LOCUS       NM_002829               6704 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 3
            (PTPN3), transcript variant 1, mRNA.
ACCESSION   NM_002829
VERSION     NM_002829.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6704)
  AUTHORS   Masuda,S., Onishi,H., Iwamoto,N., Imaizumi,A., Koga,S., Nagao,S.,
            Sakanashi,K., Itoyama,S., Fujimura,A., Komune,N., Kogo,R.,
            Umebayashi,M., Morisaki,T. and Nakagawa,T.
  TITLE     Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the
            Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer,
            Especially in Hypoxic Environments
  JOURNAL   J Immunother 47 (3), 89-97 (2024)
   PUBMED   38297883
  REMARK    GeneRIF: Inhibition of PTPN3 Expressed in Activated Lymphocytes
            Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and
            Neck Cancer, Especially in Hypoxic Environments.
REFERENCE   2  (bases 1 to 6704)
  AUTHORS   Zhou,Z., Lin,Z., Wang,M., Wang,L., Ji,Y., Yang,J., Yang,Y., Zhu,G.
            and Liu,T.
  TITLE     Identification and verification of PTPN3 as a novel biomarker in
            predicting cancer prognosis, immunity, and immunotherapeutic
            efficacy
  JOURNAL   Eur J Med Res 29 (1), 12 (2024)
   PUBMED   38173048
  REMARK    GeneRIF: Identification and verification of PTPN3 as a novel
            biomarker in predicting cancer prognosis, immunity, and
            immunotherapeutic efficacy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6704)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 6704)
  AUTHORS   Onishi,H., Iwamoto,N., Sakanashi,K., Koga,S., Oyama,Y., Yanai,K.,
            Nakamura,K., Nagai,S., Fujimura,A., Nakayama,K., Ozono,K. and
            Yamasaki,A.
  TITLE     PTPN3 Could Betae a Therapeutic Target of Pancreatic Cancer
  JOURNAL   Anticancer Res 42 (6), 2869-2874 (2022)
   PUBMED   35641270
  REMARK    GeneRIF: PTPN3 Could Betae a Therapeutic Target of Pancreatic
            Cancer.
REFERENCE   5  (bases 1 to 6704)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 6704)
  AUTHORS   Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and
            Tonks,N.K.
  TITLE     Serine phosphorylation-dependent association of the band
            4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta
            protein
  JOURNAL   J Biol Chem 272 (43), 27281-27287 (1997)
   PUBMED   9341175
REFERENCE   7  (bases 1 to 6704)
  AUTHORS   Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and
            Yachi,A.
  TITLE     Expression of cytoskeletal-associated protein tyrosine phosphatase
            PTPH1 mRNA in human hepatocellular carcinoma
  JOURNAL   J Gastroenterol 29 (6), 727-732 (1994)
   PUBMED   7874267
REFERENCE   8  (bases 1 to 6704)
  AUTHORS   Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M.,
            Ariyama,T., Inazawa,J., Imai,K. and Yachi,A.
  TITLE     Expression and chromosomal assignment of PTPH1 gene encoding a
            cytosolic protein tyrosine phosphatase homologous to
            cytoskeletal-associated proteins
  JOURNAL   Int J Cancer 55 (6), 947-951 (1993)
   PUBMED   8253532
REFERENCE   9  (bases 1 to 6704)
  AUTHORS   Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M.,
            Adachi,M., Imai,K. and Yachi,A.
  TITLE     cDNA cloning of new protein tyrosine phosphatases in the human
            colon
  JOURNAL   Tumour Biol 13 (3), 180-186 (1992)
   PUBMED   1626183
REFERENCE   10 (bases 1 to 6704)
  AUTHORS   Yang,Q. and Tonks,N.K.
  TITLE     Isolation of a cDNA clone encoding a human protein-tyrosine
            phosphatase with homology to the cytoskeletal-associated proteins
            band 4.1, ezrin, and talin
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 5949-5953 (1991)
   PUBMED   1648725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK316066.1, BC126117.1,
            BC033716.1, DB173093.1, AK096975.1 and AL359963.29.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002829.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This protein contains a C-terminal PTP
            domain and an N-terminal domain homologous to the band 4.1
            superfamily of cytoskeletal-associated proteins. P97, a cell cycle
            regulator involved in a variety of membrane related functions, has
            been shown to be a substrate of this PTP. This PTP was also found
            to interact with, and be regulated by adaptor protein 14-3-3 beta.
