LOCUS       NM_002837              11823 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type B (PTPRB),
            transcript variant 2, mRNA.
ACCESSION   NM_002837
VERSION     NM_002837.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11823)
  AUTHORS   Jia,Y., Chen,J., Zhong,J., He,X., Zeng,L., Wang,Y., Li,J., Xia,S.,
            Ye,E., Zhao,J., Ke,B. and Li,C.
  TITLE     Novel rare mutation in a conserved site of PTPRB causes human
            hypoplastic left heart syndrome
  JOURNAL   Clin Genet 103 (1), 79-86 (2023)
   PUBMED   36148623
  REMARK    GeneRIF: Novel rare mutation in a conserved site of PTPRB causes
            human hypoplastic left heart syndrome.
REFERENCE   2  (bases 1 to 11823)
  AUTHORS   Li,W., Jiang,H., Chen,X., Yang,K., Deng,X., Tang,Z., Hu,Z.,
            Zhang,X., Lin,S., Zou,Y. and Wu,H.
  TITLE     The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated
            with Graves' disease in the Chinese population
  JOURNAL   Medicine (Baltimore) 101 (45), e31501 (2022)
   PUBMED   36397361
  REMARK    GeneRIF: The variants in PTPRB, TRAF3IP3, and DISC1 genes were
            associated with Graves' disease in the Chinese population.
REFERENCE   3  (bases 1 to 11823)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
  REMARK    GeneRIF: PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic
            cancer progression.
REFERENCE   4  (bases 1 to 11823)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11823)
  AUTHORS   Luo,Y., Liu,W., Tang,P., Jiang,D., Gu,C., Huang,Y., Gong,F.,
            Rong,Y., Qian,D., Chen,J., Zhou,Z., Zhao,S., Wang,J., Xu,T.,
            Wei,Y., Yin,G., Fan,J. and Cai,W.
  TITLE     miR-624-5p promoted tumorigenesis and metastasis by suppressing
            hippo signaling through targeting PTPRB in osteosarcoma cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 488 (2019)
   PUBMED   31829261
  REMARK    GeneRIF: Study found PTPRB negatively correlated with miR-624
            expression in osteosarcoma (OS) tissues. PTPRB was confirmed as a
            downstream target of miR-624.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11823)
  AUTHORS   Ramachandran,C., Aebersold,R., Tonks,N.K. and Pot,D.A.
  TITLE     Sequential dephosphorylation of a multiply phosphorylated insulin
            receptor peptide by protein tyrosine phosphatases
  JOURNAL   Biochemistry 31 (17), 4232-4238 (1992)
   PUBMED   1373652
REFERENCE   7  (bases 1 to 11823)
  AUTHORS   Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R.
  TITLE     The gene for receptor-like protein tyrosine phosphatase (PTPRB) is
            assigned to chromosome 12q15-->q21
  JOURNAL   Cytogenet Cell Genet 61 (4), 269-270 (1992)
   PUBMED   1486802
REFERENCE   8  (bases 1 to 11823)
  AUTHORS   De Vries,L., Li,R.Y., Ragab,A., Ragab-Thomas,J.M. and Chap,H.
