LOCUS       NM_002831               2161 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 6
            (PTPN6), transcript variant 1, mRNA.
ACCESSION   NM_002831
VERSION     NM_002831.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Yang,J., Ruan,J., Zhou,B., Ye,S., Gao,S. and Zheng,X.
  TITLE     Regulation of STAT5 phosphorylation and interaction with SHP1 by
            lnc-AC004893, a long non-coding RNA overexpressed in
            myeloproliferative neoplasms
  JOURNAL   Hematology 29 (1), 2375045 (2024)
   PUBMED   39012197
  REMARK    GeneRIF: Regulation of STAT5 phosphorylation and interaction with
            SHP1 by lnc-AC004893, a long non-coding RNA overexpressed in
            myeloproliferative neoplasms.
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Fujiwara,N., Tsunedomi,R., Kimura,Y., Nakajima,M., Tomochika,S.,
            Enjoji,S., Ohama,T., Sato,K. and Nagano,H.
  TITLE     Protein phosphatase 6 promotes stemness of colorectal cancer cells
  JOURNAL   Cancer Sci 115 (9), 3067-3078 (2024)
   PUBMED   39014521
  REMARK    GeneRIF: Protein phosphatase 6 promotes stemness of colorectal
            cancer cells.
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Xu,S.L., Chen,Z., Yang,J., Fan,Z.Q., Liu,T., Zhang,X.T., Zeng,B.Q.
            and Xing,X.Q.
  TITLE     [Effect of SHP-1 knockout in airway epithelial cells on emphysema
            phenotype in chronic obstructive pulmonary disease in mice]
  JOURNAL   Zhonghua Jie He He Hu Xi Za Zhi 47 (4), 339-345 (2024)
   PUBMED   38599809
  REMARK    GeneRIF: [Effect of SHP-1 knockout in airway epithelial cells on
            emphysema phenotype in chronic obstructive pulmonary disease in
            mice].
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Jaeger-Ruckstuhl,C.A., Lo,Y., Fulton,E., Waltner,O.G.,
            Shabaneh,T.B., Simon,S., Muthuraman,P.V., Correnti,C.E.,
            Newsom,O.J., Engstrom,I.A., Kanaan,S.B., Bhise,S.S.,
            Peralta,J.M.C., Ruff,R., Price,J.P., Stull,S.M., Stevens,A.R.,
            Bugos,G., Kluesner,M.G., Voillet,V., Muhunthan,V., Morrish,F.,
            Olson,J.M., Gottardo,R., Sarthy,J.F., Henikoff,S., Sullivan,L.B.,
            Furlan,S.N. and Riddell,S.R.
  TITLE     Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell
            activation promotes memory-associated gene regulatory networks
  JOURNAL   Immunity 57 (2), 287-302 (2024)
   PUBMED   38354704
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Ukey,S., Jain,A., Dwivedi,S., Vishnoi,J.R., Chugh,A., Purohit,P.,
            Pareek,P., Elhence,P., Misra,S. and Sharma,P.
  TITLE     Global and promoter specific hypermethylation of tumor suppressor
            genes P16, SOCS1, and SHP1 in oral squamous cell carcinoma and oral
            submucous fibrosis
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S551-S559 (2023)
   PUBMED   38384018
  REMARK    GeneRIF: Global and promoter specific hypermethylation of tumor
            suppressor genes P16, SOCS1, and SHP1 in oral squamous cell
            carcinoma and oral submucous fibrosis.
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Jin,Y.J., Yu,C.L. and Burakoff,S.J.
  TITLE     Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal
            structure and catalytic activity
  JOURNAL   J Biol Chem 274 (40), 28301-28307 (1999)
   PUBMED   10497187
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G.,
            Jani-Sait,S. and Shows,T.B.
  TITLE     Chromosomal localization of an SH2-containing tyrosine phosphatase
            (PTPN6)
  JOURNAL   Genomics 13 (3), 869-872 (1992)
   PUBMED   1639416
REFERENCE   8  (bases 1 to 2161)
  AUTHORS   Plutzky,J., Neel,B.G. and Rosenberg,R.D.
