LOCUS       NM_002832               2783 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 7
            (PTPN7), transcript variant 1, mRNA.
ACCESSION   NM_002832
VERSION     NM_002832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Inamdar,V.V., Reddy,H., Dangelmaier,C., Kostyak,J.C. and
            Kunapuli,S.P.
  TITLE     The protein tyrosine phosphatase PTPN7 is a negative regulator of
            ERK activation and thromboxane generation in platelets
  JOURNAL   J Biol Chem 294 (33), 12547-12554 (2019)
   PUBMED   31266805
  REMARK    GeneRIF: PTPN7 regulates platelet functional responses downstream
            of GPCR agonists, but not GPVI agonists, through inhibition of ERK
            activation and thromboxane generation.
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Chen,T.C., Lin,K.T., Chen,C.H., Lee,S.A., Lee,P.Y., Liu,Y.W.,
            Kuo,Y.L., Wang,F.S., Lai,J.M. and Huang,C.Y.
  TITLE     Using an in situ proximity ligation assay to systematically profile
            endogenous protein-protein interactions in a pathway network
  JOURNAL   J Proteome Res 13 (12), 5339-5346 (2014)
   PUBMED   25241761
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Garcia-Closas,M., Couch,F.J., Lindstrom,S., Michailidou,K.,
            Schmidt,M.K., Brook,M.N., Orr,N., Rhie,S.K., Riboli,E.,
            Feigelson,H.S., Le Marchand,L., Buring,J.E., Eccles,D., Miron,P.,
            Fasching,P.A., Brauch,H., Chang-Claude,J., Carpenter,J.,
            Godwin,A.K., Nevanlinna,H., Giles,G.G., Cox,A., Hopper,J.L.,
            Bolla,M.K., Wang,Q., Dennis,J., Dicks,E., Howat,W.J., Schoof,N.,
            Bojesen,S.E., Lambrechts,D., Broeks,A., Andrulis,I.L., Guenel,P.,
            Burwinkel,B., Sawyer,E.J., Hollestelle,A., Fletcher,O.,
            Winqvist,R., Brenner,H., Mannermaa,A., Hamann,U., Meindl,A.,
            Lindblom,A., Zheng,W., Devillee,P., Goldberg,M.S., Lubinski,J.,
            Kristensen,V., Swerdlow,A., Anton-Culver,H., Dork,T., Muir,K.,
            Matsuo,K., Wu,A.H., Radice,P., Teo,S.H., Shu,X.O., Blot,W.,
            Kang,D., Hartman,M., Sangrajrang,S., Shen,C.Y., Southey,M.C.,
            Park,D.J., Hammet,F., Stone,J., Veer,L.J., Rutgers,E.J.,
            Lophatananon,A., Stewart-Brown,S., Siriwanarangsan,P., Peto,J.,
            Schrauder,M.G., Ekici,A.B., Beckmann,M.W., Dos Santos Silva,I.,
            Johnson,N., Warren,H., Tomlinson,I., Kerin,M.J., Miller,N.,
            Marme,F., Schneeweiss,A., Sohn,C., Truong,T., Laurent-Puig,P.,
            Kerbrat,P., Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Milne,R.L.,
            Perez,J.I., Menendez,P., Muller,H., Arndt,V., Stegmaier,C.,
            Lichtner,P., Lochmann,M., Justenhoven,C., Ko,Y.D., Muranen,T.A.,
            Aittomaki,K., Blomqvist,C., Greco,D., Heikkinen,T., Ito,H.,
            Iwata,H., Yatabe,Y., Antonenkova,N.N., Margolin,S., Kataja,V.,
            Kosma,V.M., Hartikainen,J.M., Balleine,R., Tseng,C.C., Berg,D.V.,
            Stram,D.O., Neven,P., Dieudonne,A.S., Leunen,K., Rudolph,A.,
            Nickels,S., Flesch-Janys,D., Peterlongo,P., Peissel,B., Bernard,L.,
            Olson,J.E., Wang,X., Stevens,K., Severi,G., Baglietto,L.,
            McLean,C., Coetzee,G.A., Feng,Y., Henderson,B.E., Schumacher,F.,