  TITLE     Expression of a truncated protein-tyrosine phosphatase mRNA in
            human lung
  JOURNAL   FEBS Lett 282 (2), 285-288 (1991)
   PUBMED   1645282
REFERENCE   9  (bases 1 to 11823)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
REFERENCE   10 (bases 1 to 11823)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083809.21, X54131.1,
            BC101679.1, BQ710210.1, BC143360.1, AC025569.37 and AI688145.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002837.5.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            domain, a single transmembrane segment and one intracytoplasmic
            catalytic domain, thus belongs to receptor type PTP. The
            extracellular region of this PTP is composed of multiple
            fibronectin type_III repeats, which was shown to interact with
            neuronal receptor and cell adhesion molecules, such as contactin
            and tenascin C. This protein was also found to interact with sodium
            channels, and thus may regulate sodium channels by altering
            tyrosine phosphorylation status. The functions of the interaction
            partners of this protein implicate the roles of this PTP in cell
            adhesion, neurite growth, and neuronal differentiation. Alternate
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. The resulting isoform (b) is
            shorter and has a distinct N-terminus compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101679.1, X54131.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC083809.21        70783-70962         c
            181-490             X54131.1           1-310
            491-5648            BC101679.1         310-5467
            5649-5649           BQ710210.1         146-146
            5650-5756           BC101679.1         5469-5575
            5757-6290           BC143360.1         5306-5839
            6291-11811          AC025569.37        19669-25189
            11812-11822         AI688145.1         1-11                c
            11823-11823         AC025569.37        25201-25201
FEATURES             Location/Qualifiers
     source          1..11823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..11823
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="protein tyrosine phosphatase receptor type B"
                     /db_xref="GeneID:5787"
                     /db_xref="HGNC:HGNC:9665"
                     /db_xref="MIM:176882"
     exon            1..264
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..6204
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /EC_number="3.1.3.48"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; protein tyrosine phosphatase, receptor type,
                     beta polypeptide; VE-PTP; vascular endothelial protein
                     tyrosine phosphatase"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase beta
                     isoform b precursor"
                     /protein_id="NP_002828.3"
                     /db_xref="CCDS:CCDS44944.1"
                     /db_xref="GeneID:5787"
                     /db_xref="HGNC:HGNC:9665"
                     /db_xref="MIM:176882"
                     /translation="MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQ
                     WRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEER
                     TVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQ
                     ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSL
                     LISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAG
                     LQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESR
                     VLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMR
                     SLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIV
                     ESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLL
                     IHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQG
                     MTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVT
                     TVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDG
                     KVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVS
                     NSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV
                     TVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFN
                     DMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIH
                     ISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQY
                     QIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILL
                     LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAV
                     TDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQ
                     GRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFY
                     ELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS
                     PPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
                     GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP
                     DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEV
                     VEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVRE
                     ADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEM
                     ESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPIT
                     TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVH
                     LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPE
                     NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKD
                     DFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWT
                     IREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT
                     VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQ
                     CVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH"
     exon            265..535
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            536..814
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1072
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1336
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1606
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1867
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2134
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2398
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2662
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2926
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3190
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3460
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3724
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3988
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4270
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4549
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4699
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4943
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4944..5050
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5150
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5151..5234
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5252
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5334
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5425
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5502
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5503..5637
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5638..5760
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..5924
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5925..6060
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6061..6181
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6182..11823
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7593..7598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AATAAA"
     polyA_site      7617
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
     regulatory      7773..7778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: ATTAAA"
     polyA_site      7793
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="major polyA site"
     regulatory      10816..10821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AAGAAA"
     polyA_site      10843
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
     regulatory      11802..11807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AATAAA"
     polyA_site      11823
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
ORIGIN      
        1 gcctctcgcg tccgcagccc gcccggggcg gcaggagcag cagcagcagc ggtggccgca
       61 gtggcccctg cgcgtcgcca gccccgaggg aagcgcgctg cgcccacggg gcgcgctgag
      121 cgcgcgcaac aggtgacccc ctgccccggc cctcgggccg tcccacgtcc agccccctcg
      181 gtctcctctg gatcttaact actgagcgca atgctgagcc atggagccgg gttggccttg
      241 tggatcacac tgagcctgct gcagactgga ctggcggagc cagagagatg taacttcacc
      301 ctggcggagt ccaaggcctc cagccattct gtgtctatcc agtggagaat tttgggctca
      361 ccctgtaact ttagcctcat ctatagcagt gacaccctgg gggccgcgtt gtgccctacc
      421 tttcggatag acaacaccac atacggatgt aaccttcaag atttacaagc aggaaccatc
      481 tataacttca ggattatttc tctggatgaa gagagaacag tggtcttgca aacagatcct
      541 ttacctcctg ctaggtttgg agtcagtaaa gagaagacga cttcaaccag cttgcatgtt
      601 tggtggactc cttcttccgg aaaagtcacc tcatatgagg tgcaattatt tgatgaaaat
      661 aaccaaaaga tacagggggt tcaaattcaa gaaagtactt catggaatga atacactttt
      721 ttcaatctca ctgctggtag taaatacaat attgccatca cagctgtttc tggaggaaaa
      781 cgttcttttt cagtttatac caatggatca acagtgccat ctccagtgaa agatattggt
      841 atttccacaa aagccaattc tctcctgatt tcctggtccc atggttctgg gaatgtggaa
      901 cgataccggc tgatgctaat ggataaaggg atcctagttc atggcggtgt tgtggacaaa
      961 catgctactt cctatgcttt tcacgggctg acccctggct acctctacaa cctcactgtt
     1021 atgactgagg ctgcagggct gcaaaactac aggtggaaac tagtcaggac agcccccatg
     1081 gaagtctcaa atctgaaggt gacaaatgat ggcagtttga cctctctaaa agtcaaatgg
     1141 caaagacctc ctggaaatgt ggattcttac aatatcaccc tgtctcacaa agggaccatc
     1201 aaggaatcca gagtattagc accttggatt actgaaactc actttaaaga gttagtcccc
     1261 ggtcgacttt atcaagttac tgtcagctgt gtctctggtg aactgtctgc tcagaagatg
     1321 gcagtgggca gaacatttcc agacaaagtt gcaaacctgg aggcaaacaa taatggcagg
     1381 atgaggtctc ttgtagtgag ctggtcgccc cctgctggag actgggagca gtatcggatc
     1441 ctactcttca atgattctgt ggtgctgctc aacatcactg tgggaaagga agaaacacag
     1501 tatgtcatgg atgacacggg gctcgtaccg ggaagacagt atgaggtgga agtcattgtt
     1561 gagagtggaa atttgaagaa ttctgagcgt tgccaaggca ggacagtccc cctggctgtc
     1621 ctccagcttc gtgtcaaaca tgccaatgaa acctcactga gtatcatgtg gcagacccct
     1681 gtagcagaat gggagaaata catcatttcc ctagctgaca gagacctctt actgatccac
     1741 aagtcactct ccaaagatgc caaagaattc acttttactg acctggtgcc tggacgaaaa
     1801 tacatggcta cagtcaccag tattagtgga gacttaaaaa attcctcttc agtaaaagga
     1861 agaacagtgc ctgcccaagt gactgacttg catgtggcca accaaggaat gaccagtagt
     1921 ctgtttacta actggaccca ggcacaagga gacgtagaat tttaccaagt cttactgatc
     1981 catgaaaatg tggtcattaa aaatgaaagc atctccagtg agaccagcag atacagcttc
     2041 cactctctca agtccggcag cctgtactcc gtggtggtaa caacagtgag tggagggatc
     2101 tcttcccgac aagtggttgt ggagggaaga acagtccctt ccagtgtgag tggagtaacg
     2161 gtgaacaatt ccggtcgtaa tgactacctc agcgtttcct ggctgctggc gcccggagat
     2221 gtggataact atgaggtaac attgtctcat gacggcaagg tggttcagtc ccttgtcatt
     2281 gccaagtctg tcagagaatg ttccttcagc tccctcaccc caggccgcct ctacaccgtg
     2341 accataacta caaggagtgg caagtatgaa aatcactcct tcagccaaga gcggacagtg
     2401 cctgacaaag tccagggagt cagtgttagc aactcagcca ggagtgacta tttaagggta
     2461 tcctgggtgc atgccactgg agactttgat cactatgaag tcaccattaa aaacaaaaac
