LOCUS       NM_001385305            3353 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase receptor type A (PTPRA),
            transcript variant 7, mRNA.
ACCESSION   NM_001385305
VERSION     NM_001385305.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Fang,J., Zhang,Y., Huang,C., Lu,R., Yu,J., Chen,R., Wang,Y.,
            Zhao,X., Yu,J. and Huang,J.
  TITLE     Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation
  JOURNAL   Oncogene 42 (14), 1058-1071 (2023)
   PUBMED   36765146
  REMARK    GeneRIF: Glucose-mediated N-glycosylation of RPTPalpha affects its
            subcellular localization and Src activation.
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Hill,M.A., Bentley,S.R., Walker,T.L., Mellick,G.D., Wood,S.A. and
            Sykes,A.M.
  TITLE     Does a rare mutation in PTPRA contribute to the development of
            Parkinson's disease in an Australian multi-incident family?
  JOURNAL   PLoS One 17 (7), e0271499 (2022)
   PUBMED   35900966
  REMARK    GeneRIF: Does a rare mutation in PTPRA contribute to the
            development of Parkinson's disease in an Australian multi-incident
            family?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Xie,F., Huang,C., Liu,F., Zhang,H., Xiao,X., Sun,J., Zhang,X. and
            Jiang,G.
  TITLE     CircPTPRA blocks the recognition of RNA N6-methyladenosine through
            interacting with IGF2BP1 to suppress bladder cancer progression
  JOURNAL   Mol Cancer 20 (1), 68 (2021)
   PUBMED   33853613
  REMARK    GeneRIF: CircPTPRA blocks the recognition of RNA
            N(6)-methyladenosine through interacting with IGF2BP1 to suppress
            bladder cancer progression.
            Erratum:[Mol Cancer. 2022 Nov 1;21(1):205. doi:
            10.1186/s12943-022-01677-8.. PMID: 36316700]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
  TITLE     Cell transformation and activation of pp60c-src by overexpression
            of a protein tyrosine phosphatase
  JOURNAL   Nature 359 (6393), 336-339 (1992)
   PUBMED   1383828
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
            assigned to human chromosome 20p12-pter by in situ hybridization
            (ISH and FISH)
  JOURNAL   Genomics 13 (3), 906-907 (1992)
   PUBMED   1639427
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Jirik,F.R., Anderson,L.L. and Duncan,A.M.
  TITLE     The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is
            assigned to chromosome 20p13
  JOURNAL   Cytogenet Cell Genet 60 (2), 117-118 (1992)
   PUBMED   1611910
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
            Ricca,G., Jaye,M. and Schlessinger,J.
  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
            family of receptor-linked protein-tyrosine-phosphatases expressed
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7000-7004 (1990)
   PUBMED   2169617
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
  TITLE     Cloning and expression of a widely expressed receptor tyrosine
            phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6112-6116 (1990)
   PUBMED   2166945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161656.20 and AL121905.23.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            domain, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. This PTP has been shown to dephosphorylate and
            activate Src family tyrosine kinases, and is implicated in the
            regulation of integrin signaling, cell adhesion and proliferation.
