LOCUS       NM_001278236            3939 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 5
            (PTPN5), transcript variant 4, mRNA.
ACCESSION   NM_001278236
VERSION     NM_001278236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3939)
  AUTHORS   Taylor,D., Kneynsberg,A., van Roijen,M. and Gotz,J.
  TITLE     Tyrosine phosphatase STEP61 in human dementia and in animal models
            with amyloid and tau pathology
  JOURNAL   Mol Brain 16 (1), 6 (2023)
   PUBMED   36639708
  REMARK    GeneRIF: Tyrosine phosphatase STEP61 in human dementia and in
            animal models with amyloid and tau pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3939)
  AUTHORS   Wang,H., Bu,S., Tang,J., Li,Y., Liu,C. and Dong,J.
  TITLE     PTPN5 promotes follicle-stimulating hormone secretion through
            regulating intracellular calcium homeostasis
  JOURNAL   FASEB J 35 (8), e21756 (2021)
   PUBMED   34270805
  REMARK    GeneRIF: PTPN5 promotes follicle-stimulating hormone secretion
            through regulating intracellular calcium homeostasis.
REFERENCE   3  (bases 1 to 3939)
  AUTHORS   Chatterjee,M., Singh,P., Xu,J., Lombroso,P.J. and Kurup,P.K.
  TITLE     Inhibition of striatal-enriched protein tyrosine phosphatase (STEP)
            activity reverses behavioral deficits in a rodent model of autism
  JOURNAL   Behav Brain Res 391, 112713 (2020)
   PUBMED   32461127
  REMARK    GeneRIF: Inhibition of striatal-enriched protein tyrosine
            phosphatase (STEP) activity reverses behavioral deficits in a
            rodent model of autism.
REFERENCE   4  (bases 1 to 3939)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3939)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3939)
  AUTHORS   Nguyen,T.H., Liu,J. and Lombroso,P.J.
  TITLE     Striatal enriched phosphatase 61 dephosphorylates Fyn at
            phosphotyrosine 420
  JOURNAL   J Biol Chem 277 (27), 24274-24279 (2002)
   PUBMED   11983687
REFERENCE   7  (bases 1 to 3939)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   8  (bases 1 to 3939)
  AUTHORS   Yoneya,T., Yamada,Y., Kakeda,M., Osawa,M., Arai,E., Hayashi,K.,
            Nishi,N., Inoue,H. and Nishikawa,M.
  TITLE     Molecular cloning of a novel receptor-type protein tyrosine
            phosphatase from murine fetal liver
  JOURNAL   Gene 194 (2), 241-247 (1997)
   PUBMED   9272866
REFERENCE   9  (bases 1 to 3939)
  AUTHORS   Li,X., Luna,J., Lombroso,P.J. and Francke,U.
  TITLE     Molecular cloning of the human homolog of a striatum-enriched
            phosphatase (STEP) gene and chromosomal mapping of the human and
            murine loci
  JOURNAL   Genomics 28 (3), 442-449 (1995)
   PUBMED   7490079
REFERENCE   10 (bases 1 to 3939)
  AUTHORS   Lombroso,P.J., Murdoch,G. and Lerner,M.