            Bogdanova,N.V., Labreche,F., Dumont,M., Yip,C.H., Taib,N.A.,
            Cheng,C.Y., Shrubsole,M., Long,J., Pylkas,K., Jukkola-Vuorinen,A.,
            Kauppila,S., Knight,J.A., Glendon,G., Mulligan,A.M.,
            Tollenaar,R.A., Seynaeve,C.M., Kriege,M., Hooning,M.J., van den
            Ouweland,A.M., van Deurzen,C.H., Lu,W., Gao,Y.T., Cai,H.,
            Balasubramanian,S.P., Cross,S.S., Reed,M.W., Signorello,L., Cai,Q.,
            Shah,M., Miao,H., Chan,C.W., Chia,K.S., Jakubowska,A., Jaworska,K.,
            Durda,K., Hsiung,C.N., Wu,P.E., Yu,J.C., Ashworth,A., Jones,M.,
            Tessier,D.C., Gonzalez-Neira,A., Pita,G., Alonso,M.R., Vincent,D.,
            Bacot,F., Ambrosone,C.B., Bandera,E.V., John,E.M., Chen,G.K.,
            Hu,J.J., Rodriguez-Gil,J.L., Bernstein,L., Press,M.F.,
            Ziegler,R.G., Millikan,R.M., Deming-Halverson,S.L., Nyante,S.,
            Ingles,S.A., Waisfisz,Q., Tsimiklis,H., Makalic,E., Schmidt,D.,
            Bui,M., Gibson,L., Muller-Myhsok,B., Schmutzler,R.K., Hein,R.,
            Dahmen,N., Beckmann,L., Aaltonen,K., Czene,K., Irwanto,A., Liu,J.,
            Turnbull,C., Rahman,N., Meijers-Heijboer,H., Uitterlinden,A.G.,
            Rivadeneira,F., Olswold,C., Slager,S., Pilarski,R., Ademuyiwa,F.,
            Konstantopoulou,I., Martin,N.G., Montgomery,G.W., Slamon,D.J.,
            Rauh,C., Lux,M.P., Jud,S.M., Bruning,T., Weaver,J., Sharma,P.,
            Pathak,H., Tapper,W., Gerty,S., Durcan,L., Trichopoulos,D.,
            Tumino,R., Peeters,P.H., Kaaks,R., Campa,D., Canzian,F.,
            Weiderpass,E., Johansson,M., Khaw,K.T., Travis,R.,
            Clavel-Chapelon,F., Kolonel,L.N., Chen,C., Beck,A., Hankinson,S.E.,
            Berg,C.D., Hoover,R.N., Lissowska,J., Figueroa,J.D., Chasman,D.I.,
            Gaudet,M.M., Diver,W.R., Willett,W.C., Hunter,D.J., Simard,J.,
            Benitez,J., Dunning,A.M., Sherman,M.E., Chenevix-Trench,G.,
            Chanock,S.J., Hall,P., Pharoah,P.D., Vachon,C., Easton,D.F.,
            Haiman,C.A. and Kraft,P.
  CONSRTM   Gene ENvironmental Interaction and breast CAncer (GENICA) Network;
            kConFab Investigators; Familial Breast Cancer Study (FBCS);
            Australian Breast Cancer Tissue Bank (ABCTB) Investigators
  TITLE     Genome-wide association studies identify four ER negative-specific
            breast cancer risk loci
  JOURNAL   Nat Genet 45 (4), 392-398 (2013)
   PUBMED   23535733
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P.
  TITLE     Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells
            induces tyrosine phosphorylation of the cytosolic protein-tyrosine
            phosphatase HePTP
  JOURNAL   J Biol Chem 270 (37), 21902-21906 (1995)
   PUBMED   7545170
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Zanke,B., Squire,J., Griesser,H., Henry,M., Suzuki,H.,
            Patterson,B., Minden,M. and Mak,T.W.
  TITLE     A hematopoietic protein tyrosine phosphatase (HePTP) gene that is
            amplified and overexpressed in myeloid malignancies maps to
            chromosome 1q32.1
  JOURNAL   Leukemia 8 (2), 236-244 (1994)
   PUBMED   8309248
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y.,
            Imai,K. and Yachi,A.
