LOCUS       NM_015466               5237 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 23
            (PTPN23), transcript variant 1, mRNA.
ACCESSION   NM_015466
VERSION     NM_015466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Niu,S., Ma,J., Li,Y., Yue,X., Shi,K., Pan,M., Song,L., Tan,Y.,
            Gu,L., Liu,S. and Chang,J.
  TITLE     PTPN23[Thr] variant reduces susceptibility and tumorigenesis in
            esophageal squamous cell carcinoma through dephosphorylation of
            EGFR
  JOURNAL   Cancer Lett 592, 216936 (2024)
   PUBMED   38704135
  REMARK    GeneRIF: PTPN23[Thr] variant reduces susceptibility and
            tumorigenesis in esophageal squamous cell carcinoma through
            dephosphorylation of EGFR.
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Singh,S., Yeat,N.Y., Wang,Y.T., Lin,S.Y., Kuo,I.Y., Wu,K.P.,
            Wang,W.J., Wang,W.C., Su,W.C., Wang,Y.C. and Chen,R.H.
  TITLE     PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation
            to define a lung cancer therapeutic target
  JOURNAL   Cell Death Dis 14 (10), 671 (2023)
   PUBMED   37821451
  REMARK    GeneRIF: PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET
            degradation to define a lung cancer therapeutic target.
            Erratum:[Cell Death Dis. 2024 Jul 2;15(7):468. doi:
            10.1038/s41419-024-06747-x.. PMID: 38956428]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5237)
  AUTHORS   Pashkova,N., Yu,L., Schnicker,N.J., Tseng,C.C., Gakhar,L.,
            Katzmann,D.J. and Piper,R.C.
  TITLE     Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP
            reveals role for regulation of Vps4 ATPase
  JOURNAL   Mol Biol Cell 32 (22), ar42 (2021)
   PUBMED   34586919
  REMARK    GeneRIF: Interactions of ubiquitin and CHMP5 with the V domain of
            HD-PTP reveals role for regulation of Vps4 ATPase.
REFERENCE   4  (bases 1 to 5237)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5237)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5237)
  AUTHORS   Castiglioni,S., Maier,J.A. and Mariotti,M.
  TITLE     The tyrosine phosphatase HD-PTP: A novel player in endothelial
            migration
  JOURNAL   Biochem Biophys Res Commun 364 (3), 534-539 (2007)
   PUBMED   17959146
  REMARK    GeneRIF: We suggest that HD-PTP contributes to the regulation of
            endothelial motility by modulating the tyrosine phosphorylation of
            FAK.
REFERENCE   7  (bases 1 to 5237)
  AUTHORS   Ichioka,F., Takaya,E., Suzuki,H., Kajigaya,S., Buchman,V.L.,
            Shibata,H. and Maki,M.
  TITLE     HD-PTP and Alix share some membrane-traffic related proteins that
            interact with their Bro1 domains or proline-rich regions
  JOURNAL   Arch Biochem Biophys 457 (2), 142-149 (2007)
   PUBMED   17174262
REFERENCE   8  (bases 1 to 5237)
  AUTHORS   Mariotti,M., Castiglioni,S., Beguinot,L. and Maier,J.A.
  TITLE     The tyrosine phosphatase HD-PTP is regulated by FGF-2 through
            proteasome degradation
  JOURNAL   Front Biosci 11, 2138-2143 (2006)
   PUBMED   16720300
  REMARK    GeneRIF: data suggest that HD-PTP might participate in modulating
            endothelial response to angiogenic factors and play a role in
            regulating the complex events leading to the formation of new
            vessels
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5237)
  AUTHORS   Mariotti,M., Castiglioni,S. and Maier,J.A.
  TITLE     Expression analysis and modulation by HIV-Tat of the tyrosine
            phosphatase HD-PTP
  JOURNAL   J Cell Biochem 98 (2), 301-308 (2006)
   PUBMED   16408268
  REMARK    GeneRIF: These results suggest that HD-PTP amounts might be
            regulated both at the transcriptional and post-transcriptional
            levels.
REFERENCE   10 (bases 1 to 5237)
  AUTHORS   Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A.,
            Nakamura,A., Shimizu,N. and Shimizu,K.
