., Kim,M., Kim,Y.S., Kim,W.H., Ihm,C., Noh,S.M.,
            Han,D.S., Yu,H.J., Choi,B.Y. and Kang,C.
  TITLE     A regulatory polymorphism at position -309 in PTPRCAP is associated
            with susceptibility to diffuse-type gastric cancer and gene
            expression
  JOURNAL   Neoplasia 11 (12), 1340-1347 (2009)
   PUBMED   20019842
  REMARK    GeneRIF: Data show that the minor allele of rs869736 in the PTPRCAP
            promoter is associated with increased susceptibility to
            diffuse-type gastric cancer by increasing PTPRCAP expression.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 907)
  AUTHORS   Cocco,E., Murru,M.R., Melis,C., Schirru,L., Solla,E., Lai,M.,
            Rolesu,M. and Marrosu,M.G.
  TITLE     PTPRC (CD45) C77G mutation does not contribute to multiple
            sclerosis susceptibility in Sardinian patients
  JOURNAL   J Neurol 251 (9), 1085-1088 (2004)
   PUBMED   15372250
  REMARK    GeneRIF: We analysed the C77G polymorphism in multiple sclerosis
            (MS) patients from the genetically homogeneous population of
            Sardinia. CD45 did not contribute to development of the disease in
            Sardinian MS.
REFERENCE   6  (bases 1 to 907)
  AUTHORS   Kung,C., Okumura,M., Seavitt,J.R., Noll,M.E., White,L.S.,
            Pingel,J.T. and Thomas,M.L.
  TITLE     CD45-associated protein is not essential for the regulation of
            antigen receptor-mediated signal transduction
  JOURNAL   Eur J Immunol 29 (12), 3951-3955 (1999)
   PUBMED   10602003
REFERENCE   7  (bases 1 to 907)
  AUTHORS   Shimizu,Y., Sugiyama,H., Fujii,Y., Sasaki,K., Inoue,K., Ogawa,H.,
            Tamaki,H., Miyake,S., Oji,Y., Soma,T., Yamagami,T., Hirata,M.,
            Ikeda,K., Monden,T. and Kishimoto,T.
  TITLE     Lineage- and differentiation stage-specific expression of LSM-1
            (LPAP), a possible substrate for CD45, in human hematopoietic cells
  JOURNAL   Am J Hematol 54 (1), 1-11 (1997)
   PUBMED   8980254
REFERENCE   8  (bases 1 to 907)
  AUTHORS   Bruyns,E., Mincheva,A., Bruyns,R.M., Kirchgessner,H., Weitz,S.,
            Lichter,P., Meuer,S. and Schraven,B.
  TITLE     Sequence, genomic organization, and chromosomal localization of the
            human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes
  JOURNAL   Genomics 38 (1), 79-83 (1996)
   PUBMED   8954783
REFERENCE   9  (bases 1 to 907)
  AUTHORS   Bruyns,E., Hendricks-Taylor,L.R., Meuer,S., Koretzky,G.A. and
            Schraven,B.
  TITLE     Identification of the sites of interaction between lymphocyte
            phosphatase-associated phosphoprotein (LPAP) and CD45
  JOURNAL   J Biol Chem 270 (52), 31372-31376 (1995)
   PUBMED   8537410
REFERENCE   10 (bases 1 to 907)
  AUTHORS   Schraven,B., Schoenhaut,D., Bruyns,E., Koretzky,G., Eckerskorn,C.,
            Wallich,R., Kirchgessner,H., Sakorafas,P., Labkovsky,B.,
            Ratnofsky,S. et al.
  TITLE     LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in
            human lymphocytes
  JOURNAL   J Biol Chem 269 (46), 29102-29111 (1994)
   PUBMED   7961877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X81422.1 and AP003419.3.
            
            On Nov 23, 2018 this sequence version replaced NM_005608.2.
            
            Summary: The protein encoded by this gene was identified as a
            transmembrane phosphoprotein specifically associated with tyrosine
            phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte
            activation. The interaction with PTPRC may be required for the
            stable expression of this protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81422.1, SRR1163657.120619.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326294.4/ ENSP00000325589.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                X81422.1           1-19
            20-66               AP003419.3         118082-118128       c
            67-901              AP003419.3         115981-116815       c
            902-907             X81422.1           901-906
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..907
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /note="protein tyrosine phosphatase receptor type C
                     associated protein"
                     /db_xref="GeneID:5790"
                     /db_xref="HGNC:HGNC:9667"
                     /db_xref="MIM:601577"
     exon            1..66
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..684
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /note="protein tyrosine phosphatase, receptor type, c
                     polypeptide-associated protein; CD45 associated protein;
                     PTPRC-associated protein; lymphocyte
                     phosphatase-associated phosphoprotein"
                     /codon_start=1
                     /product="protein tyrosine phosphatase receptor type
                     C-associated protein"
                     /protein_id="NP_005599.1"
                     /db_xref="CCDS:CCDS8163.1"
                     /db_xref="GeneID:5790"
                     /db_xref="HGNC:HGNC:9667"
                     /db_xref="MIM:601577"
                     /translation="MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLL
                     LLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDN
                     DLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLV
                     LGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL"
     exon            67..907
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /note="hexamer: AATAAA"
     polyA_site      907
                     /gene="PTPRCAP"
                     /gene_synonym="CD45-AP; LPAP"
                     /note="major polyA site"
ORIGIN      
        1 acttctcgct cgacacagcc agagctggag gtgggtgccc ggcacggagg ggcctgcgga
       61 ccaatggctc tgccctgcac cttagggctc gggatgctgc tggccctgcc aggggccttg
      121 ggctcgggtg gcagcgcgga ggacagcgtg ggctccagct ctgtcaccgt tgtcctgctg
      181 ctgctgctgc tcctactgct ggccactggc ctagcactgg cctggcgccg cctcagccgt
      241 gactcagggg gctactacca cccggcccgc ctaggtgccg cgctgtgggg ccgcacgcgg
      301 cgcctgctct gggccagccc cccaggtcgc tggctgcagg cccgagctga gctggggtcc
      361 acagacaatg accttgagcg acaggaggat gagcaggaca cagactatga ccacgtcgcg
      421 gatggtggcc tgcaggctga ccctggggaa ggcgagcagc aatgtggaga ggcgtccagc
      481 ccagagcagg tccccgtgcg ggctgaggaa gccagagaca gtgacacgga gggcgacctg
      541 gtcctcggct ccccaggacc agcgagcgca gggggcagtg ctgaggccct gctgagtgac
      601 ctgcacgcct ttgctggcag cgcagcctgg gatgacagcg ccagggcagc tgggggccag
      661 ggcctccatg tcaccgcact gtagaggccg gtcttggtgt cccatccctg tcacagccgc
      721 tcactccccg tgcctctgct tcccaagatg ccatggctgg actggacccc cagcccacat
      781 gaccatgcct cagactgtca ccccctacca gttcccaagt ccatgtgtac cccgctcacc
      841 acgggaacgg ccccccccaa ccacaggcat caggcaacca tttgaaataa aactccttca
      901 gcctgtg
//