            Several alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.75211.1,
                                           SRR7346977.2885267.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374541.4/ ENSP00000363667.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1107              AK316066.1         7-1113
            1108-3426           BC126117.1         1024-3342
            3427-4168           BC033716.1         1459-2200
            4169-4506           DB173093.1         253-590
            4507-4990           AK096975.1         196-679
            4991-5030           AL359963.29        93827-93866         c
            5031-6704           AK096975.1         702-2375
FEATURES             Location/Qualifiers
     source          1..6704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..6704
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /note="protein tyrosine phosphatase non-receptor type 3"
                     /db_xref="GeneID:5774"
                     /db_xref="HGNC:HGNC:9655"
                     /db_xref="MIM:176877"
     exon            1..89
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..244
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2848
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytoskeletal-associated protein tyrosine phosphatase;
                     protein-tyrosine phosphatase H1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 3
                     isoform 1"
                     /protein_id="NP_002820.3"
                     /db_xref="CCDS:CCDS6776.1"
                     /db_xref="GeneID:5774"
                     /db_xref="HGNC:HGNC:9655"
                     /db_xref="MIM:176877"
                     /translation="MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFK
                     VTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCT
                     LHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD
                     YNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYG
                     VELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQ
                     AESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK
                     SVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPR
                     HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYL
                     TQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYL
                     VLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRD
                     ISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCP
                     EGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPY
                     DTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
                     VMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEE
                     HTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTME
                     TAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS"
     exon            245..352
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..395
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..474
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..519
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..572
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..693
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..781
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..870
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..934
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1107
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1242
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1419
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1606
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1684
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1741
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1898
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2059
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2150
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2212
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2359
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2488
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2634
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2770
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..6704
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /note="hexamer: AATAAA"
     polyA_site      4168
