LOCUS       NM_007039               6443 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 21
            (PTPN21), mRNA.
ACCESSION   NM_007039
VERSION     NM_007039.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6443)
  AUTHORS   Zhu,N., Wei,J., Wang,L.M., Huang,H. and Xiao,H.
  TITLE     Overexpression of PTPN21 promotes proliferation of EGF-stimulated
            acute lymphoblastic leukemia cells via the MAPK signaling pathways
  JOURNAL   Hematology 29 (1), 2356292 (2024)
   PUBMED   38785187
  REMARK    GeneRIF: Overexpression of PTPN21 promotes proliferation of
            EGF-stimulated acute lymphoblastic leukemia cells via the MAPK
            signaling pathways.
REFERENCE   2  (bases 1 to 6443)
  AUTHORS   Lee,H.S., Kim,M.W., Jin,K.S., Shin,H.C., Kim,W.K., Lee,S.C.,
            Kim,S.J., Lee,E.W. and Ku,B.
  TITLE     Molecular Analysis of the Interaction between Human PTPN21 and the
            Oncoprotein E7 from Human Papillomavirus Genotype 18
  JOURNAL   Mol Cells 44 (1), 26-37 (2021)
   PUBMED   33431714
  REMARK    GeneRIF: Molecular Analysis of the Interaction between Human PTPN21
            and the Oncoprotein E7 from Human Papillomavirus Genotype 18.
REFERENCE   3  (bases 1 to 6443)
  AUTHORS   Wang,H., Zhu,N., Ye,X., Wang,L., Wang,B., Shan,W., Lai,X., Tan,Y.,
            Fu,S., Xiao,H. and Huang,H.
  TITLE     PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic
            leukemia cells to NK-mediated lysis via the KIR/HLA-I axis
  JOURNAL   J Cell Biochem 121 (5-6), 3298-3312 (2020)
   PUBMED   31898344
  REMARK    GeneRIF: PTPN21-CDSlong isoform inhibits the response of acute
            lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I
            axis.
REFERENCE   4  (bases 1 to 6443)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6443)
  AUTHORS   Siddiqui,N., Zwetsloot,A.J., Bachmann,A., Roth,D., Hussain,H.,
            Brandt,J., Kaverina,I. and Straube,A.
  TITLE     PTPN21 and Hook3 relieve KIF1C autoinhibition and activate
            intracellular transport
  JOURNAL   Nat Commun 10 (1), 2693 (2019)
   PUBMED   31217419
  REMARK    GeneRIF: Study demonstrates that PTPN21 activates KIF1C by binding
            to the stalk region. This function does not require catalytic
            activity of the phosphatase, and its N-terminal FERM domain alone
            is sufficient to stimulate the transport of KIF1C cargoes in cells
            as well as increasing the landing rate of KIF1C on microtubules in
            vitro. The cargo adapter Hook3 binds KIF1C in the same region and
            activates KIF1C in a similar way.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6443)
  AUTHORS   Jui,H.Y., Tseng,R.J., Wen,X., Fang,H.I., Huang,L.M., Chen,K.Y.,
            Kung,H.J., Ann,D.K. and Shih,H.M.
  TITLE     Protein-tyrosine phosphatase D1, a potential regulator and effector
            for Tec family kinases
  JOURNAL   J Biol Chem 275 (52), 41124-41132 (2000)
   PUBMED   11013262
REFERENCE   7  (bases 1 to 6443)
  AUTHORS   Tokuchi,H., Higashitsuji,H., Nishiyama,H., Nonoguchi,K., Nagao,T.,
            Xue,J.H., Itoh,K., Ogawa,O. and Fujita,J.
  TITLE     Expression of protein tyrosine phosphatase PTP-RL10 and its isoform
            in the mouse testis
  JOURNAL   Int J Urol 6 (11), 572-577 (1999)
   PUBMED   10585123
REFERENCE   8  (bases 1 to 6443)
  AUTHORS   Dorner,C., Ciossek,T., Muller,S., Moller,P.H., Ullrich,A. and
            Lammers,R.