            Three alternatively spliced variants of this gene, which encode two
            distinct isoforms, have been reported. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3811304.1,
                                           SRR14038195.2596625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399903.7/ ENSP00000382787.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AL161656.20        54172-54451
            281-359             AL121905.23        628-706
            360-402             AL121905.23        25403-25445
            403-481             AL121905.23        41693-41771
            482-823             AL121905.23        42282-42623
            824-850             AL121905.23        52636-52662
            851-935             AL121905.23        64186-64270
            936-1009            AL121905.23        65453-65526
            1010-1146           AL121905.23        65759-65895
            1147-1237           AL121905.23        82477-82567
            1238-1314           AL121905.23        84765-84841
            1315-1351           AL121905.23        93270-93306
            1352-1449           AL121905.23        95237-95334
            1450-1569           AL121905.23        98730-98849
            1570-1736           AL121905.23        99475-99641
            1737-1872           AL121905.23        100110-100245
            1873-2022           AL121905.23        101893-102042
            2023-2116           AL121905.23        104108-104201
            2117-2193           AL121905.23        104542-104618
            2194-2328           AL121905.23        105128-105262
            2329-2454           AL121905.23        113006-113131
            2455-2606           AL121905.23        113211-113362
            2607-2742           AL121905.23        114575-114710
            2743-3353           AL121905.23        115480-116090
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3353
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="protein tyrosine phosphatase receptor type A"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
     exon            1..280
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            281..359
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            360..402
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            403..481
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..2817
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 7; protein tyrosine phosphatase, receptor type,
                     alpha polypeptide; PTPase-alpha; Leukocyte common
                     antigen-related peptide (protein tyrosine phosphate);
                     tyrosine phosphatase alpha; PTPLCA-related phosphatase;
                     receptor-type tyrosine-protein phosphatase alpha;
                     protein-tyrosine phosphatase alpha"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase alpha
                     isoform 1 precursor"
                     /protein_id="NP_001372234.1"
                     /db_xref="CCDS:CCDS13038.1"
                     /db_xref="GeneID:5786"
                     /db_xref="HGNC:HGNC:9664"
                     /db_xref="MIM:176884"
                     /translation="MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVK
                     EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITIS
                     PNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALS
                     SLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKY
                     PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP
                     YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
                     TIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT
                     NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG
                     TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
                     LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQ
                     IIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEW
                     KSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR
                     ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTG
                     TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
                     ANFK"
     exon            482..823
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            824..850
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            851..935
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1009
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1146
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1237
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1314
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1351
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1449
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1569
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1736
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1872
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2022
