LOCUS       NM_002838               5357 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type C (PTPRC),
            transcript variant 1, mRNA.
ACCESSION   NM_002838
VERSION     NM_002838.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5357)
  AUTHORS   Kruglova,N.A., Mazurov,D.V. and Filatov,A.V.
  TITLE     Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45
            Protein Stability Regulator
  JOURNAL   Biochemistry (Mosc) 89 (5), 912-922 (2024)
   PUBMED   38880651
  REMARK    GeneRIF: Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as
            a CD45 Protein Stability Regulator.
REFERENCE   2  (bases 1 to 5357)
  AUTHORS   Yang,C., Wang,X., To,K.K.W., Cui,C., Luo,M., Wu,S., Huang,L.,
            Fu,K., Pan,C., Liu,Z., Fan,T., Yang,C., Wang,F. and Fu,L.
  TITLE     Circulating tumor cells shielded with extracellular vesicle-derived
            CD45 evade T cell attack to enable metastasis
  JOURNAL   Signal Transduct Target Ther 9 (1), 84 (2024)
   PUBMED   38575583
  REMARK    GeneRIF: Circulating tumor cells shielded with extracellular
            vesicle-derived CD45 evade T cell attack to enable metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5357)
  AUTHORS   Lafargue-Hauret,J., Lozac'h,K., Kabore,B. and Bobe,P.
  TITLE     [CD45 pre-exclusion from the tips of microvilli : role in their
            activation]
  JOURNAL   Med Sci (Paris) 40 (2), 212-214 (2024)
   PUBMED   38411434
  REMARK    GeneRIF: [CD45 pre-exclusion from the tips of microvilli : role in
            their activation].
REFERENCE   4  (bases 1 to 5357)
  AUTHORS   Das,M., Teli,P., Vaidya,A. and Kale,V.
  TITLE     Expression of CD45 in non-hematopoietic cells: implications in
            regenerative medicine and disease management
  JOURNAL   Regen Med 19 (7-8), 407-419 (2024)
   PUBMED   39058408
  REMARK    GeneRIF: Expression of CD45 in non-hematopoietic cells:
            implications in regenerative medicine and disease management.
            Review article
REFERENCE   5  (bases 1 to 5357)
  AUTHORS   Rai,G., Das,S., Ansari,M.A., Singh,P.K., Dar,S.A., Gupta,N.,
            Sharma,S., Ramachandran,V.G. and Jain,C.
  TITLE     Implications of CD45RA and CD45RO T cell subsets in patients of
            chronic rhinosinusitis with nasal polyposis infected with
            Aspergillus flavus
  JOURNAL   Scand J Immunol 98 (5), e13318 (2023)
   PUBMED   38441343
  REMARK    GeneRIF: Implications of CD45RA and CD45RO T cell subsets in
            patients of chronic rhinosinusitis with nasal polyposis infected
            with Aspergillus flavus.
REFERENCE   6  (bases 1 to 5357)
  AUTHORS   Jacobsen,M., Schweer,D., Ziegler,A., Gaber,R., Schock,S.,
            Schwinzer,R., Wonigeit,K., Lindert,R.B., Kantarci,O.,
            Schaefer-Klein,J., Schipper,H.I., Oertel,W.H., Heidenreich,F.,
            Weinshenker,B.G., Sommer,N. and Hemmer,B.
  TITLE     A point mutation in PTPRC is associated with the development of
            multiple sclerosis
  JOURNAL   Nat Genet 26 (4), 495-499 (2000)
   PUBMED   11101853
REFERENCE   7  (bases 1 to 5357)
  AUTHORS   Ramachandran,C., Aebersold,R., Tonks,N.K. and Pot,D.A.
  TITLE     Sequential dephosphorylation of a multiply phosphorylated insulin
            receptor peptide by protein tyrosine phosphatases
  JOURNAL   Biochemistry 31 (17), 4232-4238 (1992)
   PUBMED   1373652
REFERENCE   8  (bases 1 to 5357)
  AUTHORS   Zocchi,M.R., Poggi,A., Crosti,F., Tongiani,S. and Rugarli,C.
  TITLE     Signalling in human tumour infiltrating lymphocytes: the CD28
            molecule is functional and is physically associated with the CD45R0
            molecule
  JOURNAL   Eur J Cancer 28A (4-5), 749-754 (1992)
   PUBMED   1355979
REFERENCE   9  (bases 1 to 5357)
  AUTHORS   Schraven,B., Kirchgessner,H., Gaber,B., Samstag,Y. and Meuer,S.
