LOCUS       NM_001352526            2335 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 20
            (PTPN20), transcript variant 26, mRNA.
ACCESSION   NM_001352526
VERSION     NM_001352526.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Ma,L., Liu,Y., Wang,Y., Yang,J., Lu,J., Feng,H., Ye,S. and Liu,Y.
  TITLE     Identification of PTPN20 as an innate immunity-related gene in
            gastric cancer with Helicobacter pylori infection
  JOURNAL   Front Immunol 14, 1212692 (2023)
   PUBMED   37359510
  REMARK    GeneRIF: Identification of PTPN20 as an innate immunity-related
            gene in gastric cancer with Helicobacter pylori infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2335)
  AUTHORS   van Eekelen,M., Runtuwene,V., Masselink,W. and den Hertog,J.
  TITLE     Pair-wise regulation of convergence and extension cell movements by
            four phosphatases via RhoA
  JOURNAL   PLoS One 7 (4), e35913 (2012)
   PUBMED   22545146
REFERENCE   3  (bases 1 to 2335)
  AUTHORS   Fodero-Tavoletti,M.T., Hardy,M.P., Cornell,B., Katsis,F.,
            Sadek,C.M., Mitchell,C.A., Kemp,B.E. and Tiganis,T.
  TITLE     Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin
            polymerization
  JOURNAL   Biochem J 389 (Pt 2), 343-354 (2005)
   PUBMED   15790311
  REMARK    GeneRIF: identification of hPTPN20a as a novel and widely expressed
            phosphatase with a dynamic subcellular distribution that is
            targeted to sites of actin polymerization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX005072.20 and AL358791.24.
            
            On Aug 13, 2020 this sequence version replaced NM_001352526.1.
            
            Summary: The product of this gene belongs to the family of
            classical tyrosine-specific protein tyrosine phosphatases. Many
            protein tyrosine phosphatases have been shown to regulate
            fundamental cellular processes. The encoded protein appears to be
            targeted to sites of actin polymerization. A pseudogene of this
            gene has been defined on chromosome 10. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (26), as well as variants 16, 25,
            and 27-30, encodes isoform 12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.116526.1,
                                           SRR7410570.459145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2162841
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BX005072.20        39077-39150         c
            75-409              AL358791.24        161403-161737       c
            410-625             AL358791.24        158412-158627       c
            626-688             AL358791.24        145993-146055       c
            689-2335            AL358791.24        143645-145291       c
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2335
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="protein tyrosine phosphatase non-receptor type 20"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
     exon            1..74
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            75..409
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..754
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /EC_number="3.1.3.48"
                     /note="isoform 12 is encoded by transcript variant 26;
                     protein tyrosine phosphatase, non-receptor type 20A;
                     tyrosine-protein phosphatase non-receptor type 20; protein
                     tyrosine phosphatase, non-receptor type 20B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     20 isoform 12"
                     /protein_id="NP_001339455.1"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
                     /translation="MVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVF
                     LENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS
                     HLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQ
                     YHFCYDIVLEVLRKLLTLD"
     exon            410..625
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            626..688
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            689..2335
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      1609
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="major polyA site"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      2335
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
ORIGIN      
        1 aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg
       61 ccccgcaggc ccagatgatt caacacgcgt tcctcttgga aaaagcaagg actacatcaa
      121 tgctagttat attagaatag tcaattgtgg agaagagtat ttttatatcg ctactcaagg
      181 accactgctg agcaccatag atgacttttg gcaaatggtg ttggaaaata attcaaatgt
      241 tattgccatg ataaccagag agatagaagg tggaattatc aaatgctacc attactggcc
      301 catttctctg aagaagccat tggaattgaa acacttccgt gtattcctgg agaactacca
      361 gatacttcaa tatttcatca ttcgaatgtt tcaagttgtg gagaagtcca cgggaactag
      421 tcactctgta aaacagttgc agttcaccaa gtggccagac catggcactc ctgcctcagc
      481 agatagcttc ataaaatata ttcgttatgc aaggaagagc caccttacag gacccatggt
      541 tgttcactgc agtgccggca taggccggac aggggtgttc ctatgtgtgg atgtcgtgtt
      601 ctgtgccatc gtaaagaact gttcattcaa catcatggat atagtggccc aaatgagaga
      661 acaacgttct ggcatggttc aaacgaagga gcagtatcac ttttgttacg atattgtgct
      721 tgaagttctt cggaaacttc tgactttgga ttaagaaaga cttctgttgc ctctcacttg
      781 aaattaccaa gtgggtttgc acctcctcat aaagaacatg tttgcactgt gctgaagggc
      841 tttgctatgc atacaatctg ctttcttggt ttatcagttt attttctttc taaaagctcc
      901 ctgaagggca atatcatttg gcttggggtg atcagtgttt acttattgat cttgctagac
      961 aatatcaaaa taacttccca cattttccag tgaaacagat gttacataaa acgattgcag
     1021 cttggctatt tggttgaagg gattacagag cccaataaag gatttaaaat atattcatta
     1081 agattttatt tggaaaggtg gctggagaga gctgaggatt tccaggactt tgtaagttct
     1141 tattctggga gaacataagg ccaataatca tgacctcttc caggcatttt taagacagat
     1201 gtctattcat gttctttagc tagagcctgt actttttgct ggcatttgaa taacccagtt
     1261 taaaaagagt ccagttaggg tggactaact ttggacacaa attggcttcc atttcctaca
     1321 ttttcatact gctgccttcc tacagctgct agaccaagac ctgttggtct gggaagcatt
     1381 tcatggatag ggagagctcc tctcggtgaa cagtccaaaa ctaaaataga tgtttatata
     1441 gaaagcccaa gaggagactt ttgccatgcc tgagttcttt cctatcccac cctaacactt
     1501 aacatattac ttagtctgct ttgttaaaag caagtattac ctttaacttg cctcttactc
     1561 tttgcccttt agctaactaa taaagtttga tataggcatt attatataat tctgagtcat
     1621 tcatggtatc tctcatgttt gatgtatttt tcaaactaag atctatgata gttttttttc
     1681 cagagttcca ttaaatcatt tatttccttt actttctcac ctctgttgaa acatttagaa
     1741 actggatttg ggaacccaat tttggaaaac cagattcata gtcatgaaaa tggaaacttc
     1801 catattctgt ttttgaaaag atgtggccat tattacagta attttattat aggactttgc
     1861 ctcgtacaat taatagtgat attttggaca aggagttctg gtgacaagct atacctaatt
     1921 ataagctata aaacaataga tatgagtgtt tgtacagttt aactcaatgg agatcagaat
     1981 attctatgta ttgagaaaat gtttaatatc aatctataaa tcttgaattt ctaagaggct
     2041 tattttgttc ttttggctga atgagtatat ttgaattggt tgaataatta ataattctca
     2101 ttgtaaaaat aattatatgc caaaaatata tttgatgtta aatcaaatag atgattctgt
     2161 ttacattgtt catatgaata ataatctgtg ttaatttcat tttgataatt ggcctttaat
     2221 atttgtatct ctaattttat tttctctctg ttactgtaaa ataatagcta taatgtataa
     2281 caattttctt cagaagaatt ctatgctatt attaaaataa aatatttact gtgta
//
