LOCUS       NM_002833               7839 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 9
            (PTPN9), mRNA.
ACCESSION   NM_002833 XM_936591
VERSION     NM_002833.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7839)
  AUTHORS   Li,X., Wang,J., Liao,C., Yang,X., Zhao,Z., Liu,Y., Xue,Q., Luo,Y.,
            Liu,X. and Liu,Z.
  TITLE     The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated
            microglial hyperalgesia during inflammatory pain
  JOURNAL   FASEB J 38 (8), e23590 (2024)
   PUBMED   38656553
  REMARK    GeneRIF: The binding of PKCepsilon and MEG2 to STAT3 regulates
            IL-6-mediated microglial hyperalgesia during inflammatory pain.
REFERENCE   2  (bases 1 to 7839)
  AUTHORS   Desouky,E.M., Khaliefa,A.K., Hozayen,W.G., Shaaban,S.M. and
            Hasona,N.A.
  TITLE     Signature of miR-21 and MEG-2 and their correlation with TGF-beta
            signaling in breast cancer
  JOURNAL   Hum Exp Toxicol 42, 9603271231159799 (2023)
   PUBMED   36825546
  REMARK    GeneRIF: Signature of miR-21 and MEG-2 and their correlation with
            TGF-beta signaling in breast cancer.
REFERENCE   3  (bases 1 to 7839)
  AUTHORS   Xiong,J., Niu,Y., Liu,W., Zeng,F., Cheng,J.F., Chen,S.Q. and
            Zeng,X.Z.
  TITLE     Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced
            ONFH in Chinese Han population
  JOURNAL   Neurol Sci 43 (4), 2823-2830 (2022)
   PUBMED   34373992
  REMARK    GeneRIF: Effect of L3MBTL3/PTPN9 polymorphisms on risk to
            alcohol-induced ONFH in Chinese Han population.
REFERENCE   4  (bases 1 to 7839)
  AUTHORS   Zhu,L., Guo,T., Chen,W., Lin,Z., Ye,M. and Pan,X.
  TITLE     CircMMD_007 promotes oncogenic effects in the progression of lung
            adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase
            non-receptor type 9 axis
  JOURNAL   Bioengineered 13 (3), 4991-5004 (2022)
   PUBMED   35156900
  REMARK    GeneRIF: CircMMD_007 promotes oncogenic effects in the progression
            of lung adenocarcinoma through microRNA-197-3p/protein tyrosine
            phosphatase non-receptor type 9 axis.
REFERENCE   5  (bases 1 to 7839)
  AUTHORS   Bao,Z., Gao,S., Zhang,B., Shi,W., Li,A. and Tian,Q.
  TITLE     The Critical Role of the miR-21-MEG2 Axis in Colorectal Cancer
  JOURNAL   Crit Rev Eukaryot Gene Expr 30 (6), 509-518 (2020)
   PUBMED   33463918
  REMARK    GeneRIF: The Critical Role of the miR-21-MEG2 Axis in Colorectal
            Cancer.
REFERENCE   6  (bases 1 to 7839)
  AUTHORS   Pasquali,C., Curchod,M.L., Walchli,S., Espanel,X., Guerrier,M.,
            Arigoni,F., Strous,G. and Hooft van Huijsduijnen,R.
  TITLE     Identification of protein tyrosine phosphatases with specificity
            for the ligand-activated growth hormone receptor
  JOURNAL   Mol Endocrinol 17 (11), 2228-2239 (2003)
   PUBMED   12907755
REFERENCE   7  (bases 1 to 7839)
  AUTHORS   Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C.,
            Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P.
  TITLE     Protein-tyrosine phosphatase MEG2 is expressed by human
            neutrophils. Localization to the phagosome and activation by
            polyphosphoinositides
  JOURNAL   J Biol Chem 277 (4), 2620-2628 (2002)
   PUBMED   11711529
REFERENCE   8  (bases 1 to 7839)
  AUTHORS   Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J.
  TITLE     Purification and characterization of protein tyrosine phosphatase
            PTP-MEG2
  JOURNAL   J Cell Biochem 86 (1), 79-89 (2002)
   PUBMED   12112018
  REMARK    GeneRIF: Purification and characterization of protein tyrosine
            phosphatase PTP-MEG2
REFERENCE   9  (bases 1 to 7839)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   10 (bases 1 to 7839)
  AUTHORS   Gu,M., Warshawsky,I. and Majerus,P.W.