  TITLE     Characterization of KIF1C, a new kinesin-like protein involved in
            vesicle transport from the Golgi apparatus to the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 273 (32), 20267-20275 (1998)
   PUBMED   9685376
REFERENCE   9  (bases 1 to 6443)
  AUTHORS   Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y.,
            Takenawa,J., Nakayama,H. and Fujita,J.
  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
            the regenerating mouse liver: isolation of PTP-RL10, a novel
            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
            protein 4.1
  JOURNAL   Oncogene 10 (2), 407-414 (1995)
   PUBMED   7838537
REFERENCE   10 (bases 1 to 6443)
  AUTHORS   Moller,N.P., Moller,K.B., Lammers,R., Kharitonenkov,A., Sures,I.
            and Ullrich,A.
  TITLE     Src kinase associates with a member of a distinct subfamily of
            protein-tyrosine phosphatases containing an ezrin-like domain
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7477-7481 (1994)
   PUBMED   7519780
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162171.4, X79510.1,
            BM930068.1, DA860560.1 and AL049834.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007039.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an N-terminal domain,
            similar to cytoskeletal- associated proteins including band 4.1,
            ezrin, merlin, and radixin. This PTP was shown to specially
            interact with BMX/ETK, a member of Tec tyrosine kinase family
            characterized by a multimodular structures including PH, SH3, and
            SH2 domains. The interaction of this PTP with BMX kinase was found
            to increase the activation of STAT3, but not STAT2 kinase. Studies
            of the similar gene in mice suggested the possible roles of this
            PTP in liver regeneration and spermatogenesis. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79510.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556564.6/ ENSP00000452414.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AL162171.4         92777-93004
            229-1711            X79510.1           2-1484
            1712-1860           BM930068.1         377-525
            1861-2742           X79510.1           1634-2515
            2743-2743           AL162171.4         168537-168537
            2744-3365           X79510.1           2517-3138
            3366-3781           DA860560.1         142-557
            3782-4307           X79510.1           3555-4080
            4308-5556           AL162171.4         179871-181119
            5557-6443           AL049834.3         170519-171405       c
FEATURES             Location/Qualifiers
     source          1..6443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3"
     gene            1..6443
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /note="protein tyrosine phosphatase non-receptor type 21"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
     exon            1..357
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            358..739
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..4084
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /EC_number="3.1.3.48"
                     /note="dJ1175B15.2 (protein tyrosine phosphatase,
                     non-receptor type 21); protein-tyrosine phosphatase D1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     21"
                     /protein_id="NP_008970.2"
                     /db_xref="CCDS:CCDS9884.1"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
                     /translation="MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVEST
                     GQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVV
                     FYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYES
                     QDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYG
                     EESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANK
                     EETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKP
                     QPYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNG
                     SVYSAHSTNSLNNPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSAVIPPSYRPTPD
                     YETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAA
                     HCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRTQVYRPP
                     PPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPL
                     TAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERT
                     QREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLA
                     QDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTTAEAQRPWRDGLLMPSMSE
                     SDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAA
                     LNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECS
                     TARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQG
                     PLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITT
                     RFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVR
                     RHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQ
                     RMMLVQTLCQYTFVYRVLIQFLKSSRLI"
     exon            740..909
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1007
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1075
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1146
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1234
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1323
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1411
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1491
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1552
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1637
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..3070
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3208
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3430
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3559
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3794
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3955
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..6443
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6423..6428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /note="hexamer: AATAAA"
     polyA_site      6443
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /note="major polyA site"
ORIGIN      
        1 acgcctgggc ccggccgccc cgctgctccg gccgcgcgtc ccgcgtcggt ccgacggtct
       61 gtccgtcctc ctgccacccc ccgcccccac ggggcttctt tgtgcggcgc tcctcgccgg
      121 ccggtcccac ctccaggcct cgcccctcgc cgtcgccacc gccggactct gcccagggga
      181 atggtctgcg agccgggttt ttggagacag gaagtgaggc gtgcgagccc catgagcgcg
      241 ccgcggcccg ggctggcgtg cgggtgcggc tgcggcggcc gcgcggcggg gccccgggag
      301 gcgggtcgct gagcggggcg cgcggccccg aggatgcggg agcgggagcg ggagcagcgc
      361 tggcgtcaat gctcccttcc tcgggccatt ggagactccg ttgcttttta atggcggcag
      421 cggctgctgg gtgagcagct ggaggccgga cagtgttcgt cccatccgga gaggatcgct
      481 ttctcctggc gtcaccagcg ctgggttggt gggggtagct tttccctctt tgctcctcca
      541 ttcttgaaga aagaagaaga tgccactgcc atttgggttg aaactgaaac gcacccggcg
      601 ctacacggtg tccagcaaga gttgcctggt tgcccggatc caactgctta ataacgagtt
