LOCUS       NM_001385321            2903 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type A (PTPRA),
            transcript variant 22, mRNA.
ACCESSION   NM_001385321
VERSION     NM_001385321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Fang,J., Zhang,Y., Huang,C., Lu,R., Yu,J., Chen,R., Wang,Y.,
            Zhao,X., Yu,J. and Huang,J.
  TITLE     Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation
  JOURNAL   Oncogene 42 (14), 1058-1071 (2023)
   PUBMED   36765146
  REMARK    GeneRIF: Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation.
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Hill,M.A., Bentley,S.R., Walker,T.L., Mellick,G.D., Wood,S.A. and
            Sykes,A.M.
  TITLE     Does a rare mutation in PTPRA contribute to the development of
            Parkinson's disease in an Australian multi-incident family?
  JOURNAL   PLoS One 17 (7), e0271499 (2022)
   PUBMED   35900966
  REMARK    GeneRIF: Does a rare mutation in PTPRA contribute to the
            development of Parkinson's disease in an Australian multi-incident
            family?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Xie,F., Huang,C., Liu,F., Zhang,H., Xiao,X., Sun,J., Zhang,X. and
            Jiang,G.
  TITLE     CircPTPRA blocks the recognition of RNA N6-methyladenosine through
            interacting with IGF2BP1 to suppress bladder cancer progression
  JOURNAL   Mol Cancer 20 (1), 68 (2021)
   PUBMED   33853613
  REMARK    GeneRIF: CircPTPRA blocks the recognition of RNA
            N(6)-methyladenosine through interacting with IGF2BP1 to suppress
            bladder cancer progression.
            Erratum:[Mol Cancer. 2022 Nov 1;21(1):205. doi:
            10.1186/s12943-022-01677-8.. PMID: 36316700]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
  TITLE     Cell transformation and activation of pp60c-src by overexpression
            of a protein tyrosine phosphatase
  JOURNAL   Nature 359 (6393), 336-339 (1992)
   PUBMED   1383828
REFERENCE   7  (bases 1 to 2903)
  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
            assigned to human chromosome 20p12-pter by in situ hybridization
            (ISH and FISH)
  JOURNAL   Genomics 13 (3), 906-907 (1992)
   PUBMED   1639427
REFERENCE   8  (bases 1 to 2903)
  AUTHORS   Jirik,F.R., Anderson,L.L. and Duncan,A.M.
  TITLE     The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is
            assigned to chromosome 20p13
  JOURNAL   Cytogenet Cell Genet 60 (2), 117-118 (1992)
   PUBMED   1611910
REFERENCE   9  (bases 1 to 2903)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
REFERENCE   10 (bases 1 to 2903)
  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
  TITLE     Cloning and expression of a widely expressed receptor tyrosine
            phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6112-6116 (1990)
   PUBMED   2166945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161656.20 and AL121905.23.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            domain, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. This PTP has been shown to dephosphorylate and
            activate Src family tyrosine kinases, and is implicated in the
            regulation of integrin signaling, cell adhesion and proliferation.
            Three alternatively spliced variants of this gene, which encode two
            distinct isoforms, have been reported. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.882851.1,
                                           SRR14038196.1514188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AL161656.20        54172-54451
            281-359             AL121905.23        628-706
            360-402             AL121905.23        25403-25445
            403-481             AL121905.23        41693-41771
            482-823             AL121905.23        42282-42623
            824-908             AL121905.23        64186-64270
            909-982             AL121905.23        65453-65526
            983-1119            AL121905.23        65759-65895
            1120-1210           AL121905.23        82477-82567
            1211-1287           AL121905.23        84765-84841
            1288-1324           AL121905.23        93270-93306
            1325-1422           AL121905.23        95237-95334
            1423-1572           AL121905.23        101893-102042
            1573-1666           AL121905.23        104108-104201
            1667-1743           AL121905.23        104542-104618
            1744-1878           AL121905.23        105128-105262
            1879-2004           AL121905.23        113006-113131
            2005-2156           AL121905.23        113211-113362
            2157-2292           AL121905.23        114575-114710
            2293-2903           AL121905.23        115480-116090
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2903
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="protein tyrosine phosphatase receptor type A"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
     exon            1..280
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            281..359
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            360..402
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            403..481
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..2367
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /EC_number="3.1.3.48"
                     /note="isoform 14 precursor is encoded by transcript
                     variant 22; protein tyrosine phosphatase, receptor type,
                     alpha polypeptide; PTPase-alpha; Leukocyte common
                     antigen-related peptide (protein tyrosine phosphate);
                     tyrosine phosphatase alpha; PTPLCA-related phosphatase;
                     receptor-type tyrosine-protein phosphatase alpha;