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /note="major polyA site"
     regulatory      6681..6686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
                     /note="hexamer: TATAAA"
     polyA_site      6704
                     /gene="PTPN3"
                     /gene_synonym="PTP-H1; PTPH1"
ORIGIN      
        1 agacggcggc caggtcgcgc cgcgagcgag cttccgcgcc gcccgcacgc gcgacctacc
       61 tgggcgctcc gcgcccccgg atgctgcagg ttattcagcg atagttatga cctcccggtt
      121 acgtgcgttg ggtggaagaa ttaataatat acgcacctcg gagttaccca aagagaaaac
      181 tcgatcagaa gtcatttgca gcatccactt tttagatggc gtggtacaga cctttaaagt
      241 tactaaacaa gacactggcc aggttcttct ggatatggtg cacaaccacc tgggtgtgac
      301 tgaaaaggaa tattttggtt tacagcatga tgacgactcc gtggactctc ctagatggct
      361 ggaagcaagc aaagccatca ggaagcagtt aaaaggaggt ttcccctgta ccctgcattt
      421 tcgagtaaga ttttttatac ctgatcccaa cacactgcag caagaacaaa ccaggcactt
      481 gtatttctta caactgaaga tggatatttg cgaaggaagg ttaacctgcc ctcttaactc
      541 agcagtggtt ctagcgtcct atgccgtaca atctcatttt ggagactata attcttccat
      601 acatcatcca ggctatcttt ccgatagtca ctttataccc gatcaaaatg aggacttttt
      661 aacaaaagtc gaatctctgc atgagcagca cagtgggcta aaacaatcag aagcagaatc
      721 ctgctatatc aacatagcgc ggaccctcga cttctatgga gtagaactgc acagtggtag
      781 ggatctgcac aatttagacc taatgattgg aattgcttcc gcgggtgttg ctgtgtaccg
      841 aaaatacatt tgcacaagtt tctatccttg ggtgaacatt ctcaaaattt ctttcaaaag
      901 gaaaaagttc ttcatacatc agcgacagaa acaggctgaa tccagggaac atattgtggc
      961 cttcaacatg ctgaattacc gatcttgcaa aaacttgtgg aaatcctgtg ttgagcacca
     1021 tacgttcttt caggcaaaga agctactacc tcaggaaaag aatgttctgt ctcagtactg
     1081 gactatgggc tctcggaaca ccaaaaagtc ggtaaataac caatattgca aaaaggtgat
     1141 tggcgggatg gtgtggaacc cagccatgcg gagatcctta tcagtggagc acttagaaac
     1201 caagagtctg ccttctcgtt cccctcccat tactcccaac tggcgaagtc ctcggctccg
     1261 gcacgaaatc cgaaagccac gccactcttc tgcagataac cttgcaaatg aaatgaccta
     1321 catcacggaa acggaagatg tattttacac gtacaagggc tctctggccc ctcaagacag
     1381 cgattctgaa gtttctcaga accgaagccc gcaccaagag agtttatccg agaacaatcc
     1441 ggcacaaagc tacctgaccc agaagtcatc cagttctgtg tctccatctt caaatgctcc
     1501 aggctcctgc tcacctgacg gcgttgatca gcagctctta gatgacttcc acagggtgac
     1561 caaagggggc tccaccgagg acgccagcca gtactactgt gacaagaatg ataatggtga
     1621 cagctactta gtcttgatcc gtatcacacc agatgaagat ggaaaatttg gatttaatct
     1681 taagggagga gtggatcaaa agatgcctct tgtggtatca aggataaacc cagagtcacc
     1741 tgcggacacc tgcattccta agctgaacga aggggatcaa atcgtgttaa tcaatggccg
     1801 ggacatctca gaacacacgc atgaccaagt ggtgatgttc atcaaagcca gccgggagtc
     1861 ccactcacgg gagctggccc tggtgatcag gaggagagct gtccgctcat ttgctgactt
     1921 caagtctgaa gatgaactga accagctttt ccccgaagcc attttcccca tgtgtccgga
     1981 gggtggggac actttggagg gatccatggc acagctaaag aagggcctcg aaagcgggac
     2041 ggtgctgatc cagtttgagc aactctacag aaaaaagcca ggtttggcca tcacgtttgc
     2101 aaagctgcct caaaatttgg acaaaaaccg atataaagat gtgctgcctt atgacaccac
     2161 ccgggtatta ttgcagggaa atgaagatta tattaatgca agttacgtga acatggaaat
     2221 tcctgctgct aaccttgtga acaagtacat cgccactcag gggcccctgc cgcatacctg
     2281 tgcacagttt tggcaggttg tctgggatca gaagttgtca ctcattgtca tgttgacgac
     2341 tctcacagaa cgagggcgga ccaaatgtca ccagtactgg ccagatcccc ccgacgtcat
     2401 gaaccacggc ggctttcaca tccagtgtca gtcagaggac tgcaccatcg cctatgtgtc
     2461 ccgagaaatg ctggtcacaa acacccagac cggggaagaa cacacagtga cacatctcca
     2521 gtacgtcgca tggcctgacc acggtgtgcc cgatgactcc tccgactttc tggaatttgt
     2581 aaactatgtg aggtctctga gagtggacag cgagcccgtc ctagttcact gcagtgctgg
     2641 aataggtcga accggtgtgt tggtcactat ggaaacagcc atgtgcctaa ctgagaggaa
     2701 cctgcccatt tacccactgg atattgtccg aaaaatgcga gaccagcgcg ccatgatggt
     2761 gcagacatca agccagtaca agtttgtgtg tgaagcgatt cttcgtgtgt atgaagaagg
     2821 tttagtccaa atgctggatc ctagttaaga caactgtgaa aaagttcatt cctctttccc
     2881 aagggcatcc tccttgaaag aggaggacag acctctctgg aagcagcaag aggaaccagt
     2941 agctgtggga aaggaatggg cacctctgaa cccaggcact ttaaacttct atagaaaaga
     3001 tatcgtgtac ataggaactg gtgtagataa gcatgcaatt atggcatcat ttaggcctgt
     3061 atttctatgg aaagatacaa aaaggatctc agtttggggc ctgtcctaat gccttcttcc
     3121 ctaacatcac cacacacacc cctgtcggca tcctggagca attgagaccg gacacccaca
     3181 gagctgttgt cctcccagca acaagatggt gtggttatct tgggtcattt ggatgttttg
