LOCUS       NM_001109754           12301 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type B (PTPRB),
            transcript variant 1, mRNA.
ACCESSION   NM_001109754
VERSION     NM_001109754.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12301)
  AUTHORS   Jia,Y., Chen,J., Zhong,J., He,X., Zeng,L., Wang,Y., Li,J., Xia,S.,
            Ye,E., Zhao,J., Ke,B. and Li,C.
  TITLE     Novel rare mutation in a conserved site of PTPRB causes human
            hypoplastic left heart syndrome
  JOURNAL   Clin Genet 103 (1), 79-86 (2023)
   PUBMED   36148623
  REMARK    GeneRIF: Novel rare mutation in a conserved site of PTPRB causes
            human hypoplastic left heart syndrome.
REFERENCE   2  (bases 1 to 12301)
  AUTHORS   Li,W., Jiang,H., Chen,X., Yang,K., Deng,X., Tang,Z., Hu,Z.,
            Zhang,X., Lin,S., Zou,Y. and Wu,H.
  TITLE     The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated
            with Graves' disease in the Chinese population
  JOURNAL   Medicine (Baltimore) 101 (45), e31501 (2022)
   PUBMED   36397361
  REMARK    GeneRIF: The variants in PTPRB, TRAF3IP3, and DISC1 genes were
            associated with Graves' disease in the Chinese population.
REFERENCE   3  (bases 1 to 12301)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
  REMARK    GeneRIF: PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic
            cancer progression.
REFERENCE   4  (bases 1 to 12301)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12301)
  AUTHORS   Luo,Y., Liu,W., Tang,P., Jiang,D., Gu,C., Huang,Y., Gong,F.,
            Rong,Y., Qian,D., Chen,J., Zhou,Z., Zhao,S., Wang,J., Xu,T.,
            Wei,Y., Yin,G., Fan,J. and Cai,W.
  TITLE     miR-624-5p promoted tumorigenesis and metastasis by suppressing
            hippo signaling through targeting PTPRB in osteosarcoma cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 488 (2019)
   PUBMED   31829261
  REMARK    GeneRIF: Study found PTPRB negatively correlated with miR-624
            expression in osteosarcoma (OS) tissues. PTPRB was confirmed as a
            downstream target of miR-624.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12301)
  AUTHORS   Ramachandran,C., Aebersold,R., Tonks,N.K. and Pot,D.A.
  TITLE     Sequential dephosphorylation of a multiply phosphorylated insulin
            receptor peptide by protein tyrosine phosphatases
  JOURNAL   Biochemistry 31 (17), 4232-4238 (1992)
   PUBMED   1373652
REFERENCE   7  (bases 1 to 12301)
  AUTHORS   Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R.
  TITLE     The gene for receptor-like protein tyrosine phosphatase (PTPRB) is
            assigned to chromosome 12q15-->q21
  JOURNAL   Cytogenet Cell Genet 61 (4), 269-270 (1992)
   PUBMED   1486802
REFERENCE   8  (bases 1 to 12301)
  AUTHORS   De Vries,L., Li,R.Y., Ragab,A., Ragab-Thomas,J.M. and Chap,H.
