LOCUS       NM_001042357            3041 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 20
            (PTPN20), transcript variant 1, mRNA.
ACCESSION   NM_001042357 XM_011539604
VERSION     NM_001042357.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3041)
  AUTHORS   Ma,L., Liu,Y., Wang,Y., Yang,J., Lu,J., Feng,H., Ye,S. and Liu,Y.
  TITLE     Identification of PTPN20 as an innate immunity-related gene in
            gastric cancer with Helicobacter pylori infection
  JOURNAL   Front Immunol 14, 1212692 (2023)
   PUBMED   37359510
  REMARK    GeneRIF: Identification of PTPN20 as an innate immunity-related
            gene in gastric cancer with Helicobacter pylori infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3041)
  AUTHORS   van Eekelen,M., Runtuwene,V., Masselink,W. and den Hertog,J.
  TITLE     Pair-wise regulation of convergence and extension cell movements by
            four phosphatases via RhoA
  JOURNAL   PLoS One 7 (4), e35913 (2012)
   PUBMED   22545146
REFERENCE   3  (bases 1 to 3041)
  AUTHORS   Fodero-Tavoletti,M.T., Hardy,M.P., Cornell,B., Katsis,F.,
            Sadek,C.M., Mitchell,C.A., Kemp,B.E. and Tiganis,T.
  TITLE     Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin
            polymerization
  JOURNAL   Biochem J 389 (Pt 2), 343-354 (2005)
   PUBMED   15790311
  REMARK    GeneRIF: identification of hPTPN20a as a novel and widely expressed
            phosphatase with a dynamic subcellular distribution that is
            targeted to sites of actin polymerization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648913.1, AL050040.1,
            BC036539.2, AY704146.1, BC093750.1 and AL358791.24.
            
            On Aug 13, 2020 this sequence version replaced NM_001042357.4.
            
            Summary: The product of this gene belongs to the family of
            classical tyrosine-specific protein tyrosine phosphatases. Many
            protein tyrosine phosphatases have been shown to regulate
            fundamental cellular processes. The encoded protein appears to be
            targeted to sites of actin polymerization. A pseudogene of this
            gene has been defined on chromosome 10. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.459898.1,
                                           SRR1803614.244317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374339.5/ ENSP00000363459.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX648913.1         34-43
            11-74               AL050040.1         1-64
            75-120              BC036539.2         64-109
            121-176             AY704146.1         1-56
            177-757             BC093750.1         63-643
            758-780             AL358791.24        177920-177942       c
            781-1508            AY704146.1         661-1388
            1509-3039           BC036539.2         948-2478
            3040-3041           AL358791.24        143645-143646       c
FEATURES             Location/Qualifiers
     source          1..3041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..3041
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="protein tyrosine phosphatase non-receptor type 20"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
     exon            1..74
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            75..231
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1460
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase, non-receptor type 20A;
                     tyrosine-protein phosphatase non-receptor type 20; protein
                     tyrosine phosphatase, non-receptor type 20B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     20 isoform 1"
                     /protein_id="NP_001035816.1"
                     /db_xref="CCDS:CCDS73110.1"
                     /db_xref="GeneID:26095"
                     /db_xref="HGNC:HGNC:23423"
                     /db_xref="MIM:610630"
                     /translation="MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKV
                     FENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAA
                     GPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIM
                     QEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVN
                     CGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKP
                     LELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFI
                     KYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQR
                     SGMVQTKEQYHFCYDIVLEVLRKLLTLD"
     exon            232..326
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            327..424
