LOCUS       NM_001385318            2860 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type A (PTPRA),
            transcript variant 19, mRNA.
ACCESSION   NM_001385318
VERSION     NM_001385318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2860)
  AUTHORS   Fang,J., Zhang,Y., Huang,C., Lu,R., Yu,J., Chen,R., Wang,Y.,
            Zhao,X., Yu,J. and Huang,J.
  TITLE     Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation
  JOURNAL   Oncogene 42 (14), 1058-1071 (2023)
   PUBMED   36765146
  REMARK    GeneRIF: Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation.
REFERENCE   2  (bases 1 to 2860)
  AUTHORS   Hill,M.A., Bentley,S.R., Walker,T.L., Mellick,G.D., Wood,S.A. and
            Sykes,A.M.
  TITLE     Does a rare mutation in PTPRA contribute to the development of
            Parkinson's disease in an Australian multi-incident family?
  JOURNAL   PLoS One 17 (7), e0271499 (2022)
   PUBMED   35900966
  REMARK    GeneRIF: Does a rare mutation in PTPRA contribute to the
            development of Parkinson's disease in an Australian multi-incident
            family?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2860)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2860)
  AUTHORS   Xie,F., Huang,C., Liu,F., Zhang,H., Xiao,X., Sun,J., Zhang,X. and
            Jiang,G.
  TITLE     CircPTPRA blocks the recognition of RNA N6-methyladenosine through
            interacting with IGF2BP1 to suppress bladder cancer progression
  JOURNAL   Mol Cancer 20 (1), 68 (2021)
   PUBMED   33853613
  REMARK    GeneRIF: CircPTPRA blocks the recognition of RNA
            N(6)-methyladenosine through interacting with IGF2BP1 to suppress
            bladder cancer progression.
            Erratum:[Mol Cancer. 2022 Nov 1;21(1):205. doi:
            10.1186/s12943-022-01677-8.. PMID: 36316700]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2860)
  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
  TITLE     Cell transformation and activation of pp60c-src by overexpression
            of a protein tyrosine phosphatase
  JOURNAL   Nature 359 (6393), 336-339 (1992)
   PUBMED   1383828
REFERENCE   7  (bases 1 to 2860)
  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
            assigned to human chromosome 20p12-pter by in situ hybridization
            (ISH and FISH)
  JOURNAL   Genomics 13 (3), 906-907 (1992)
   PUBMED   1639427
REFERENCE   8  (bases 1 to 2860)
  AUTHORS   Jirik,F.R., Anderson,L.L. and Duncan,A.M.
  TITLE     The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is
            assigned to chromosome 20p13
  JOURNAL   Cytogenet Cell Genet 60 (2), 117-118 (1992)
   PUBMED   1611910
REFERENCE   9  (bases 1 to 2860)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
REFERENCE   10 (bases 1 to 2860)
  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
  TITLE     Cloning and expression of a widely expressed receptor tyrosine
            phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6112-6116 (1990)
   PUBMED   2166945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161656.20 and AL121905.23.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            domain, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. This PTP has been shown to dephosphorylate and
            activate Src family tyrosine kinases, and is implicated in the
            regulation of integrin signaling, cell adhesion and proliferation.
            Three alternatively spliced variants of this gene, which encode two
            distinct isoforms, have been reported. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.186363.1,
                                           SRR14038193.1992225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AL161656.20        54172-54451
            281-359             AL121905.23        628-706
            360-438             AL121905.23        41693-41771
            439-780             AL121905.23        42282-42623
            781-865             AL121905.23        64186-64270
            866-939             AL121905.23        65453-65526
            940-1076            AL121905.23        65759-65895
            1077-1167           AL121905.23        82477-82567
            1168-1244           AL121905.23        84765-84841
            1245-1281           AL121905.23        93270-93306
            1282-1379           AL121905.23        95237-95334
            1380-1529           AL121905.23        101893-102042
            1530-1623           AL121905.23        104108-104201
            1624-1700           AL121905.23        104542-104618
            1701-1835           AL121905.23        105128-105262
            1836-1961           AL121905.23        113006-113131
            1962-2113           AL121905.23        113211-113362
            2114-2249           AL121905.23        114575-114710
            2250-2860           AL121905.23        115480-116090
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2860
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="protein tyrosine phosphatase receptor type A"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
     exon            1..280
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            281..359
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2324
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /EC_number="3.1.3.48"
                     /note="isoform 12 precursor is encoded by transcript
                     variant 19; protein tyrosine phosphatase, receptor type,
                     alpha polypeptide; PTPase-alpha; Leukocyte common
                     antigen-related peptide (protein tyrosine phosphate);
                     tyrosine phosphatase alpha; PTPLCA-related phosphatase;
                     receptor-type tyrosine-protein phosphatase alpha;
                     protein-tyrosine phosphatase alpha"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase alpha
                     isoform 12 precursor"