  TITLE     Expression of a truncated protein-tyrosine phosphatase mRNA in
            human lung
  JOURNAL   FEBS Lett 282 (2), 285-288 (1991)
   PUBMED   1645282
REFERENCE   9  (bases 1 to 12301)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J 9 (10), 3241-3252 (1990)
   PUBMED   2170109
REFERENCE   10 (bases 1 to 12301)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN999550.1, BC051329.1,
            BC101679.1, BQ710210.1, BC143360.1, AC025569.37 and AI688145.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001109754.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            domain, a single transmembrane segment and one intracytoplasmic
            catalytic domain, thus belongs to receptor type PTP. The
            extracellular region of this PTP is composed of multiple
            fibronectin type_III repeats, which was shown to interact with
            neuronal receptor and cell adhesion molecules, such as contactin
            and tenascin C. This protein was also found to interact with sodium
            channels, and thus may regulate sodium channels by altering
            tyrosine phosphorylation status. The functions of the interaction
            partners of this protein implicate the roles of this PTP in cell
            adhesion, neurite growth, and neuronal differentiation. Alternate
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648245.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334414.11/ ENSP00000334928.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DN999550.1         34-48
            16-968              BC051329.1         1-953
            969-6126            BC101679.1         310-5467
            6127-6127           BQ710210.1         146-146
            6128-6234           BC101679.1         5469-5575
            6235-6768           BC143360.1         5306-5839
            6769-12289          AC025569.37        19669-25189
            12290-12300         AI688145.1         1-11                c
            12301-12301         AC025569.37        25201-25201
FEATURES             Location/Qualifiers
     source          1..12301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..12301
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="protein tyrosine phosphatase receptor type B"
                     /db_xref="GeneID:5787"
                     /db_xref="HGNC:HGNC:9665"
                     /db_xref="MIM:176882"
     exon            1..89
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..6682
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     protein tyrosine phosphatase, receptor type, beta
                     polypeptide; VE-PTP; vascular endothelial protein tyrosine
                     phosphatase"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase beta
                     isoform a"
                     /protein_id="NP_001103224.1"
                     /db_xref="CCDS:CCDS44943.1"
                     /db_xref="GeneID:5787"
                     /db_xref="HGNC:HGNC:9665"
                     /db_xref="MIM:176882"
                     /translation="MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCN
                     RTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAPRWTCYDQEGFL
                     EVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVR
                     STRNTAPPQILTTFNAVPDGLVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGIT
                     DTSWVLSTTQPFSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIY
                     SSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARF
                     GVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLT
                     AGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERY
                     RLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPM
                     EVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKEL
                     VPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWE
                     QYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGR
                     TVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF
                     TDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQG
                     DVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVE
                     GRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRE
                     CSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVH
                     ATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQ
                     GNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTA
                     TEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNW
                     TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQ
                     INVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEP
                     ATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLS
                     FRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGE
                     LSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKEN
                     WKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTS
                     LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKT
                     VSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKM
                     DTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPP
                     PPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHP
                     LPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKF
                     CDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVS
                     AGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCP
                     IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
                     ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNI
                     VMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDA
                     HRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTF
                     IALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSE
                     QENPLFPIYENVNPEYHRDPVYSRH"
     exon            90..485
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            486..742
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1013
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1292
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1550
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1814
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2084
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2345
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2612
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2876
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3140
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3404
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3668
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3938
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4202
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4466
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4748
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..5027
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5177
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5178..5421
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5528
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5628
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5629..5712
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5713..5730
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5731..5812
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5813..5903
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5904..5980
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            5981..6115
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6116..6238
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6239..6402
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6403..6538
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6539..6659
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            6660..12301
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8071..8076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AATAAA"
     polyA_site      8095
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
     regulatory      8251..8256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: ATTAAA"
     polyA_site      8271
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="major polyA site"
     regulatory      11294..11299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AAGAAA"
     polyA_site      11321
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
     regulatory      12280..12285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
                     /note="hexamer: AATAAA"
     polyA_site      12301
                     /gene="PTPRB"
                     /gene_synonym="HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP"
ORIGIN      
        1 cccaagcgaa gcatgaacag ttgctaagtg gaaaatggag gctgaatttt acatggtgat
       61 tcttacctgc ttgatcttca ggaactcaga agggtttcag attgtccatg tccagaaaca
      121 acagtgtctt ttcaaaaatg agaaagtggt cgtgggctca tgcaacagga ccatccagaa
      181 ccagcagtgg atgtggactg aggatgaaaa gctccttcat gttaaatctg cactgtgctt
      241 ggccatctcc aactcttccc gcggcccctc ccgctcagcc atcttggacc gctgttccca
      301 ggcaccccga tggacctgct atgatcagga aggcttcctt gaggtggaaa atgcctctct
      361 ctttctccag aaacaaggct ccagagtagt ggtcaagaag gccaggaaat acctccatag
      421 ctggatgaaa atagatgtca acaaggaggg aaaactggtc aatgaaagcc tctgtttaca
      481 aaaagctggc ctgggagcag aagtttcggt gaggagcact agaaacacgg ctccacccca
      541 gattctcact acctttaatg cagttccaga tggcctggta ttccttatta ggaataccac
      601 agaggccttc atcagaaatg ctgcagaaaa ctacagccaa aacagcagcg agaggcagca
      661 tcccaatctg cacatgactg gaattacaga cacatcatgg gttttgtcga ctactcagcc
      721 cttctccagc accactgaag agactggact ggcggagcca gagagatgta acttcaccct
      781 ggcggagtcc aaggcctcca gccattctgt gtctatccag tggagaattt tgggctcacc
      841 ctgtaacttt agcctcatct atagcagtga caccctgggg gccgcgttgt gccctacctt
      901 tcggatagac aacaccacat acggatgtaa ccttcaagat ttacaagcag gaaccatcta
      961 taacttcagg attatttctc tggatgaaga gagaacagtg gtcttgcaaa cagatccttt
     1021 acctcctgct aggtttggag tcagtaaaga gaagacgact tcaaccagct tgcatgtttg
     1081 gtggactcct tcttccggaa aagtcacctc atatgaggtg caattatttg atgaaaataa
     1141 ccaaaagata cagggggttc aaattcaaga aagtacttca tggaatgaat acactttttt
     1201 caatctcact gctggtagta aatacaatat tgccatcaca gctgtttctg gaggaaaacg
     1261 ttctttttca gtttatacca atggatcaac agtgccatct ccagtgaaag atattggtat
     1321 ttccacaaaa gccaattctc tcctgatttc ctggtcccat ggttctggga atgtggaacg
     1381 ataccggctg atgctaatgg ataaagggat cctagttcat ggcggtgttg tggacaaaca
     1441 tgctacttcc tatgcttttc acgggctgac ccctggctac ctctacaacc tcactgttat
     1501 gactgaggct gcagggctgc aaaactacag gtggaaacta gtcaggacag cccccatgga
     1561 agtctcaaat ctgaaggtga caaatgatgg cagtttgacc tctctaaaag tcaaatggca
     1621 aagacctcct ggaaatgtgg attcttacaa tatcaccctg tctcacaaag ggaccatcaa
     1681 ggaatccaga gtattagcac cttggattac tgaaactcac tttaaagagt tagtccccgg
     1741 tcgactttat caagttactg tcagctgtgt ctctggtgaa ctgtctgctc agaagatggc
     1801 agtgggcaga acatttccag acaaagttgc aaacctggag gcaaacaata atggcaggat
     1861 gaggtctctt gtagtgagct ggtcgccccc tgctggagac tgggagcagt atcggatcct
     1921 actcttcaat gattctgtgg tgctgctcaa catcactgtg ggaaaggaag aaacacagta
     1981 tgtcatggat gacacggggc tcgtaccggg aagacagtat gaggtggaag tcattgttga
     2041 gagtggaaat ttgaagaatt ctgagcgttg ccaaggcagg acagtccccc tggctgtcct
     2101 ccagcttcgt gtcaaacatg ccaatgaaac ctcactgagt atcatgtggc agacccctgt
     2161 agcagaatgg gagaaataca tcatttccct agctgacaga gacctcttac tgatccacaa
     2221 gtcactctcc aaagatgcca aagaattcac ttttactgac ctggtgcctg gacgaaaata
     2281 catggctaca gtcaccagta ttagtggaga cttaaaaaat tcctcttcag taaaaggaag
     2341 aacagtgcct gcccaagtga ctgacttgca tgtggccaac caaggaatga ccagtagtct
     2401 gtttactaac tggacccagg cacaaggaga cgtagaattt taccaagtct tactgatcca
     2461 tgaaaatgtg gtcattaaaa atgaaagcat ctccagtgag accagcagat acagcttcca
     2521 ctctctcaag tccggcagcc tgtactccgt ggtggtaaca acagtgagtg gagggatctc