  TITLE     HD-PTP: A novel protein tyrosine phosphatase gene on human
            chromosome 3p21.3
  JOURNAL   Biochem Biophys Res Commun 278 (3), 671-678 (2000)
   PUBMED   11095967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB040904.2, AF290614.1 and
            BU173747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015466.3.
            
            Summary: This gene encodes a member of the non-receptor type
            protein-tyrosine phosphatase family. The encoded protein may be
            involved in the regulation of small nuclear ribonucleo protein
            assembly and pre-mRNA splicing by modifying the survival motor
            neuron (SMN) complex. The encoded protein additionally plays a role
            in ciliogenesis and is part of endosomal sorting complex required
            for transport (ESCRT) pathways. This gene may serve a tumor
            suppressor function. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025194.1, AF290614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265562.5/ ENSP00000265562.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AB040904.2         40-63
            25-4710             AF290614.1         10-4695
            4711-4711           BU173747.1         798-798
            4712-5237           AF290614.1         4697-5222
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5237
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /note="protein tyrosine phosphatase non-receptor type 23"
                     /db_xref="GeneID:25930"
                     /db_xref="HGNC:HGNC:14406"
                     /db_xref="MIM:606584"
     exon            1..160
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..4987
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase TD14; his domain-containing
                     protein tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     23 isoform 1"
                     /protein_id="NP_056281.1"
                     /db_xref="CCDS:CCDS2754.1"
                     /db_xref="GeneID:25930"
                     /db_xref="HGNC:HGNC:14406"
                     /db_xref="MIM:606584"
                     /translation="MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEE
                     LKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSG
                     KSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREH
                     FPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEAC
                     RALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSA
                     LDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVK
                     GAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNE
                     VLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFT
                     DVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKA
                     SFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEM
                     RDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQD
                     RVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADL
                     ESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGD
                     PPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSG
                     PTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPP
                     VAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPP
                     PQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPP
                     QQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAH
                     SGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSP
                     APSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKV
                     DAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEH
                     DARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVAT
                     QAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
                     SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHY
                     LHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHML
                     QEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVP
                     ISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPL
                     PEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHN
                     GQGLRATRPSDDPLSLLDPLWTLNKT"
     exon            161..235
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            236..363
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            364..440
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            441..490
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            491..622
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            623..703
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            704..835
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            836..883
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            884..940
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            941..999
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1079
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1194
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1260
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1406
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1718
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1873
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2025
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2205
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..3964
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4149
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4254
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4393
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4507
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..5237
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5217..5222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /note="hexamer: AATAAA"
     polyA_site      5237
                     /gene="PTPN23"
                     /gene_synonym="HD-PTP; HDPTP; NEDBASS; PTP-TD14"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggc tcgtggctga gccagcagct gcagcagcta cgggagtggc cgggtggccg
       61 gcgggtgcca gccgccatgg aggccgtgcc ccgcatgccc atgatctggc tggacctgaa
      121 ggaggccggt gactttcact tccagccagc tgtgaagaag tttgtcctga agaattatgg
      181 agagaaccca gaagcctaca atgaagaact gaagaagctg gagttgctca gacagaatgc
      241 tgtccgtgtc ccacgagact ttgagggctg tagtgtcctc cgcaagtacc tcggccagct
      301 tcattacctg cagagtcggg tccccatggg ctcgggccag gaggccgctg tccctgtcac
      361 ctggacagag atcttctcag gcaagtctgt ggcccatgag gacatcaagt acgagcaggc
      421 ctgtattctc tacaaccttg gagcgctgca ctccatgctg ggggccatgg acaagcgggt
      481 gtctgaggag ggcatgaagg tctcctgtac ccatttccag tgcgcagccg gcgccttcgc
      541 ctacctacgg gagcacttcc ctcaagccta cagcgtcgac atgagccgcc agatccttac
      601 gctcaacgtc aacctcatgc tgggccaggc tcaggagtgc ctcctggaga agtcgatgtt
      661 ggacaacagg aagagctttc tggtggcccg catcagtgca caggtggtag attactacaa
      721 ggaggcatgc cgggccttgg agaaccccga cactgcctca ctgctgggcc ggatccagaa
      781 ggactggaag aaacttgtgc agatgaagat ctactacttc gcagccgtgg ctcatctgca
      841 catgggaaag caggccgagg agcagcagaa gttcggggag cgggttgcat acttccagag
      901 cgccctggac aagctcaatg aagccatcaa gttggccaag ggccagcctg acactgtgca
      961 agacgcgctt cgcttcacta tggatgtcat tgggggaaag tacaattctg ccaagaagga
     1021 caacgacttc atttaccatg aggctgtccc agcattggac actcttcagc ctgtaaaagg
     1081 agcccccttg gtgaagccct tgccagtgaa ccccacagac ccagctgtta caggccctga
     1141 catctttgcc aaactggtac ccatggctgc ccacgaggcc tcgtcactgt acagtgagga
     1201 gaaggccaag ctgctccggg agatgatggc caagattgag gacaagaatg aggtcctgga
     1261 ccagttcatg gattcaatgc agttggatcc cgagacggtg gacaaccttg atgcctacag
     1321 ccacatccca ccccagctca tggagaagtg cgcggctctc agcgtccggc ccgacactgt
     1381 caggaacctt gtacagtcca tgcaagtgct gtcaggtgtg ttcacggatg tggaggcttc
     1441 cctgaaggac atcagagatc tgttggagga ggatgagctg ctagagcaga agtttcagga
     1501 ggcggtgggc caggcagggg ccatctccat cacctccaag gctgagctgg cagaggtgag
     1561 gcgagaatgg gccaagtaca tggaagtcca tgagaaggcc tccttcacca acagtgagct
     1621 gcaccgtgcc atgaacctgc acgtcggcaa cctgcgcctg ctcagcgggc cgcttgacca
     1681 ggtccgggct gccctgccca caccggccct ctccccagag gacaaggccg tgctgcaaaa
     1741 cctaaagcgc atcctggcta aggtgcagga gatgcgggac cagcgcgtgt ccctggagca
     1801 gcagctgcgt gagcttatcc agaaagatga catcactgcc tcgctggtca ccacagacca