                     /protein_id="NP_001372247.1"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
                     /translation="MDDAVQITKISMDSWFILVLLGSGLICVSANNATTVAPSVGITR
                     LINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRT
                     ASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVA
                     LSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNR
                     KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNI
                     LPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQN
                     TATIVMVTNLKERKEMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNN
                     GLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYV
                     NASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW
                     PSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSD
                     GKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQT
                     VKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK"
     exon            360..438
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            439..780
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            781..865
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            866..939
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1076
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1167
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1244
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1281
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1379
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1529
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1623
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1700
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1835
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1961
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2113
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2249
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2860
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: ATTAAA"
     polyA_site      2550
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: AATAAA"
     polyA_site      2860
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="major polyA site"
ORIGIN      
        1 gggtcgggag cgaggctgcg gcgagtgcgg cgctgacaga gacgcgcgcg cgcgcgatcg
       61 cgctcggacc ccggccgctg ccgccatcac tgtcgcccgc ccagtcgccc ctcagccgct
      121 tcccctcgcc atggaggcga ggccgccgcc gccgccgcgg ggctcggagc cgcgggccgg
      181 gcggcggccc tgagggctag tggcggcccg aaacgccgcc gcggagccga ggcggagccg
      241 ctgtcctcgt ccccagcggt cccgcccaac gcccgactct gtgacacaac taaaaaaaaa
      301 caaaggtatt tatggaattc cactgagtgg taatggatga tgcagttcaa ataactaaga
      361 taagcatgga ttcctggttc attcttgttc tgctcggcag tggtctgata tgtgtcagtg
      421 ccaacaatgc taccacagtt gcaccttctg taggaattac aagattaatt aactcatcaa
      481 cggcagaacc agttaaagaa gaggccaaaa cttcaaatcc aacttcttca ctaacttctc
      541 tttctgtggc accaacattc agcccaaata taactctggg acccacctat ttaaccactg
      601 tcaattcttc agactctgac aatgggacca caagaacagc aagcaccaat tctataggca
      661 ttacaatttc accaaatgga acgtggcttc cagataacca gttcacggat gccagaacag
      721 aaccctggga ggggaattcc agcaccgcag caaccactcc agaaactttc cctccttcag
      781 atgagacacc aattattgcg gtgatggtgg ccctgtcctc tctgctagtg atcgtgttta
      841 ttatcatagt tttgtacatg ttaaggttta agaaatacaa gcaagctggg agccattcca
      901 attctttccg cttatccaac ggccgcactg aggatgtgga gccccagagt gtgccacttc
      961 tggccagatc cccaagcacc aacaggaaat acccacccct gcccgtggac aagctggaag
     1021 aggaaattaa ccggagaatg gcagacgaca ataagctctt cagggaggaa ttcaacgctc
     1081 tccctgcatg tcctatccag gccacctgtg aggctgcttc caaggaggaa aacaaggaaa
     1141 aaaatcgata tgtaaacatc ttgccttatg accactctag agtccacctg acaccggttg
     1201 aaggggttcc agattctgat tacatcaatg cttcattcat caacggctac caagaaaaga
     1261 acaaattcat tgctgcacaa ggaccaaaag aagaaacggt gaatgatttc tggcggatga
     1321 tctgggaaca aaacacagcc accatcgtca tggttaccaa cctgaaggag agaaaggaga
     1381 tgcagtatgt cttcatatac caagcccttc tggagcatta tctctatgga gatacagaac
     1441 tggaagtgac ctctctagaa acccacctgc agaaaattta caacaaaatc ccagggacca
     1501 gcaacaatgg attagaggag gagtttaaga agttaacatc aatcaaaatc cagaatgaca
     1561 agatgcggac tggaaacctt ccagccaaca tgaagaagaa ccgtgtttta cagatcattc
     1621 catatgaatt caacagagtg atcattccag ttaagcgggg cgaagagaat acagactatg
     1681 tgaacgcatc ctttattgat ggctaccggc agaaggactc ctatatcgcc agccagggcc
     1741 ctcttctcca cacaattgag gacttctggc gaatgatctg ggagtggaaa tcctgctcta
     1801 tcgtgatgct aacagaactg gaggagagag gccaggagaa gtgtgcccag tactggccat
     1861 ctgatggact ggtgtcctat ggagatatta cagtggaact gaagaaggag gaggaatgtg
     1921 agagctacac cgtccgagac ctcctggtca ccaacaccag ggagaataag agccggcaga
     1981 tccggcagtt ccacttccat ggctggcctg aagtgggcat ccccagtgac ggaaagggca
     2041 tgatcagcat catcgccgcc gtgcagaagc agcagcagca gtcagggaac caccccatca
     2101 ccgtgcactg cagcgccggg gcaggaagga cggggacctt ctgtgccctg agcaccgtcc
     2161 tggagcgtgt gaaagcagag gggattttgg atgtcttcca gactgtcaag agcctgcggc
     2221 tacagaggcc acacatggtc cagacactgg aacagtatga gttctgctac aaggtggtgc
     2281 aggagtatat tgatgcattc tcagattatg ccaacttcaa gtaagcggca acaagggtcc
     2341 gtggaccagg aggattgcct ttaatatttt gtaatattct gttttgttaa tataccccaa
     2401 attgtgtata tatcttataa ctgttttaga aattggtaca taggcttcta ttacctatta
     2461 ggtggaaatt ttatatgtaa atgtgttagc actgatagtc ctttttccaa tgttttattg
     2521 gggaattaaa tagtgtgatg tttggattga tatcgtgaaa tcctcagccg agaaattggg
     2581 ctggattgtg ctttggttaa tacatctttc cctaaagaag ataaacacaa aatccattcc
     2641 aggtagctcg gcaccaacta agaaaaaaag cacaaagttc tcagagctct cgaggaaagt
     2701 ggttgtcccc gtaccaccat gcactgtaaa tatccctccc ctctctccct ggtcccctcc
     2761 cccatcccca ccactgatat catggggagt aataggacca gagcggtatc tctggcacca
     2821 cactagggac tatcaggtaa taaaagcttt gactccctga
//