     2581 ttcccgacaa gtggttgtgg agggaagaac agtcccttcc agtgtgagtg gagtaacggt
     2641 gaacaattcc ggtcgtaatg actacctcag cgtttcctgg ctgctggcgc ccggagatgt
     2701 ggataactat gaggtaacat tgtctcatga cggcaaggtg gttcagtccc ttgtcattgc
     2761 caagtctgtc agagaatgtt ccttcagctc cctcacccca ggccgcctct acaccgtgac
     2821 cataactaca aggagtggca agtatgaaaa tcactccttc agccaagagc ggacagtgcc
     2881 tgacaaagtc cagggagtca gtgttagcaa ctcagccagg agtgactatt taagggtatc
     2941 ctgggtgcat gccactggag actttgatca ctatgaagtc accattaaaa acaaaaacaa
     3001 cttcattcaa actaaaagca ttcccaagtc agaaaacgaa tgtgtatttg ttcagctagt
     3061 ccctggacgg ttgtacagtg tcactgttac tacaaaaagt ggacaatatg aagccaatga
     3121 acaagggaat gggagaacaa ttccagagcc tgttaaggat ctaacattgc gcaacaggag
     3181 cactgaggac ttgcatgtga cttggtcagg agctaatggg gatgtcgacc aatatgagat
     3241 ccagctgctc ttcaatgaca tgaaagtatt tcctcctttt caccttgtaa ataccgcaac
     3301 cgagtatcga tttacttccc taacaccagg ccgccaatac aaaattcttg tcttgacgat
     3361 tagcggggat gtacagcagt cagccttcat tgagggcttc acagttccta gtgctgtcaa
     3421 aaatattcac atttctccca atggagcaac agatagcctg acggtgaact ggactcctgg
     3481 tgggggagac gttgattcct acacggtgtc ggcattcagg cacagtcaaa aggttgactc
     3541 tcagactatt cccaagcacg tctttgagca cacgttccac agactggagg ccggggagca
     3601 gtaccagatc atgattgcct cagtcagcgg gtccctgaag aatcagataa atgtggttgg
     3661 gcggacagtt ccagcatctg tccaaggagt aattgcagac aatgcataca gcagttattc
     3721 cttaatagta agttggcaaa aagctgctgg tgtggcagaa agatatgata tcctgcttct
     3781 aactgaaaat ggaatccttc tgcgcaacac atcagagcca gccaccacta agcaacacaa
     3841 atttgaagat ctaacaccag gcaagaaata caagatacag atcctaactg tcagtggagg
     3901 cctctttagc aaggaagccc agactgaagg ccgaacagtc ccagcagctg tcaccgacct
     3961 gaggatcaca gagaactcca ccaggcacct gtccttccgc tggaccgcct cagaggggga
     4021 gctcagctgg tacaacatct ttttgtacaa cccagatggg aatctccagg agagagctca
     4081 agttgaccca ctagtccaga gcttctcttt ccagaacttg ctacaaggca gaatgtacaa
     4141 gatggtgatt gtaactcaca gtggggagct gtctaatgag tctttcatat ttggtagaac
     4201 agtcccagcc tctgtgagtc atctcagggg gtccaatcgg aacacgacag acagcctttg
     4261 gttcaactgg agtccagcct ctggggactt tgacttttat gagctgattc tctataatcc
     4321 caatggcaca aagaaggaaa actggaaaga caaggacctg acggagtggc ggtttcaagg
     4381 ccttgttcct ggaaggaagt acgtgctgtg ggtggtaact cacagtggag atctcagcaa
     4441 taaagtcaca gcggagagca gaacagctcc aagtcctccc agtcttatgt catttgctga
     4501 cattgcaaac acatccttgg ccatcacgtg gaaagggccc ccagactgga cagactacaa
     4561 cgactttgag ctgcagtggt tgcccagaga tgcacttact gtcttcaacc cctacaacaa
     4621 cagaaaatca gaaggacgca ttgtgtatgg tcttcgtcca gggagatcct atcaattcaa
     4681 cgtcaagact gtcagtggtg attcctggaa aacttacagc aaaccaattt ttggatctgt
     4741 gaggacaaag cctgacaaga tacaaaacct gcattgccgg cctcagaact ccacggccat
     4801 tgcctgttct tggatccctc ctgattctga ctttgatggt tatagtattg aatgccggaa
     4861 aatggacacc caagaagttg agttttccag aaagctggag aaagaaaaat ctctgctcaa
     4921 catcatgatg ctagtgcccc ataagaggta cctggtgtcc atcaaagtgc agtcggccgg
     4981 catgaccagc gaggtggttg aagacagcac tatcacaatg atagaccgcc cccctcctcc
     5041 acccccacac attcgtgtga atgaaaagga tgtgctaatt agcaagtctt ccatcaactt
     5101 tactgtcaac tgcagctggt tcagcgacac caatggagct gtgaaatact tcacagtggt
     5161 ggtgagagag gctgatggca gtgatgagct gaagccagaa cagcagcacc ctctcccttc
     5221 ctacctggag tacaggcaca atgcctccat tcgggtgtat cagactaatt attttgccag
     5281 caaatgtgcc gaaaatccta acagcaactc caagagtttt aacattaagc ttggagcaga
     5341 gatggagagc ctaggtggaa aatgcgatcc cactcagcaa aaattctgtg atggaccact
     5401 gaagccacac actgcctaca gaatcagcat tcgagctttt acacagctct ttgatgagga
     5461 cctgaaggaa ttcacaaagc cactctattc agacacattt ttttctttac ccatcactac
     5521 tgaatcagag cccttgtttg gagctattga aggtgtgagt gctggtctgt ttttaattgg
     5581 catgctagtg gctgttgttg ccttattgat ctgcagacag aaagtgagcc atggtcgaga
     5641 aagaccctct gcccgtctga gcattcgtag ggatcgacca ttatctgtcc acttaaacct
     5701 gggccagaaa ggtaaccgga aaacttcttg tccaataaaa ataaatcagt ttgaagggca
     5761 tttcatgaag ctacaggctg actccaacta ccttctatcc aaggaatacg aggagttaaa