  TITLE     Cloning and expression of a cytosolic megakaryocyte
            protein-tyrosine-phosphatase with sequence homology to
            retinaldehyde-binding protein and yeast SEC14p
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2980-2984 (1992)
   PUBMED   1557404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105036.14, M83738.1,
            BC071574.1 and AC105137.18.
            
            On May 17, 2019 this sequence version replaced NM_002833.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an N-terminal domain
            that shares a significant similarity with yeast SEC14, which is a
            protein that has phosphatidylinositol transfer activity and is
            required for protein secretion through the Golgi complex in yeast.
            This PTP was found to be activated by polyphosphoinositide, and is
            thought to be involved in signaling events regulating phagocytosis.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3944431.1, M83738.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618819.5/ ENSP00000482732.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC105036.14        118457-118487       c
            32-2786             M83738.1           1-2755
            2787-2845           BC071574.1         2683-2741
            2846-3831           M83738.1           2815-3800
            3832-3832           AC105137.18        163922-163922       c
            3833-3969           M83738.1           3802-3938
            3970-7839           AC105137.18        159915-163784       c
FEATURES             Location/Qualifiers
     source          1..7839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..7839
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /note="protein tyrosine phosphatase non-receptor type 9"
                     /db_xref="GeneID:5780"
                     /db_xref="HGNC:HGNC:9661"
                     /db_xref="MIM:600768"
     exon            1..602
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..2321
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase MEG2; PTPase-MEG2"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     9"
                     /protein_id="NP_002824.1"
                     /db_xref="CCDS:CCDS10280.1"
                     /db_xref="GeneID:5780"
                     /db_xref="HGNC:HGNC:9661"
                     /db_xref="MIM:600768"
                     /translation="MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSW
                     NVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVR
                     DPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNY
                     ANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILK
                     TSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWD
                     SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG
                     DVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWE
                     QKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIH
                     NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPE
                     PPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYF
                     CYKAILEFAEKEGMVSSGQNLLAVESQ"
     exon            603..746
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..836
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..961
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1067
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1178
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1507
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1601