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            425..537
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            538..689
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            690..780
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1115
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1331
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1394
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..3041
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="major polyA site"
     regulatory      3022..3027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
                     /note="hexamer: AATAAA"
     polyA_site      3041
                     /gene="PTPN20"
                     /gene_synonym="bA142I17.1; bA42B19.1; CT126; PTPN20A;
                     PTPN20B"
ORIGIN      
        1 aggctaggcg tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg
       61 ccccgcaggc ccaggtgaac aaaaattgtt tgctggcccc caggatacta actagacctt
      121 tggcctgact cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt
      181 taggggatgg gaacaacatg tcttcaccta gggactttag agcagagcct gtaaacgatt
      241 atgagggaaa tgactctgaa gcagaagact tgaatttcag ggagactttg ccttcatcaa
      301 gtcaggaaaa cacacctaga tcaaaggttt ttgaaaataa agttaattca gagaaggtaa
      361 aactttctct tcggaatttc ccacataatg attatgagga tgtttttgaa gagccttcag
      421 aaagtggcag tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga
      481 gcagtgagga tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgata
      541 cgcgcaaaat tgtttctgaa ggagaactag atcagttggc tcagattcgg ccattaatat
      601 tcaattttca tgagcagaca gccatcaagg attgtttgaa aatccttgag gaaaaaacag
      661 cagcgtatga tatcatgcag gaatttatgg ctttagaact taagaatctg cctggtgagt
      721 tcaactctgg gaatcaacca agcaacagag aaaaaaatag ataccgagat attcttccat
      781 atgattcaac acgcgttcct cttggaaaaa gcaaggacta catcaatgct agttatatta
      841 gaatagtcaa ttgtggagaa gagtattttt atatcgctac tcaaggacca ctgctgagca
      901 ccatagatga cttttggcaa atggtgttgg aaaataattc aaatgttatt gccatgataa
      961 ccagagagat agaaggtgga attatcaaat gctaccatta ctggcccatt tctctgaaga
     1021 agccattgga attgaaacac ttccgtgtat tcctggagaa ctaccagata cttcaatatt
     1081 tcatcattcg aatgtttcaa gttgtggaga agtccacggg aactagtcac tctgtaaaac
     1141 agttgcagtt caccaagtgg ccagaccatg gcactcctgc ctcagcagat agcttcataa
     1201 aatatattcg ttatgcaagg aagagccacc ttacaggacc catggttgtt cactgcagtg
     1261 ccggcatagg ccggacaggg gtgttcctat gtgtggatgt cgtgttctgt gccatcgtaa
     1321 agaactgttc attcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca
     1381 tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga
     1441 aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg
     1501 gtttgcacct cctcataaag aacatgtttg cactgtgctg aagggctttg ctatgcatac
     1561 aatctgcttt cttggtttat cagtttattt tctttctaaa agctccctga agggcaatat
     1621 catttggctt ggggtgatca gtgtttactt attgatcttg ctagacaata tcaaaataac
     1681 ttcccacatt ttccagtgaa acagatgtta cataaaacga ttgcagcttg gctatttggt
     1741 tgaagggatt acagagccca ataaaggatt taaaatatat tcattaagat tttatttgga
     1801 aaggtggctg gagagagctg aggatttcca ggactttgta agttcttatt ctgggagaac
     1861 ataaggccaa taatcatgac ctcttccagg catttttaag acagatgtct attcatgttc
     1921 tttagctaga gcctgtactt tttgctggca tttgaataac ccagtttaaa aagagtccag
     1981 ttagggtgga ctaactttgg acacaaattg gcttccattt cctacatttt catactgctg
     2041 ccttcctaca gctgctagac caagacctgt tggtctggga agcatttcat ggatagggag
     2101 agctcctctc ggtgaacagt ccaaaactaa aatagatgtt tatatagaaa gcccaagagg
     2161 agacttttgc catgcctgag ttctttccta tcccacccta acacttaaca tattacttag
     2221 tctgctttgt taaaagcaag tattaccttt aacttgcctc ttactctttg ccctttagct
     2281 aactaataaa gtttgatata ggcattatta tataattctg agtcattcat ggtatctctc
     2341 atgtttgatg tatttttcaa actaagatct atgatagttt tttttccaga gttccattaa
     2401 atcatttatt tcctttactt tctcacctct gttgaaacat ttagaaactg gatttgggaa
     2461 cccaattttg gaaaaccaga ttcatagtca tgaaaatgga aacttccata ttctgttttt
     2521 gaaaagatgt ggccattatt acagtaattt tattatagga ctttgcctcg tacaattaat
     2581 agtgatattt tggacaagga gttctggtga caagctatac ctaattataa gctataaaac
     2641 aatagatatg agtgtttgta cagtttaact caatggagat cagaatattc tatgtattga
     2701 gaaaatgttt aatatcaatc tataaatctt gaatttctaa gaggcttatt ttgttctttt
     2761 ggctgaatga gtatatttga attggttgaa taattaataa ttctcattgt aaaaataatt
     2821 atatgccaaa aatatatttg atgttaaatc aaatagatga ttctgtttac attgttcata
     2881 tgaataataa tctgtgttaa tttcattttg ataattggcc tttaatattt gtatctctaa
     2941 ttttattttc tctctgttac tgtaaaataa tagctataat gtataacaat tttcttcaga
     3001 agaattctat gctattatta aaataaaata tttactgtgt a
//