     3241 tttgtttctg tgtgtcagac tgtaagggct gagctttctg tgcttctagg tggagctgga
     3301 acaattcaga ttcacccgcc ctgatgctaa ggaaaccctg acgtatgtac tagatggcag
     3361 ggcactgggg gtcaggctga aggctgagca acacctctct gccctccctc cctttgtccc
     3421 atctcccagc gacttccaat attcatgttt ctgagaattg tgtccctctt caggttccct
     3481 cttggtgcct aacctggatt agtaatgtgc attcaggtga attttcagct gaggctctga
     3541 gaactggtac tctcagtgtg ttctggtcat cttgtggctt agttgtagaa gcaggtgtgt
     3601 ctcttgcctc tgcttgcctc ctactgcaca ctcagcaccc aggactggaa tcaccgacta
     3661 ctgaatctcc tacatgtatt gctgctactt caagctcctc cacttgaaac cttatgattt
     3721 tcccaagggg agatgggaca gtgtcatcta aatattccga atgtttggcc ttctgagaaa
     3781 agagcttcta gtaattgaac catgggaaac ccagcttctg gagggttggc cgtggggctg
     3841 tgtacatgtg tgtgcccagg ggtgagtgtt tctcaggatt cctaacgatt caaattaccg
     3901 ttgagtatat ataaagaatg agtctctgta tggaagaaca aatgtgtgca ttcaccccca
     3961 gtcacaatgg tctccattgc atttcaaagg agaggatcag actatctgaa tataaacaca
     4021 atctgatgtt aatttattct aagaacacca tcattttgat tgtcctaaag aattctgcct
     4081 ttgtgaatac cgtgttaaat ttttttaaat ttgtgacagg attgtagcaa attattattt
     4141 aaggaaaata aattgtgtaa acatttaatg tggtattttt gaacagcggt ttttatgtac
     4201 tcagaagagg aagtaaagcc aggttcttaa tggtatttat agaaaagatg ttttcatatt
     4261 ataatgcaca taaatgaagc cattttgata ttcagcaaat tcggtgccaa ttgaatagtt
     4321 tgctggtagc aagacggatg aagacctata tgggagattc tttatctcta gagctagcat
     4381 atttacttgc atactttgtt tcttttccac atggatattt tactgctaaa tggcagaggt
     4441 gggagggaga tgtcacacag taccataacc ccatattgaa aacaagaaac caccagaaag
     4501 tttgcagcta aggggcaggg gattcagttc ctacgcccac tcagcactaa ctacttgcgg
     4561 gcctggttgc ttagaagctc tacctctctt tcattatctg taaaatagaa acaatactta
     4621 ggactttagt tggaacatga ggattgaata agatcacgct attcatgtga ctttttatcg
     4681 gctagaacag caacagacac tgctgtgggt gagttactta gaaaagttta gttatcagtg
     4741 attagcccaa aaacacatca gtcaaaaata gaatccactg gatttttgtc tctcttttta
     4801 gagacagggt ctcactgtcg cccaggctgg agtacagtgg catgatcatt gttcactgca
     4861 gcctcaaatt cctgggctca agcaatcctc gcacctcagc ctcctgagta gccgggacta
     4921 taggcacatg ccacctcacc tggcttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4981 gtgtgtgtgt gtgtgtgtgt gtgtgtgtag agacaggatc ttgatgtgtt gcctaggctg
     5041 gtctcaaact cctggcctca agtgatcttc ccacctcagc ctccaaaact gttgggatta
     5101 taggcgtgag ccactgtgcc cagcctaact gggtttttat gagaggaaaa tagaaaatgc
     5161 tcttctagaa gagagagaac aagagcacaa aataatctgg actcacaaaa attcagcaag
     5221 ctccaagaaa gggggatgga gggaacgctg gcaaaaattt aaatgccatt aggatattta
     5281 gcaagttatt actgtttggt aaaaatgcat catcaccctg tgtgcaaaat gcttgcaaag
     5341 tagtctaaat gtctttggag atgggtgttt tactgctttt ttccaaaaac aaattgttta
     5401 ttatggttgc agaaatgcag ccattacggt cacataaatt tctaaaaagc ctaccaaagg
     5461 ttgcaagcag tcttctgcca ctgggcaggc cagcagttca gacccagcga ggttgccagg
     5521 aacaaatcca ggaaatactg ggaagaacaa gacaagagaa ttacctaaaa gagcaaacaa
     5581 ttcaagtaaa tcctgtagct attaccactt aaaatccgta gctcaagatt cctgtttcac
     5641 caccttatac acttaagcaa ttatacttaa gccttttttt agtcctaagt gaagaactac
     5701 atcagaatca ggataagtat tttgcctggg aaatttggct gcatatgaat ggagaagaca
     5761 tttacatcct atgttctggc actttctgaa agatctaatt aaacatgttg atgtgccaat
     5821 ttaatcaaga tgagagatcc ctgctggtgt caccctctag aacctgcact tggtgttttg
     5881 actttccaga agaaaaaaat gcaactttgg ttagggggca gtggttggat cacacagttg
     5941 tctttcgttt cctaccacag taattcatat ttaaatatgc ttttagatta gtgtggatac
     6001 tattgctgct gtgttgctac ctgacctttt tctggggggg gtacctcaga aatgagcatt
     6061 tgagggcaag cgaaaaagcc ctcttcatcc tccagaggca acaaagaggc agcagaaatg
     6121 gggaaagatt gtgagaggca gggcttgggt ctagacctgg acttaggcaa gatatgttgc
     6181 cctcaaccct gagttttctt atatgtaaaa agggaaggtt gggctggact agatgaggtc
     6241 aagatttgcc attctgggag gctgatattc cagagaatca aaattaatcc taaaccaaag
     6301 ctttatggct gctacagaga catgtcacat ttctgagact tgtcaccaag agtttgtccc
     6361 tcagactttg gcgctgttga atgcaaagac aaggatggcc accttctggt tcttgcctgt
     6421 tgtcctcagc tgagagcagt ctcggtaaag gtggcaaaga ttctgtgacc tcagaccggg
     6481 gaccaaatgc ttgggagtct gatggccggg ctgggccacc attctcatag ctctcattct
     6541 gtttggagca accaaaggat ttgtgtgaag ttatttggaa aaggacctta actgagcagt
     6601 aatctttttt ctgtatattt ggaatgtttt tcattctgac ctgttctgtc agtgattcta
     6661 ctgaaaaaca atttaatcaa tataaaaatg ttcaagctat gcaa
//