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1668
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1747
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1898
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2106
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..7839
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /note="hexamer: AATATA"
     polyA_site      3967
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /note="major polyA site"
     regulatory      4438..4443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /note="hexamer: AGTAAA"
     polyA_site      4461
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
     regulatory      7815..7820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
                     /note="hexamer: AATAAA"
     polyA_site      7839
                     /gene="PTPN9"
                     /gene_synonym="MEG2; PTPMEG2"
ORIGIN      
        1 ccctttcgct gcggccgccc gcgaggagcc tggctgaggc agccgcgcag gtcgcagggc
       61 cagcgtccgc gaggacggcc cggctgggcg gccccgagct ctgtggcgct gtggaggagc
      121 gggagcgcgg ccgaggaagc ggggcgccga gggggtcggc ggccttcggg aaatttccgc
      181 cgacccttcg ctcccggctc taaaagttcc tgatttccta tttcctttta aatcccgagt
      241 ggctgttagc tcttcgcctg cactttttct tccccaggag ataaggggga gtgtgaggaa
      301 cggagcgaat aatataaaaa aggatttcct cccggaagag agcggcagtt cggagagatt
      361 tttcttaagg aagcagaagc ggcgtttgcg gccgctgcag gcgccgggcc ctgccggcca
      421 cactatgcgc gagccggccc cgggctgctg aggcgcgggg acgcggaagc ggaggccgag
      481 cgcgccgggc tcccgcgctc gcgagcgagt tttgtccgcc cggcggcggt ggcgggggga
      541 tggagcccgc gaccgcgccc cggcccgaca tggcgccgga gctgaccccg gaggaggagc
      601 aggctaccaa gcagtttctc gaagagatta acaagtggac agttcagtac aatgtttccc
      661 cgctgtcttg gaatgtggct gtcaagttcc tcatggcaag gaagtttgat gtgctccgtg
      721 ccatagaatt gttccactcc tacagagaaa ctcgaaggaa ggaaggcatt gtaaagctga
      781 aacctcatga ggaacctctt cgttctgaga tcctcagtgg aaaattcacc atcttaaatg
      841 ttcgggaccc aacaggagcc tccattgccc tctttactgc caggttgcat catccccaca
      901 agtcagtcca acatgtggta cttcaggctc tgttttactt gctagacaga gctgtggata
      961 gctttgaaac tcagaggaat ggactggtgt ttatctatga catgtgtggt tctaattatg
     1021 ccaactttga gctggatctt ggcaagaaag tcctaaacct gctgaaggga gcatttccag
     1081 ctcgtttgaa gaaggtgctg attgtggggg cacccatatg gttccgagtg ccctattcca
     1141 tcatcagtct cctcctgaag gacaaagtcc gggagaggat tcaaatatta aagacatctg
     1201 aggtcacgca gcatctgccc agggagtgtc ttccagaaaa cctgggtggg tacgtcaaaa
     1261 ttgatctcgc cacttggaat ttccagttcc taccccaggt gaacggccac ccagatccct
     1321 tcgatgagat catcctgttc tccctccctc ctgccttaga ctgggactca gtacatgttc
     1381 caggtcccca tgctatgacc atccaagagt tggtggacta tgttaatgcc aggcaaaagc
     1441 aaggaatcta tgaggaatat gaagacattc gtcgtgagaa ccctgttggc actttccact
     1501 gttccatgtc tccaggaaac ctagagaaaa accgttatgg ggatgtaccc tgcctggacc
     1561 aaactagagt gaagctaaca aagcgaagtg gccatactca gacagattac atcaatgcca
     1621 gtttcatgga tggctacaag cagaagaatg cttacattgg cacacaaggt cctttggaga
     1681 atacctatcg tgatttctgg ctcatggtat gggagcaaaa agtcttggtg attgtcatga
     1741 ccacccgctt tgaggaaggc ggcaggagaa agtgtggcca gtactggcct ttagaaaaag
     1801 actctcggat ccgatttggc ttcctcacag tgaccaatct aggcgtggag aacatgaatc
     1861 attataagaa aacaacgcta gaaattcaca acacagagga acggcagaaa cgccaggtga
     1921 cccacttcca gttcttgagc tggccagact atggtgtccc ttcctcagca gcttccctca
     1981 ttgacttctt gagagtggtc agaaaccagc agagtctggc tgtgagcaac atgggagcac
     2041 gctccaaagg gcagtgccct gagccaccca ttgtggtcca ttgcagtgca ggcattggca