  TITLE     Molecular cloning and chromosomal mapping of a human
            protein-tyrosine phosphatase LC-PTP
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1607-1615 (1992)
   PUBMED   1510684
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
            Imai,K. and Yachi,A.
  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
  JOURNAL   Cancer Res 52 (3), 737-740 (1992)
   PUBMED   1370651
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A.
            and Mak,T.W.
  TITLE     Cloning and expression of an inducible lymphoid-specific, protein
            tyrosine phosphatase (HePTPase)
  JOURNAL   Eur J Immunol 22 (1), 235-239 (1992)
   PUBMED   1530918
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592300.16.
            
            On May 21, 2020 this sequence version replaced NM_002832.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This gene is preferentially expressed in
            a variety of hematopoietic cells, and is an early response gene in
            lymphokine stimulated cells. The non-catalytic N-terminus of this
            PTP can interact with MAP kinases and suppress the MAP kinase
            activities. This PTP was shown to be involved in the regulation of
            T cell antigen receptor (TCR) signaling, which was thought to
            function through dephosphorylating the molecules related to MAP
            kinase pathway. Multiple alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691036.1/ ENSP00000509436.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL592300.16        43628-43685         c
            59-232              AL592300.16        42364-42537         c
            233-416             AL592300.16        41201-41384         c
            417-501             AL592300.16        40822-40906         c
            502-578             AL592300.16        38616-38692         c
            579-716             AL592300.16        37269-37406         c
            717-827             AL592300.16        36808-36918         c
            828-985             AL592300.16        35625-35782         c
            986-1099            AL592300.16        33394-33507         c
            1100-2783           AL592300.16        30099-31782         c
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2783
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /note="protein tyrosine phosphatase non-receptor type 7"
                     /db_xref="GeneID:5778"
                     /db_xref="HGNC:HGNC:9659"
                     /db_xref="MIM:176889"
     exon            1..58
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            59..232
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1193
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic protein-tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 7;
                     protein-tyrosine phosphatase, nonreceptor-type, stress
                     induced; dual specificity phosphatase 1; protein-tyrosine
                     phosphatase LC-PTP"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 7
                     isoform 1"
                     /protein_id="NP_002823.4"
                     /db_xref="CCDS:CCDS1423.3"
                     /db_xref="GeneID:5778"
                     /db_xref="HGNC:HGNC:9659"
                     /db_xref="MIM:176889"
                     /translation="MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGS
                     NVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFL
                     KIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDG
                     KEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPF
                     QIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEE
                     SPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMI
                     QTAEQYQFLHHTLALYAGQLPEEPSP"
     exon            233..416
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            417..501
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            502..578