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2116
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2193
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2328
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2454
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2606
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2742
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..3353
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: ATTAAA"
     polyA_site      3043
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="hexamer: AATAAA"
     polyA_site      3353
                     /gene="PTPRA"
                     /gene_synonym="HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA;
                     PTPRL2; R-PTP-alpha; RPTPA"
                     /note="major polyA site"
ORIGIN      
        1 gggtcgggag cgaggctgcg gcgagtgcgg cgctgacaga gacgcgcgcg cgcgcgatcg
       61 cgctcggacc ccggccgctg ccgccatcac tgtcgcccgc ccagtcgccc ctcagccgct
      121 tcccctcgcc atggaggcga ggccgccgcc gccgccgcgg ggctcggagc cgcgggccgg
      181 gcggcggccc tgagggctag tggcggcccg aaacgccgcc gcggagccga ggcggagccg
      241 ctgtcctcgt ccccagcggt cccgcccaac gcccgactct gtgacacaac taaaaaaaaa
      301 caaaggtatt tatggaattc cactgagtgg taatggatga tgcagttcaa ataactaagg
      361 acacatgttc aaagagcata attaactttt taaaagaagc taataagcat ggattcctgg
      421 ttcattcttg ttctgctcgg cagtggtctg atatgtgtca gtgccaacaa tgctaccaca
      481 gttgcacctt ctgtaggaat tacaagatta attaactcat caacggcaga accagttaaa
      541 gaagaggcca aaacttcaaa tccaacttct tcactaactt ctctttctgt ggcaccaaca
      601 ttcagcccaa atataactct gggacccacc tatttaacca ctgtcaattc ttcagactct
      661 gacaatggga ccacaagaac agcaagcacc aattctatag gcattacaat ttcaccaaat
      721 ggaacgtggc ttccagataa ccagttcacg gatgccagaa cagaaccctg ggaggggaat
      781 tccagcaccg cagcaaccac tccagaaact ttccctcctt caggtaattc tgactcgaag
      841 gacagaagag atgagacacc aattattgcg gtgatggtgg ccctgtcctc tctgctagtg
      901 atcgtgttta ttatcatagt tttgtacatg ttaaggttta agaaatacaa gcaagctggg
      961 agccattcca attctttccg cttatccaac ggccgcactg aggatgtgga gccccagagt
     1021 gtgccacttc tggccagatc cccaagcacc aacaggaaat acccacccct gcccgtggac
     1081 aagctggaag aggaaattaa ccggagaatg gcagacgaca ataagctctt cagggaggaa
     1141 ttcaacgctc tccctgcatg tcctatccag gccacctgtg aggctgcttc caaggaggaa
     1201 aacaaggaaa aaaatcgata tgtaaacatc ttgccttatg accactctag agtccacctg
     1261 acaccggttg aaggggttcc agattctgat tacatcaatg cttcattcat caacggctac
     1321 caagaaaaga acaaattcat tgctgcacaa ggaccaaaag aagaaacggt gaatgatttc
     1381 tggcggatga tctgggaaca aaacacagcc accatcgtca tggttaccaa cctgaaggag
     1441 agaaaggagt gcaagtgcgc ccagtactgg ccagaccaag gctgctggac ctatgggaat
     1501 attcgggtgt ctgtagagga tgtgactgtc ctggtggact acacagtacg gaagttctgc
     1561 atccagcagg tgggcgacat gaccaacaga aagccacagc gcctcatcac tcagttccac
     1621 tttaccagct ggccagactt tggggtgcct tttaccccga tcggcatgct caagttcctc
     1681 aagaaggtga aggcctgtaa ccctcagtat gcaggggcca tcgtggtcca ctgcagtgca
     1741 ggtgtagggc gtacaggtac ctttgtcgtc attgatgcca tgctggacat gatgcataca
     1801 gaacggaagg tggacgtgta tggctttgtg agccggatcc gggcacagcg ctgccagatg
     1861 gtgcaaaccg atatgcagta tgtcttcata taccaagccc ttctggagca ttatctctat
     1921 ggagatacag aactggaagt gacctctcta gaaacccacc tgcagaaaat ttacaacaaa
     1981 atcccaggga ccagcaacaa tggattagag gaggagttta agaagttaac atcaatcaaa
     2041 atccagaatg acaagatgcg gactggaaac cttccagcca acatgaagaa gaaccgtgtt
     2101 ttacagatca ttccatatga attcaacaga gtgatcattc cagttaagcg gggcgaagag
     2161 aatacagact atgtgaacgc atcctttatt gatggctacc ggcagaagga ctcctatatc
     2221 gccagccagg gccctcttct ccacacaatt gaggacttct ggcgaatgat ctgggagtgg
     2281 aaatcctgct ctatcgtgat gctaacagaa ctggaggaga gaggccagga gaagtgtgcc
     2341 cagtactggc catctgatgg actggtgtcc tatggagata ttacagtgga actgaagaag
     2401 gaggaggaat gtgagagcta caccgtccga gacctcctgg tcaccaacac cagggagaat
     2461 aagagccggc agatccggca gttccacttc catggctggc ctgaagtggg catccccagt
     2521 gacggaaagg gcatgatcag catcatcgcc gccgtgcaga agcagcagca gcagtcaggg
     2581 aaccacccca tcaccgtgca ctgcagcgcc ggggcaggaa ggacggggac cttctgtgcc
     2641 ctgagcaccg tcctggagcg tgtgaaagca gaggggattt tggatgtctt ccagactgtc
     2701 aagagcctgc ggctacagag gccacacatg gtccagacac tggaacagta tgagttctgc
     2761 tacaaggtgg tgcaggagta tattgatgca ttctcagatt atgccaactt caagtaagcg
     2821 gcaacaaggg tccgtggacc aggaggattg cctttaatat tttgtaatat tctgttttgt
     2881 taatataccc caaattgtgt atatatctta taactgtttt agaaattggt acataggctt
     2941 ctattaccta ttaggtggaa attttatatg taaatgtgtt agcactgata gtcctttttc
     3001 caatgtttta ttggggaatt aaatagtgtg atgtttggat tgatatcgtg aaatcctcag
     3061 ccgagaaatt gggctggatt gtgctttggt taatacatct ttccctaaag aagataaaca
     3121 caaaatccat tccaggtagc tcggcaccaa ctaagaaaaa aagcacaaag ttctcagagc
     3181 tctcgaggaa agtggttgtc cccgtaccac catgcactgt aaatatccct cccctctctc
     3241 cctggtcccc tcccccatcc ccaccactga tatcatgggg agtaatagga ccagagcggt
     3301 atctctggca ccacactagg gactatcagg taataaaagc tttgactccc tga
//