     2521 aacttcattc aaactaaaag cattcccaag tcagaaaacg aatgtgtatt tgttcagcta
     2581 gtccctggac ggttgtacag tgtcactgtt actacaaaaa gtggacaata tgaagccaat
     2641 gaacaaggga atgggagaac aattccagag cctgttaagg atctaacatt gcgcaacagg
     2701 agcactgagg acttgcatgt gacttggtca ggagctaatg gggatgtcga ccaatatgag
     2761 atccagctgc tcttcaatga catgaaagta tttcctcctt ttcaccttgt aaataccgca
     2821 accgagtatc gatttacttc cctaacacca ggccgccaat acaaaattct tgtcttgacg
     2881 attagcgggg atgtacagca gtcagccttc attgagggct tcacagttcc tagtgctgtc
     2941 aaaaatattc acatttctcc caatggagca acagatagcc tgacggtgaa ctggactcct
     3001 ggtgggggag acgttgattc ctacacggtg tcggcattca ggcacagtca aaaggttgac
     3061 tctcagacta ttcccaagca cgtctttgag cacacgttcc acagactgga ggccggggag
     3121 cagtaccaga tcatgattgc ctcagtcagc gggtccctga agaatcagat aaatgtggtt
     3181 gggcggacag ttccagcatc tgtccaagga gtaattgcag acaatgcata cagcagttat
     3241 tccttaatag taagttggca aaaagctgct ggtgtggcag aaagatatga tatcctgctt
     3301 ctaactgaaa atggaatcct tctgcgcaac acatcagagc cagccaccac taagcaacac
     3361 aaatttgaag atctaacacc aggcaagaaa tacaagatac agatcctaac tgtcagtgga
     3421 ggcctcttta gcaaggaagc ccagactgaa ggccgaacag tcccagcagc tgtcaccgac
     3481 ctgaggatca cagagaactc caccaggcac ctgtccttcc gctggaccgc ctcagagggg
     3541 gagctcagct ggtacaacat ctttttgtac aacccagatg ggaatctcca ggagagagct
     3601 caagttgacc cactagtcca gagcttctct ttccagaact tgctacaagg cagaatgtac
     3661 aagatggtga ttgtaactca cagtggggag ctgtctaatg agtctttcat atttggtaga
     3721 acagtcccag cctctgtgag tcatctcagg gggtccaatc ggaacacgac agacagcctt
     3781 tggttcaact ggagtccagc ctctggggac tttgactttt atgagctgat tctctataat
     3841 cccaatggca caaagaagga aaactggaaa gacaaggacc tgacggagtg gcggtttcaa
     3901 ggccttgttc ctggaaggaa gtacgtgctg tgggtggtaa ctcacagtgg agatctcagc
     3961 aataaagtca cagcggagag cagaacagct ccaagtcctc ccagtcttat gtcatttgct
     4021 gacattgcaa acacatcctt ggccatcacg tggaaagggc ccccagactg gacagactac
     4081 aacgactttg agctgcagtg gttgcccaga gatgcactta ctgtcttcaa cccctacaac
     4141 aacagaaaat cagaaggacg cattgtgtat ggtcttcgtc cagggagatc ctatcaattc
     4201 aacgtcaaga ctgtcagtgg tgattcctgg aaaacttaca gcaaaccaat ttttggatct
     4261 gtgaggacaa agcctgacaa gatacaaaac ctgcattgcc ggcctcagaa ctccacggcc
     4321 attgcctgtt cttggatccc tcctgattct gactttgatg gttatagtat tgaatgccgg
     4381 aaaatggaca cccaagaagt tgagttttcc agaaagctgg agaaagaaaa atctctgctc
     4441 aacatcatga tgctagtgcc ccataagagg tacctggtgt ccatcaaagt gcagtcggcc
     4501 ggcatgacca gcgaggtggt tgaagacagc actatcacaa tgatagaccg cccccctcct
     4561 ccacccccac acattcgtgt gaatgaaaag gatgtgctaa ttagcaagtc ttccatcaac
     4621 tttactgtca actgcagctg gttcagcgac accaatggag ctgtgaaata cttcacagtg
     4681 gtggtgagag aggctgatgg cagtgatgag ctgaagccag aacagcagca ccctctccct
     4741 tcctacctgg agtacaggca caatgcctcc attcgggtgt atcagactaa ttattttgcc
     4801 agcaaatgtg ccgaaaatcc taacagcaac tccaagagtt ttaacattaa gcttggagca
     4861 gagatggaga gcctaggtgg aaaatgcgat cccactcagc aaaaattctg tgatggacca
     4921 ctgaagccac acactgccta cagaatcagc attcgagctt ttacacagct ctttgatgag
     4981 gacctgaagg aattcacaaa gccactctat tcagacacat ttttttcttt acccatcact
     5041 actgaatcag agcccttgtt tggagctatt gaaggtgtga gtgctggtct gtttttaatt
     5101 ggcatgctag tggctgttgt tgccttattg atctgcagac agaaagtgag ccatggtcga
     5161 gaaagaccct ctgcccgtct gagcattcgt agggatcgac cattatctgt ccacttaaac
     5221 ctgggccaga aaggtaaccg gaaaacttct tgtccaataa aaataaatca gtttgaaggg
     5281 catttcatga agctacaggc tgactccaac taccttctat ccaaggaata cgaggagtta
     5341 aaagacgtgg gccgaaacca gtcatgtgac attgcactct tgccggagaa tagagggaaa
     5401 aatcgataca acaatatatt gccctatgat gccacgcgag tgaagctctc caatgtagat
     5461 gatgatcctt gctctgacta catcaatgcc agctacatcc ctggcaacaa cttcagaaga
     5521 gaatacattg tcactcaggg accgcttcct ggcaccaagg atgacttctg gaaaatggtg
     5581 tgggaacaaa acgttcacaa catcgtcatg gtgacccagt gtgttgagaa gggccgagta