     5821 agacgtgggc cgaaaccagt catgtgacat tgcactcttg ccggagaata gagggaaaaa
     5881 tcgatacaac aatatattgc cctatgatgc cacgcgagtg aagctctcca atgtagatga
     5941 tgatccttgc tctgactaca tcaatgccag ctacatccct ggcaacaact tcagaagaga
     6001 atacattgtc actcagggac cgcttcctgg caccaaggat gacttctgga aaatggtgtg
     6061 ggaacaaaac gttcacaaca tcgtcatggt gacccagtgt gttgagaagg gccgagtaaa
     6121 gtgtgatcat tactggccag cggaccagga ttccctctac tatggggacc tcatcctgca
     6181 gatgctctca gagtccgtcc tgcctgagtg gaccatccgg gagtttaaga tatgcggtga
     6241 ggaacagctt gatgcacaca gactcatccg ccactttcac tatacggtgt ggccagacca
     6301 tggagtccca gaaaccaccc agtctctgat ccagtttgtg agaactgtca gggactacat
     6361 caacagaagc ccgggtgctg ggcccactgt ggtgcactgc agtgctggtg tgggtaggac
     6421 tggaaccttt attgcattgg accgaatcct ccagcagtta gactccaaag actctgtgga
     6481 catttatgga gcagtgcacg acctaagact tcacagggtt cacatggtcc agactgagtg
     6541 tcagtatgtc tacctacatc agtgtgtaag agatgtcctc agagcaagaa agctacggag
     6601 tgaacaagaa aaccccttgt ttccaatcta tgaaaatgtg aatccagagt atcacagaga
     6661 tccagtctat tcaaggcatt gagaatgtac ctgaagagct cctggataaa aattattcac
     6721 tgtgtgattt gtttttaaaa acttgcttca tgccctacag aggtgccagc tatttctgtt
     6781 gatactatgt ataatttatt aatctggaga atgtttaaaa ttttatataa tttaaaggta
     6841 acagatatta ttgtacatag ttgtattttg tagtttcttc tgtaaatatg tatttttcat
     6901 aatgtttaat attaagcttt atataatact atttttccac actaaagtgt tcatgacttg
     6961 ttctacataa aactaattca acctgtatga caggactact ggtaaaatgc atatggaggt
     7021 ggtggcagag acaatccttc aggccatgtt ttctacctgt tttgatattc actggacagg
     7081 aaaaagggca gggctagaga gagcaaatac tatggctaga tttgctgcat tgctgtccca
     7141 tgaatctcga gagccaacag acatgtccta acttgctatt aggacaaatg tgacagtcaa
     7201 aaaaaggatt agagggaggg agaaaaaaga attaagcagt accaaagctg aactagatgc
     7261 ttgtgtctga actagttgct ctctctctcc tttctccttc cagggattca agccaaagtg
     7321 gtcagctcag ggatcatgta acttgcagtg caagcccagg atggtaggat gcagggttga
     7381 gggttctgat agagaatgat tccaaacaga agtgatgaat tccttttgtt aataagatgc
     7441 cagctatacc cagactggaa acataacatg caaagcacta tctacagtga ttagagatcc
     7501 tttcattgca ttcatggtgt ggagtgtgaa catccacacc catactgtaa tgtatttata
     7561 cacactagtt tctgtctcat tttcagtggt ctccattcct agaaaagtca caattatcca
     7621 ttcctacttg atttcccatt aaaagaatat tatggtagca gattgtgccc ctcattaaaa
     7681 ggcttaatgc caacattttc atagaaatga ctacaaacat catatatagt aaatttaaaa
     7741 acaatagcaa aaacaaaaac agtggtcttc agtaaaattt tcaaaacttc ttttagtaaa
     7801 tcaatgaagt caaaatgtca agtaatcacc caaagttgca tttaataaca aaaggcacta
     7861 catactgtac caagtttatc ttcaatattt gtgccttact tactttgact ataacaaatt
     7921 ccaatgagtc agaaagtatt tccttcatca aggtccagtt ccgacagcat tcctgggaaa
     7981 aatttgaaag gagtttgtac ggaatcttca tagatacctg agaagatgag ctggagatgt
     8041 ttgccttttt cacactacaa atttttctgt aataaacttg ggaattagag gtcaagtttg
     8101 ttgatggcat agcttccttt gcataaagag tatatttctt ttcaaagtat atatttttgt
     8161 aacctaccat aaagtccgta agtgaataca acgaatgtaa ttgacataat aattgaaaat
     8221 cattgactat acctaaaata gttctttata attaaataac tctacaccca atctggaaat
     8281 ttttccaagg ttatttgaag tttacaaaaa tgtgaagcat aatcataagc ttcaaagatt
     8341 cacagtttca ttgtgctcaa tgctcttgtg aaatgacagt cttaagctct gattctgtat
     8401 caaggaacta agtgaatctt ctggaaatga aaaggaacaa catatgtgta agtgcagtag
     8461 atgtaccacc agcgagaaaa tagaggtcag agatctacaa cgtgtggcat ccattagaaa
     8521 tcacctttcc tacattgaaa agaaaaaaga gaaaaagcag aattttacac taatgttgct
     8581 tgatgcaaag cacattaatg cttggaagga tacattcatt ttcgactttt cattcactca
     8641 gaaaacttct agtaagtatc tgcaacctgc taggcactgt tccagaatct acacatttct
     8701 actcacataa agagaatcct cataaagtta ggattgttgt tactaccttc aattgagctt
     8761 aaaagacagc ctcatcaagg gaatgggata actgagccag tctaggacag tggtcacctt
     8821 ccacaggcca cacactggaa agtgctaatg ctactttaat agcaaacctc tggatctagg
     8881 agagagagca attaattgca caaaccagga gttaaaacca taaaaaaaac ctatgcatct
     8941 gtaatagtaa ataacactca cgtactctgg caacatctag ggtagtatca gaattatgta
     9001 aatggacatg acagggaaaa atcgtaggtt tttttagtct aatccaaccc aggaaatgtt