     1861 ctcagagatg aagaagttgt tcgaggagca gctgaaaaag tatgaccagc tgaaggtgta
     1921 cctggagcag aacctggccg cccaggaccg tgtcctctgt gcactgacag aggccaacgt
     1981 gcagtacgca gccgtgcggc gggtactcag cgacttggac caaaagtgga actccacgct
     2041 gcagaccctg gtggcctcgt atgaagccta tgaggacctg atgaagaagt cgcaggaggg
     2101 cagggacttc tacgcagatc tggagagcaa ggtggctgct ctgctggagc gcacgcagtc
     2161 cacctgccag gcccgcgagg ctgcccgcca gcagctcctg gacagggagc tgaagaagaa
     2221 gccgccgcca cggcccacag ccccaaagcc gctgctgccc cgcagggagg agagtgaggc
     2281 agtggaagca ggagaccccc ctgaggagct gcgcagcctc ccccctgaca tggtggctgg
     2341 cccacgactg cctgacacct tcctgggaag tgccaccccg ctccactttc ctcccagccc
     2401 cttccccagc tccacaggcc caggacccca ctatctctca ggccccttgc cccctggtac
     2461 ctactcgggc cccacccagc tgatacagcc cagggcccca gggccccatg caatgcccgt
     2521 agcacctggg cctgccctct acccagcccc tgcctacaca ccggagctgg gccttgtgcc
     2581 ccgatcctcc ccacagcatg gcgtggtgag cagtccctat gtgggggtag ggccggcccc
     2641 accagttgca ggtctcccct cggccccacc tcctcaattc tcaggccccg agttggccat
     2701 ggcggttcgg ccagccacca ccacagtaga tagcatccag gcgcccatcc ccagccacac
     2761 agccccacgg ccaaacccca cccctgctcc tcccccgccc tgcttccctg tgcccccacc
     2821 gcagccactg cccacgcctt acacctaccc tgcaggggct aagcaaccca tcccggcaca
     2881 gcaccacttc tcttctggga tccccgcagg ttttccagcc ccaaggattg ggccccagcc
     2941 ccagccccat cctcagcccc atccttcaca agcgtttggg cctcagcccc cacagcagcc
     3001 ccttccactc cagcatccac atctcttccc accccaggcc ccaggactcc tacccccaca
     3061 atccccctac ccctatgccc ctcagcctgg ggtcctgggg cagccgccac cccccctaca
     3121 cacccagctc tacccaggtc ccgctcaaga ccctctgcca gcccactcag gggctctgcc
     3181 tttccccagc cctgggcccc ctcagcctcc ccatccccca ctggcatatg gtcctgcccc
     3241 ttctaccaga cccatgggcc cccaggcagc ccctcttacc attcgagggc cctcgtctgc
     3301 tggccagtcc acccctagtc cccacctggt gccttcacct gccccatctc cagggcctgg
     3361 tccggtaccc cctcgccccc cagcagcaga accaccccct tgcctgcgcc gaggcgccgc
     3421 agctgcagac ctgctctcct ccagcccgga gagccagcat ggcggcactc agtctcctgg
     3481 gggtgggcag cccctgctgc agcccaccaa ggtggatgca gctgagggtc gtcggccgca
     3541 ggccctgcgg ctgattgagc gggaccccta tgagcatcct gagaggctgc ggcagttgca
     3601 gcaggagctg gaggcctttc ggggtcagct gggggatgtg ggagctctgg acactgtctg
     3661 gcgagagctg caagatgcgc aggaacatga tgcccgaggc cgttccatcg ccattgcccg
     3721 ctgctactca ctgaagaacc ggcaccagga tgtcatgccc tatgacagta accgtgtggt
     3781 gctgcgctca ggcaaggatg actacatcaa tgccagctgc gtggaggggc tctccccata
     3841 ctgccccccg ctagtggcaa cccaggcccc actgcctggc acagctgctg acttctggct
     3901 catggtccat gagcagaaag tgtcagtcat tgtcatgctg gtttctgagg ctgagatgga
     3961 gaagcaaaaa gtggcacgct acttccccac cgagaggggc cagcccatgg tgcacggtgc
     4021 cctgagcctg gcattgagca gcgtccgcag caccgaaacc catgtggagc gcgtgctgag
     4081 cctgcagttc cgagaccaga gcctcaagcg ctctcttgtg cacctgcact tccccacttg
     4141 gcctgagtta ggcctgcccg acagccccag caacttgctg cgcttcatcc aggaggtgca
     4201 cgcacattac ctgcatcagc ggccgctgca cacgcccatc attgtgcact gcagctctgg
     4261 tgtgggccgc acgggagcct ttgcactgct ctatgcagct gtgcaggagg tggaggctgg
     4321 gaacggaatc cctgagctgc ctcagctggt gcggcgcatg cggcagcaga gaaagcacat
     4381 gctgcaggag aagctgcacc tcaggttctg ctatgaggca gtggtgagac acgtggagca
     4441 ggtcctgcag cgccatggtg tgcctcctcc atgcaaaccc ttggccagtg caagcatcag
     4501 ccagaagaac caccttcctc aggactccca ggacctggtc ctcggtgggg atgtgcccat
     4561 cagctccatc caggccacca ttgccaagct cagcattcgg cctcctgggg ggttggagtc
     4621 cccggttgcc agcttgccag gccctgcaga gcccccaggc ctcccgccag ccagcctccc
     4681 agagtctacc ccaatcccat cttcctcccc gccccccctt tcctccccac tacctgaggc
     4741 tccccagcct aaggaggagc cgccagtgcc tgaagccccc agctcggggc ccccctcctc
     4801 ctccctggaa ttgctggcct ccttgacccc agaggccttc tccctggaca gctccctgcg
     4861 gggcaaacag cggatgagca agcataactt tctgcaggcc cataacgggc aagggctgcg
     4921 ggccacccgg ccctctgacg accccctcag ccttctggat ccactctgga cactcaacaa
     4981 gacctgaaca ggttttgcct acctggtcct tacactacat catcatcatc tcatgcccac
     5041 ctgcccacac ccagcagagc ttctcagtgg gcacagtctc ttactcccat ttctgctgcc
     5101 tttggccctg cctggcccag cctgcacccc tgtggggtgg aaatgtactg caggctctgg
     5161 gtcaggttct gctcctttat gggacccgac atttttcagc tctttgctat tgaaataata
     5221 aaccaccctg ttctgtg
//