     2101 ggacaggtac cttctgctca ctggacatct gcctggcaca gctggaggag cttggcaccc
     2161 ttaatgtgtt ccagacggtg tcacgcatga ggacccagag ggccttcagc atccagaccc
     2221 ctgagcagta ctatttttgc tacaaggcca tcctggagtt cgcagagaag gagggcatgg
     2281 tatcctctgg ccaaaacctg ctggccgtgg agagtcagta actctcctac gaacctccta
     2341 cctgttggcc agccttcctt aaactaccct ggacaccgct gagcctatag gttgccatca
     2401 gttacgctga agccatggat caacttcttt cttgtgtctc ccagcacacg tgtgcacgca
     2461 aggcagcctt tccctttggc tagataaatg tggtgaaatt gccactagaa agggccagta
     2521 gcaatgtgtt cttaattcct agcatctgct atcaaactgt gccttattaa aaccaaattg
     2581 tggctattga tttttgctag ggtccccgag gtaagtgggg aaggaacctc cctcctcctt
     2641 tctcccgcca ttctttttct gaggtctcct gtctcccact ccttcccttt cctaggattt
     2701 tatggggagg tttgatgagc atttgccttt ctccccagag agcttgacca agttacatat
     2761 tctagagatc gtcctgagtg ccaagcacgt ttataagtag ggcgtgtatt ccagtccttt
     2821 ctgtcattct gtgtgtgtgt gtgtgtgcac ttatgtgtat gggtccatat gtacgtgtgt
     2881 atataatata tattgtatgt gataatatga tcgtattcta taaatacata tacacacgat
     2941 actcctttcc agaagttcct ggggctccgt gttgcagttc aggactcctt gcttcttgga
     3001 ccctactatt tatcctggac tagcttgggt tggtgatcat gtctcctctt gtcaggctac
     3061 agagtggtgg aagaggacac acacacatct cctccatgtt cctgccacag ggccccttcc
     3121 ttaagtaatg acttatctcc ttccagttgc cacctgttgg agccaagaat gtattagttt
     3181 gtggtgacac tgggttagct cagcatggat ttcccttatc cgatgatttt tctacattta
     3241 cttggccaat ttggggaaca gacctccact gtgattccat actctctctt tgctttcact
     3301 atcccaggga tgggaggcgg agggtagaga tgaactcact gagcagccag agccaaatgc
     3361 aatcggtacg aatcttagaa ggaaggaggg ggagcccagg tatgagaaag aaaaaaccac
     3421 taagaaaata cctccctggg aggatgagct ggggcccttt ttcttttgct ggatggttcc
     3481 tttatgcagc ttggccctgt ctaccgagat gcccatctct tcctgcctgc tagcctgcta
     3541 gaccctcaaa ctgggtgggt tctgtgtcaa taaaaagctt caccccctgg ctgagtgagg
     3601 tggtcccctg caatcactgt ttgtccccta cccacccaac ctgtccctgc ctgctcccag
     3661 cccactcatc cttatgtgct agggataaat caagagtcct cagcactcca cattcccaaa
     3721 aaatcccagg aactcctaaa ccttcccctg tgacagaaga tgaggttggc agctgatcag
     3781 acctcaataa ttttatactg taataagctc tttgaatgtg tatattatta ttttttacaa
     3841 tcatttcatt ttgtatttaa tatcaatgga ctgagtctga ttcagaaaat aattgtaatg
     3901 ttcatattca atatcttaca gtgatacagt tttgtattta catataaata taccgacatg
     3961 atcaaaaccc ttttagcttc atcaatttag cagcctggga catgagggag ggggtccagg
     4021 agctggtctg ggagggatga gggaggcagg gagggaccca agccttcagt atctgagact
     4081 ttgagttctg acactatgag ttcaccttgt ctgtaggcca tggccctatc tctggacaga
     4141 gggaccagca ccagttcagt gcttgagatg tgctaagcac tatgctaggt gcttttcccc
     4201 caccctgcct cattcaaacc tcacaacaat tcagtgagat attatcttct ctcccttctc
     4261 ctgtgcaccc ctttctcatt tctatataga tgaggaaggt gaggtccaga gggttacagt
     4321 gatttgctct aaaacgagct caagttggtc tgcttacaaa gcctgtggtc tcttcactgc
     4381 atggaagatg gagatcttgt gtttggagaa cagaggtttg tttagctctc ctttcagagt
     4441 aaaaaaagtt cttaaattcc aggttgttgt tcttgtgccc atgcttcatg tagtagacgc
     4501 gaagggtgac agggttggtg actgactgtc ctagctagga cctcctgatg tagggtcctc
     4561 atgtctgcag cgtaccaaag gggttatcat tctccccagg agactccata tctatgggta
     4621 catggtcttt gtgagaagat cttgagtcat ttgcatttat ctcttagaaa gaaaggaacc
     4681 agaagctttg tacatggaag accactcccc atatcatacc tgttggctgt tgatggcctg
     4741 cccagttggg gcagttgtgg ctgggaaata ttggggtgtt cttaataata gtcatagcag
     4801 ccaatttact ggatgctcac tctattccag gcactgttca gagtaatttc taggtatcat
     4861 ctcattcacc ctcaacaacc ttttgaggta ggtattgaca gaagaaaaaa attgagagac
     4921 aggaatgtta atttgctaca gccaggatcc cagaccatct gactccaaag tatcttcttt