     5641 aagtgtgatc attactggcc agcggaccag gattccctct actatgggga cctcatcctg
     5701 cagatgctct cagagtccgt cctgcctgag tggaccatcc gggagtttaa gatatgcggt
     5761 gaggaacagc ttgatgcaca cagactcatc cgccactttc actatacggt gtggccagac
     5821 catggagtcc cagaaaccac ccagtctctg atccagtttg tgagaactgt cagggactac
     5881 atcaacagaa gcccgggtgc tgggcccact gtggtgcact gcagtgctgg tgtgggtagg
     5941 actggaacct ttattgcatt ggaccgaatc ctccagcagt tagactccaa agactctgtg
     6001 gacatttatg gagcagtgca cgacctaaga cttcacaggg ttcacatggt ccagactgag
     6061 tgtcagtatg tctacctaca tcagtgtgta agagatgtcc tcagagcaag aaagctacgg
     6121 agtgaacaag aaaacccctt gtttccaatc tatgaaaatg tgaatccaga gtatcacaga
     6181 gatccagtct attcaaggca ttgagaatgt acctgaagag ctcctggata aaaattattc
     6241 actgtgtgat ttgtttttaa aaacttgctt catgccctac agaggtgcca gctatttctg
     6301 ttgatactat gtataattta ttaatctgga gaatgtttaa aattttatat aatttaaagg
     6361 taacagatat tattgtacat agttgtattt tgtagtttct tctgtaaata tgtatttttc
     6421 ataatgttta atattaagct ttatataata ctatttttcc acactaaagt gttcatgact
     6481 tgttctacat aaaactaatt caacctgtat gacaggacta ctggtaaaat gcatatggag
     6541 gtggtggcag agacaatcct tcaggccatg ttttctacct gttttgatat tcactggaca
     6601 ggaaaaaggg cagggctaga gagagcaaat actatggcta gatttgctgc attgctgtcc
     6661 catgaatctc gagagccaac agacatgtcc taacttgcta ttaggacaaa tgtgacagtc
     6721 aaaaaaagga ttagagggag ggagaaaaaa gaattaagca gtaccaaagc tgaactagat
     6781 gcttgtgtct gaactagttg ctctctctct cctttctcct tccagggatt caagccaaag
     6841 tggtcagctc agggatcatg taacttgcag tgcaagccca ggatggtagg atgcagggtt
     6901 gagggttctg atagagaatg attccaaaca gaagtgatga attccttttg ttaataagat
     6961 gccagctata cccagactgg aaacataaca tgcaaagcac tatctacagt gattagagat
     7021 cctttcattg cattcatggt gtggagtgtg aacatccaca cccatactgt aatgtattta
     7081 tacacactag tttctgtctc attttcagtg gtctccattc ctagaaaagt cacaattatc
     7141 cattcctact tgatttccca ttaaaagaat attatggtag cagattgtgc ccctcattaa
     7201 aaggcttaat gccaacattt tcatagaaat gactacaaac atcatatata gtaaatttaa
     7261 aaacaatagc aaaaacaaaa acagtggtct tcagtaaaat tttcaaaact tcttttagta
     7321 aatcaatgaa gtcaaaatgt caagtaatca cccaaagttg catttaataa caaaaggcac
     7381 tacatactgt accaagttta tcttcaatat ttgtgcctta cttactttga ctataacaaa
     7441 ttccaatgag tcagaaagta tttccttcat caaggtccag ttccgacagc attcctggga
     7501 aaaatttgaa aggagtttgt acggaatctt catagatacc tgagaagatg agctggagat
     7561 gtttgccttt ttcacactac aaatttttct gtaataaact tgggaattag aggtcaagtt
     7621 tgttgatggc atagcttcct ttgcataaag agtatatttc ttttcaaagt atatattttt
     7681 gtaacctacc ataaagtccg taagtgaata caacgaatgt aattgacata ataattgaaa
     7741 atcattgact atacctaaaa tagttcttta taattaaata actctacacc caatctggaa
     7801 atttttccaa ggttatttga agtttacaaa aatgtgaagc ataatcataa gcttcaaaga
     7861 ttcacagttt cattgtgctc aatgctcttg tgaaatgaca gtcttaagct ctgattctgt
     7921 atcaaggaac taagtgaatc ttctggaaat gaaaaggaac aacatatgtg taagtgcagt
     7981 agatgtacca ccagcgagaa aatagaggtc agagatctac aacgtgtggc atccattaga
     8041 aatcaccttt cctacattga aaagaaaaaa gagaaaaagc agaattttac actaatgttg
     8101 cttgatgcaa agcacattaa tgcttggaag gatacattca ttttcgactt ttcattcact
     8161 cagaaaactt ctagtaagta tctgcaacct gctaggcact gttccagaat ctacacattt
     8221 ctactcacat aaagagaatc ctcataaagt taggattgtt gttactacct tcaattgagc
     8281 ttaaaagaca gcctcatcaa gggaatggga taactgagcc agtctaggac agtggtcacc
     8341 ttccacaggc cacacactgg aaagtgctaa tgctacttta atagcaaacc tctggatcta
     8401 ggagagagag caattaattg cacaaaccag gagttaaaac cataaaaaaa acctatgcat
     8461 ctgtaatagt aaataacact cacgtactct ggcaacatct agggtagtat cagaattatg
     8521 taaatggaca tgacagggaa aaatcgtagg tttttttagt ctaatccaac ccaggaaatg
     8581 tttattccta ccctacacct aattttaaac cttcttagca acaaatattt cactattcgc
     8641 tcctactcct gggaagacta aatatataat tgacttattt attaaattta ggagaaaaaa
     8701 aaagttttcc ttgacattca gctctattgg atttatttcc atttaattgc atcatgtgtt