  TITLE     Isolation of a src homology 2-containing tyrosine phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 1123-1127 (1992)
   PUBMED   1736296
REFERENCE   9  (bases 1 to 2161)
  AUTHORS   Yi,T.L., Cleveland,J.L. and Ihle,J.N.
  TITLE     Protein tyrosine phosphatase containing SH2 domains:
            characterization, preferential expression in hematopoietic cells,
            and localization to human chromosome 12p12-p13
  JOURNAL   Mol Cell Biol 12 (2), 836-846 (1992)
   PUBMED   1732748
REFERENCE   10 (bases 1 to 2161)
  AUTHORS   Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P.
  TITLE     A protein-tyrosine phosphatase with sequence similarity to the SH2
            domain of the protein-tyrosine kinases
  JOURNAL   Nature 352 (6337), 736-739 (1991)
   PUBMED   1652101
  REMARK    Erratum:[Nature 1991 Oct 31;353(6347):868]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U47924.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002831.5.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. N-terminal part of this PTP contains two
            tandem Src homolog (SH2) domains, which act as protein
            phospho-tyrosine binding domains, and mediate the interaction of
            this PTP with its substrates. This PTP is expressed primarily in
            hematopoietic cells, and functions as an important regulator of
            multiple signaling pathways in hematopoietic cells. This PTP has
            been shown to interact with, and dephosphorylate a wide spectrum of
            phospho-proteins involved in hematopoietic cell signaling. Multiple
            alternatively spliced variants of this gene, which encode distinct
            isoforms, have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the shortest isoform (1, also known as
            SHP-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223629.1, SRR1163655.423425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318974.14/ ENSP00000326010.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               U47924.1           163365-163529
            166-288             U47924.1           163618-163740
            289-483             U47924.1           163992-164186
            484-673             U47924.1           166814-167003
            674-790             U47924.1           167160-167276
            791-904             U47924.1           167381-167494
            905-1001            U47924.1           167669-167765
            1002-1081           U47924.1           168151-168230
            1082-1231           U47924.1           168428-168577
            1232-1363           U47924.1           169663-169794
            1364-1518           U47924.1           169928-170082
            1519-1586           U47924.1           171936-172003
            1587-1738           U47924.1           172097-172248
            1739-1830           U47924.1           172353-172444
            1831-1970           U47924.1           172815-172954
            1971-2161           U47924.1           173135-173325
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2161
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="protein tyrosine phosphatase non-receptor type 6"
                     /db_xref="GeneID:5777"
                     /db_xref="HGNC:HGNC:9658"
                     /db_xref="MIM:176883"
     exon            1..165
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1945
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine phosphatase 1C; hematopoietic cell
                     protein-tyrosine phosphatase; tyrosine-protein phosphatase
                     non-receptor type 6; hematopoietic cell phosphatase;
                     protein-tyrosine phosphatase SHP-1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 6
                     isoform 1"
                     /protein_id="NP_002822.2"
                     /db_xref="CCDS:CCDS44820.1"
                     /db_xref="GeneID:5777"
                     /db_xref="HGNC:HGNC:9658"
                     /db_xref="MIM:176883"
                     /translation="MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVR
                     VGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNC
                     SDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGS
                     PLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRV
                     NAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRY
                     KNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND
                     FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL
                     RTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPII
                     VHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI
                     YVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYEN
                     LHTKNKREEKVKKQRSADKEKSKGSLKRK"
     exon            166..288
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..483
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..673
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..790
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..904
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1001
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1081
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1231
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1363
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1518
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1586
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1738
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1830
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1970
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2161
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2139..2144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="major polyA site"
ORIGIN      
        1 agtggagtgg cagccccaga actgggacca ccgggggtgg tgaggcggcc cggcactggg
       61 agctgcatct gaggcttagt ccctgagctc tctgcctgcc cagactagct gcacctcctc
      121 attccctgcg cccccttcct ctccggaagc ccccaggatg gtgaggtggt ttcaccgaga
      181 cctcagtggg ctggatgcag agaccctgct caagggccga ggtgtccacg gtagcttcct
      241 ggctcggccc agtcgcaaga accagggtga cttctcgctc tccgtcaggg tgggggatca
      301 ggtgacccat attcggatcc agaactcagg ggatttctat gacctgtatg gaggggagaa
      361 gtttgcgact ctgacagagc tggtggagta ctacactcag cagcagggtg tcctgcagga
      421 ccgcgacggc accatcatcc acctcaagta cccgctgaac tgctccgatc ccactagtga
      481 gaggtggtac catggccaca tgtctggcgg gcaggcagag acgctgctgc aggccaaggg
      541 cgagccctgg acgtttcttg tgcgtgagag cctcagccag cctggagact tcgtgctttc
      601 tgtgctcagt gaccagccca aggctggccc aggctccccg ctcagggtca cccacatcaa
      661 ggtcatgtgc gagggtggac gctacacagt gggtggtttg gagaccttcg acagcctcac
      721 ggacctggtg gagcatttca agaagacggg gattgaggag gcctcaggcg cctttgtcta
      781 cctgcggcag ccgtactatg ccacgagggt gaatgcggct gacattgaga accgagtgtt
      841 ggaactgaac aagaagcagg agtccgagga tacagccaag gctggcttct gggaggagtt
      901 tgagagtttg cagaagcagg aggtgaagaa cttgcaccag cgtctggaag ggcagcggcc
      961 agagaacaag ggcaagaacc gctacaagaa cattctcccc tttgaccaca gccgagtgat
     1021 cctgcaggga cgggacagta acatccccgg gtccgactac atcaatgcca actacatcaa
     1081 gaaccagctg ctaggccctg atgagaacgc taagacctac atcgccagcc agggttgtct
     1141 ggaggccacg gtcaatgact tctggcagat ggcgtggcag gagaacagcc gtgtcatcgt
     1201 catgaccacc cgagaggtgg agaaaggccg gaacaaatgc gtcccatact ggcccgaggt
     1261 gggcatgcag cgtgcttatg ggccctactc tgtgaccaac tgcggggagc atgacacaac
     1321 cgaatacaaa ctccgtacct tacaggtctc cccgctggac aatggagacc tgattcggga
     1381 gatctggcat taccagtacc tgagctggcc cgaccatggg gtccccagtg agcctggggg
     1441 tgtcctcagc ttcctggacc agatcaacca gcggcaggaa agtctgcctc acgcagggcc
     1501 catcatcgtg cactgcagcg ccggcatcgg ccgcacaggc accatcattg tcatcgacat
     1561 gctcatggag aacatctcca ccaagggcct ggactgtgac attgacatcc agaagaccat
     1621 ccagatggtg cgggcgcagc gctcgggcat ggtgcagacg gaggcgcagt acaagttcat
     1681 ctacgtggcc atcgcccagt tcattgaaac cactaagaag aagctggagg tcctgcagtc
     1741 gcagaagggc caggagtcgg agtacgggaa catcacctat cccccagcca tgaagaatgc
     1801 ccatgccaag gcctcccgca cctcgtccaa acacaaggag gatgtgtatg agaacctgca
     1861 cactaagaac aagagggagg agaaagtgaa gaagcagcgg tcagcagaca aggagaagag
     1921 caagggttcc ctcaagagga agtgagcggt gctgtcctca ggtggccatg cctcagccct
     1981 gaccctgtgg aagcatttcg cgatggacag actcacaacc tgaacctagg agtgccccat
     2041 tcttttgtaa tttaaatggc tgcatccccc ccacctctcc ctgaccctgt atatagccca
     2101 gccaggcccc aggcagggcc aacccttctc ctcttgtaaa taaagccctg ggatcactgt
     2161 g
//