  TITLE     A functional complex is formed in human T lymphocytes between the
            protein tyrosine phosphatase CD45, the protein tyrosine kinase
            p56lck and pp32, a possible common substrate
  JOURNAL   Eur J Immunol 21 (10), 2469-2477 (1991)
   PUBMED   1655467
REFERENCE   10 (bases 1 to 5357)
  AUTHORS   Justement,L.B., Campbell,K.S., Chien,N.C. and Cambier,J.C.
  TITLE     Regulation of B cell antigen receptor signal transduction and
            phosphorylation by CD45
  JOURNAL   Science 252 (5014), 1839-1842 (1991)
   PUBMED   1648262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA819314.1, Y00638.1,
            AK292131.1, Y00062.1, BM791051.1 and AA403163.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002838.4.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitosis, and oncogenic
            transformation. This PTP contains an extracellular domain, a single
            transmembrane segment and two tandem intracytoplasmic catalytic
            domains, and thus is classified as a receptor type PTP. This PTP
            has been shown to be an essential regulator of T- and B-cell
            antigen receptor signaling. It functions through either direct
            interaction with components of the antigen receptor complexes, or
            by activating various Src family kinases required for the antigen
            receptor signaling. This PTP also suppresses JAK kinases, and thus
            functions as a regulator of cytokine receptor signaling.
            Alternatively spliced transcripts variants of this gene, which
            encode distinct isoforms, have been reported. [provided by RefSeq,
            Jun 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00638.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442510.8/ ENSP00000411355.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               DA819314.1         73-204
            133-2095            Y00638.1           72-2034
            2096-4322           AK292131.1         1558-3784
            4323-4577           Y00062.1           3839-4093
            4578-5090           BM791051.1         89-601
            5091-5357           AA403163.1         3-269               c
FEATURES             Location/Qualifiers
     source          1..5357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.3-q32.1"
     gene            1..5357
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="protein tyrosine phosphatase receptor type C"
                     /db_xref="GeneID:5788"
                     /db_xref="HGNC:HGNC:9666"
                     /db_xref="MIM:151460"
     exon            1..98
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            99..214
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..4062
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, receptor type, c
                     polypeptide; T200 glycoprotein; CD45 antigen; T200
                     leukocyte common antigen; glycoprotein 180"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase C
                     isoform 1 precursor"
                     /protein_id="NP_002829.3"
                     /db_xref="CCDS:CCDS1397.2"
                     /db_xref="GeneID:5788"
                     /db_xref="HGNC:HGNC:9666"
                     /db_xref="MIM:151460"
                     /translation="MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVP
                     LSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVS
                     SVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPT
                     DPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTT
                     IATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTEC
                     KNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCD
                     TQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSP
                     GEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLK
                     PYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPP
                     RDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPF
                     ILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDE
                     KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNR
                     YVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI
                     WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLN
                     IVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAG
                     VGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
                     FGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKN
                     RNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPE
                     VMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEV
                     DLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQ
                     KLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL
                     RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV
                     NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS"
     exon            215..241
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            242..439
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            440..580
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            581..724
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            725..799
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            800..826
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1045
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1174
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1312
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1432
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1591
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1800
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1861
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1970
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2005
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2115
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2206
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2283
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2320
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2418
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2544
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2702
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2838
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2988
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3079
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3213
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3348
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3471
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3650
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3786
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..5357
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4865..4870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="hexamer: AATAAA"
     polyA_site      4885
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
     regulatory      5059..5064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="hexamer: ATTAAA"
     polyA_site      5082
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="major polyA site"
     regulatory      5129..5134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
     regulatory      5336..5341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
                     /note="hexamer: AATAAA"
     polyA_site      5357
                     /gene="PTPRC"
                     /gene_synonym="B220; CD45; CD45R; GP180; IMD105; L-CA;
                     LCA; LY5; T200"
ORIGIN      
        1 gacatcatca cctagcagtt catgcagcta gcaagtggtt tgttcttagg gtaacagagg
       61 aggaaattgt tcctcgtctg ataagacaac agtggagaaa ggacgcatgc tgtttcttag
      121 ggacacggct gacttccaga tatgaccatg tatttgtggc ttaaactctt ggcatttggc
      181 tttgcctttc tggacacaga agtatttgtg acagggcaaa gcccaacacc ttcccccact
      241 ggattgacta cagcaaagat gcccagtgtt ccactttcaa gtgacccctt acctactcac
      301 accactgcat tctcacccgc aagcaccttt gaaagagaaa atgacttctc agagaccaca
      361 acttctctta gtccagacaa tacttccacc caagtatccc cggactcttt ggataatgct
      421 agtgctttta ataccacagg tgtttcatca gtacagacgc ctcaccttcc cacgcacgca
      481 gactcgcaga cgccctctgc tggaactgac acgcagacat tcagcggctc cgccgccaat
      541 gcaaaactca accctacccc aggcagcaat gctatctcag atgtcccagg agagaggagt
      601 acagccagca cctttcctac agacccagtt tccccattga caaccaccct cagccttgca
      661 caccacagct ctgctgcctt acctgcacgc acctccaaca ccaccatcac agcgaacacc
      721 tcagatgcct accttaatgc ctctgaaaca accactctga gcccttctgg aagcgctgtc
      781 atttcaacca caacaatagc tactactcca tctaagccaa catgtgatga aaaatatgca
      841 aacatcactg tggattactt atataacaag gaaactaaat tatttacagc aaagctaaat
      901 gttaatgaga atgtggaatg tggaaacaat acttgcacaa acaatgaggt gcataacctt
      961 acagaatgta aaaatgcgtc tgtttccata tctcataatt catgtactgc tcctgataag
     1021 acattaatat tagatgtgcc accaggggtt gaaaagtttc agttacatga ttgtacacaa
     1081 gttgaaaaag cagatactac tatttgttta aaatggaaaa atattgaaac ctttacttgt
     1141 gatacacaga atattaccta cagatttcag tgtggtaata tgatatttga taataaagaa
     1201 attaaattag aaaaccttga acccgaacat gagtataagt gtgactcaga aatactctat
     1261 aataaccaca agtttactaa cgcaagtaaa attattaaaa cagattttgg gagtccagga
     1321 gagcctcaga ttattttttg tagaagtgaa gctgcacatc aaggagtaat tacctggaat
     1381 ccccctcaaa gatcatttca taattttacc ctctgttata taaaagagac agaaaaagat
     1441 tgcctcaatc tggataaaaa cctgatcaaa tatgatttgc aaaatttaaa accttatacg
