LOCUS       NM_001352531            2247 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 20
            (PTPN20), transcript variant 31, mRNA.
ACCESSION   NM_001352531 XM_017016060
VERSION     NM_001352531.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Ma,L., Liu,Y., Wang,Y., Yang,J., Lu,J., Feng,H., Ye,S. and Liu,Y.
  TITLE     Identification of PTPN20 as an innate immunity-related gene in
            gastric cancer with Helicobacter pylori infection
  JOURNAL   Front Immunol 14, 1212692 (2023)
   PUBMED   37359510
  REMARK    GeneRIF: Identification of PTPN20 as an innate immunity-related
            gene in gastric cancer with Helicobacter pylori infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2247)
  AUTHORS   van Eekelen,M., Runtuwene,V., Masselink,W. and den Hertog,J.
  TITLE     Pair-wise regulation of convergence and extension cell movements by
            four phosphatases via RhoA
  JOURNAL   PLoS One 7 (4), e35913 (2012)
   PUBMED   22545146
REFERENCE   3  (bases 1 to 2247)
  AUTHORS   Fodero-Tavoletti,M.T., Hardy,M.P., Cornell,B., Katsis,F.,
            Sadek,C.M., Mitchell,C.A., Kemp,B.E. and Tiganis,T.
  TITLE     Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin
            polymerization
  JOURNAL   Biochem J 389 (Pt 2), 343-354 (2005)
   PUBMED   15790311
  REMARK    GeneRIF: identification of hPTPN20a as a novel and widely expressed
            phosphatase with a dynamic subcellular distribution that is
            targeted to sites of actin polymerization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX005072.20 and AL358791.24.
            
            On Aug 14, 2020 this sequence version replaced NM_001352531.1.
            
            Summary: The product of this gene belongs to the family of
            classical tyrosine-specific protein tyrosine phosphatases. Many
            protein tyrosine phosphatases have been shown to regulate
            fundamental cellular processes. The encoded protein appears to be
            targeted to sites of actin polymerization. A pseudogene of this
            gene has been defined on chromosome 10. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.529283.1,
                                           SRR1660803.73748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BX005072.20        39077-39150         c
            75-231              BX005072.20        18045-18201         c
            232-326             BX005072.20        9861-9955           c
            327-424             BX005072.20        6563-6660           c
            425-537             BX005072.20        3903-4015           c
            538-600             AL358791.24        145993-146055       c
            601-2247            AL358791.24        143645-145291       c
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2247
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="protein tyrosine phosphatase non-receptor type 20"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
     exon            1..74
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            75..231
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..635
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /EC_number="3.1.3.48"
                     /note="isoform 31 is encoded by transcript variant 31;
                     protein tyrosine phosphatase, non-receptor type 20A;
                     tyrosine-protein phosphatase non-receptor type 20; protein
                     tyrosine phosphatase, non-receptor type 20B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     20 isoform 31"
                     /protein_id="NP_001339460.1"
                     /db_xref="CCDS:CCDS86087.1"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
                     /translation="MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKV
                     FENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAA
                     GPSQALSPLLSVQHHGYSGPNERTTFWHGSNEGAVSLLLRYCA"
     exon            232..326
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            327..424
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            425..537
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            538..600
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            601..2247
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="major polyA site"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      2247
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
ORIGIN      
        1 aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg
       61 ccccgcaggc ccaggtgaac aaaaattgtt tgctggcccc caggatacta actagacctt
      121 tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt
      181 taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct gtaaacgatt
      241 atgagggaaa tgactctgaa gcagaagact tgaatttcag ggagactttg ccttcatcaa
      301 gtcaggaaaa cacacctaga tcaaaggttt ttgaaaataa agttaattca gagaaggtaa
      361 aactttctct tcggaatttc ccacataatg attatgagga tgtttttgaa gagccttcag
      421 aaagtggcag tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga
      481 gcagtgagga tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgttc
      541 aacatcatgg atatagtggc ccaaatgaga gaacaacgtt ctggcatggt tcaaacgaag
      601 gagcagtatc acttttgtta cgatattgtg cttgaagttc ttcggaaact tctgactttg
      661 gattaagaaa gacttctgtt gcctctcact tgaaattacc aagtgggttt gcacctcctc
      721 ataaagaaca tgtttgcact gtgctgaagg gctttgctat gcatacaatc tgctttcttg
      781 gtttatcagt ttattttctt tctaaaagct ccctgaaggg caatatcatt tggcttgggg
      841 tgatcagtgt ttacttattg atcttgctag acaatatcaa aataacttcc cacattttcc
      901 agtgaaacag atgttacata aaacgattgc agcttggcta tttggttgaa gggattacag
      961 agcccaataa aggatttaaa atatattcat taagatttta tttggaaagg tggctggaga
     1021 gagctgagga tttccaggac tttgtaagtt cttattctgg gagaacataa ggccaataat
     1081 catgacctct tccaggcatt tttaagacag atgtctattc atgttcttta gctagagcct
     1141 gtactttttg ctggcatttg aataacccag tttaaaaaga gtccagttag ggtggactaa
     1201 ctttggacac aaattggctt ccatttccta cattttcata ctgctgcctt cctacagctg
     1261 ctagaccaag acctgttggt ctgggaagca tttcatggat agggagagct cctctcggtg
     1321 aacagtccaa aactaaaata gatgtttata tagaaagccc aagaggagac ttttgccatg
     1381 cctgagttct ttcctatccc accctaacac ttaacatatt acttagtctg ctttgttaaa
     1441 agcaagtatt acctttaact tgcctcttac tctttgccct ttagctaact aataaagttt
     1501 gatataggca ttattatata attctgagtc attcatggta tctctcatgt ttgatgtatt
     1561 tttcaaacta agatctatga tagttttttt tccagagttc cattaaatca tttatttcct
     1621 ttactttctc acctctgttg aaacatttag aaactggatt tgggaaccca attttggaaa
     1681 accagattca tagtcatgaa aatggaaact tccatattct gtttttgaaa agatgtggcc
     1741 attattacag taattttatt ataggacttt gcctcgtaca attaatagtg atattttgga
     1801 caaggagttc tggtgacaag ctatacctaa ttataagcta taaaacaata gatatgagtg
     1861 tttgtacagt ttaactcaat ggagatcaga atattctatg tattgagaaa atgtttaata
     1921 tcaatctata aatcttgaat ttctaagagg cttattttgt tcttttggct gaatgagtat
     1981 atttgaattg gttgaataat taataattct cattgtaaaa ataattatat gccaaaaata
     2041 tatttgatgt taaatcaaat agatgattct gtttacattg ttcatatgaa taataatctg
     2101 tgttaatttc attttgataa ttggccttta atatttgtat ctctaatttt attttctctc
     2161 tgttactgta aaataatagc tataatgtat aacaattttc ttcagaagaa ttctatgcta
     2221 ttattaaaat aaaatattta ctgtgta
//