                     protein-tyrosine phosphatase alpha"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase alpha
                     isoform 14 precursor"
                     /protein_id="NP_001372250.1"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
                     /translation="MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVK
                     EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITIS
                     PNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFII
                     IVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLE
                     EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT
                     PVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
                     ERKEMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTS
                     IKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
                     DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDI
                     TVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV
                     QKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHM
                     VQTLEQYEFCYKVVQEYIDAFSDYANFK"
     exon            482..823
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            824..908
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            909..982
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1119
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1210
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1287
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1324
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1422
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1572
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1666
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1743
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1878
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2004
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2156
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2292
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2903
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: ATTAAA"
     polyA_site      2593
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="major polyA site"
ORIGIN      
        1 gggtcgggag cgaggctgcg gcgagtgcgg cgctgacaga gacgcgcgcg cgcgcgatcg
       61 cgctcggacc ccggccgctg ccgccatcac tgtcgcccgc ccagtcgccc ctcagccgct
      121 tcccctcgcc atggaggcga ggccgccgcc gccgccgcgg ggctcggagc cgcgggccgg
      181 gcggcggccc tgagggctag tggcggcccg aaacgccgcc gcggagccga ggcggagccg
      241 ctgtcctcgt ccccagcggt cccgcccaac gcccgactct gtgacacaac taaaaaaaaa
      301 caaaggtatt tatggaattc cactgagtgg taatggatga tgcagttcaa ataactaagg
      361 acacatgttc aaagagcata attaactttt taaaagaagc taataagcat ggattcctgg
      421 ttcattcttg ttctgctcgg cagtggtctg atatgtgtca gtgccaacaa tgctaccaca
      481 gttgcacctt ctgtaggaat tacaagatta attaactcat caacggcaga accagttaaa
      541 gaagaggcca aaacttcaaa tccaacttct tcactaactt ctctttctgt ggcaccaaca
      601 ttcagcccaa atataactct gggacccacc tatttaacca ctgtcaattc ttcagactct
      661 gacaatggga ccacaagaac agcaagcacc aattctatag gcattacaat ttcaccaaat
      721 ggaacgtggc ttccagataa ccagttcacg gatgccagaa cagaaccctg ggaggggaat
      781 tccagcaccg cagcaaccac tccagaaact ttccctcctt cagatgagac accaattatt
      841 gcggtgatgg tggccctgtc ctctctgcta gtgatcgtgt ttattatcat agttttgtac
      901 atgttaaggt ttaagaaata caagcaagct gggagccatt ccaattcttt ccgcttatcc
      961 aacggccgca ctgaggatgt ggagccccag agtgtgccac ttctggccag atccccaagc
     1021 accaacagga aatacccacc cctgcccgtg gacaagctgg aagaggaaat taaccggaga
     1081 atggcagacg acaataagct cttcagggag gaattcaacg ctctccctgc atgtcctatc
     1141 caggccacct gtgaggctgc ttccaaggag gaaaacaagg aaaaaaatcg atatgtaaac
     1201 atcttgcctt atgaccactc tagagtccac ctgacaccgg ttgaaggggt tccagattct
     1261 gattacatca atgcttcatt catcaacggc taccaagaaa agaacaaatt cattgctgca
     1321 caaggaccaa aagaagaaac ggtgaatgat ttctggcgga tgatctggga acaaaacaca
     1381 gccaccatcg tcatggttac caacctgaag gagagaaagg agatgcagta tgtcttcata
     1441 taccaagccc ttctggagca ttatctctat ggagatacag aactggaagt gacctctcta
     1501 gaaacccacc tgcagaaaat ttacaacaaa atcccaggga ccagcaacaa tggattagag
     1561 gaggagttta agaagttaac atcaatcaaa atccagaatg acaagatgcg gactggaaac
     1621 cttccagcca acatgaagaa gaaccgtgtt ttacagatca ttccatatga attcaacaga
     1681 gtgatcattc cagttaagcg gggcgaagag aatacagact atgtgaacgc atcctttatt
     1741 gatggctacc ggcagaagga ctcctatatc gccagccagg gccctcttct ccacacaatt
     1801 gaggacttct ggcgaatgat ctgggagtgg aaatcctgct ctatcgtgat gctaacagaa
     1861 ctggaggaga gaggccagga gaagtgtgcc cagtactggc catctgatgg actggtgtcc
     1921 tatggagata ttacagtgga actgaagaag gaggaggaat gtgagagcta caccgtccga
     1981 gacctcctgg tcaccaacac cagggagaat aagagccggc agatccggca gttccacttc
     2041 catggctggc ctgaagtggg catccccagt gacggaaagg gcatgatcag catcatcgcc
     2101 gccgtgcaga agcagcagca gcagtcaggg aaccacccca tcaccgtgca ctgcagcgcc
     2161 ggggcaggaa ggacggggac cttctgtgcc ctgagcaccg tcctggagcg tgtgaaagca
     2221 gaggggattt tggatgtctt ccagactgtc aagagcctgc ggctacagag gccacacatg
     2281 gtccagacac tggaacagta tgagttctgc tacaaggtgg tgcaggagta tattgatgca
     2341 ttctcagatt atgccaactt caagtaagcg gcaacaaggg tccgtggacc aggaggattg
     2401 cctttaatat tttgtaatat tctgttttgt taatataccc caaattgtgt atatatctta
     2461 taactgtttt agaaattggt acataggctt ctattaccta ttaggtggaa attttatatg
     2521 taaatgtgtt agcactgata gtcctttttc caatgtttta ttggggaatt aaatagtgtg
     2581 atgtttggat tgatatcgtg aaatcctcag ccgagaaatt gggctggatt gtgctttggt
     2641 taatacatct ttccctaaag aagataaaca caaaatccat tccaggtagc tcggcaccaa
     2701 ctaagaaaaa aagcacaaag ttctcagagc tctcgaggaa agtggttgtc cccgtaccac
     2761 catgcactgt aaatatccct cccctctctc cctggtcccc tcccccatcc ccaccactga
     2821 tatcatgggg agtaatagga ccagagcggt atctctggca ccacactagg gactatcagg
     2881 taataaaagc tttgactccc tga
//