     1501 aaatatgttt tatcattaca tgcctacatc attgcaaaag tgcaacgtaa tggaagtgct
     1561 gcaatgtgtc atttcacaac taaaagtgct cctccaagcc aggtctggaa catgactgtc
     1621 tccatgacat cagataatag tatgcatgtc aagtgtaggc ctcccaggga ccgtaatggc
     1681 ccccatgaac gttaccattt ggaagttgaa gctggaaata ctctggttag aaatgagtcg
     1741 cataagaatt gcgatttccg tgtaaaagat cttcaatatt caacagacta cacttttaag
     1801 gcctattttc acaatggaga ctatcctgga gaacccttta ttttacatca ttcaacatct
     1861 tataattcta aggcactgat agcatttctg gcatttctga ttattgtgac atcaatagcc
     1921 ctgcttgttg ttctctacaa aatctatgat ctacataaga aaagatcctg caatttagat
     1981 gaacagcagg agcttgttga aagggatgat gaaaaacaac tgatgaatgt ggagccaatc
     2041 catgcagata ttttgttgga aacttataag aggaagattg ctgatgaagg aagacttttt
     2101 ctggctgaat ttcagagcat cccgcgggtg ttcagcaagt ttcctataaa ggaagctcga
     2161 aagcccttta accagaataa aaaccgttat gttgacattc ttccttatga ttataaccgt
     2221 gttgaactct ctgagataaa cggagatgca gggtcaaact acataaatgc cagctatatt
     2281 gatggtttca aagaacccag gaaatacatt gctgcacaag gtcccaggga tgaaactgtt
     2341 gatgatttct ggaggatgat ttgggaacag aaagccacag ttattgtcat ggtcactcga
     2401 tgtgaagaag gaaacaggaa caagtgtgca gaatactggc cgtcaatgga agagggcact
     2461 cgggcttttg gagatgttgt tgtaaagatc aaccagcaca aaagatgtcc agattacatc
     2521 attcagaaat tgaacattgt aaataaaaaa gaaaaagcaa ctggaagaga ggtgactcac
     2581 attcagttca ccagctggcc agaccacggg gtgcctgagg atcctcactt gctcctcaaa
     2641 ctgagaagga gagtgaatgc cttcagcaat ttcttcagtg gtcccattgt ggtgcactgc
     2701 agtgctggtg ttgggcgcac aggaacctat atcggaattg atgccatgct agaaggcctg
     2761 gaagccgaga acaaagtgga tgtttatggt tatgttgtca agctaaggcg acagagatgc
     2821 ctgatggttc aagtagaggc ccagtacatc ttgatccatc aggctttggt ggaatacaat
     2881 cagtttggag aaacagaagt gaatttgtct gaattacatc catatctaca taacatgaag
     2941 aaaagggatc cacccagtga gccgtctcca ctagaggctg aattccagag acttccttca
     3001 tataggagct ggaggacaca gcacattgga aatcaagaag aaaataaaag taaaaacagg
     3061 aattctaatg tcatcccata tgactataac agagtgccac ttaaacatga gctggaaatg
     3121 agtaaagaga gtgagcatga ttcagatgaa tcctctgatg atgacagtga ttcagaggaa
     3181 ccaagcaaat acatcaatgc atcttttata atgagctact ggaaacctga agtgatgatt
     3241 gctgctcagg gaccactgaa ggagaccatt ggtgactttt ggcagatgat cttccaaaga
     3301 aaagtcaaag ttattgttat gctgacagaa ctgaaacatg gagaccagga aatctgtgct
     3361 cagtactggg gagaaggaaa gcaaacatat ggagatattg aagttgacct gaaagacaca
     3421 gacaaatctt caacttatac ccttcgtgtc tttgaactga gacattccaa gaggaaagac
     3481 tctcgaactg tgtaccagta ccaatataca aactggagtg tggagcagct tcctgcagaa
     3541 cccaaggaat taatctctat gattcaggtc gtcaaacaaa aacttcccca gaagaattcc
     3601 tctgaaggga acaagcatca caagagtaca cctctactca ttcactgcag ggatggatct
     3661 cagcaaacgg gaatattttg tgctttgtta aatctcttag aaagtgcgga aacagaagag
     3721 gtagtggata tttttcaagt ggtaaaagct ctacgcaaag ctaggccagg catggtttcc
     3781 acattcgagc aatatcaatt cctatatgac gtcattgcca gcacctaccc tgctcagaat
     3841 ggacaagtaa agaaaaacaa ccatcaagaa gataaaattg aatttgataa tgaagtggac
     3901 aaagtaaagc aggatgctaa ttgtgttaat ccacttggtg ccccagaaaa gctccctgaa
     3961 gcaaaggaac aggctgaagg ttctgaaccc acgagtggca ctgaggggcc agaacattct
     4021 gtcaatggtc ctgcaagtcc agctttaaat caaggttcat aggaaaagac ataaatgagg
     4081 aaactccaaa cctcctgtta gctgttattt ctatttttgt agaagtagga agtgaaaata
     4141 ggtatacagt ggattaatta aatgcagcga accaatattt gtagaagggt tatattttac
     4201 tactgtggaa aaatatttaa gatagttttg ccagaacagt ttgtacagac gtatgcttat
     4261 tttaaaattt tatctcttat tcagtaaaaa acaacttctt tgtaatcgtt atgtgtgtat
     4321 atgtatgtgt gtatgggtgt gtgtttgtgt gagagacaga gaaagagaga gaattctttc
     4381 aagtgaatct aaaagctttt gcttttcctt tgtttttatg aagaaaaaat acattttata
     4441 ttagaagtgt taacttagct tgaaggatct gtttttaaaa atcataaact gtgtgcagac
     4501 tcaataaaat catgtacatt tctgaaatga cctcaagatg tcctccttgt tctactcata
     4561 tatatctatc ttatatagtt tactatttta cttctagaga tagtacataa aggtggtatg
     4621 tgtgtgtatg ctactacaaa aaagttgtta actaaattaa cattgggaaa tcttatattc
     4681 catatattag catttagtcc aatgtctttt taagcttatt taattaaaaa atttccagtg
     4741 agcttatcat gctgtcttta catggggttt tcaattttgc atgctcgatt attccctgta
     4801 caatatttaa aatttattgc ttgatacttt tgacaacaaa ttaggttttg tacaattgaa
     4861 cttaaataaa tgtcattaaa ataaataaat gcaatatgta ttaatattca ttgtataaaa
     4921 atagaagaat acaaacatat ttgttaaata tttacatatg aaatttaata tagctatttt
     4981 tatggaattt ttcattgata tgaaaaatat gatattgcat atgcatagtt cccatgttaa
     5041 atcccattca taactttcat taaagcattt actttgaatt tctccaatgc ttagaatgtt
     5101 tttaccagga atggatgtcg ctaatcataa taaaattcaa ccattatttt tttcttgttt
     5161 ataatacatt gtgttatatg ttcaaatatg aaatgtgtat gcacctattg aaatatgttt
     5221 aatgcattta ttaacatttg caggacactt ttacaggccc caattatcca atagtctaat
     5281 aattgtttaa gatctagaaa aaaaaaatca agaatagtgg tatttttcat gaagtaataa
     5341 aaactcgttt tggtgaa
//