     9061 tattcctacc ctacacctaa ttttaaacct tcttagcaac aaatatttca ctattcgctc
     9121 ctactcctgg gaagactaaa tatataattg acttatttat taaatttagg agaaaaaaaa
     9181 agttttcctt gacattcagc tctattggat ttatttccat ttaattgcat catgtgttat
     9241 gtcttggtaa acactccatt tcctgtcttg gtgggcatcc tgtctgtgta cctgtgcagt
     9301 acactttaat catcaagact tcaaagtgct tttgagctat caaatcttgg gagagtccca
     9361 tctagcatct taataattat ttttccaagt tcgttataat taactccttt aacctcatct
     9421 cattaaatca attttgtatt gtcattctgt tgttctctgg aaagcagcca attgttcagc
     9481 tcttgaatca gaattttcaa agactcacct ctcttacctg ggcttgcaca tatttgtcct
     9541 aagtaattct ctatccctta aacctctgag tccctctgtt ttattacttg ccccactcct
     9601 cctacttgaa tatgtttgtt ttcccagttg aatgtgattt ttatctactg ttcatattat
     9661 cttttatacc catgagtata atttcatagt cctttcaggt tccacatcat caaagagatg
     9721 accataattt cacttttttt tgaaatgaag tcttgctctg ttgcccaggc tggagtgcag
     9781 tggcacaatc tcagctcact acaacctccg cctcccaggt tcaagcgatt ctgccttagc
     9841 ctcccaagta gctggaatta caggtgcctg ccaccatgtc tggctaattt ttgtgttttt
     9901 agtagagatg gggtttcacc atgttggcca ggctggtctt gaactcgtga ccttaggtga
     9961 tccacccacc tcaacctccc aaagtgctag gattacaaga gtgagccacc gcacctggcc
    10021 aattcacttt taaatactaa aaggcacaca gcacacagac attttcgggg cagttttctt
    10081 tgggagggtc tttgataaat tttgtaatca cctctcggaa gaaagcccaa aatgacatgt
    10141 gaaaataata ttaaaccatt taccagatgt ccagcaatat aaaaatagac ctcacatgct
    10201 acccttcaca tgctgattct cttgccttgc tgtttaagga tccagtttct tatgttaaac
    10261 attttcctta ccttttgcaa taatattatt ggccatatac taaattctca ttcacttagc
    10321 tttctaagaa ttctttgagg ttggaatcct gaaatcataa agctaccaga tctgcacaac
    10381 agcagtggta gtatctgagc ccaaactctg agacgctcta gagttttagt ttacaaacat
    10441 gagccagacc aaacctgacc tggtgaaaat caataggtaa taaactgctt gtatatgata
    10501 gcagttcaag ggctttctgg gttccatttc actgaggaaa tgaaaatata actgattagc
    10561 caagacagag tggcaataag gaataactga tcctcctcca agttgcagtg agcaagccct
    10621 caagcctacc tcattcctga agagttgaag gagaaaatgc cgtgctaatt ttctgccctg
    10681 ctatttttaa cctgaaattt agaattacat caggtattca aagaatgttc cctatcaaag
    10741 gaaaatctgt aaacgatgac tgcaaaaagc aagtgaaatg atgcaaagag aaaatatttg
    10801 caaaacagaa tctaaccaga catcatcatg aagataaaat ggcatctctt ctgtgtggcc
    10861 tgggtgtgct tggacaatcc tgtcacacgt ttctattagg acatgttgcc cttttgagga
    10921 ttcactctat gttggccaga tggtttaact gattaaacaa ttgaatcaat ttattttgct
    10981 ttttgaattg accagatatt taactaaatg tactgggttt ggcattttag acacactgcc
    11041 ttagattctt gtagtgcatg atgactttga aaatgtttgg ccattttagt taaaatgcag
    11101 ggtaacattt gatgcagcca tgataacagg aaaaatctgt tctgttctaa aaatgtttct
    11161 agcaatagaa gtatttctgg ctaagagaat actcttgact tgtagggagg ctccctcgga
    11221 ataaatgtat gcaacacaaa taaggcattt tattttttaa aagattgtct atataagata
    11281 cacttattaa ataaagaaat tgttggtgaa tgctctgaaa atagaggctt atgtaatgga
    11341 aataagagat taacaggttt accaaagatt atttttataa cctctatgcc aattcacatg
    11401 atcttatata agacaccaaa ataagttatt caaaactgtg aataatgtca gacaaatgca
    11461 atgtgtccct tctagaacag tcacaaaaag aattggttat agctatttta ataaataata
    11521 tcctcacccc aagaacaaac gttcagttat gctgagatgt tctaatagct gtgtgcgtag
    11581 ataagcacct ccatcaagaa aggaacacat gaaattgtgg ctttaagagt ttgtggcaga
    11641 gttggacagc attccatctg caggttagta ggaaagcctg taccagcctt tgtggaatgt
    11701 cctagtctgc cacactgaca agagggtgca ccagtgctct actggaagag tatttctggt
    11761 tttctatgca ggactattgg gcttataaat tcctcaagaa caaggaccaa gtctttaatc
    11821 tcgtctcgac tcctaccttg tggaaattag tgcacagctc atagacattc tacacacact
    11881 tcttgaaatt gctcctggcc tgatattttg gatgttaggt agtcagtgtc caataatact
    11941 gttgtccgtg caggttaatc tagccattcc ttcatttgtg tgaagcataa ataatgtaag
    12001 taaatacagc aactgaactt tttatgttct ataatagagc acttttatgt ttttaatatc
    12061 atttattatt tctctgaaaa tccagttaag atggcagatg attctatttt ttcatattat
    12121 agcatctacc cacaatattt ctaactaact gtatttgaac aaagaacttc cttagtcttt
    12181 caatttaaat tatgtatttg cttaatacat ttttatattt gtaactgtgg taaaaaaaaa
    12241 atctatatag catcttgcat acattctcac tagtacagga ataaaactgc agtttgttga
    12301 a
//