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            579..716
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            717..827
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            828..985
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1099
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..2783
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="PTPN7"
                     /gene_synonym="BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI"
                     /note="major polyA site"
ORIGIN      
        1 agaccgacag acagacagac agctggcaag aggcagcctg ggggccacag ctgcttcagc
       61 agacctcatg gctgagtgag cctcccctgg gcccagcacc ccacctcagc atggtccaag
      121 cccatggggg gcgctccaga gcacagccgt tgaccttgtc tttgggggca gccatgaccc
      181 agcctccgcc tgaaaaaacg ccagccaaga agcatgtgcg actgcaggag aggcggggct
      241 ccaatgtggc tctgatgctg gacgttcggt ccctgggggc cgtagaaccc atctgctctg
      301 tgaacacacc ccgggaggtc accctacact ttctgcgcac tgctggacac ccccttaccc
      361 gctgggccct tcagcgccag ccacccagcc ccaagcaact ggaagaagaa ttcttgaaga
      421 tcccttcaaa ctttgtcagc cccgaagacc tggacatccc tggccacgcc tccaaggacc
      481 gatacaagac catcttgcca aatccccaga gccgtgtctg tctaggccgg gcacagagcc
      541 aggaggacgg agattacatc aatgccaact acatccgagg ctatgacggg aaggagaagg
      601 tctacattgc cacccagggc cccatgccca acactgtgtc ggacttctgg gagatggtgt
      661 ggcaagagga agtgtccctc attgtcatgc tcactcagct ccgagagggc aaggagaaat
      721 gtgtccacta ctggcccaca gaagaggaaa cctatggacc cttccagatc cgcatccagg
      781 acatgaaaga gtgcccagaa tacactgtgc ggcagctcac catccagtac caggaagagc
      841 gccggtcagt aaagcacatc ctcttttcgg cctggccaga ccatcagaca ccagaatcag
      901 ctgggcccct gctgcgccta gtggcagagg tggaggagag cccggagaca gccgcccacc
      961 ccgggcctat cgtagtccac tgcagtgcag ggattggccg gacgggctgc ttcatcgcca
     1021 cgcgaattgg ctgtcaacag ctgaaagccc gaggagaagt ggacattctg ggtattgtgt
     1081 gccaactgcg gctagacaga ggggggatga tccagacggc agagcagtac cagttcctgc
     1141 accacacttt ggccctgtat gcaggccagc tgcctgagga acccagcccc tgacccctgc
     1201 caccctccgg tggcccaggt gcctacctcc ctcaagcctg ggaaggtggg tctggggaaa
     1261 gtgggccgag tgatctgggg gtaccccttg ggttggtgtg gggaaggagt gcctccttag
     1321 tggtgcttgc agtcacagga agcagcagca gtaaggacaa ggggccggat tccaggtctt
     1381 caacactggc cactcctctg cttcctctgt tggccccaga tggacagtaa ggggaacctc
     1441 caatgtctct ctgaacttaa agacaggagc tggcatttat gacagacaaa gaaagaagcc
     1501 caggtgtcct ggtgttctct gagacactct ttgtgagctt cagtttcctg ttctataaca
     1561 tgaacataag tgcttagctg ccatgaggga aaagtaatga gagaagtttc tagaagccac
     1621 tccagccact ccttcctggg gctgacaaaa gggtgattcc aagatcatcc ttcacccgag
     1681 gtcctgccca agcacaggcc agatgcaaga atggggaaaa gtctggtcct gatctccaag
     1741 tctcaacatc ctatcagtga ctctgctccc tgaccacaca tcggaagggc tggatgaccc
     1801 caatcaaaag aaagaacaag gactctggtt acccttgcct ccacccatgt gtcataagag
     1861 taggctacag aggtgaccag gcctggcagt tgaaatctct ggaagaggga acatgtgggg
     1921 actactcaga ggcaaagagg agctgctcct gcctccatgg ttgctggcca ctcccaccaa
     1981 ctactcttag ggaggctaag cagtctctgt tttgcttcca tggctcaaat aataccctgg
     2041 gtatgcagga cccactatac cttgcatttg ctgagtacac ctagagagct tggctgtttc
     2101 caaaaacaat cagggtcata accatccatg cagacatgga ggctcggctg aaccaggact
     2161 cctcactgtc tacctgagag aatgagcacc cctcatccat ctcagcatca acacaatttc
     2221 caggggacct caggtctacc tcaggactga acgccacacc tcaggattcc tcctccttga
     2281 atctgagact ggctgcccat tctgagatgg ggatgaaggt aagatgccgc atcaccaggc
     2341 acgccgcccc tgacagctgc cttgatacca gctctctgtg gaaacccccg aggagttgga
     2401 tctggagaac agctgggcct cctcactcag gacttctctc ctgaagaaca cgcagtgcta
     2461 aaactgagga tgatttccct aatgcttctg cttggcctta tggaggagct gctccttcct
     2521 tacagccttg gggatggact tgcccacacc tccacctccc ctgagccctg tgagaggcac
     2581 gactgtctat gccaatgagg ctcggtgggg ggctctcaag tgcctgatcc tgccctgggc
     2641 tcagagccag cccagaggga agcaactgca cagccccaca ggccctccct ggcactgtcc
     2701 ccccaacccc atctcagagc tcagagggta caagctccag aacagtaacc aagtgggaaa
     2761 ataaagactt cttggatgac tga
//
