LOCUS       NM_006906               3091 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 5
            (PTPN5), transcript variant 1, mRNA.
ACCESSION   NM_006906
VERSION     NM_006906.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Taylor,D., Kneynsberg,A., van Roijen,M. and Gotz,J.
  TITLE     Tyrosine phosphatase STEP61 in human dementia and in animal models
            with amyloid and tau pathology
  JOURNAL   Mol Brain 16 (1), 6 (2023)
   PUBMED   36639708
  REMARK    GeneRIF: Tyrosine phosphatase STEP61 in human dementia and in
            animal models with amyloid and tau pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Wang,H., Bu,S., Tang,J., Li,Y., Liu,C. and Dong,J.
  TITLE     PTPN5 promotes follicle-stimulating hormone secretion through
            regulating intracellular calcium homeostasis
  JOURNAL   FASEB J 35 (8), e21756 (2021)
   PUBMED   34270805
  REMARK    GeneRIF: PTPN5 promotes follicle-stimulating hormone secretion
            through regulating intracellular calcium homeostasis.
REFERENCE   3  (bases 1 to 3091)
  AUTHORS   Chatterjee,M., Singh,P., Xu,J., Lombroso,P.J. and Kurup,P.K.
  TITLE     Inhibition of striatal-enriched protein tyrosine phosphatase (STEP)
            activity reverses behavioral deficits in a rodent model of autism
  JOURNAL   Behav Brain Res 391, 112713 (2020)
   PUBMED   32461127
  REMARK    GeneRIF: Inhibition of striatal-enriched protein tyrosine
            phosphatase (STEP) activity reverses behavioral deficits in a
            rodent model of autism.
REFERENCE   4  (bases 1 to 3091)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3091)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3091)
  AUTHORS   Nguyen,T.H., Liu,J. and Lombroso,P.J.
  TITLE     Striatal enriched phosphatase 61 dephosphorylates Fyn at
            phosphotyrosine 420
  JOURNAL   J Biol Chem 277 (27), 24274-24279 (2002)
   PUBMED   11983687
REFERENCE   7  (bases 1 to 3091)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   8  (bases 1 to 3091)
  AUTHORS   Yoneya,T., Yamada,Y., Kakeda,M., Osawa,M., Arai,E., Hayashi,K.,
            Nishi,N., Inoue,H. and Nishikawa,M.
  TITLE     Molecular cloning of a novel receptor-type protein tyrosine
            phosphatase from murine fetal liver
  JOURNAL   Gene 194 (2), 241-247 (1997)
   PUBMED   9272866
REFERENCE   9  (bases 1 to 3091)
  AUTHORS   Li,X., Luna,J., Lombroso,P.J. and Francke,U.
  TITLE     Molecular cloning of the human homolog of a striatum-enriched
            phosphatase (STEP) gene and chromosomal mapping of the human and
            murine loci
  JOURNAL   Genomics 28 (3), 442-449 (1995)
   PUBMED   7490079
REFERENCE   10 (bases 1 to 3091)
  AUTHORS   Lombroso,P.J., Murdoch,G. and Lerner,M.
  TITLE     Molecular characterization of a protein-tyrosine-phosphatase
            enriched in striatum
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7242-7246 (1991)
   PUBMED   1714595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832541.1, BC064807.1 and BC046435.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006906.1.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064807.1, AL832541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358540.7/ ENSP00000351342.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               AL832541.1         45-722
            679-1949            BC064807.1         487-1757
            1950-3091           BC046435.1         473-1614
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..3091
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="protein tyrosine phosphatase non-receptor type 5"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
     exon            1..274
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            275..407
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2085
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     protein-tyrosine phosphatase striatum-enriched;
                     neural-specific protein-tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 5;
                     striatum-enriched protein-tyrosine phosphatase; protein
                     tyrosine phosphatase, non-receptor type 5
                     (striatum-enriched); striatal-enriched protein tyrosine
                     phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform a"
                     /protein_id="NP_008837.1"
                     /db_xref="CCDS:CCDS7845.1"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
                     /translation="MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALD
                     EAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGV
                     LWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTT
                     LVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFD
                     CVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESARE
                     YLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPN
                     PHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHT
                     PIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERG
                     LKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIA
                     TSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE"
     exon            408..484
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            485..678
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            679..786
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            787..870
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1112
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1302
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1387
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1467
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1605
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1716
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1877
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1991
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..3091
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="hexamer: AATAAA"
     polyA_site      3091
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="major polyA site"
ORIGIN      
        1 gactctgcag ctgaagcgca tttggtgagg cggtcgggcg agggagcgcg cacggagcgc
       61 gggacggagc gccaggcgga cggaccgaag gacggaggca ccgaaggacg gacgcccccg
      121 cacacgcaga cgcacagagc tcggcgcggc ccccgtcgca tacacactgg cacagacaca
      181 agcagggaca cacgcagaca cacgcacact cgcgcgcgca tcctcccgcc agcctgcccg
      241 cctgctcgcc ggcgcccgga gcccgctctg gccgctggat gatctgaagc tgccctctct
      301 ccttcattta tatcaccagc ttgctttttg ctgagaaagc ttcctgccct ggaagatggc
      361 acccttcccc atccagacac cttgggaatg aattatgagg gagccaggag tgagagagag
      421 aaccacgctg ctgatgactc cgagggaggg gccctggaca tgtgctgcag tgagaggcta
      481 ccgggtctcc cccagccgat agtgatggag gcactggacg aggctgaagg gctccaggac
      541 tcacagagag agatgccgcc accccctcct ccctcgccgc cctcagatcc agctcagaag
      601 ccaccacctc gaggcgctgg gagccactcc ctcactgtca ggagcagcct gtgcctgttc
      661 gctgcctcac agttcctgct tgcctgtggg gtgctctggt tcagcggtta tggccacatc
      721 tggtcacaga acgccacaaa cctcgtctcc tctttgctga cgctcctgaa acagctggaa
      781 cccacggcct ggcttgactc tgggacgtgg ggagtcccca gtctgctgct ggtctttctg
      841 tccgtgggcc tggtcctcgt taccaccctg gtgtggcacc tcctgaggac acccccagag
      901 ccacccaccc cactgccccc tgaggacagg cgccagtcag tgagccgcca gccctccttc
      961 acctactcag agtggatgga ggagaagatc gaggatgact tcctggacct cgacccggtg
     1021 cccgagactc ctgtgtttga ttgtgtgatg gacatcaagc ctgaggctga ccccacctca
     1081 ctcaccgtca agtccatggg tctgcaggag aggaggggtt ccaatgtctc cctgaccctg
     1141 gacatgtgca ctccgggctg caacgaggag ggctttggct atctcatgtc cccacgtgag
     1201 gagtccgccc gcgagtacct gctcagcgcc tcccgtgtcc tccaagcaga agagcttcat
     1261 gaaaaggccc tggacccttt cctgctgcag gcggaattct ttgaaatccc catgaacttt
     1321 gtggatccga aagagtacga catccctggg ctggtgcgga agaaccggta caaaaccata
     1381 cttcccaacc ctcacagcag agtgtgtctg acctcaccag accctgacga ccctctgagt
     1441 tcctacatca atgccaacta catccggggc tatggtgggg aggagaaggt gtacatcgcc
     1501 actcagggac ccatcgtcag cacggtcgcc gacttctggc gcatggtgtg gcaggagcac
     1561 acgcccatca ttgtcatgat caccaacatc gaggagatga acgagaaatg caccgagtat
     1621 tggccggagg agcaggtggc gtacgacggt gttgagatca ctgtgcagaa agtcattcac
     1681 acggaggatt accggctgcg actcatctcc ctcaagagtg ggactgagga gcgaggcctg
     1741 aagcattact ggttcacatc ctggcccgac cagaagaccc cagaccgggc ccccccactc
     1801 ctgcacctgg tgcgggaggt ggaggaggca gcccagcagg aggggcccca ctgtgccccc
     1861 atcatcgtcc actgcagtgc agggattggg aggaccggct gcttcattgc caccagcatc
     1921 tgctgccagc agctgcggca ggagggtgtg gtggacatcc tgaagaccac gtgccagctc
     1981 cgtcaggaca ggggcggcat gatccagaca tgcgagcagt accagtttgt gcaccacgtc
     2041 atgagcctct acgaaaagca gctgtcccac cagtccccag aatgactgcg cttctcctac
     2101 aaggttctct gggcactgcc cagcctgagt ctcggccctc acccagggcc ctgcctcggg
     2161 tcctgggcct gctccccgct tcctcccctt cagtcagctc cctctgtcct ctgtcagcct
     2221 ggcctgaccc ctaccctcca gcattgctct tcctactgta catattgggg agtggggggc
     2281 agggtcggga agggacatgc caggccaggc ctggggcccc ggggcctgac ccacaccacg
     2341 cagaccccgg gctccagttt ttaacgatgg ttccatcaat acctgatcca gaatgtttcc
     2401 gtgctacact ttgtgtcctg ctgcaatgtg ttctgtctgt ccatccatct ctgccctctg
     2461 taccggacac tgtgtctcct cagccaggaa ggggtaatga gctccagccc ctaagcaacc
     2521 ggacttgcct gcctcggcct cacccgcact tctcccaaaa ggcagatgac ggggagttag
     2581 gcatggggag ctccagaagg tcaccagaga gctttcagct gagggagagt tctctaggtt
     2641 ggagtgggca tcacagccag ggtggcctct gggtgtcaga tgctctcagg agggtgccca
     2701 gcctgtgagg cactggcaag gtagggggca gatggggcat ggagaaccca gaggatctag
     2761 gccctgttgg ggaggggagg ggagctcaag gtttgggtgg ggactcagcc cagatctacg
     2821 tgagacattt ttctgtgtca ctgtgggaaa gccttcccag aagtctcact gcgtgttgct
     2881 ctgcgtgtgt tcccatgtcc atgcgtgtgt tgagagccca tcaggagggc atgcatgact
     2941 ctttggcaac atgtattatc ttggagccac gtgtttttat tgctgacttt aaatatttat
     3001 cccacggcag acagagacat ttggtgtctt tttataattc gctcgtggtc attgaataga
     3061 gcaataaacg gagcattttg agcaaaacta a
//