      661 tgtggagttc accctgtccg tggagagcac tggccaggaa agcctcgagg ccgtggccca
      721 gaggctggag ctgcgggagg tcacttactt cagcctctgg tactacaaca agcaaaatca
      781 gcgccggtgg gtagatttgg aaaaaccttt gaagaagcag ctggataaat atgcattgga
      841 acctaccgtc tattttggag tggtgtttta tgtgccttca gtttctcagc tgcagcagga
      901 gattaccagg tatcagtatt atctgcaact gaagaaagat atcttggaag gaagtattcc
      961 ttgtacctta gaacaagcaa ttcagctagc aggcttagct gttcaagcgg attttggtga
     1021 ctttgatcag tatgaatccc aggactttct tcagaaattt gccttgtttc ctgtgggatg
     1081 gttacaagat gaaaaagtat tggaagaagc aacccaaaaa gtggccttac tacatcagaa
     1141 atacagaggg ctcacagctc ctgatgctga aatgctgtac atgcaggagg tagagagaat
     1201 ggatggctat ggagaagaga gctaccctgc taaggatagc caaggaagtg acatatccat
     1261 tggagcgtgt cttgaaggta tctttgtgaa acacaagaat ggaaggcatc ctgtggtatt
     1321 taggtggcat gacattgcca acatgtccca caacaagtcc ttttttgcat tagagctggc
     1381 aaataaagag gagaccattc aatttcaaac tgaagacatg gaaacagcaa aatacatttg
     1441 gagactctgt gttgcgcgac acaagtttta cagactaaac cagtgtaacc tgcaaactca
     1501 gactgtcaca gtgaacccaa tcaggaggag gtcttcttca aggatgtctc tgcctaaacc
     1561 ccagccctac gtgatgcctc ccccaccgca gttgcactat aatggacatt atacagaacc
     1621 atatgcttct tcccaagata acctctttgt gcccaaccag aacggatact actgtcactc
     1681 tcagacaagc ttggatagag cccagattga cctcaacggt cggatccgta atggcagtgt
     1741 ctacagtgca cacagcacca actccttaaa taatcctcag ccctacttgc agccctcgcc
     1801 gatgtcgtcc aaccctagca tcaccgggag tgacgtcatg aggcctgact acctcccgtc
     1861 ccatcggcac agcgccgtga tacccccgtc ctaccgcccc accccagact atgagactgt
     1921 gatgaagcag ctcaacaggg gcctggtgca tgcggaacgg cagagccact cgctgcgaaa
     1981 cctcaacatc ggcagctcgt acgcctacag caggcccgcg gcgctggtct acagccagcc
     2041 cgagatccgc gagcacgcac agctcccctc gccagcggcc gcacactgcc cgttcagcct
     2101 gagctacagc ttccacagcc cgtctcccta cccctaccct gccgagcggc ggcccgtggt
     2161 gggcgcggtc agcgtgccgg agctgaccaa tgcgcagctg caggcgcagg actacccgtc
     2221 tcccaacatc atgcggacgc aggtgtaccg gccaccccca ccctacccgc cccccaggcc
     2281 cgccaacagc acgccagacc tgtcccgcca cctttacatc agcagcagca accccgacct
     2341 catcacgcgg cgcgtgcacc actcggtgca aacgttccag gaggacagcc tgcccgtggc
     2401 gcactcgctg caggaggtca gcgagcccct caccgccgcg cgccacgcgc agctgcacaa
     2461 acggaacagc atcgaggtgg ccgggctcag ccacggcctg gagggcctgc ggctcaagga
     2521 gcgcacccta tccgcgtcgg cggcagaggt ggcgccgcga gccgtctcgg tgggctccca
     2581 gcccagcgtt ttcaccgaga ggacacagcg agaagggccg gaggaggcgg agggcttgag
     2641 gtacggccat aagaagtccc tgtcggacgc caccatgcta atccacagca gcgaggagga
     2701 ggaggacgag gacttcgagg aggagagcgg ggcccgggcg cctcctgcac gtgcgcgcga
     2761 gcctcggccc ggcctggccc aggacccacc tggctgccct cgcgtcctgc tcgccgggcc
     2821 cctgcacatc ctggagccca aggcccacgt cccagacgcg gagaagagga tgatggacag
     2881 cagccccgtc cgcacgaccg cagaggccca gcggccctgg agagacgggc tgctgatgcc
     2941 ctccatgtcg gagtccgacc tcaccacgtc aggccgctac cgagcccgga gggactctct
     3001 gaagaaaagg ccggtgtcgg accttctctc tgggaagaag aacatcgtgg aagggctccc
     3061 gcctctaggg ggaatgaaaa agactcgagt agatgcaaaa aaaattggtc ctcttaaact
     3121 ggctgcccta aatggactct ccctatctcg agtgcctctg cctgatgaag gaaaggaagt
     3181 ggctaccaga gcaacgaatg atgaaaggtg taaaattctg gaacaacgat tagaacaagg
     3241 aatggtattc acagaatatg aaagaattct taagaaacgg ctagttgatg gggagtgctc
     3301 aacagcacga ctccctgaaa atgcagaaag aaatcgattc caagatgttc ttccttatga
     3361 tgatgtgaga gtggagttgg tcccaactaa agaaaacaac actggttaca tcaacgcatc
     3421 acatattaag gtctctgtca gtggaatcga atgggattat attgccacac agggaccatt
     3481 acagaatacc tgtcaagatt tttggcagat ggtatgggaa cagggaattg caattatagc