  TITLE     Molecular characterization of a protein-tyrosine-phosphatase
            enriched in striatum
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7242-7246 (1991)
   PUBMED   1714595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127312.1, AL832541.1 and BC046435.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The resulting isoform (b)
            lacks an internal segment, compared to isoform a. Variants 3 and 4
            encode the same isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127312.1, SRR1803612.174581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2731              AK127312.1         1-2731
            2732-3101           AL832541.1         1993-2362
            3102-3871           AK127312.1         3102-3871
            3872-3939           BC046435.1         1613-1680
FEATURES             Location/Qualifiers
     source          1..3939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..3939
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="protein tyrosine phosphatase non-receptor type 5"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
     exon            1..1197
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1285
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     CDS             1266..2867
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /EC_number="3.1.3.48"
                     /note="isoform b is encoded by transcript variant 4;
                     protein-tyrosine phosphatase striatum-enriched;
                     neural-specific protein-tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 5;
                     striatum-enriched protein-tyrosine phosphatase; protein
                     tyrosine phosphatase, non-receptor type 5
                     (striatum-enriched); striatal-enriched protein tyrosine
                     phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform b"
                     /protein_id="NP_001265165.1"
                     /db_xref="CCDS:CCDS41626.1"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
                     /translation="MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALD
                     EAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLEPTA
                     WLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFT
                     YSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLT
                     LDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIP
                     MNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEE
                     KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEI
                     TVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAA
                     QQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
                     TCEQYQFVHHVMSLYEKQLSHQSPE"
     exon            1286..1362
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1556
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1568
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1652
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1894
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2084
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2169
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2249
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2387
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2498
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2659
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2773
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3873
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="hexamer: AATAAA"
     polyA_site      3873
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /note="major polyA site"
ORIGIN      
        1 agctacgtgg tggctcgcct ctgattcccc gtgtaaaaaa tggagtttag gatccctgcc
       61 ctgtgtgcag cccacagcct caagccccca tggggatgga atgccggaaa cctctggcca
      121 gcgcactagc agcctggaga atacggaaga ttgtggcagg attgtggggc acatgggcag
      181 ctccctgctc gtccgggccc ctggtgccca cgagaaaacc aaaacaggtg cgtgccccgc
      241 gccgcacgtc aggagggcaa gactcagtgg agggaggggc tgtccactcg ctctagctcc
      301 ccagaggctg aacagggaga actgggaaaa aggacgcctc ctcagcgtcc tagaacgagt
      361 cctcggcacc tggtattgca tgcgccctag tatggggccg ctccacttgc gcaggtgttg
      421 gcaacatgcg gggagcgcca cggcatgccc ccaatgagcc gactccctcc cccaactctg