     8761 atgtcttggt aaacactcca tttcctgtct tggtgggcat cctgtctgtg tacctgtgca
     8821 gtacacttta atcatcaaga cttcaaagtg cttttgagct atcaaatctt gggagagtcc
     8881 catctagcat cttaataatt atttttccaa gttcgttata attaactcct ttaacctcat
     8941 ctcattaaat caattttgta ttgtcattct gttgttctct ggaaagcagc caattgttca
     9001 gctcttgaat cagaattttc aaagactcac ctctcttacc tgggcttgca catatttgtc
     9061 ctaagtaatt ctctatccct taaacctctg agtccctctg ttttattact tgccccactc
     9121 ctcctacttg aatatgtttg ttttcccagt tgaatgtgat ttttatctac tgttcatatt
     9181 atcttttata cccatgagta taatttcata gtcctttcag gttccacatc atcaaagaga
     9241 tgaccataat ttcacttttt tttgaaatga agtcttgctc tgttgcccag gctggagtgc
     9301 agtggcacaa tctcagctca ctacaacctc cgcctcccag gttcaagcga ttctgcctta
     9361 gcctcccaag tagctggaat tacaggtgcc tgccaccatg tctggctaat ttttgtgttt
     9421 ttagtagaga tggggtttca ccatgttggc caggctggtc ttgaactcgt gaccttaggt
     9481 gatccaccca cctcaacctc ccaaagtgct aggattacaa gagtgagcca ccgcacctgg
     9541 ccaattcact tttaaatact aaaaggcaca cagcacacag acattttcgg ggcagttttc
     9601 tttgggaggg tctttgataa attttgtaat cacctctcgg aagaaagccc aaaatgacat
     9661 gtgaaaataa tattaaacca tttaccagat gtccagcaat ataaaaatag acctcacatg
     9721 ctacccttca catgctgatt ctcttgcctt gctgtttaag gatccagttt cttatgttaa
     9781 acattttcct taccttttgc aataatatta ttggccatat actaaattct cattcactta
     9841 gctttctaag aattctttga ggttggaatc ctgaaatcat aaagctacca gatctgcaca
     9901 acagcagtgg tagtatctga gcccaaactc tgagacgctc tagagtttta gtttacaaac
     9961 atgagccaga ccaaacctga cctggtgaaa atcaataggt aataaactgc ttgtatatga
    10021 tagcagttca agggctttct gggttccatt tcactgagga aatgaaaata taactgatta
    10081 gccaagacag agtggcaata aggaataact gatcctcctc caagttgcag tgagcaagcc
    10141 ctcaagccta cctcattcct gaagagttga aggagaaaat gccgtgctaa ttttctgccc
    10201 tgctattttt aacctgaaat ttagaattac atcaggtatt caaagaatgt tccctatcaa
    10261 aggaaaatct gtaaacgatg actgcaaaaa gcaagtgaaa tgatgcaaag agaaaatatt
    10321 tgcaaaacag aatctaacca gacatcatca tgaagataaa atggcatctc ttctgtgtgg
    10381 cctgggtgtg cttggacaat cctgtcacac gtttctatta ggacatgttg cccttttgag
    10441 gattcactct atgttggcca gatggtttaa ctgattaaac aattgaatca atttattttg
    10501 ctttttgaat tgaccagata tttaactaaa tgtactgggt ttggcatttt agacacactg
    10561 ccttagattc ttgtagtgca tgatgacttt gaaaatgttt ggccatttta gttaaaatgc
    10621 agggtaacat ttgatgcagc catgataaca ggaaaaatct gttctgttct aaaaatgttt
    10681 ctagcaatag aagtatttct ggctaagaga atactcttga cttgtaggga ggctccctcg
    10741 gaataaatgt atgcaacaca aataaggcat tttatttttt aaaagattgt ctatataaga
    10801 tacacttatt aaataaagaa attgttggtg aatgctctga aaatagaggc ttatgtaatg
    10861 gaaataagag attaacaggt ttaccaaaga ttatttttat aacctctatg ccaattcaca
    10921 tgatcttata taagacacca aaataagtta ttcaaaactg tgaataatgt cagacaaatg
    10981 caatgtgtcc cttctagaac agtcacaaaa agaattggtt atagctattt taataaataa
    11041 tatcctcacc ccaagaacaa acgttcagtt atgctgagat gttctaatag ctgtgtgcgt
    11101 agataagcac ctccatcaag aaaggaacac atgaaattgt ggctttaaga gtttgtggca
    11161 gagttggaca gcattccatc tgcaggttag taggaaagcc tgtaccagcc tttgtggaat
    11221 gtcctagtct gccacactga caagagggtg caccagtgct ctactggaag agtatttctg
    11281 gttttctatg caggactatt gggcttataa attcctcaag aacaaggacc aagtctttaa
    11341 tctcgtctcg actcctacct tgtggaaatt agtgcacagc tcatagacat tctacacaca
    11401 cttcttgaaa ttgctcctgg cctgatattt tggatgttag gtagtcagtg tccaataata
    11461 ctgttgtccg tgcaggttaa tctagccatt ccttcatttg tgtgaagcat aaataatgta
    11521 agtaaataca gcaactgaac tttttatgtt ctataataga gcacttttat gtttttaata
    11581 tcatttatta tttctctgaa aatccagtta agatggcaga tgattctatt ttttcatatt
    11641 atagcatcta cccacaatat ttctaactaa ctgtatttga acaaagaact tccttagtct
    11701 ttcaatttaa attatgtatt tgcttaatac atttttatat ttgtaactgt ggtaaaaaaa
    11761 aaatctatat agcatcttgc atacattctc actagtacag gaataaaact gcagtttgtt
    11821 gaa
//