     3541 aatggtgaca gcagaagagg agggtggaag ggagaagagc tttaggtact ggccacgact
     3601 tggttccagg cacaacactg tcacctatgg aaggtttaag atcacgaccc ggttccgcac
     3661 agactctggc tgctatgcca ccacaggcct gaagatgaag cacctcctta ctgggcaaga
     3721 gaggaccgtc tggcacctcc aatacacaga ctggcctgaa catggctgtc cagaagacct
     3781 caagggattt ttatcatatc ttgaagagat ccagtctgtt cgacgccata caaatagcac
     3841 aagtgatccc caaagcccca accctccgtt gttggtccac tgcagtgctg gggtaggaag
     3901 gactggcgtg gtgattttgt cggagatcat gatcgcctgc ctggaacaca atgaggtgct
     3961 ggacatcccg agagtgctgg acatgctgag gcaacagaga atgatgctgg tgcagactct
     4021 ctgccagtac acatttgtgt acagagtcct catccagttc ctgaaaagct ccaggctcat
     4081 ctaagctccc acaatttctt acggggccag tcatgtgaag cgtttacagc ttaaaaaaaa
     4141 agcgcttgcc taactcatac tttcccgttg acacttgatc cacgcagcgt ggcactggga
     4201 cgtaagtggc gcagtctgaa tggcggcacg ctgaaggaaa cgtgcgaagc acaggctgaa
     4261 gaggggtttc taacctggga aaggtgctca aggaggactt ggtttcaagg gccttgccct
     4321 gccccggtct gtccggtttg cagtacttgc acacattttg gagattgtat tttctagaca
     4381 attctctatt ttactgaagc tatgctgggc aattctggca atcattaaag tgcatagatt
     4441 tctatcttaa actaattttt gataatggag tttttatttt atgacaaata tttagggatt
     4501 tttctagtga gaaacaactt tgtgtaagga tgatccacag atatgagttg ctcctatata
     4561 actttgtatt taaaaatcat gttattatct tttgttattt tttaaaaacc ttgggtactt
     4621 aataatggtt tagttgccaa actgaaaact atactgagaa tctgtgttat tttgaaacat
     4681 caaaaggatt tttctatcca gaacattttt tatcctaaaa attctatata gttgtacctt
     4741 ctgtttttca aatgagagct caattcattt agatactgaa atgagtcagt taatgtaaag
     4801 ttgaggatga aggcacatta tttaaaatgt aagagaataa gcattatttt ttcagtatta
     4861 ttcatagatc taaatgaatt tgattttatt ggttgaaaat gaagtgaaaa acaattgcct
     4921 agggtggttt taagcacttt tttgttaaaa acaaatctga gttttaatat atgtgttgct
     4981 ttgtagatga cacaataaca atgggcgctg agaagcgttt tgggagagat taaggactaa
     5041 gagtatgtaa gatgactagg acaagagtag gtggagtgtg atggtaaatg caggatgcct
     5101 tcgtctttac aaaaatgcag tattatctat actcagactg aggtgctggg atggcgagca
     5161 ggggacccca cagcactgtc cccagggaat tcaagtcctg tgaccgccag tgacttactc
     5221 cgtttccttg gggcttttcc cacctcaacc tgtattgttt ctttttcata aataaattca
     5281 gcattatagt atcattaaaa gaagccttaa agaggcgtat ttttcctttt ggttgaagga
     5341 agggaatagt taataatagt tttcacctct tctcccaaaa agtacagtcc aaatttgtgc
     5401 acagagattg ctgtggtatt caagaggtac ttgcatttta gctccttaat aattccctgg
     5461 ccagtgttag ctgtttagtg ccccctcacc catcccattt aggcacatcc caatagacag
     5521 agccaggctg agttacaggg ggagagtgtc atctctggcc ccgattaaga tggccttgtc
     5581 acagtgaccg ctgagtaggc atggatgagt gggatattta gctgaggaac cctttccctt
     5641 ttccttcttt ttggggtctc ttcttacagt gaacttccaa aatgtcaaat ctagggctgt
     5701 ttcccaaatt acactattct aggcatcatt ttgattccca tgtcactcct taactcactt
     5761 ccttgagcac tacatgtatg ttgtcagcca cgagacagga cttcctaaat agtgtgtgca
     5821 ccagcctaac tctgccttac ccagaaacca accacctaag aggaaaactc agaagatatt
     5881 aatgaaaact aattgaaagt acgcacactt ctcatgtagg aacaaaatta aaattttaca
     5941 tttttatttt acaaaattaa aaaattacat tttgtaggaa caaaatgtaa attttgtaaa
     6001 tacaaaattc tttttaaagt cctgtttaaa gaacagtaga actaagtgaa aatattcaga
     6061 acgagctcct tagaagaaag gaataagaac tttttactgg aactattttc catctctaga
     6121 aaaagtgctt cttcccctcc ccctccctct ccatggtacg tttttgtgaa aatgcttttc
     6181 tgtcaggttt aaacaaacag tttgacatag ctcgttgaca agaacatatt gtaaaacaaa
     6241 tctaattaaa gagtaatatg tggtctattt gtgttcctgt tgtaataatt tgataagtaa
     6301 acttctgagg gcaaaattac tgtttaatat tactcttaaa atgttgcatg tttggcgtca
     6361 ttcctaagag ccatgtaatt ttaaactttt aattgcagtt agtgaatatg aaaggatttc
     6421 tgaataaaaa tctatccaca tta
//