      481 ccccctttgt ctcgctggcc cctactcctt ctgtctgcct gtctgtcccg tcccaggttc
      541 agcgcgcacg gccctgccgg ggtccctctg gcagttgccg tagccgcgcg gcccgacccg
      601 gggctcccaa gaggagaaaa aatcatgaat gaaatggatg cgctgctccc actcctccgc
      661 cctccttgtc caagcaacct tggcatgggg gcgacgactg cggagactcc gcgcagagtt
      721 gctcgggaga gggaggcacc tgagatgagg tcaggggtta agggtctgtg atccggcccc
      781 cttcgtgccc cgggagcagg ccgctctccc ggtcccccgc cccgccagcc ctgcgcaatt
      841 cccggcgagc ggcggaagcc cgcccggggg cggggcggag ccggggctgg ggggtgccaa
      901 acccacccgg cggctgcgcc agcgactctg cagctgaagc gcatttggtg aggcggtcgg
      961 gcgagggagc gcgcacggag cgcgggacgg agcgccaggc ggacggaccg aaggacggag
     1021 gcaccgaagg acggacgccc ccgcacacgc agacgcacag agctcggcgc ggcccccgtc
     1081 gcatacacac tggcacagac acaagcaggg acacacgcag acacacgcac actcgcgcgc
     1141 gcatcctccc gccagcctgc ccgcctgctc gccggcgccc ggagcccgct ctggccgctt
     1201 gctttttgct gagaaagctt cctgccctgg aagatggcac ccttccccat ccagacacct
     1261 tgggaatgaa ttatgaggga gccaggagtg agagagagaa ccacgctgct gatgactccg
     1321 agggaggggc cctggacatg tgctgcagtg agaggctacc gggtctcccc cagccgatag
     1381 tgatggaggc actggacgag gctgaagggc tccaggactc acagagagag atgccgccac
     1441 cccctcctcc ctcgccgccc tcagatccag ctcagaagcc accacctcga ggcgctggga
     1501 gccactccct cactgtcagg agcagcctgt gcctgttcgc tgcctcacag ttcctgctgg
     1561 aacccacggc ctggcttgac tctgggacgt ggggagtccc cagtctgctg ctggtctttc
     1621 tgtccgtggg cctggtcctc gttaccaccc tggtgtggca cctcctgagg acacccccag
     1681 agccacccac cccactgccc cctgaggaca ggcgccagtc agtgagccgc cagccctcct
     1741 tcacctactc agagtggatg gaggagaaga tcgaggatga cttcctggac ctcgacccgg
     1801 tgcccgagac tcctgtgttt gattgtgtga tggacatcaa gcctgaggct gaccccacct
     1861 cactcaccgt caagtccatg ggtctgcagg agaggagggg ttccaatgtc tccctgaccc
     1921 tggacatgtg cactccgggc tgcaacgagg agggctttgg ctatctcatg tccccacgtg
     1981 aggagtccgc ccgcgagtac ctgctcagcg cctcccgtgt cctccaagca gaagagcttc
     2041 atgaaaaggc cctggaccct ttcctgctgc aggcggaatt ctttgaaatc cccatgaact
     2101 ttgtggatcc gaaagagtac gacatccctg ggctggtgcg gaagaaccgg tacaaaacca
     2161 tacttcccaa ccctcacagc agagtgtgtc tgacctcacc agaccctgac gaccctctga
     2221 gttcctacat caatgccaac tacatccggg gctatggtgg ggaggagaag gtgtacatcg
     2281 ccactcaggg acccatcgtc agcacggtcg ccgacttctg gcgcatggtg tggcaggagc
     2341 acacgcccat cattgtcatg atcaccaaca tcgaggagat gaacgagaaa tgcaccgagt
     2401 attggccgga ggagcaggtg gcgtacgacg gtgttgagat cactgtgcag aaagtcattc
     2461 acacggagga ttaccggctg cgactcatct ccctcaagag tgggactgag gagcgaggcc
     2521 tgaagcatta ctggttcaca tcctggcccg accagaagac cccagaccgg gcccccccac
     2581 tcctgcacct ggtgcgggag gtggaggagg cagcccagca ggaggggccc cactgtgccc
     2641 ccatcatcgt ccactgcagt gcagggattg ggaggaccgg ctgcttcatt gccaccagca
     2701 tctgctgcca gcagctgcgg caggagggtg tggtggacat cctgaagacc acgtgccagc
     2761 tccgtcagga caggggcggc atgatccaga catgcgagca gtaccagttt gtgcaccacg
     2821 tcatgagcct ctacgaaaag cagctgtccc accagtcccc agaatgactg cgcttctcct
     2881 acaaggttct ctgggcactg cccagcctga gtctcggccc tcacccaggg ccctgcctcg
     2941 ggtcctgggc ctgctccccg cttcctcccc ttcagtcagc tccctctgtc ctctgtcagc
     3001 ctggcctgac ccctaccctc cagcattgct cttcctactg tacatattgg ggagtggggg
     3061 gcagggtcgg gaagggacat gccaggccag gcctggggcc ccggggcctg acccacacca
     3121 cgcagacccc gggctccagt ttttaacgat ggttccatca atacctgatc cagaatgttt
     3181 ccgtgctaca ctttgtgtcc tgctgcaatg tgttctgtct gtccatccat ctctgccctc
     3241 tgtaccggac actgtgtctc ctcagccagg aaggggtaat gagctccagc ccctaagcaa
     3301 ccggacttgc ctgcctcggc ctcacccgca cttctcccaa aaggcagatg acggggagtt
     3361 aggcatgggg agctccagaa ggtcaccaga gagctttcag ctgagggaga gttctctagg
     3421 ttggagtggg catcacagcc agggtggcct ctgggtgtca gatgctctca ggagggtgcc
     3481 cagcctgtga ggcactggca aggtaggggg cagatggggc atggagaacc cagaggatct
     3541 aggccctgtt ggggagggga ggggagctca aggtttgggt ggggactcag cccagatcta
     3601 cgtgagacat ttttctgtgt cactgtggga aagccttccc agaagtctca ctgcgtgttg
     3661 ctctgcgtgt gttcccatgt ccatgcgtgt gttgagagcc catcaggagg gcatgcatga
     3721 ctctttggca acatgtatta tcttggagcc acgtgttttt attgctgact ttaaatattt
     3781 atcccacggc agacagagac atttggtgtc tttttataat tcgctcgtgg tcattgaata
     3841 gagcaataaa cggagcattt tgagcaaaac taaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