     4981 cacctcttac actagacttc ctctaaggat ccatcttctg atctgccaat aaatttttat
     5041 cgagtttctt accataatca ggagctcaag tgtagagcag aagattaatc tagttccttc
     5101 tccagatgag cctccattct cttgggagtg cacaaacata agaagtgaac agagattctt
     5161 ggaaatctga gaaaccagag aggtcagggg tttggtggaa catgtaagaa atgggattaa
     5221 tgataaacgg cctggaggag gtaactttaa attgtcattt atttgaagag gctgtaaccc
     5281 gactgccctg tgaatttaag gttatgcatg agttcctcat tgcatatctg aagactggtg
     5341 aggttatcta tcacttcagc tccataaaat gctgatttct gggcccatcc agtaggttgt
     5401 tagtgagtga caggattatc caggtttggg aaccatagat ttagttcatg tttctgaccc
     5461 tatagagagt taacaaattg atgtctccta aattttcagt aaaactcaga ggaactcctc
     5521 ccactgccat tgtttgtagc ttttaccagc gtgaacctac ctgtgttagg tgttaaagga
     5581 ggaggtaaag gaaagggaag gcagagacgc aacccagaat ctgtttggca agtcagggtt
     5641 ctcatacagg agacttagtg aacaaagcaa gagaaaatgc tcagggtcca agtgcagtgg
     5701 ctttatgcct gtaatcccag tactttggaa ggccgaggtg ggcagatcac ctgaggtcag
     5761 gagtttgaga ccagcctgac caatatgatg aaaccccatc tctactaaaa atataaaaat
     5821 tacccgggtg tggtggtatg tgcttgtaat cccagctact cgggaggctg aaatgggaga
     5881 atcacttgaa tctgggaggc agaggttgca atgagccgag atcgcgccat tgcactctag
     5941 cctgggcaac aagagtaaaa ctccatctca aaaaaaataa ataaataaaa aagaaagaca
     6001 gtgttcagga aagaagaaaa cactgagcta aagcaggctt ctgcttctga tttgatggct
     6061 gtttgtttca cctttctcta acattcccat gctatataat ttttcaaaca tgagataatc
     6121 cctgtgtcct ttttcccatt gctcccttca tcttgcccat cctcattggc taggatggga
     6181 ctcctgagac gaagggtgcc ccagcatcct cagcctcgga ggcccaccct tatcagtctt
     6241 catgtgacag tatgcaggta aatgacagag taggacttgt tcttgggaga atggactatt
     6301 tagcatcata gccctaggga aatttggttc cttccctgaa aggaatgctt cctgtctctt
     6361 gggacagaca gacacacata caaaaacttt tataaatcag agacctagag ggaattgggc
     6421 caagaggcat tggccaagta gaaaagcttc tctagagtga cccagctctt ttgtggtttt
     6481 gaggtcttac cactgaacca aacccaagtc ctaggttccc tctgtaaaag aaggggctac
     6541 actagatgat cctaccatgg gtcctctgac tgtcagggtc cagttctttg ttagacagtg
     6601 caaacaccca tagaggagct attaggcctt tacttgggtt gagttggctc ccactagcac
     6661 tccccacttt tcattttttt tactttcaga gacagagtct cactctgttg cctaggttag
     6721 aggggagtgg catgatcatg gctcactgca gtctcaacaa ctgggctcaa gcaggaaccc
     6781 agcttttttt ttttttctct ctctctctct agagacagga tctcactatg ttgcccaggc
     6841 tggtctcgaa ctccagcctc aagcaatcct cctgcctcgg cctcccaaag tgagaggatt
     6901 acaggcatgg gccaccacac ccagcctctc cagttttagt gtgttttcag agtctcttct
     6961 ttcaagctgc tgctacttcc ctagcttccc tcagttctct tcccccttgg ccttccaatt
     7021 ggaggaaaag caggtcaggt ctctgtcatc tccaagacca gcctataggc ctttaaagtt
     7081 tccctgtttc ttaatgtggg gtctacaggg tttctcagag gcaaagcatg aacagaccaa
     7141 gggtcctata gctcccaacc tagtccttag atttctctct ggccttggtt actcccacaa
     7201 accactgtga gcctaccaag ggcaggaatg gaaatgccca tcagcctggg aaccatcttt
     7261 ttctcttagg aggtatccgc cctatagtta cctttacaca acacttgtga atatcaagtg
     7321 ttctagactg cactgttcat aattgactac agagaagact aggatcttct ccacaaatag
     7381 aaatatatca cttttacttg gagatgtttt cttgggggaa aaaaaatcta gcaccttgaa
     7441 acctgttaca atgtttaaat ctcccttctt taccttggct gtcataaaat cctcctgttt
     7501 gagctaaatg tggcctgctg aagtcttaaa tgcccatatt tttcaggcta aggccatggt
     7561 ggacatagct aactccacta gaatcctagc tgggggtgtt ggaaaaaacg gtacagtgcc
     7621 cctctcagac tccaggctca cgtccgtctc ccctccccgc acattataat ctactacttc
     7681 tctaatgctg ctgcgtagtt tgtcttaaag cctcaagact ggccagatgt gcacctgagt
     7741 aaaggtcagc catttcatct gggggctctt tcttgacttt taatgaattt tcttctgtga
     7801 aaaaatgtat ttttaataaa aaattttctg tggccagca
//
